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VMPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALMAVIEEVTAAYEKERVNQDFLDLLDKLQA NYAGRPSPLYEATRLSEYAGSVRIFLKREDLNHTGSHKINNVLGQTLLAQRMGKTRVIAETGAGQHGVAT ATACALFGLDCVIYMGALDTARQALNVARMRLLGAEVVSVETGSRTLKDAINDAFRDWVTNADNTYYCFG TASGPHPFPTMVRDLQRVIGLETRRQIQYQAGRLPDAVTACIGGGSNAIGIFHAFLDDPGVRLVGFEAAG DGVETGRHAATLTGGLPGAFQGTFSYLLQDEDGQTIESHSIAAGLDYPGVGPEHAWLRETGRAEYQPITD SEAIEAFRLLCRTEGILPALESAHAVAGALKLASEIGKGAVIVVNLSGRGDKDIEAAAKWFGLLGTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01272 | trpB | - | 100% (417) | tryptophan synthase subunit beta |
| M. leprae Br4923 | MLBr_01130 | thrC | 2e-10 | 22.86% (350) | threonine synthase |
| M. leprae Br4923 | MLBr_01209 | ilvA | 1e-09 | 24.85% (330) | threonine dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1638 | trpB | 0.0 | 86.73% (407) | tryptophan synthase subunit beta |
| M. gilvum PYR-GCK | Mflv_3599 | - | 0.0 | 79.85% (412) | tryptophan synthase subunit beta |
| M. tuberculosis H37Rv | Rv1612 | trpB | 0.0 | 86.73% (407) | tryptophan synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_2644c | - | 0.0 | 80.05% (406) | tryptophan synthase subunit beta |
| M. marinum M | MMAR_2414 | trpB | 0.0 | 85.68% (412) | tryptophan synthase, beta subunit TrpB |
| M. avium 104 | MAV_3174 | trpB | 0.0 | 84.54% (414) | tryptophan synthase subunit beta |
| M. smegmatis MC2 155 | MSMEG_3220 | trpB | 0.0 | 82.77% (412) | tryptophan synthase subunit beta |
| M. thermoresistible (build 8) | TH_1075 | trpB | 0.0 | 82.61% (414) | Probable tryptophan synthase, beta subunit trpB |
| M. ulcerans Agy99 | MUL_1592 | trpB | 0.0 | 85.19% (412) | tryptophan synthase subunit beta |
| M. vanbaalenii PYR-1 | Mvan_2817 | - | 0.0 | 79.61% (412) | tryptophan synthase subunit beta |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3220|M.smegmatis_MC2_155 ----MAYHAGPDLPRSSAGVAEPTSHDPDARGHFG---PYGGRLVPEALM
TH_1075|M.thermoresistible__bu ----MADLAGPELPRSSAAVAEPTRHDPDDRGHFG---VYGGRLVAEALM
Mflv_3599|M.gilvum_PYR-GCK ----MVDFAGPDLPRASAAVAEPTPHDPDARGHFG---AYGGRLVPEALM
Mvan_2817|M.vanbaalenii_PYR-1 ----MVDFAGPDLPRASAAVAEPTTHDPDARGHFG---VYGGRYVPEALM
MAB_2644c|M.abscessus_ATCC_199 -------MKNTGLPQMSTAIAEPTAHDPDARGHFG---PYGGRYVAEALM
MAV_3174|M.avium_104 MTVDISPRTRPDLPLPSAAIAEPTRHEPDAGGHFG---VYGGRYVAEALM
Mb1638|M.bovis_AF2122/97 ---------------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALM
Rv1612|M.tuberculosis_H37Rv ---------------MSAAIAEPTSHDPDSGGHFGGPSGWGGRYVPEALM
