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LSERAITKLLVANRGEIAIRAFRAAYELGISTVAVFAYEDRNSPHRLKADEAYQIGETGHPVRAYLSVDE IIRVAKHSGADAIYPGYGFLSENPELAAACHQAGIVFVGPRAHVLELTGNKFKAITAAREAGLPVLASSA PSANVAELVSAAEAMDFPLFVKAVSGGGGRGMRRVTEPAALAESIEAASREAESAFGDPMVYLEQAVLNP RHIEVQVLADRTGEIIHLFERDCSMQRRHQKVIELAPAPNLSDTQRQRICADAVSFARQIDYFCAGTVEF LLDERGHHVFIECNPRIQVEHTVTEEITDVDLVASQLRLASGETLGDLGLSQDAVRIRGTAMQCRITTED PANGFRPDTGRVTAYRSPGGAGVRLDGGTHTGAEISAHFDSMLVKLTCRGQDFTGSAARARRALAEFRIR GVATNIGFLLAVLDDPDFRAGRVTTSFIDERPHLLAAHTPADRGSRILNYLADVTVNKPHGERPSAVYPH DKLPAIDLSEPPPPGTRQRLESLGPQGFSDWLRDSPAVGVTDTTFRDAHQSLLATRVRTSGLVTVAPYIA RMMPELLSIECWGGATYDVALRFLKEDPWERLAVLREAAPNICLQMLLRGRNTVGYTPYPESVTDAFVAE ATATGIDIFRIFDALNNVESMRPAIDAVRATGTAVAEVAMSYTSDLSDPAENLYTLDYYLKLAEQIVEAG AHVLAIKDMAGLLRPPAAATLVSALRSRFDLPVHVHTHDTPGGQLATYLAAWQAGASAVDGAAAPLAGTT SQPALSSIVAATAHTEYDTGLPLQAVCDLEPYWEALRKVYAPFESGLPAPTGRVYHHEIPGGQLSNLRQQ AIALGLGDRFEEIEASYAAADRVLGRLVKVTPSSKVVGDLALALVGAGVSAEELGADPARYNIPDSVIGF LRGELGDPPGGWPEPLRSKALAGRPPAKPQVELGAEDEAVLAQAGPKRQAALNRLLFPSPTKEFEQHREA YGDTSQLSANQFFYGLRSGEEHRVQLERGVELLIGLEAISEPDERGMRTVMCILNGQLRPVLVRDRSIAS DIPAAEKADRSNPDHIAAPFAGVVTVNVEPGDDVTAGQTVATIEAMKMEAAITAPKRGVVDRLAVSGTTQ VESGDLLLVIR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6648 | pyc | - | 100% (1131) | pyruvate carboxylase |
| M. smegmatis MC2 155 | MSMEG_2412 | pyc | 0.0 | 84.27% (1125) | pyruvate carboxylase |
| M. smegmatis MC2 155 | MSMEG_4716 | - | e-101 | 44.52% (465) | acetyl-/propionyl-coenzyme A carboxylase alpha chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2991c | pca | 0.0 | 80.52% (1124) | pyruvate carboxylase |
| M. gilvum PYR-GCK | Mflv_4198 | - | 0.0 | 83.24% (1128) | pyruvate carboxylase |
| M. tuberculosis H37Rv | Rv2967c | pca | 0.0 | 80.52% (1124) | pyruvate carboxylase |
| M. leprae Br4923 | MLBr_00726 | bccA | 9e-91 | 43.88% (433) | acetyl/propionyl CoA carboxylase alpha subunit |
| M. abscessus ATCC 19977 | MAB_3267c | - | 0.0 | 80.07% (1124) | pyruvate carboxylase |
| M. marinum M | MMAR_1749 | pca | 0.0 | 80.69% (1129) | pyruvate carboxylase Pca |
| M. avium 104 | MAV_0342 | pyc | 0.0 | 82.13% (1125) | pyruvate carboxylase |
| M. thermoresistible (build 8) | TH_1229 | pyc | 0.0 | 83.20% (1125) | pyruvate carboxylase |
| M. ulcerans Agy99 | MUL_1992 | pca | 0.0 | 80.43% (1129) | pyruvate carboxylase |
| M. vanbaalenii PYR-1 | Mvan_2165 | - | 0.0 | 83.69% (1128) | pyruvate carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2991c|M.bovis_AF2122/97 -------MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRL
Rv2967c|M.tuberculosis_H37Rv -------MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRL
MMAR_1749|M.marinum_M -------MISKVLVANRGEIAIRAFRAAYELGVGTVAVYAYEDRNSLHRS
MUL_1992|M.ulcerans_Agy99 -------MISKVLVANRGEIAIRAFRAAYELGVGTVAVYAYEDRNSLHRT
MAV_0342|M.avium_104 -------MLAKVLVANRGEIAIRAFRAAYELEMATVAVYPYEDRNSVHRL
MAB_3267c|M.abscessus_ATCC_199 -------MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRL
Mflv_4198|M.gilvum_PYR-GCK ----MAGQITKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRL
Mvan_2165|M.vanbaalenii_PYR-1 ----MAGQISKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRL
TH_1229|M.thermoresistible__bu -------VISKVLVANRGEIAIRAFRAAYELGIATVAVYPYEDRNSLHRL
MSMEG_6648|M.smegmatis_MC2_155 ---MSERAITKLLVANRGEIAIRAFRAAYELGISTVAVFAYEDRNSPHRL
MLBr_00726|M.leprae_Br4923 MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVR
::*:*********:*.:*** : :***:. * :: *
Mb2991c|M.bovis_AF2122/97 KADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLA
Rv2967c|M.tuberculosis_H37Rv KADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLA
MMAR_1749|M.marinum_M KADESYQIGEVGHPVRAYLSVDEIVETALRAGADAIYPGYGFLSENPDLA
MUL_1992|M.ulcerans_Agy99 KADESYQIGEVGHPVRAYLSVDEIVETALRAGADAIYPGYGFLSENPDLA
MAV_0342|M.avium_104 KADESYQIGEEGHPVRAYLSVDEIVGTALACGADAIYPGYGFLSENPDLA
MAB_3267c|M.abscessus_ATCC_199 KADEAYQIGEKGHPVRAYLSVSEVVNAARNAGADAIYPGYGFLSENPDLA
Mflv_4198|M.gilvum_PYR-GCK KADESYQIGDVGHPVRAYLSVDEIMRVALDAGCDAVYPGYGFLSENPELA
Mvan_2165|M.vanbaalenii_PYR-1 KADESYQIGEIGHPVRAYLSVAEIMRVAVEAGCDAVYPGYGFLSENPELA
TH_1229|M.thermoresistible__bu KADESYQIGEIGHPVRAYLSVDEIIRVARHAGADAVYPGYGFLSENPRLA
MSMEG_6648|M.smegmatis_MC2_155 KADEAYQIGETGHPVRAYLSVDEIIRVAKHSGADAIYPGYGFLSENPELA
MLBr_00726|M.leprae_Br4923 LADEAFALGG-HTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFA
***:: :* ...:**.. ::: .* .*.:*::******:**. :*
Mb2991c|M.bovis_AF2122/97 AACAAAGISFVGPSAEVLELAGNKSRAIAAAREAGLPVLMSS-APSASVD
Rv2967c|M.tuberculosis_H37Rv AACAAAGISFVGPSAEVLELAGNKSRAIAAAREAGLPVLMSS-APSASVD
MMAR_1749|M.marinum_M GACAAAGITFVGPRAELLQLTGNKSRAVTAAREAGLPVLRSS-APSASVQ
MUL_1992|M.ulcerans_Agy99 GACAAAGITFVGPRAELLQLTGNKSRAVTAAREAGLPVLRSS-APSASVQ
MAV_0342|M.avium_104 AACAAAGITFVGPSAEVLELTGDKSRAIAAARAAGLPVLASS-PPSTSVQ
MAB_3267c|M.abscessus_ATCC_199 AACAEAGITFVGPPADVLELTGNKARAIAAAREAGLPVLASS-EPSASVE
Mflv_4198|M.gilvum_PYR-GCK AACASAGITFVGPSAHVLELTGNKARAIAAARSAGLPVLASS-EPSASVE
Mvan_2165|M.vanbaalenii_PYR-1 AACADAGITFVGPSANVLELTGNKARAIQAARAAGLPVLTSS-APSASVD
TH_1229|M.thermoresistible__bu AACEQAGITFIGPSAEILALTGNKSRAVAAARAAGIPVLASS-APSSSPE
MSMEG_6648|M.smegmatis_MC2_155 AACHQAGIVFVGPRAHVLELTGNKFKAITAAREAGLPVLASS-APSANVA
MLBr_00726|M.leprae_Br4923 QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNAD
* **: ::** .. : *:* * * * *:: .: * .
