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VAGQISKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRLKADESYQIGEIGHPVRAYLSVAEI MRVAVEAGCDAVYPGYGFLSENPELAAACADAGITFVGPSANVLELTGNKARAIQAARAAGLPVLTSSAP SASVDELVAAADGMEFPLFVKAVSGGGGRGMRRVTDRAALAEAVEAASREAESAFGDPNVYLEQAVLNPR HIEVQILADTAGHVMHLFERDCSVQRRHQKVIELAPAPNLPDELRQKICDDAVAFAKEIDYSCAGTVEFL LDERGHHVFIECNPRIQVEHTVTEEITDVDLVSSQLRIASGETLADLGLSQETLVIRGAALQCRITTEDP ANGFRPDTGRITAYRSPGGAGIRLDGGAHLGAEIGAHFDSMLVKLTCRGRDFATAVARAHRALAEFRVRG VSTNIPFLQAVIDDPDFRAGRVNTSFIDDRPYLLTSRSPADRGTKILNYLADVTVNQPHGPRPSTVYPHD KLPQIDLDAMPPRGSKHLLSEVGPEAFARWMRESKSVGVTDTTFRDAHQSLLATRIRTSGLLMVAPYIAR MTPQLLSIECWGGATYDVALRFLKEDPWERLAALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEA TATGVDIYRIFDALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSNPEENLYTLDYYLKLAEQIVDAGA HVLGIKDMAGLLRPQAAAMLVGALRSRFDLPVHVHTHDTPGGQLATYLAAWQAGASAVDGASAPLAGTTS QPALSSIVAATAHTEFDTGLSLSAVCDLEPYWEALRKVYAPFDVAAAGPTTPTGRVYHHEIPGGQLSNLR QQAIALGLGDRFEEIEASYAAADRILGRLVKVTPSSKVVGDLALALVGAGVSADEFTQDPGRFDIPDSVI GFLRGELGDPPGGWPEPLRSKALAGRAPAKPQAELSAEDTEVLADAGPKRQAALNRLLFPAPTKEFEAHR EIYGDTSSLSANQFFYGLRHGDEHRVTLERGVELLIGLEAISDPDERGMRTVMCILNGQLRPVVVRDRSV ASDIPAAEKADRTNPDHVAAPFAGVVTVNIAEGDKVDAGQTIATIEAMKMEAGITAPKSGTVARVAVSAT AQVEGGDLLVVIGSAGRSEATGESS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2165 | - | - | 100% (1145) | pyruvate carboxylase |
| M. vanbaalenii PYR-1 | Mvan_4090 | - | e-101 | 45.64% (447) | carbamoyl-phosphate synthase L chain, ATP-binding |
| M. vanbaalenii PYR-1 | Mvan_0345 | - | 2e-96 | 44.64% (448) | carbamoyl-phosphate synthase L chain, ATP-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2991c | pca | 0.0 | 81.46% (1127) | pyruvate carboxylase |
| M. gilvum PYR-GCK | Mflv_4198 | - | 0.0 | 91.72% (1148) | pyruvate carboxylase |
| M. tuberculosis H37Rv | Rv2967c | pca | 0.0 | 81.46% (1127) | pyruvate carboxylase |
| M. leprae Br4923 | MLBr_00726 | bccA | 3e-91 | 41.94% (453) | acetyl/propionyl CoA carboxylase alpha subunit |
| M. abscessus ATCC 19977 | MAB_3267c | - | 0.0 | 82.17% (1127) | pyruvate carboxylase |
| M. marinum M | MMAR_1749 | pca | 0.0 | 81.54% (1132) | pyruvate carboxylase Pca |
| M. avium 104 | MAV_0342 | pyc | 0.0 | 82.80% (1128) | pyruvate carboxylase |
| M. smegmatis MC2 155 | MSMEG_2412 | pyc | 0.0 | 85.99% (1128) | pyruvate carboxylase |
| M. thermoresistible (build 8) | TH_1229 | pyc | 0.0 | 84.93% (1128) | pyruvate carboxylase |
| M. ulcerans Agy99 | MUL_1992 | pca | 0.0 | 81.27% (1132) | pyruvate carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2991c|M.bovis_AF2122/97 -------MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRL
Rv2967c|M.tuberculosis_H37Rv -------MFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRL
MMAR_1749|M.marinum_M -------MISKVLVANRGEIAIRAFRAAYELGVGTVAVYAYEDRNSLHRS
MUL_1992|M.ulcerans_Agy99 -------MISKVLVANRGEIAIRAFRAAYELGVGTVAVYAYEDRNSLHRT
MAV_0342|M.avium_104 -------MLAKVLVANRGEIAIRAFRAAYELEMATVAVYPYEDRNSVHRL
Mvan_2165|M.vanbaalenii_PYR-1 ----MAGQISKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRL
Mflv_4198|M.gilvum_PYR-GCK ----MAGQITKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRL
TH_1229|M.thermoresistible__bu -------VISKVLVANRGEIAIRAFRAAYELGIATVAVYPYEDRNSLHRL
MSMEG_2412|M.smegmatis_MC2_155 -------MISKVLVANRGEIAIRAFRAAYEMGIATVAVYPYEDRNSLHRL
MAB_3267c|M.abscessus_ATCC_199 -------MFSKVLVANRGEIAIRAFRAAYELGAETVAVYPYEDRNSGHRL
MLBr_00726|M.leprae_Br4923 MASHASSRIAKVLVANRGEIAVRVIRAARDARLPSVAVYAEPDAEAPHVR
::***********:*.:*** : :****. * :: *
Mb2991c|M.bovis_AF2122/97 KADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLA
Rv2967c|M.tuberculosis_H37Rv KADESYQIGDIGHPVHAYLSVDEIVATARRAGADAIYPGYGFLSENPDLA
MMAR_1749|M.marinum_M KADESYQIGEVGHPVRAYLSVDEIVETALRAGADAIYPGYGFLSENPDLA
MUL_1992|M.ulcerans_Agy99 KADESYQIGEVGHPVRAYLSVDEIVETALRAGADAIYPGYGFLSENPDLA
MAV_0342|M.avium_104 KADESYQIGEEGHPVRAYLSVDEIVGTALACGADAIYPGYGFLSENPDLA
Mvan_2165|M.vanbaalenii_PYR-1 KADESYQIGEIGHPVRAYLSVAEIMRVAVEAGCDAVYPGYGFLSENPELA
Mflv_4198|M.gilvum_PYR-GCK KADESYQIGDVGHPVRAYLSVDEIMRVALDAGCDAVYPGYGFLSENPELA
TH_1229|M.thermoresistible__bu KADESYQIGEIGHPVRAYLSVDEIIRVARHAGADAVYPGYGFLSENPRLA
MSMEG_2412|M.smegmatis_MC2_155 KADESYQIGEVGHPVRAYLSVDEIIRVAKHSGADAVYPGYGFLSENPDLA
MAB_3267c|M.abscessus_ATCC_199 KADEAYQIGEKGHPVRAYLSVSEVVNAARNAGADAIYPGYGFLSENPDLA
MLBr_00726|M.leprae_Br4923 LADEAFALGG-HTSAESYLDFGKILDAAAKSGANAIHPGYGFLAENADFA
***:: :* ...:**.. ::: .* .*.:*::******:**. :*
Mb2991c|M.bovis_AF2122/97 AACAAAGISFVGPSAEVLELAGNKSRAIAAAREAGLPVLM-SSAPSASVD
Rv2967c|M.tuberculosis_H37Rv AACAAAGISFVGPSAEVLELAGNKSRAIAAAREAGLPVLM-SSAPSASVD
MMAR_1749|M.marinum_M GACAAAGITFVGPRAELLQLTGNKSRAVTAAREAGLPVLR-SSAPSASVQ
MUL_1992|M.ulcerans_Agy99 GACAAAGITFVGPRAELLQLTGNKSRAVTAAREAGLPVLR-SSAPSASVQ
MAV_0342|M.avium_104 AACAAAGITFVGPSAEVLELTGDKSRAIAAARAAGLPVLA-SSPPSTSVQ
Mvan_2165|M.vanbaalenii_PYR-1 AACADAGITFVGPSANVLELTGNKARAIQAARAAGLPVLT-SSAPSASVD
Mflv_4198|M.gilvum_PYR-GCK AACASAGITFVGPSAHVLELTGNKARAIAAARSAGLPVLA-SSEPSASVE
TH_1229|M.thermoresistible__bu AACEQAGITFIGPSAEILALTGNKSRAVAAARAAGIPVLA-SSAPSSSPE
MSMEG_2412|M.smegmatis_MC2_155 AKCAEAGITFVGPSAEVLQLTGNKARAIAAARAAGLPVLS-SSEPSSSVD
MAB_3267c|M.abscessus_ATCC_199 AACAEAGITFVGPPADVLELTGNKARAIAAAREAGLPVLA-SSEPSASVE
MLBr_00726|M.leprae_Br4923 QAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKNAD
**: ::** .. : *:* * * * *:: :. * . :
Mb2991c|M.bovis_AF2122/97 ELLSVAA----GMPFPLFVKAVAGGGGRGMRRVGDIAALPEAIEAASREA
Rv2967c|M.tuberculosis_H37Rv ELLSVAA----GMPFPLFVKAVAGGGGRGMRRVGDIAALPEAIEAASREA
MMAR_1749|M.marinum_M ELVAAAQSETTGLRFPLFVKAVAGGGGRGMRRVNDISALAEAIEAASREA
MUL_1992|M.ulcerans_Agy99 ELVAAAQSETTGLRFPLFVKAVAGGGGRGMRRVNDISALAEAIEAASREA
MAV_0342|M.avium_104 ELLSAAET----MTFPLFVKAVAGGGGRGMRRVTDPGALAEAIEAASREA
Mvan_2165|M.vanbaalenii_PYR-1 ELVAAADG----MEFPLFVKAVSGGGGRGMRRVTDRAALAEAVEAASREA
Mflv_4198|M.gilvum_PYR-GCK ELVEAART----MEFPLFVKAVSGGGGRGMRRVAEPEGLAEAVEAASREA
TH_1229|M.thermoresistible__bu ELMAAADE----IGFPLFVKAVSGGGGRGMRRVADRAGLAEAIEAAGREA
MSMEG_2412|M.smegmatis_MC2_155 ELMAAAAD----MEFPLFVKAVSGGGGRGMRRVTDRESLAEAIEAASREA
MAB_3267c|M.abscessus_ATCC_199 ELLAAAES----MEFPVFVKAVAGGGGRGMRRVAERDQLREAIEAASREA
MLBr_00726|M.leprae_Br4923 EVVAFAKE----HGVPIAIKAAFGGGGKGMKVARTLEEISELYESAVREA
*:: * .*: :**. ****:**: . : * *:* ***
Mb2991c|M.bovis_AF2122/97 ESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKV
Rv2967c|M.tuberculosis_H37Rv ESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKV
MMAR_1749|M.marinum_M ESAFGDPTVYLEQAVLNPRHIEVQILADTQGNVIHLYERDCSVQRRHQKV
MUL_1992|M.ulcerans_Agy99 ESAFGDPTVYLEQAVLNPRHIEVQILADTQGNVIHLYERDCSVQRRHQKV
MAV_0342|M.avium_104 ESAFGDASVFLEQAVINPRHIEVQILADTHGNVMHLYERDCSVQRRHQKV
Mvan_2165|M.vanbaalenii_PYR-1 ESAFGDPNVYLEQAVLNPRHIEVQILADTAGHVMHLFERDCSVQRRHQKV
Mflv_4198|M.gilvum_PYR-GCK ESAFGDPSVYLEQAVLNPRHIEVQILADSRGNVMHLFERDCSVQRRHQKV
TH_1229|M.thermoresistible__bu ESAFGDPSLYLEQAVVNPRHIEVQILADTAGNVMHLYERDCSVQRRHQKV
MSMEG_2412|M.smegmatis_MC2_155 ESAFGDASVYLEQAVLNPRHIEVQILADGAGNVMHLFERDCSVQRRHQKV
MAB_3267c|M.abscessus_ATCC_199 ESAFGDPTVFLEQAVINPRHIEVQILADTAGNVIHLYERDCSVQRRHQKV
MLBr_00726|M.leprae_Br4923 TVAFGRGECFVERYLDKPRHVEAQVIADQHGNIVVAGTRDCSLQRRFQKL
*** ::*: : :***:*.*::** *.:: ****:***.**:
Mb2991c|M.bovis_AF2122/97 IELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIE
Rv2967c|M.tuberculosis_H37Rv IELAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIE
MMAR_1749|M.marinum_M IELAPAPNLPGELRDKICADAVAFARHIGYTCAGTVEFLLDQSGEYVFIE
MUL_1992|M.ulcerans_Agy99 IELAPAPNLPGELRDKICADAVAFARHIGYTCAGTVEFLLDQSGEYVFIE
MAV_0342|M.avium_104 IEIAPAPNLDPALRERICADAVAFARSIGYTCAGTVEFLLDERGNHVFIE
Mvan_2165|M.vanbaalenii_PYR-1 IELAPAPNLPDELRQKICDDAVAFAKEIDYSCAGTVEFLLDERGHHVFIE
Mflv_4198|M.gilvum_PYR-GCK IELAPAPNLPEELRQQICADAVAYAREIGYTCAGTVEFLLDERGHHVFIE
TH_1229|M.thermoresistible__bu IELAPAPNLPDELRERICADAVAFAREVGYAYAGTVEFLVDEQGRHVFIE
MSMEG_2412|M.smegmatis_MC2_155 VELAPAPNLSDELRQQICADAVAFARQIGYSCAGTVEFLLDERGHHVFIE
MAB_3267c|M.abscessus_ATCC_199 IELAPAPNLPPELREKICSDAVAFARHIGYSCAGTVEFLLDERGHHVFIE
MLBr_00726|M.leprae_Br4923 VEEAPAPFLTDAQRKEIHESAKRICKEAHYYGAGTVEYLVGQDGLISFLE
:* **** * * .: .* .: * *****:*:.: * *:*
Mb2991c|M.bovis_AF2122/97 MNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAAL
Rv2967c|M.tuberculosis_H37Rv MNPRVQVEHTVTEEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAAL
MMAR_1749|M.marinum_M MNPRIQVEHTVTEEITDVDLVSSQMRIAAGESLEDLGLRQETVRPHGAAL
MUL_1992|M.ulcerans_Agy99 MNPRIQVEHTVTEEITDVDLVSSQMRIAAGESLEDLGLRQETVRPHGAAL
MAV_0342|M.avium_104 MNPRIQVEHTVTEEITDVDLVSAQLRIASGQTLEEIGLSQDSVISRGAAL
Mvan_2165|M.vanbaalenii_PYR-1 CNPRIQVEHTVTEEITDVDLVSSQLRIASGETLADLGLSQETLVIRGAAL
Mflv_4198|M.gilvum_PYR-GCK CNPRIQVEHTVTEEITDVDLVASQIRIASGQTLADLGLSQEDLVIRGAAM
TH_1229|M.thermoresistible__bu MNPRIQVEHTVTEEITDVDLVGAQLRIADGQTLADLGLSQETLRTRGTAL
MSMEG_2412|M.smegmatis_MC2_155 CNPRIQVEHTVTEEITDVDLVSSQLRIAAGETLADLGLSQDRLVVRGAAM
MAB_3267c|M.abscessus_ATCC_199 MNPRIQVEHTVTEEITDVDLVASQLRIASGETLDDLGLHQDSITPRGAAL
MLBr_00726|M.leprae_Br4923 VNTRLQVEHPVTEETTGIDLVLQQFKIANGEKLELI----KDPIPCGHAI
*.*:****.**** *.:*** *::** *:.* : . * *:
Mb2991c|M.bovis_AF2122/97 QCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSM
Rv2967c|M.tuberculosis_H37Rv QCRITTEDPANGFRPDTGRISALRTAGGAGVRLDGSTNLGAEISPYFDSM
MMAR_1749|M.marinum_M QCRITTEDPTNGFRPDTGRISALRAPGGAGIRLDGSTNLGAEISAHFDSM
MUL_1992|M.ulcerans_Agy99 QCRITTEDPTNGFRPDTGRISALRAPGGAGIRLDGSTNLGAEISAHFDSM
MAV_0342|M.avium_104 QCRITTEDPANGFRPDTGRITAYRTPGGAGIRLDGGTTLGAEISAHFDSM
Mvan_2165|M.vanbaalenii_PYR-1 QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGAHLGAEIGAHFDSM
Mflv_4198|M.gilvum_PYR-GCK QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGAVLGGEIGAHFDSM
TH_1229|M.thermoresistible__bu QCRITTEDPANGFRPDVGRVTGYRSPGGAGIRLDGGTHVGAEISPHFDSM
MSMEG_2412|M.smegmatis_MC2_155 QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTNLGAEISAHFDSM
MAB_3267c|M.abscessus_ATCC_199 QCRITTEDPANGFRPDTGRITAYRSPGGAGIRLDGGTTLGAEVGAHFDSM
MLBr_00726|M.leprae_Br4923 EFRINGEDAGRNFLPSPGPVSKFHPPTGPGVRLDSGVETGSVIGGQFDSM
: **. **. ..* *. * :: :.. *.*:***... *. :. ****
Mb2991c|M.bovis_AF2122/97 LVKLTCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGR
Rv2967c|M.tuberculosis_H37Rv LVKLTCRGRDLPTAVSRARRAIAEFRIRGVSTNIPFLQAVLDDPDFRAGR
MMAR_1749|M.marinum_M LVKLTCRGRDFSTAVNRARRAIAEFRIRGVSTNIPFLQAVLDDPDFQAGR
MUL_1992|M.ulcerans_Agy99 LVKLTCRGRDLSTAVNRARRAIAEFRIRGVSTNIPFLQAVLDDPDFQAGR
MAV_0342|M.avium_104 LIKLTCRGRDFPTAVRRARRAVAEFRIRGVSTNIPFLQAVLDDPDFQAGR
Mvan_2165|M.vanbaalenii_PYR-1 LVKLTCRGRDFATAVARAHRALAEFRVRGVSTNIPFLQAVIDDPDFRAGR
Mflv_4198|M.gilvum_PYR-GCK LVKLTCRGRDFATAAARAHRALAEFRVRGVSTNIPFLQAVIDDPDFRAGR
TH_1229|M.thermoresistible__bu LVKLTCRGRDFATAVARARRALAEFRVRGVSTNIPFLQAVIADPDFRAGR
MSMEG_2412|M.smegmatis_MC2_155 LVKLTCRGRDFSAAASRARRALAEFRIRGVSTNIPFLQAVIDDPDFRAGR
MAB_3267c|M.abscessus_ATCC_199 LVKLTCRGRDFQTAVARARRAVAEFRIRGVATNIPFLQAVLDDPDFRAGH
MLBr_00726|M.leprae_Br4923 LAKLIVHGATRQEALARARRALDEFEVEGLATVIPFHRAVVSDPALIGD-
* ** :* * **:**: **.:.*::* *** :**: ** : ..
Mb2991c|M.bovis_AF2122/97 VTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDK
Rv2967c|M.tuberculosis_H37Rv VTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRPSTIYPDDK
MMAR_1749|M.marinum_M ITTAFIDERPQLLTARTSADRGTKILNYLADVTVNKPHGSRPSKVYPNDK
MUL_1992|M.ulcerans_Agy99 ITTAFIDERPQLLTARTSADRGTKILNYLADVTVNKPYGSRPSKVYPNDK
MAV_0342|M.avium_104 ITTSFIEQRPQLLTARSSADRGTKILNYLADVTVNKPHGERPSAVYPHDK
Mvan_2165|M.vanbaalenii_PYR-1 VNTSFIDDRPYLLTSRSPADRGTKILNYLADVTVNQPHGPRPSTVYPHDK
Mflv_4198|M.gilvum_PYR-GCK VTTSFIDERPGLLTSHTPADRGTKILNYLADVTVNQPHGPRPSTVYPQDK
TH_1229|M.thermoresistible__bu INTSFIDERPHLLTARIPADRGTKILNYLADVTVNKPHGERPSAVYAQDK
MSMEG_2412|M.smegmatis_MC2_155 VTTSFIDDRPHLLTSRSPADRGTRILNYLADITVNKPHGERPSTVYPQDK
MAB_3267c|M.abscessus_ATCC_199 VTTSFIEERPQLLTARSSADRGTKILNYLADVTVNKPHGAKPSTVYPHDK
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 LPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSL
Rv2967c|M.tuberculosis_H37Rv LPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSL
MMAR_1749|M.marinum_M LPQVDLDAPPPAGSKQRLVELGPEGFARWLRESPAVGVTDTTFRDAHQSL
MUL_1992|M.ulcerans_Agy99 LPQVDLDAPPPAGSKQRLVELGPEGFARWLRESPAVGVTDTTFRDAHQSL
MAV_0342|M.avium_104 LPDIDLAASPPAGSKQRLTELGPERFAAWLRESGGVGVTDTTFRDAHQSL
Mvan_2165|M.vanbaalenii_PYR-1 LPQIDLDAMPPRGSKHLLSEVGPEAFARWMRESKSVGVTDTTFRDAHQSL
Mflv_4198|M.gilvum_PYR-GCK LPQIDLNTMPPRGSKHLLSEVGPEGFARWMRESKAVGVTDTTFRDAHQSL
TH_1229|M.thermoresistible__bu LPSVDLQAPPPAGSKQRLEELGPDGFAAWLRDEPAVGVTDTTFRDAHQSL
MSMEG_2412|M.smegmatis_MC2_155 LPPLDLQAPPPAGSKQRLVELGPEGFAGWLRESKAVGVTDTTFRDAHQSL
MAB_3267c|M.abscessus_ATCC_199 LPPIDLSVPPPDGSRQRLLALGPEGFAKALREQKAVGLTDTTFRDAHQSL
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 LATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
Rv2967c|M.tuberculosis_H37Rv LATRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MMAR_1749|M.marinum_M LATRLRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MUL_1992|M.ulcerans_Agy99 LATRLRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERL
MAV_0342|M.avium_104 LATRVRTSGLLKVAPYIARTMPQLLSVECWGGATYDVALRFLKEDPWERL
Mvan_2165|M.vanbaalenii_PYR-1 LATRIRTSGLLMVAPYIARMTPQLLSIECWGGATYDVALRFLKEDPWERL
Mflv_4198|M.gilvum_PYR-GCK LATRIRTSGMLMVAPYVARMTPQLLSIECWGGATYDVALRFLKEDPWERL
TH_1229|M.thermoresistible__bu LATRVRTNGLVMVAPYVARMMPQLLSIECWGGATYDVALRFLKEDPWDRL
MSMEG_2412|M.smegmatis_MC2_155 LATRVRTTGLLMVAPYVARSMPQLLSIECWGGATYDVALRFLKEDPWERL
MAB_3267c|M.abscessus_ATCC_199 LATRVRTTGLLAVAPYVARLTPELLSIEAWGGATYDVALRFLKEDPWERL
MLBr_00726|M.leprae_Br4923 -------------------------------NNSFSVHTRWI-ETEWN--
. ::.* *:: * *:
Mb2991c|M.bovis_AF2122/97 ATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIF
Rv2967c|M.tuberculosis_H37Rv ATLRAAMPNICLQMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIF
MMAR_1749|M.marinum_M ATLRAAMPNICLQMLLRGRNTVGYTPYPEVVTSSFIEEATATGIDIFRIF
MUL_1992|M.ulcerans_Agy99 ATLRAAMPNICLQMLLRGRNTVGYTPYPEVVTSSFIEEATATGIDIFRIF
MAV_0342|M.avium_104 TALREAMPNICLQMLLRGRNTVGYTPYPETVTTAFVAEATETGIDIFRIF
Mvan_2165|M.vanbaalenii_PYR-1 AALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEATATGVDIYRIF
Mflv_4198|M.gilvum_PYR-GCK AALREAVPNICLQMLLRGRNTVGYTPYPESVTHAFVQEATATGIDIYRIF
TH_1229|M.thermoresistible__bu AAIREAVPNICLQMLLRGRNTVGYTPYPDTVTKAFVAEATAVGIDIYRIF
MSMEG_2412|M.smegmatis_MC2_155 AALRESVPNICLQMLLRGRNTVGYTPYPELVTSAFVEEAAATGIDIFRIF
MAB_3267c|M.abscessus_ATCC_199 ADLREAVPNICLQMLLRGRNTVGYTPYPETVTKAFIREASATGVDIYRIF
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 DALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKL
Rv2967c|M.tuberculosis_H37Rv DALNNIESMRPAIDAVRETGSAIAEVAMCYTGDLTDPGEQLYTLDYYLKL
MMAR_1749|M.marinum_M DALNNLESMRPAIDAVRETGSAIAEVAMCYTGDLSDPAEQLYTLDYYLRL
MUL_1992|M.ulcerans_Agy99 DALNNLESMRPAIDAVRETGSAIAEVAMCYTGDLSDPAEQLYTLDYYLRL
MAV_0342|M.avium_104 DALNNVDSMRPAIDAVRETGSAIAEVAMSYTGDLSDPAEKLYTLDYYLKL
Mvan_2165|M.vanbaalenii_PYR-1 DALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSNPEENLYTLDYYLKL
Mflv_4198|M.gilvum_PYR-GCK DALNNVDSMRPAIDAVRETGTAVAEVAMSYTGDLSDPAENLYTLDYYLKL
TH_1229|M.thermoresistible__bu DALNNVDSMRPAIDAVRETGTAVAEVAMCYTGDLSDPGERLYTLDYYLRL
MSMEG_2412|M.smegmatis_MC2_155 DALNNVESMRPAIDAVRETGSTIAEVAMCYTGDLSDPAENLYTLDYYLKL
MAB_3267c|M.abscessus_ATCC_199 DALNNIEAMRPAIDAVREVGTSVAEVAMCYTGDLSNPGENLYTLDYYLKL
MLBr_00726|M.leprae_Br4923 ------NTIEPFIDNQ----------------------------------
:::.* **
Mb2991c|M.bovis_AF2122/97 AEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPG
Rv2967c|M.tuberculosis_H37Rv AEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSALRSRFDLPVHLHTHDTPG
MMAR_1749|M.marinum_M AEQIVEAGAHVLAIKDMAGLLRAPAAHQLVTALRSRFDLPVHVHTHDTPG
MUL_1992|M.ulcerans_Agy99 AEQIVEAGAHVLAIKDMAGLLRAPAAHQLVTALRSRFDLPVHVHTHDTPG
MAV_0342|M.avium_104 ADQIVEAGAHVLAIKDMAGLLRAPAAATLVSALKSRFDLPVHVHTHDTPG
Mvan_2165|M.vanbaalenii_PYR-1 AEQIVDAGAHVLGIKDMAGLLRPQAAAMLVGALRSRFDLPVHVHTHDTPG
Mflv_4198|M.gilvum_PYR-GCK AEQIVDAGAHVLGIKDMAGLLRPQAADTLVRALRSRFDLPVHVHTHDTPG
TH_1229|M.thermoresistible__bu AEQIVAAGAHVLAIKDMAGLLRPPAAATLVGALRSRFDLPVHVHTHDTPG
MSMEG_2412|M.smegmatis_MC2_155 AEQIVEAGAHVLAIKDMAGLLRAPAAHTLVSALRSRFDLPVHVHTHDTPG
MAB_3267c|M.abscessus_ATCC_199 AEQIVDAGAHVLAIKDMAGLLRPPAAATLVTALRSRFDLPVHVHTHDTAG
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLS
Rv2967c|M.tuberculosis_H37Rv GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAHTEYDTGLS
MMAR_1749|M.marinum_M GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVGAAAHTEYDTGLS
MUL_1992|M.ulcerans_Agy99 GQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVGAAAHTEYDTGLS
MAV_0342|M.avium_104 GQLATYVAAWQAGADAVDGAAAPLAGTTSQPALSSIVAAAANTEYDTGLS
Mvan_2165|M.vanbaalenii_PYR-1 GQLATYLAAWQAGASAVDGASAPLAGTTSQPALSSIVAATAHTEFDTGLS
Mflv_4198|M.gilvum_PYR-GCK GQLATYLAAWQAGASAVDGASSPLAGTTSQPALSSIVAATAHTEFDTGLS
TH_1229|M.thermoresistible__bu GQLATYLAAWQAGASAVDGAAAPLAGTTSQPALSAIVAATAHTEHDTGLD
MSMEG_2412|M.smegmatis_MC2_155 GQLATYLAAWSAGADAVDGASAPMAGTTSQPALSSIVAAAAHTQYDTGLD
MAB_3267c|M.abscessus_ATCC_199 GQLATYLAAWQAGADAVDGAAAPMAGTTSQPSLSAIVAAAAHSEYDTGVS
MLBr_00726|M.leprae_Br4923 ----------------------PLDEEDTRPQQTVIVEVD----------
*: ::* : ** .
Mb2991c|M.bovis_AF2122/97 LSAVCALEPYWEALRKVYAPFESGLPG---PTGRVYHHEIPGGQLSNLRQ
Rv2967c|M.tuberculosis_H37Rv LSAVCALEPYWEALRKVYAPFESGLPG---PTGRVYHHEIPGGQLSNLRQ
MMAR_1749|M.marinum_M LAAVCALEPYWEAVRKVYAPFESGLPG---PTGRVYHHEIPGGQLSNLRQ
MUL_1992|M.ulcerans_Agy99 LAAVCALEPYWEAVRKVYAPFESGLPG---PTGRVYHHEIPGGQLSNLRQ
MAV_0342|M.avium_104 LPAVCDLEPYWEALRKVYAPFESGLPA---PTGRVYHHEIPGGQLSNLRQ
Mvan_2165|M.vanbaalenii_PYR-1 LSAVCDLEPYWEALRKVYAPFDVAAAGPTTPTGRVYHHEIPGGQLSNLRQ
Mflv_4198|M.gilvum_PYR-GCK LEAVCDLEPYWEALRKVYAPFDVAAAGPTTPTGRVYHHEIPGGQLSNLRQ
TH_1229|M.thermoresistible__bu LSAVCDLEPYWEALRKMYAPFESGLP---APTGRVYTHEIPGGQLSNLRQ
MSMEG_2412|M.smegmatis_MC2_155 LRAVCDLEPYWEAVRKVYAPFESGLPG---PTGRVYTHEIPGGQLSNLRQ
MAB_3267c|M.abscessus_ATCC_199 LTSVCDLEPYWEALRKVYAPFESGLPS---PTGRVYTHEIPGGQLSNLRQ
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 QAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGV
Rv2967c|M.tuberculosis_H37Rv QAIALGLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGV
MMAR_1749|M.marinum_M QAIALGLGDRFEEVEEAYAGADRVLGRLIKVTPSSKVVGDLALALVGAGV
MUL_1992|M.ulcerans_Agy99 QAIALGLGDRFEEVEEAYAGADRVLGRLIKVTPSSKVVGDLALALVGAGV
MAV_0342|M.avium_104 QAIALGLGDRFEDIENAYAGADAILGHLVKVTPSSKVVGDLALALVGAGV
Mvan_2165|M.vanbaalenii_PYR-1 QAIALGLGDRFEEIEASYAAADRILGRLVKVTPSSKVVGDLALALVGAGV
Mflv_4198|M.gilvum_PYR-GCK QAIALGLGDRFEQIEASYAAADRILGRLVKVTPSSKVVGDLALALVGAGV
TH_1229|M.thermoresistible__bu QAIALGLGDRFEDIEAAYAGADRVLGRLVKVTPSSKVVGDLALALVGAGV
MSMEG_2412|M.smegmatis_MC2_155 QAIALGLGDRFEEIEANYAAADRVLGRLVKVTPSSKVVGDLALALVGAGI
MAB_3267c|M.abscessus_ATCC_199 QAIALGLGDQFEEIEARYAAADRMLGRLVKVTPSSKVVGDLALALVGTGV
MLBr_00726|M.leprae_Br4923 -------------------------GRRLEVS----LPADLALANPAG--
*: ::*: : .***** .
Mb2991c|M.bovis_AF2122/97 SADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARP
Rv2967c|M.tuberculosis_H37Rv SADEFASDPARFGIPESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARP
MMAR_1749|M.marinum_M SADEFAAEPARFDIPDSVLGFLRGDLGDPVGGWPEPLRSAALAGRAPAKP
MUL_1992|M.ulcerans_Agy99 SADEFAAEPARFDIPDAVLGFLRGDLGDPVGGWPEPLRSAALAGRAPAKP
MAV_0342|M.avium_104 GAQDFAEDPSRYDIPDSVIGFLRGELGDPPGGWPEPLRTKALQGRGPAKP
Mvan_2165|M.vanbaalenii_PYR-1 SADEFTQDPGRFDIPDSVIGFLRGELGDPPGGWPEPLRSKALAGRAPAKP
Mflv_4198|M.gilvum_PYR-GCK SADEFAADPERFDIPDSVIGFLRGELGDPPGGWPEPLRSKALAGRAPAKP
TH_1229|M.thermoresistible__bu SAEEFAADPSRVDIPDSVIGFLRGELGDPPGGWPEPLRSTALAGRRPARP
MSMEG_2412|M.smegmatis_MC2_155 TAEEFAEDPAKYDIPDSVIGFLRGELGDPPGGWPEPLRTKALQGRGPARP
MAB_3267c|M.abscessus_ATCC_199 SADEFASDPGRFDIPESVIGFLRGELGDPPGGWPEPFRTRALQGRGPARA
MLBr_00726|M.leprae_Br4923 --------------------------CNPAG-----------VIRKKPKP
:* * * .:.
Mb2991c|M.bovis_AF2122/97 TAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSA
Rv2967c|M.tuberculosis_H37Rv TAQLAADDEIALSSVGAKRQATLNRLLFPSPTKEFNEHREAYGDTSQLSA
MMAR_1749|M.marinum_M VGQLTGEDHSALAAPGPKRQATLNRLLFPAPTKEFEEHREAYGDTSQMSA
MUL_1992|M.ulcerans_Agy99 VGQLTGEDHSALAAPGPKRQATLNRLLFPAPTKEFEEHREAYGDTSQMSA
MAV_0342|M.avium_104 EQPLTAEDEAALAAPGARRQAALNRLLFPGPTKELEEHREQYGDTSGLSA
Mvan_2165|M.vanbaalenii_PYR-1 QAELSAEDTEVLADAGPKRQAALNRLLFPAPTKEFEAHREIYGDTSSLSA
Mflv_4198|M.gilvum_PYR-GCK ATELSAEDTAALADAGATRRATLNRLLFPGPTKEFEAHREQYGDTSSLSA
TH_1229|M.thermoresistible__bu TVELSAEDQAVLAQPGPKRQAALNRLLFPGPTAEFEAHRETYGDTTSLSA
MSMEG_2412|M.smegmatis_MC2_155 VEKLTADDEALLAQPGPKRQAALNRLLFPGPTAEFEAHRETYGDTSSLSA
MAB_3267c|M.abscessus_ATCC_199 EVALTADDESQLDGDSATRRAALNRLLFPGPTKEFLAHREQYGDTSRLSA
MLBr_00726|M.leprae_Br4923 --------------------------------------RKRGGHTGAATS