MMAR_2414|M.marinum_M ----MADLSRPDLPRTSSAIAERTSHDPDSGGHFG---AYGGRYVPEALM
MUL_1592|M.ulcerans_Agy99 ----MADLSRPDLPRTSSAIAERTSHDPDSGGHFG---AYGGRYVPEALM
MLBr_01272|M.leprae_Br4923 --------MMPNLSCFSVAISEPTCHDPDSGGHFGGPDGYGGRYVPEALM
* .::* * *:** **** :*** *.****
MSMEG_3220|M.smegmatis_MC2_155 AVIEEVTAAYEKCRGDQTFLDELDRLQRHYSGRPSPLYEATRLSEHAGGA
TH_1075|M.thermoresistible__bu AVIEEVTAAYEKARGDQTFLDELDRLQRHYTGRPSPLYEAVRLSEHAG-V
Mflv_3599|M.gilvum_PYR-GCK AVIEEVTAAYEKARSDQTFLDELDRLQRHYTGRPSPLYEAERLSEHAGGA
Mvan_2817|M.vanbaalenii_PYR-1 AVIEEVTAAYEKARGDQTFLDELDRLQKHYTGRPSPVFEAERLSEHAGGA
MAB_2644c|M.abscessus_ATCC_199 AVIEEVTAAYEKIRSDRSFLDELDRLQTHYVGRPSPLYEAERLSAHAGGA
MAV_3174|M.avium_104 AVIEEVTTAYEKERVNQDFLDTLDYLQANYAGRPSPLYEAPRLSEQAG-A
Mb1638|M.bovis_AF2122/97 AVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSA
Rv1612|M.tuberculosis_H37Rv AVIEEVTAAYQKERVSQDFLDDLDRLQANYAGRPSPLYEATRLSQHAGSA
MMAR_2414|M.marinum_M AVIEEVTVAYEKERVNQDFLDTLDRLQTHYAGRPSPLYEATRLSEHAGSA
MUL_1592|M.ulcerans_Agy99 AVIEEVAVAYEKERVNQDFLDTLDRLQTHYAGRPSPLYEATRLSAHAGSA
MLBr_01272|M.leprae_Br4923 AVIEEVTAAYEKERVNQDFLDLLDKLQANYAGRPSPLYEATRLSEYAGSV
******:.**:* * .: *** ** ** :* *****::** *** ** .
MSMEG_3220|M.smegmatis_MC2_155 RIFLKREDLNHTGSHKINNVLGQALLARQMGKTRVIAETGAGQHGVATAT
TH_1075|M.thermoresistible__bu RIFLKREDLSHTGSHKINNVLGQALLAKQMGKTRVIAETGAGQHGVATAT
Mflv_3599|M.gilvum_PYR-GCK RIFLKREDLNHTGSHKINNVLGQALLAKQMGKTRVIAETGAGQHGVATAT
Mvan_2817|M.vanbaalenii_PYR-1 RIFLKREDLNHTGSHKINNVLGQALLAKQMGKTRVIAETGAGQHGVATAT
MAB_2644c|M.abscessus_ATCC_199 RIFLKREDLNHTGSHKINNVLGQVLLAKKMGKTRVIAETGAGQHGVATAT
MAV_3174|M.avium_104 RIFLKREDLNHTGSHKINNVLGQALLAQRMGKKRVIAETGAGQHGVATAT
Mb1638|M.bovis_AF2122/97 RIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATAT
Rv1612|M.tuberculosis_H37Rv RIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATAT
MMAR_2414|M.marinum_M RIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATAT
MUL_1592|M.ulcerans_Agy99 RIFLKREDLNHTGSHKINNVLGQALLARRMGKTRVIAETGAGQHGVATAT
MLBr_01272|M.leprae_Br4923 RIFLKREDLNHTGSHKINNVLGQTLLAQRMGKTRVIAETGAGQHGVATAT
*********.*************.***::***.*****************
MSMEG_3220|M.smegmatis_MC2_155 ACALLGLECVIYMGAVDTARQALNVARMRLLGATVVSVEAGSKTLKDAIN
TH_1075|M.thermoresistible__bu ACALLGLECVIYMGAVDTARQALNVARMRLLGAEVVSVEAGSKTLKDAIN
Mflv_3599|M.gilvum_PYR-GCK ACALLGLECVIYMGAVDTARQALNVARMRLLGASVVSVESGSKTLKDAIN
Mvan_2817|M.vanbaalenii_PYR-1 ACALMGLECVIYMGAVDTARQALNVARMRLLGASVVAVESGSKTLKDAIN
MAB_2644c|M.abscessus_ATCC_199 ACALLGLECVIYMGAVDTARQALNVARMRLLGSTVVSVESGSKTLKDAIN