Mb2991c|M.bovis_AF2122/97 ELLSVAA----GMPFPLFVKAVAGGGGRGMRRVGDIAALPEAIEAASREA
Rv2967c|M.tuberculosis_H37Rv ELLSVAA----GMPFPLFVKAVAGGGGRGMRRVGDIAALPEAIEAASREA
MMAR_1749|M.marinum_M ELVAAAQSETTGLRFPLFVKAVAGGGGRGMRRVNDISALAEAIEAASREA
MUL_1992|M.ulcerans_Agy99 ELVAAAQSETTGLRFPLFVKAVAGGGGRGMRRVNDISALAEAIEAASREA
MAV_0342|M.avium_104 ELLSAAET----MTFPLFVKAVAGGGGRGMRRVTDPGALAEAIEAASREA
MAB_3267c|M.abscessus_ATCC_199 ELLAAAES----MEFPVFVKAVAGGGGRGMRRVAERDQLREAIEAASREA
Mflv_4198|M.gilvum_PYR-GCK ELVEAART----MEFPLFVKAVSGGGGRGMRRVAEPEGLAEAVEAASREA
Mvan_2165|M.vanbaalenii_PYR-1 ELVAAADG----MEFPLFVKAVSGGGGRGMRRVTDRAALAEAVEAASREA
TH_1229|M.thermoresistible__bu ELMAAADE----IGFPLFVKAVSGGGGRGMRRVADRAGLAEAIEAAGREA
MSMEG_6648|M.smegmatis_MC2_155 ELVSAAEA----MDFPLFVKAVSGGGGRGMRRVTEPAALAESIEAASREA
MLBr_00726|M.leprae_Br4923 EVVAFAKE----HGVPIAIKAAFGGGGKGMKVARTLEEISELYESAVREA
*:: * .*: :**. ****:**: . : * *:* ***
Mb2991c|M.bovis_AF2122/97 ESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKV
Rv2967c|M.tuberculosis_H37Rv ESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKV
MMAR_1749|M.marinum_M ESAFGDPTVYLEQAVLNPRHIEVQILADTQGNVIHLYERDCSVQRRHQKV
MUL_1992|M.ulcerans_Agy99 ESAFGDPTVYLEQAVLNPRHIEVQILADTQGNVIHLYERDCSVQRRHQKV
MAV_0342|M.avium_104 ESAFGDASVFLEQAVINPRHIEVQILADTHGNVMHLYERDCSVQRRHQKV
MAB_3267c|M.abscessus_ATCC_199 ESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKV
Mflv_4198|M.gilvum_PYR-GCK ESAFGDPSVYLEQAVLNPRHIEVQILADSRGNVMHLFERDCSVQRRHQKV
Mvan_2165|M.vanbaalenii_PYR-1 ESAFGDPNVYLEQAVLNPRHIEVQILADTAGHVMHLFERDCSVQRRHQKV
TH_1229|M.thermoresistible__bu ESAFGDPSLYLEQAVVNPRHIEVQILADTAGNVMHLYERDCSVQRRHQKV
MSMEG_6648|M.smegmatis_MC2_155 ESAFGDPMVYLEQAVLNPRHIEVQVLADRTGEIIHLFERDCSMQRRHQKV
MLBr_00726|M.leprae_Br4923 TVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQRRFQKL
*** ::*: : :***:*.*::** *.:: ****:***.**:
Mb2991c|M.bovis_AF2122/97 IELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIE
Rv2967c|M.tuberculosis_H37Rv IELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIE
MMAR_1749|M.marinum_M IELAPAPNLPGELRDKICADAVAFARHIGYTCAGTVEFLLDQSGEYVFIE
MUL_1992|M.ulcerans_Agy99 IELAPAPNLPGELRDKICADAVAFARHIGYTCAGTVEFLLDQSGEYVFIE
MAV_0342|M.avium_104 IEIAPAPNLDPALRERICADAVAFARSIGYTCAGTVEFLLDERGNHVFIE
MAB_3267c|M.abscessus_ATCC_199 IELAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIE
Mflv_4198|M.gilvum_PYR-GCK IELAPAPNLPEELRQQICADAVAYAREIGYTCAGTVEFLLDERGHHVFIE
Mvan_2165|M.vanbaalenii_PYR-1 IELAPAPNLPDELRQKICDDAVAFAKEIDYSCAGTVEFLLDERGHHVFIE
TH_1229|M.thermoresistible__bu IELAPAPNLPDELRERICADAVAFAREVGYAYAGTVEFLVDEQGRHVFIE
MSMEG_6648|M.smegmatis_MC2_155 IELAPAPNLSDTQRQRICADAVSFARQIDYFCAGTVEFLLDERGHHVFIE
MLBr_00726|M.leprae_Br4923 VEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLE
:* **** * * .: .* .: * *****:*:.: * *:*
Mb2991c|M.bovis_AF2122/97 MNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAAL
Rv2967c|M.tuberculosis_H37Rv MNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAAL
MMAR_1749|M.marinum_M MNPRIQVEHTVTEEITDVDLVSSQMRIAAGESLEDLGLRQETVRPHGAAL
MUL_1992|M.ulcerans_Agy99 MNPRIQVEHTVTEEITDVDLVSSQMRIAAGESLEDLGLRQETVRPHGAAL
MAV_0342|M.avium_104 MNPRIQVEHTVTEEITDVDLVSAQLRIASGQTLEEIGLSQDSVISRGAAL
MAB_3267c|M.abscessus_ATCC_199 MNPRIQVEHTVTEEITDVDLVASQLRIASGETLDDLGLHQDSITPRGAAL
Mflv_4198|M.gilvum_PYR-GCK CNPRIQVEHTVTEEITDVDLVASQIRIASGQTLADLGLSQEDLVIRGAAM
Mvan_2165|M.vanbaalenii_PYR-1 CNPRIQVEHTVTEEITDVDLVSSQLRIASGETLADLGLSQETLVIRGAAL
TH_1229|M.thermoresistible__bu MNPRIQVEHTVTEEITDVDLVGAQLRIADGQTLADLGLSQETLRTRGTAL
MSMEG_6648|M.smegmatis_MC2_155 CNPRIQVEHTVTEEITDVDLVASQLRLASGETLGDLGLSQDAVRIRGTAM
MLBr_00726|M.leprae_Br4923 VNTRLQVEHPVTEETTGIDLVLQQFKIANGEKLELI----KDPIPCGHAI
*.*:****.**** *.:*** *:::* *:.* : . * *:
Mb2991c|M.bovis_AF2122/97 QCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSM
Rv2967c|M.tuberculosis_H37Rv QCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSM
MMAR_1749|M.marinum_M QCRITTEDPTNGFRPDTGRISALRAPGGAGIRLDGSTNLGAEISAHFDSM
MUL_1992|M.ulcerans_Agy99 QCRITTEDPTNGFRPDTGRISALRAPGGAGIRLDGSTNLGAEISAHFDSM
MAV_0342|M.avium_104 QCRITTEDPANGFRPDTGRITAYRTPGGAGIRLDGGTTLGAEISAHFDSM
MAB_3267c|M.abscessus_ATCC_199 QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTTLGAEVGAHFDSM
Mflv_4198|M.gilvum_PYR-GCK QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGAVLGGEIGAHFDSM
Mvan_2165|M.vanbaalenii_PYR-1 QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGAHLGAEIGAHFDSM
TH_1229|M.thermoresistible__bu QCRITTEDPANGFRPDVGRVTGYRSPGGAGIRLDGGTHVGAEISPHFDSM
MSMEG_6648|M.smegmatis_MC2_155 QCRITTEDPANGFRPDTGRVTAYRSPGGAGVRLDGGTHTGAEISAHFDSM
MLBr_00726|M.leprae_Br4923 EFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSM
: **. **. ..* *. * :: :.. *.*:***... *. :. ****
Mb2991c|M.bovis_AF2122/97 LVKLTCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGR
Rv2967c|M.tuberculosis_H37Rv LVKLTCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGR
MMAR_1749|M.marinum_M LVKLTCRGRDFSTAVNRARRAIAEFRIRGVSTNIPFLQAVLDDPDFQAGR
MUL_1992|M.ulcerans_Agy99 LVKLTCRGRDLSTAVNRARRAIAEFRIRGVSTNIPFLQAVLDDPDFQAGR
MAV_0342|M.avium_104 LIKLTCRGRDFPTAVRRARRAVAEFRIRGVSTNIPFLQAVLDDPDFQAGR
MAB_3267c|M.abscessus_ATCC_199 LVKLTCRGRDFQTAVARARRAVAEFRIRGVATNIPFLQAVLDDPDFRAGH
Mflv_4198|M.gilvum_PYR-GCK LVKLTCRGRDFATAAARAHRALAEFRVRGVSTNIPFLQAVIDDPDFRAGR
Mvan_2165|M.vanbaalenii_PYR-1 LVKLTCRGRDFATAVARAHRALAEFRVRGVSTNIPFLQAVIDDPDFRAGR
TH_1229|M.thermoresistible__bu LVKLTCRGRDFATAVARARRALAEFRVRGVSTNIPFLQAVIADPDFRAGR
MSMEG_6648|M.smegmatis_MC2_155 LVKLTCRGQDFTGSAARARRALAEFRIRGVATNIGFLLAVLDDPDFRAGR
MLBr_00726|M.leprae_Br4923 LAKLIVHGATRQEALARARRALDEFEVEGLATVIPFHRAVVSDP------
* ** :* : **:**: **.:.*::* * * **: **
Mb2991c|M.bovis_AF2122/97 VTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDK
Rv2967c|M.tuberculosis_H37Rv VTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDK
MMAR_1749|M.marinum_M ITTAFIDERPQLLTARTSADRGTKILNYLADVTVNKPHGSRPSKVYPNDK
MUL_1992|M.ulcerans_Agy99 ITTAFIDERPQLLTARTSADRGTKILNYLADVTVNKPYGSRPSKVYPNDK
MAV_0342|M.avium_104 ITTSFIEQRPQLLTARSSADRGTKILNYLADVTVNKPHGERPSAVYPHDK
MAB_3267c|M.abscessus_ATCC_199 VTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKPSTVYPHDK
Mflv_4198|M.gilvum_PYR-GCK VTTSFIDERPGLLTSHTPADRGTKILNYLADVTVNQPHGPRPSTVYPQDK
Mvan_2165|M.vanbaalenii_PYR-1 VNTSFIDDRPYLLTSRSPADRGTKILNYLADVTVNQPHGPRPSTVYPHDK
TH_1229|M.thermoresistible__bu INTSFIDERPHLLTARIPADRGTKILNYLADVTVNKPHGERPSAVYAQDK
MSMEG_6648|M.smegmatis_MC2_155 VTTSFIDERPHLLAAHTPADRGSRILNYLADVTVNKPHGERPSAVYPHDK
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 LPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSL
Rv2967c|M.tuberculosis_H37Rv LPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSL
MMAR_1749|M.marinum_M LPQVDLDAPPPAGSKQRLVELGPEGFARWLRESPAVGVTDTTFRDAHQSL
MUL_1992|M.ulcerans_Agy99 LPQVDLDAPPPAGSKQRLVELGPEGFARWLRESPAVGVTDTTFRDAHQSL
MAV_0342|M.avium_104 LPDIDLAASPPAGSKQRLTELGPERFAAWLRESGGVGVTDTTFRDAHQSL
MAB_3267c|M.abscessus_ATCC_199 LPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSL
Mflv_4198|M.gilvum_PYR-GCK LPQIDLNTMPPRGSKHLLSEVGPEGFARWMRESKAVGVTDTTFRDAHQSL
Mvan_2165|M.vanbaalenii_PYR-1 LPQIDLDAMPPRGSKHLLSEVGPEAFARWMRESKSVGVTDTTFRDAHQSL
TH_1229|M.thermoresistible__bu LPSVDLQAPPPAGSKQRLEELGPDGFAAWLRDEPAVGVTDTTFRDAHQSL
MSMEG_6648|M.smegmatis_MC2_155 LPAIDLSEPPPPGTRQRLESLGPQGFSDWLRDSPAVGVTDTTFRDAHQSL
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 LATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
Rv2967c|M.tuberculosis_H37Rv LATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MMAR_1749|M.marinum_M LATRLRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MUL_1992|M.ulcerans_Agy99 LATRLRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MAV_0342|M.avium_104 LATRVRTSGLLKVAPYIARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MAB_3267c|M.abscessus_ATCC_199 LATRVRTTGLLAVAPYVARLTPELLSIEAWGGATYDVALRFLKEDPWERL
Mflv_4198|M.gilvum_PYR-GCK LATRIRTSGMLMVAPYVARMTPQLLSIECWGGATYDVALRFLKEDPWERL
Mvan_2165|M.vanbaalenii_PYR-1 LATRIRTSGLLMVAPYIARMTPQLLSIECWGGATYDVALRFLKEDPWERL
TH_1229|M.thermoresistible__bu LATRVRTNGLVMVAPYVARMMPQLLSIECWGGATYDVALRFLKEDPWDRL
MSMEG_6648|M.smegmatis_MC2_155 LATRVRTSGLVTVAPYIARMMPELLSIECWGGATYDVALRFLKEDPWERL
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 ATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIF
Rv2967c|M.tuberculosis_H37Rv ATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIF
MMAR_1749|M.marinum_M ATLRAAMPNICLQMLLRGRNTVGYTPYPEVVTSSFIEEATATGIDIFRIF
MUL_1992|M.ulcerans_Agy99 ATLRAAMPNICLQMLLRGRNTVGYTPYPEVVTSSFIEEATATGIDIFRIF
MAV_0342|M.avium_104 TALREAMPNICLQMLLRGRNTVGYTPYPETVTTAFVAEATETGIDIFRIF
MAB_3267c|M.abscessus_ATCC_199 ADLREAVPNICLQMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIF
Mflv_4198|M.gilvum_PYR-GCK AALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEATATGIDIYRIF
Mvan_2165|M.vanbaalenii_PYR-1 AALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEATATGVDIYRIF
TH_1229|M.thermoresistible__bu AAIREAVPNICLQMLLRGRNTVGYTPYPDTVTKAFVAEATAVGIDIYRIF
MSMEG_6648|M.smegmatis_MC2_155 AVLREAAPNICLQMLLRGRNTVGYTPYPESVTDAFVAEATATGIDIFRIF
MLBr_00726|M.leprae_Br4923 ---------------------------------ALIGDNNSFSVHTRWIE
::: : . .:. *
Mb2991c|M.bovis_AF2122/97 DALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKL
Rv2967c|M.tuberculosis_H37Rv DALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKL
MMAR_1749|M.marinum_M DALNNLESMRPAIDAVRETGSAIAEVAMCYTGDLSDPAEQLYTLDYYLRL
MUL_1992|M.ulcerans_Agy99 DALNNLESMRPAIDAVRETGSAIAEVAMCYTGDLSDPAEQLYTLDYYLRL
MAV_0342|M.avium_104 DALNNVDSMRPAIDAVRETGSAIAEVAMSYTGDLSDPAEKLYTLDYYLKL
MAB_3267c|M.abscessus_ATCC_199 DALNNIEAMRPAIDAVREVGTSVAEVAMCYTGDLSNPGENLYTLDYYLKL
Mflv_4198|M.gilvum_PYR-GCK DALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSDPAENLYTLDYYLKL
Mvan_2165|M.vanbaalenii_PYR-1 DALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSNPEENLYTLDYYLKL
TH_1229|M.thermoresistible__bu DALNNVDSMRPAIDAVRETGTAVAEVAMCYTGDLSDPGERLYTLDYYLRL
MSMEG_6648|M.smegmatis_MC2_155 DALNNVESMRPAIDAVRATGTAVAEVAMSYTSDLSDPAENLYTLDYYLKL
MLBr_00726|M.leprae_Br4923 TEWN--NTIEPFIDNQ----------------------------------
* :::.* **
Mb2991c|M.bovis_AF2122/97 AEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPG
Rv2967c|M.tuberculosis_H37Rv AEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPG
MMAR_1749|M.marinum_M AEQIVEAGAHVLAIKDMAGLLRAPAAHQLVTALRSRFDLPVHVHTHDTPG
MUL_1992|M.ulcerans_Agy99 AEQIVEAGAHVLAIKDMAGLLRAPAAHQLVTALRSRFDLPVHVHTHDTPG
MAV_0342|M.avium_104 ADQIVEAGAHVLAIKDMAGLLRAPAAATLVSALKSRFDLPVHVHTHDTPG
MAB_3267c|M.abscessus_ATCC_199 AEQIVDAGAHVLAIKDMAGLLRPPAAATLVTALRSRFDLPVHVHTHDTAG
Mflv_4198|M.gilvum_PYR-GCK AEQIVDAGAHVLGIKDMAGLLRPQAADTLVRALRSRFDLPVHVHTHDTPG
Mvan_2165|M.vanbaalenii_PYR-1 AEQIVDAGAHVLGIKDMAGLLRPQAAAMLVGALRSRFDLPVHVHTHDTPG
TH_1229|M.thermoresistible__bu AEQIVAAGAHVLAIKDMAGLLRPPAAATLVGALRSRFDLPVHVHTHDTPG
MSMEG_6648|M.smegmatis_MC2_155 AEQIVEAGAHVLAIKDMAGLLRPPAAATLVSALRSRFDLPVHVHTHDTPG
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLS
Rv2967c|M.tuberculosis_H37Rv GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLS
MMAR_1749|M.marinum_M GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVGAAAHTEYDTGLS
MUL_1992|M.ulcerans_Agy99 GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVGAAAHTEYDTGLS
MAV_0342|M.avium_104 GQLATYVAAWQAGADAVDGAAAPLAGTTSQPALSSIVAAAANTEYDTGLS
MAB_3267c|M.abscessus_ATCC_199 GQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAHSEYDTGVS
Mflv_4198|M.gilvum_PYR-GCK GQLATYLAAWQAGASAVDGASSPLAGTTSQPALSSIVAATAHTEFDTGLS
Mvan_2165|M.vanbaalenii_PYR-1 GQLATYLAAWQAGASAVDGASAPLAGTTSQPALSSIVAATAHTEFDTGLS
TH_1229|M.thermoresistible__bu GQLATYLAAWQAGASAVDGAAAPLAGTTSQPALSAIVAATAHTEHDTGLD
MSMEG_6648|M.smegmatis_MC2_155 GQLATYLAAWQAGASAVDGAAAPLAGTTSQPALSSIVAATAHTEYDTGLP
MLBr_00726|M.leprae_Br4923 ----------------------PLDEEDTRPQQTVIVEVDGR--------
*: ::* : ** . ..
Mb2991c|M.bovis_AF2122/97 LSAVCALEPYWEALRKVYAPFESGLP---GPTGRVYHHEIPGGQLSNLRQ
Rv2967c|M.tuberculosis_H37Rv LSAVCALEPYWEALRKVYAPFESGLP---GPTGRVYHHEIPGGQLSNLRQ
MMAR_1749|M.marinum_M LAAVCALEPYWEAVRKVYAPFESGLP---GPTGRVYHHEIPGGQLSNLRQ
MUL_1992|M.ulcerans_Agy99 LAAVCALEPYWEAVRKVYAPFESGLP---GPTGRVYHHEIPGGQLSNLRQ
MAV_0342|M.avium_104 LPAVCDLEPYWEALRKVYAPFESGLP---APTGRVYHHEIPGGQLSNLRQ
MAB_3267c|M.abscessus_ATCC_199 LTSVCDLEPYWEALRKVYAPFESGLP---SPTGRVYTHEIPGGQLSNLRQ
Mflv_4198|M.gilvum_PYR-GCK LEAVCDLEPYWEALRKVYAPFDVAAAGPTTPTGRVYHHEIPGGQLSNLRQ
Mvan_2165|M.vanbaalenii_PYR-1 LSAVCDLEPYWEALRKVYAPFDVAAAGPTTPTGRVYHHEIPGGQLSNLRQ
TH_1229|M.thermoresistible__bu LSAVCDLEPYWEALRKMYAPFESGLP---APTGRVYTHEIPGGQLSNLRQ
MSMEG_6648|M.smegmatis_MC2_155 LQAVCDLEPYWEALRKVYAPFESGLP---APTGRVYHHEIPGGQLSNLRQ
MLBr_00726|M.leprae_Br4923 -------------------RLEVSLP------------------------
:: . .
Mb2991c|M.bovis_AF2122/97 QAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGV
Rv2967c|M.tuberculosis_H37Rv QAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGV
MMAR_1749|M.marinum_M QAIALGLGDRFEEVEEAYAGADRVLGRLIKVTPSSKVVGDLALALVGAGV
MUL_1992|M.ulcerans_Agy99 QAIALGLGDRFEEVEEAYAGADRVLGRLIKVTPSSKVVGDLALALVGAGV
MAV_0342|M.avium_104 QAIALGLGDRFEDIENAYAGADAILGHLVKVTPSSKVVGDLALALVGAGV
MAB_3267c|M.abscessus_ATCC_199 QAIALGLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALALVGTGV
Mflv_4198|M.gilvum_PYR-GCK QAIALGLGDRFEQIEASYAAADRILGRLVKVTPSSKVVGDLALALVGAGV
Mvan_2165|M.vanbaalenii_PYR-1 QAIALGLGDRFEEIEASYAAADRILGRLVKVTPSSKVVGDLALALVGAGV
TH_1229|M.thermoresistible__bu QAIALGLGDRFEDIEAAYAGADRVLGRLVKVTPSSKVVGDLALALVGAGV
MSMEG_6648|M.smegmatis_MC2_155 QAIALGLGDRFEEIEASYAAADRVLGRLVKVTPSSKVVGDLALALVGAGV
MLBr_00726|M.leprae_Br4923 --------------------------------------ADLALANP-AG-
.***** :*
Mb2991c|M.bovis_AF2122/97 SADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARP
Rv2967c|M.tuberculosis_H37Rv SADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARP
MMAR_1749|M.marinum_M SADEFAAEPARFDIPDSVLGFLRGDLGDPVGGWPEPLRSAALAGRAPAKP
MUL_1992|M.ulcerans_Agy99 SADEFAAEPARFDIPDAVLGFLRGDLGDPVGGWPEPLRSAALAGRAPAKP
MAV_0342|M.avium_104 GAQDFAEDPSRYDIPDSVIGFLRGELGDPPGGWPEPLRTKALQGRGPAKP
MAB_3267c|M.abscessus_ATCC_199 SADEFASDPGRFDIPESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARA
Mflv_4198|M.gilvum_PYR-GCK SADEFAADPERFDIPDSVIGFLRGELGDPPGGWPEPLRSKALAGRAPAKP
Mvan_2165|M.vanbaalenii_PYR-1 SADEFTQDPGRFDIPDSVIGFLRGELGDPPGGWPEPLRSKALAGRAPAKP
TH_1229|M.thermoresistible__bu SAEEFAADPSRVDIPDSVIGFLRGELGDPPGGWPEPLRSTALAGRRPARP
MSMEG_6648|M.smegmatis_MC2_155 SAEELGADPARYNIPDSVIGFLRGELGDPPGGWPEPLRSKALAGRPPAKP
MLBr_00726|M.leprae_Br4923 --------------------------CNPAG-----------VIRKKPKP
:* * * .:.
Mb2991c|M.bovis_AF2122/97 TAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSA
Rv2967c|M.tuberculosis_H37Rv TAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSA
MMAR_1749|M.marinum_M VGQLTGEDHSALAAPGPKRQATLNRLLFPAPTKEFEEHREAYGDTSQMSA
MUL_1992|M.ulcerans_Agy99 VGQLTGEDHSALAAPGPKRQATLNRLLFPAPTKEFEEHREAYGDTSQMSA
MAV_0342|M.avium_104 EQPLTAEDEAALAAPGARRQAALNRLLFPGPTKELEEHREQYGDTSGLSA
MAB_3267c|M.abscessus_ATCC_199 EVALTADDESQLDGDSATRRAALNRLLFPGPTKEFLAHREQYGDTSRLSA
Mflv_4198|M.gilvum_PYR-GCK ATELSAEDTAALADAGATRRATLNRLLFPGPTKEFEAHREQYGDTSSLSA
Mvan_2165|M.vanbaalenii_PYR-1 QAELSAEDTEVLADAGPKRQAALNRLLFPAPTKEFEAHREIYGDTSSLSA
TH_1229|M.thermoresistible__bu TVELSAEDQAVLAQPGPKRQAALNRLLFPGPTAEFEAHRETYGDTTSLSA
MSMEG_6648|M.smegmatis_MC2_155 QVELGAEDEAVLAQAGPKRQAALNRLLFPSPTKEFEQHREAYGDTSQLSA
MLBr_00726|M.leprae_Br4923 --------------------------------------RKRGGHTGAATS
*: *.* ::
Mb2991c|M.bovis_AF2122/97 NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLR
Rv2967c|M.tuberculosis_H37Rv NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLR
MMAR_1749|M.marinum_M NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCIMNGQLR
MUL_1992|M.ulcerans_Agy99 NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCIMNGQLR
MAV_0342|M.avium_104 NQFFYGLRQGDEHRVELERGVELLIGLEAISDPDERGMRTVMCILNGQLR
MAB_3267c|M.abscessus_ATCC_199 NQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADEHGMRTVMCILNGQLR
Mflv_4198|M.gilvum_PYR-GCK NQFFYGLRHGDEHRVTLEKGVQLLIGLEAISDADERGMRTVMCILNGQLR
Mvan_2165|M.vanbaalenii_PYR-1 NQFFYGLRHGDEHRVTLERGVELLIGLEAISDPDERGMRTVMCILNGQLR
TH_1229|M.thermoresistible__bu NQFFYGLRHGEEHRVRLERGVELIIGLEAISDPDERGMRTVMCIINGQLR
MSMEG_6648|M.smegmatis_MC2_155 NQFFYGLRSGEEHRVQLERGVELLIGLEAISEPDERGMRTVMCILNGQLR
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 PVLVRDRSIASAVPAAEKADRGNPGHIAAPFAG-VVTVGVCVGERVGAGQ
Rv2967c|M.tuberculosis_H37Rv PVLVRDRSIASAVPAAEKADRGNPGHIAAPFAG-VVTVGVCVGERVGAGQ
MMAR_1749|M.marinum_M PVLVRDRSIASAVPTAEKADRGNPGHIAAPFAG-VVSVGVAVGDRVSAGQ
MUL_1992|M.ulcerans_Agy99 PVLVRDRSIASAVPTAEKADRGNPGHIAAPFAG-VVSVGVAVGDRVSAGQ
MAV_0342|M.avium_104 PVVVRDRSIAIDVPAAEKADRANPDHIAAPFAG-VVTVAAEVGRQVEAGQ
MAB_3267c|M.abscessus_ATCC_199 PVQVRDRSIESAVASAEKADRANADHVPAPFAG-VVTLNVVSGQEVSAGE
Mflv_4198|M.gilvum_PYR-GCK PVVVRDRSVASEVPAAEKADRNNPDHVAAPFAG-VVTVNVAEGDQVETGQ
Mvan_2165|M.vanbaalenii_PYR-1 PVVVRDRSVASDIPAAEKADRTNPDHVAAPFAG-VVTVNIAEGDKVDAGQ
TH_1229|M.thermoresistible__bu PVQVRDKSIASQIPAAEKADRANPDHIAAPFAG-VVTLNISTGDRVEAGQ
MSMEG_6648|M.smegmatis_MC2_155 PVLVRDRSIASDIPAAEKADRSNPDHIAAPFAG-VVTVNVEPGDDVTAGQ
MLBr_00726|M.leprae_Br4923 -----------------------GDAVTAPMQGTVVKVAVAEGQTVMTGD
. :.**: * **.: * * :*:
Mb2991c|M.bovis_AF2122/97 TIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS-------
Rv2967c|M.tuberculosis_H37Rv TIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS-------
MMAR_1749|M.marinum_M TIATIEAMKMEAPITAPNDGTVERVAVSSTAQVEGGDLLVVVS-------
MUL_1992|M.ulcerans_Agy99 TIATIEAMKMEAPITAPNDGTVERVAVSSTAQVEGGDLLVVVS-------
MAV_0342|M.avium_104 TIATIEAMKMEAAVTSPKSGKVARIAVSRTAQVEGGDLLMVID-------
MAB_3267c|M.abscessus_ATCC_199 TIGTIEAMKMEASITAPKAGTVARVALTETAQVEGGDLLVVIS-------
Mflv_4198|M.gilvum_PYR-GCK TIATIEAMKMEAAITAPKAGAVGRVAVSATAQVEGGDLLVVIGSAGAKVS
Mvan_2165|M.vanbaalenii_PYR-1 TIATIEAMKMEAGITAPKSGTVARVAVSATAQVEGGDLLVVIGSAGR---
TH_1229|M.thermoresistible__bu TIATIEAMKMEAAITAPKAGTISRIAVSETAQVEGGDLLAVLN-------
MSMEG_6648|M.smegmatis_MC2_155 TVATIEAMKMEAAITAPKRGVVDRLAVSGTTQVESGDLLLVIR-------
MLBr_00726|M.leprae_Br4923 LVVVLEAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK-------
: .:****** :*: * : :*: : : * :* :
Mb2991c|M.bovis_AF2122/97 --------
Rv2967c|M.tuberculosis_H37Rv --------
MMAR_1749|M.marinum_M --------
MUL_1992|M.ulcerans_Agy99 --------
MAV_0342|M.avium_104 --------
MAB_3267c|M.abscessus_ATCC_199 --------
Mflv_4198|M.gilvum_PYR-GCK SDGAGESS
Mvan_2165|M.vanbaalenii_PYR-1 SEATGESS
TH_1229|M.thermoresistible__bu --------
MSMEG_6648|M.smegmatis_MC2_155 --------
MLBr_00726|M.leprae_Br4923 --------