*: *.* ::
Mb2991c|M.bovis_AF2122/97 NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLR
Rv2967c|M.tuberculosis_H37Rv NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCILNGQLR
MMAR_1749|M.marinum_M NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCIMNGQLR
MUL_1992|M.ulcerans_Agy99 NQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDERGMRTVMCIMNGQLR
MAV_0342|M.avium_104 NQFFYGLRQGDEHRVELERGVELLIGLEAISDPDERGMRTVMCILNGQLR
Mvan_2165|M.vanbaalenii_PYR-1 NQFFYGLRHGDEHRVTLERGVELLIGLEAISDPDERGMRTVMCILNGQLR
Mflv_4198|M.gilvum_PYR-GCK NQFFYGLRHGDEHRVTLEKGVQLLIGLEAISDADERGMRTVMCILNGQLR
TH_1229|M.thermoresistible__bu NQFFYGLRHGEEHRVRLERGVELIIGLEAISDPDERGMRTVMCIINGQLR
MSMEG_2412|M.smegmatis_MC2_155 NQFFYGLRYGEEHRVQLERGVELLIGLEAISEADERGMRTVMCIINGQLR
MAB_3267c|M.abscessus_ATCC_199 NQFFYGLRYGEEHRVKLEKGVELLIGLEAISDADEHGMRTVMCILNGQLR
MLBr_00726|M.leprae_Br4923 --------------------------------------------------
Mb2991c|M.bovis_AF2122/97 PVLVRDRSIASAVPAAEKADRGNPGHIAAPFAG-VVTVGVCVGERVGAGQ
Rv2967c|M.tuberculosis_H37Rv PVLVRDRSIASAVPAAEKADRGNPGHIAAPFAG-VVTVGVCVGERVGAGQ
MMAR_1749|M.marinum_M PVLVRDRSIASAVPTAEKADRGNPGHIAAPFAG-VVSVGVAVGDRVSAGQ
MUL_1992|M.ulcerans_Agy99 PVLVRDRSIASAVPTAEKADRGNPGHIAAPFAG-VVSVGVAVGDRVSAGQ
MAV_0342|M.avium_104 PVVVRDRSIAIDVPAAEKADRANPDHIAAPFAG-VVTVAAEVGRQVEAGQ
Mvan_2165|M.vanbaalenii_PYR-1 PVVVRDRSVASDIPAAEKADRTNPDHVAAPFAG-VVTVNIAEGDKVDAGQ
Mflv_4198|M.gilvum_PYR-GCK PVVVRDRSVASEVPAAEKADRNNPDHVAAPFAG-VVTVNVAEGDQVETGQ
TH_1229|M.thermoresistible__bu PVQVRDKSIASQIPAAEKADRANPDHIAAPFAG-VVTLNISTGDRVEAGQ
MSMEG_2412|M.smegmatis_MC2_155 PVLVRDRSIASEVPAAEKADRNNADHIAAPFAG-VVTVGVAEGDSVDAGQ
MAB_3267c|M.abscessus_ATCC_199 PVQVRDRSIESAVASAEKADRANADHVPAPFAG-VVTLNVVSGQEVSAGE
MLBr_00726|M.leprae_Br4923 -----------------------GDAVTAPMQGTVVKVAVAEGQTVMTGD
. :.**: * **.: * * :*:
Mb2991c|M.bovis_AF2122/97 TIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS-------
Rv2967c|M.tuberculosis_H37Rv TIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS-------
MMAR_1749|M.marinum_M TIATIEAMKMEAPITAPNDGTVERVAVSSTAQVEGGDLLVVVS-------
MUL_1992|M.ulcerans_Agy99 TIATIEAMKMEAPITAPNDGTVERVAVSSTAQVEGGDLLVVVS-------
MAV_0342|M.avium_104 TIATIEAMKMEAAVTSPKSGKVARIAVSRTAQVEGGDLLMVID-------
Mvan_2165|M.vanbaalenii_PYR-1 TIATIEAMKMEAGITAPKSGTVARVAVSATAQVEGGDLLVVIGSAGR---
Mflv_4198|M.gilvum_PYR-GCK TIATIEAMKMEAAITAPKAGAVGRVAVSATAQVEGGDLLVVIGSAGAKVS
TH_1229|M.thermoresistible__bu TIATIEAMKMEAAITAPKAGTISRIAVSETAQVEGGDLLAVLN-------
MSMEG_2412|M.smegmatis_MC2_155 TIATIEAMKMEAAITAPKAGTVARVAVAATAQVEGGDLLVVVS-------
MAB_3267c|M.abscessus_ATCC_199 TIGTIEAMKMEASITAPKAGTVARVALTETAQVEGGDLLVVIS-------
MLBr_00726|M.leprae_Br4923 LVVVLEAMKMENPVTAHKDGIITGLAVEAGTAITQGTVLAEIK-------
: .:****** :*: * : :*: : : * :* :
Mb2991c|M.bovis_AF2122/97 --------
Rv2967c|M.tuberculosis_H37Rv --------
MMAR_1749|M.marinum_M --------
MUL_1992|M.ulcerans_Agy99 --------
MAV_0342|M.avium_104 --------
Mvan_2165|M.vanbaalenii_PYR-1 SEATGESS
Mflv_4198|M.gilvum_PYR-GCK SDGAGESS
TH_1229|M.thermoresistible__bu --------
MSMEG_2412|M.smegmatis_MC2_155 --------
MAB_3267c|M.abscessus_ATCC_199 --------
MLBr_00726|M.leprae_Br4923 --------