MAV_3174|M.avium_104 ACALLGLECVIYMGAVDTERQALNVARMRLLGATVVSVQSGSKTLKDAIN
Mb1638|M.bovis_AF2122/97 ACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAIN
Rv1612|M.tuberculosis_H37Rv ACALLGLDCVIYMGGIDTARQALNVARMRLLGAEVVAVQTGSKTLKDAIN
MMAR_2414|M.marinum_M ACALLGLECVIYMGAVDTARQALNVARMRLLGAEVVAVETGSKTLKDAIN
MUL_1592|M.ulcerans_Agy99 ACALLGLECVIYMGAVDTARQALNVARMRLLGAEVVAVETGSKTLKDAIN
MLBr_01272|M.leprae_Br4923 ACALFGLDCVIYMGALDTARQALNVARMRLLGAEVVSVETGSRTLKDAIN
****:**:******.:** *************: **:*::**:*******
MSMEG_3220|M.smegmatis_MC2_155 EAFRDWVTNADETYYCFGTAAGPHPFPLMVRDFQRIIGLEARVQVQDQAG
TH_1075|M.thermoresistible__bu EAFRDWVTNADSTYYCFGTAAGPHPFPMMVRDFQRVIGLETRAQIQAQAG
Mflv_3599|M.gilvum_PYR-GCK ETFRDWVADADNTYYCFGTAAGPHPFPMMVRDFQRVIGMEARAQMLDQAG
Mvan_2817|M.vanbaalenii_PYR-1 ETFRDWVTNADNTYYCFGTAAGPHPFPMMVRDFQRVIGLEARAQMLDQAG
MAB_2644c|M.abscessus_ATCC_199 DAMRDWVTNAHNTYYCFGTAAGPHPFPVMVRDFQRIIGMEARAQVLDQVG
MAV_3174|M.avium_104 EAFRDWVTNADNTFYCFGTAAGPHPFPAMVRDFQRIIGLEARAQIQAQAG
Mb1638|M.bovis_AF2122/97 EAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAG
Rv1612|M.tuberculosis_H37Rv EAFRDWVANADNTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAG
MMAR_2414|M.marinum_M EAFRDWVTNADRTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAG
MUL_1592|M.ulcerans_Agy99 EAFRDWVTNADRTYYCFGTAAGPHPFPTMVRDFQRIIGMEARVQIQGQAG
MLBr_01272|M.leprae_Br4923 DAFRDWVTNADNTYYCFGTASGPHPFPTMVRDLQRVIGLETRRQIQYQAG
:::****::*. *:******:****** ****:**:**:*:* *: *.*
MSMEG_3220|M.smegmatis_MC2_155 RLPDAVTACVGGGSNAIGIFHAFIDDPGVRLIGFEAAGDGVETGRHAATF
TH_1075|M.thermoresistible__bu RLPDAVTACIGGGSNAIGIFHAFIDDPGVRLIGFEAAGDGVETGRHAATF
Mflv_3599|M.gilvum_PYR-GCK RLPDAVVACVGGGSNAIGIFHAFIDDPGVDLIGYEAAGDGVETGRHAATF
Mvan_2817|M.vanbaalenii_PYR-1 RLPDAVVACVGGGSNAIGIFHAFIDDPGVQLVGYEAAGEGVETGRHAATF
MAB_2644c|M.abscessus_ATCC_199 RLPDAAVACVGGGSNAIGLFHAFIDDPAVRLVGYEAAGDGVETGRHAATF
MAV_3174|M.avium_104 RLPDAVVACIGGGSNAIGIFHPFIDDPGVRLVGFEAAGDGVETGRHAATF
Mb1638|M.bovis_AF2122/97 RLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATF
Rv1612|M.tuberculosis_H37Rv RLPDAVVACVGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATF
MMAR_2414|M.marinum_M KLPDAVVACVGGGSNAIGIFHAFLDDPDVRLVGFEAAGDGVETGRHAATF
MUL_1592|M.ulcerans_Agy99 KLPDAVVACVGGGSNAIGIFHAFLDDPDVRLVGFEAAGDGVETGRHAATF
MLBr_01272|M.leprae_Br4923 RLPDAVTACIGGGSNAIGIFHAFLDDPGVRLVGFEAAGDGVETGRHAATL
:****..**:********:**.*:*** * *:*:****:**********:
MSMEG_3220|M.smegmatis_MC2_155 TGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHALLKDIGR
TH_1075|M.thermoresistible__bu TGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAHLKDVGR
Mflv_3599|M.gilvum_PYR-GCK TGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHALLKDVGR
Mvan_2817|M.vanbaalenii_PYR-1 TGGSPGAFQGSYSYLLQDEDGQTIESHSISAGLDYPGVGPEHALLKDVGR
MAB_2644c|M.abscessus_ATCC_199 TGGTPGAFQGSYSYLLQDDDGQTIESHSISAGLDYPGVGPEHAWLRESGR
MAV_3174|M.avium_104 SGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAYLRETGR
Mb1638|M.bovis_AF2122/97 TAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGR
Rv1612|M.tuberculosis_H37Rv TAGSPGAFHGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKEAGR
MMAR_2414|M.marinum_M AGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKDIGR
MUL_1592|M.ulcerans_Agy99 AGGSPGAFQGSFSYLLQDEDGQTIESHSISAGLDYPGVGPEHAWLKDIGR
MLBr_01272|M.leprae_Br4923 TGGLPGAFQGTFSYLLQDEDGQTIESHSIAAGLDYPGVGPEHAWLRETGR
:.* ****:*::******:**********:************* *:: **
MSMEG_3220|M.smegmatis_MC2_155 AEYRPITDTEAMDAFRLLCRTEGIIPAIESAHAVAGALKLGPELGAGSVI
TH_1075|M.thermoresistible__bu AEYRPITDAEAMDAFALLCRTEGIIPAIESAHAVAGALKLGPELGSDAIV
Mflv_3599|M.gilvum_PYR-GCK ARYLPITDSEAMDALSLLSRTEGIIPAIESAHAIAGALKLGVERGPGTVI
Mvan_2817|M.vanbaalenii_PYR-1 AQYRPITDTEAMDALSLLSRTEGIIPAIESAHAVAGALKLGGELGPGSII
MAB_2644c|M.abscessus_ATCC_199 ADYRPITDGEAMDAFLLLSRAEGIIPAIESAHAVAGALKLGGELSEGAVI
MAV_3174|M.avium_104 AEYRPITDAEAMDAFRVLCRTEGIIPAIESAHAVAGALKLGPELGRGAII
Mb1638|M.bovis_AF2122/97 VDYRPITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVI
Rv1612|M.tuberculosis_H37Rv VDYRPITDSEAMDAFGLLCRMEGIIPAIESAHAVAGALKLGVELGRGAVI
MMAR_2414|M.marinum_M VTYQPITDSEAMEAFGLLCRMEGIIPAIESAHAVAGALKLGRELGKGAVI
MUL_1592|M.ulcerans_Agy99 VTYQPITDSEAMEAFGLLCRMEGIIPAIESAHAVAGALKLGRELGKGAVI
MLBr_01272|M.leprae_Br4923 AEYQPITDSEAIEAFRLLCRTEGILPALESAHAVAGALKLASEIGKGAVI
. * **** **::*: :*.* ***:**:*****:******. * . .:::
MSMEG_3220|M.smegmatis_MC2_155 VVNLSGRGDKDVETAAKWFGLLDEGQGEGEAR
TH_1075|M.thermoresistible__bu VVNLSGRGDKDVETAAKWFDLLDTG-GAG---
Mflv_3599|M.gilvum_PYR-GCK LVNLSGRGDKDVETAAKWFGLMEDGAR-----
Mvan_2817|M.vanbaalenii_PYR-1 LVNVSGRGDKDVETAAKWFGLLEDGTK-----
MAB_2644c|M.abscessus_ATCC_199 VVSLSGRGDKDVETAAKWFDLLEKDGSQS---
MAV_3174|M.avium_104 VVNLSGRGDKDVETAAKWFGLLGSSDR-----
Mb1638|M.bovis_AF2122/97 VVNLSGRGDKDVETAAKWFGLLGND-------
Rv1612|M.tuberculosis_H37Rv VVNLSGRGDKDVETAAKWFGLLGND-------
MMAR_2414|M.marinum_M VVNLSGRGDKDVETAAKWFGLLTPGGSANKSV
MUL_1592|M.ulcerans_Agy99 VVNLSGRGDKDVETAAKWFGLLTPGGSANKSV
MLBr_01272|M.leprae_Br4923 VVNLSGRGDKDIEAAAKWFGLLGTR-------
:*.:*******:*:*****.*: