For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SNWQTMLQRRSFLEGDALTRARNLLDPEGVQVLCGPFDRIESPWLVPQGIVPQSDDGVVIARGTIDGRPV VVASIEQRFQGGAVGEVSGAKITQALRLAAQDSRSGRTTAAVLLLETGGVRLQEANLGLNAVAEICSALL DLRPLAPVVGVVAGEVGSFGGVSIAAGLCTTLVVTPQGRIGLNGPAVIEQEAGAAEFDASDRALIWSIDG GEKRHADGLADVLVPDDADALRAAVSAAVAAGPRAPGAHRSEQVHALGARLPTTPEPHNTSAPSRGRTWL TELAGTQPIPVIGSVIRADTGDRAYLAVVPDPENAYHRARHGEVGLAESLALAGAVDDVIRTDAGKNDKR AIVAVVDLPSQAYGRLEETVGLHQTIAAAVDAYHRARTAGHPVVALVVGEALSGGFLAHGLQAQRIVALD DPGVRIHAMHEEAAARITLRTVDELEALGKTVLPLSFDVRDWARLGFCDGLLHVTDADTPTEDDIATVRA AVDTQIAAARTGPRDLSNRLDSPAAEQTRQASRRVRTTMFTQWYSQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6632 | - | - | 100% (538) | beta subunit of malonate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_6391 | - | 6e-12 | 24.60% (439) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_6577 | - | 3e-11 | 24.34% (419) | methylmalonyl-CoA carboxyltransferase 12S subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2271 | accD6 | 4e-12 | 23.71% (388) | acetyl/propionyl-CoA carboxylase beta subunit AccD6 |
| M. gilvum PYR-GCK | Mflv_1170 | - | 2e-09 | 30.17% (179) | carboxyl transferase |
| M. tuberculosis H37Rv | Rv2247 | accD6 | 4e-12 | 23.71% (388) | acetyl/propionyl-CoA carboxylase beta subunit AccD6 |
| M. leprae Br4923 | MLBr_01657 | - | 1e-11 | 26.82% (179) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 8e-11 | 25.62% (406) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_3340 | accD6 | 1e-11 | 24.24% (429) | acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 |
| M. avium 104 | MAV_2190 | - | 6e-10 | 22.94% (388) | propionyl-CoA carboxylase beta chain |
| M. thermoresistible (build 8) | TH_1608 | - | 7e-11 | 32.14% (140) | PROBABLE PROPIONYL-CoA CARBOXYLASE BETA CHAIN 4 ACCD4 (PCCASE) |
| M. ulcerans Agy99 | MUL_1302 | accD6 | 9e-12 | 24.24% (429) | acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 |
| M. vanbaalenii PYR-1 | Mvan_3758 | - | 2e-09 | 25.71% (175) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2271|M.bovis_AF2122/97 -----------MTIM----APEAVGESLDPRD--------------PLLR
Rv2247|M.tuberculosis_H37Rv -----------MTIM----APEAVGESLDPRD--------------PLLR
MMAR_3340|M.marinum_M -----------MTIM----APEAVGESLDPRD--------------PLLR
MUL_1302|M.ulcerans_Agy99 -----------MTIM----APEAVGESLDPRD--------------PLLR
MAV_2190|M.avium_104 -----------MTIT----APETVGESLDPRD--------------PLLR
MLBr_01657|M.leprae_Br4923 -----------MTIT----APKVVGKSIDPRD--------------PLLR
Mvan_3758|M.vanbaalenii_PYR-1 -----------MTTIENPPAPESVNESLDPRD--------------PLLR
Mflv_1170|M.gilvum_PYR-GCK -------MTERTTAELLAELREKLELAKEPGGEKAVAKREKKGIPSARAR
TH_1608|M.thermoresistible__bu VSQESGLRPPKTTAEQLAELREKLEQAKEPGGAKAAAKRDAKGIPSPRAR
MAB_0181|M.abscessus_ATCC_1997 -------MPPHTTAEKLADLRERIALTREPGDAKAIARRDKKGIPSARAR
MSMEG_6632|M.smegmatis_MC2_155 --MSNWQTMLQRRSFLEGDALTRARNLLDPEG------------VQVLCG
:* .
Mb2271|M.bovis_AF2122/97 LSNFFDDGSVELLHERDRS----------GVLAAAGTVNGVRTIAFCTDG
Rv2247|M.tuberculosis_H37Rv LSNFFDDGSVELLHERDRS----------GVLAAAGTVNGVRTIAFCTDG
MMAR_3340|M.marinum_M LSNFFDDGTVVLLHERDRS----------GVLAASGTVNGVRTIAFCTDG
MUL_1302|M.ulcerans_Agy99 LSNFFDDGTVVLLHERDRS----------GVLAASGTVNGVRTIAFCTDG
MAV_2190|M.avium_104 LSNFFDDGSVALLHERDRS----------GVLAAAGTVNGVRTIAFCTDG
MLBr_01657|M.leprae_Br4923 LSNFFDDGRVEPLHERNQS----------GVFAATGTVNGLRTIAFCTDG
Mvan_3758|M.vanbaalenii_PYR-1 LATFFDDGTVELLHERDKS----------GILAASGSVNGVRTIAFCTDG
Mflv_1170|M.gilvum_PYR-GCK IHSLLDPGSFLEIGALAKTPGDPDALYGDGVVTGHGTINGRPVGVFSHDQ
TH_1608|M.thermoresistible__bu IHALLDPGSFVEIGMLAKTPGDPNALYGDGVVTGHGTIDGRPVGVFSHDQ
MAB_0181|M.abscessus_ATCC_1997 IDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGRIDGRPVAVFSHDQ
MSMEG_6632|M.smegmatis_MC2_155 PFDRIESPWLVPQGIVPQS--------DDGVVIARGTIDGRPVVVASIEQ
:: . :: *:. . * ::* . . . :
Mb2271|M.bovis_AF2122/97 TVMGGAMGVEGCTHIVNAYDTAIEDQ-----SPIVGIWHSGGARLAEGVR
Rv2247|M.tuberculosis_H37Rv TVMGGAMGVEGCTHIVNAYDTAIEDQ-----SPIVGIWHSGGARLAEGVR
MMAR_3340|M.marinum_M TVMGGAMGVEGCAHIVNAYDTAIDEQ-----SPIVGIWHSGGARLAEGVR
MUL_1302|M.ulcerans_Agy99 TVMGGAMGVEGCAHIVNAYDTAIDEQ-----SPIVGIWHSGGARLAEGVR
MAV_2190|M.avium_104 TVMGGAMGIEGCSHIVDAYDTAIEEQ-----SPIVGIWHSGGARLAEGVK
MLBr_01657|M.leprae_Br4923 TVMGGAMGIEGCAHIVNAYDTAIEEQ-----SPIVGIWHSGGARLAEGVR
Mvan_3758|M.vanbaalenii_PYR-1 TVMGGAMGVDGCAHIVNAYDLAIEEQ-----SPIVGIWHSGGARLAEGVK
Mflv_1170|M.gilvum_PYR-GCK TVFQGSVGEMFGRKVAKLMEWVAMVG-----CPIIGINDSAGARIQDTAT
TH_1608|M.thermoresistible__bu TVFGGSVGEMFGRKVSRLMEWVAMVG-----CPIIGINDSGGARIQDLAT
MAB_0181|M.abscessus_ATCC_1997 TVYQGSVGEMFGRKVAKLMEWAATNG-----CPVIGINDSAGARIQDTAT
MSMEG_6632|M.smegmatis_MC2_155 RFQGGAVGEVSGAKITQALRLAAQDSRSGRTTAAVLLLETGGVRLQEANL
. *::* :: . . : : .:.*.*: :
Mb2271|M.bovis_AF2122/97 ALHAVGQVFEAMIRASGYIPQISVVVGFAA--GGAAYGPALTDVVVMAPE
Rv2247|M.tuberculosis_H37Rv ALHAVGQVFEAMIRASGYIPQISVVVGFAA--GGAAYGPALTDVVVMAPE
MMAR_3340|M.marinum_M ALHAVGQVFEAMIRASGYVPQVSVVVGFAA--GGAAYGPALTDVVVMAPE
MUL_1302|M.ulcerans_Agy99 ALHAVGQVFEAMIRASGYVPQVSVVVGFAA--GGAAYGPALTDVVVMAPE
MAV_2190|M.avium_104 ALHAVGLVFEAMIRASGYIPQISVVVGFAA--GGAAYGPALTDVVVMAPE
MLBr_01657|M.leprae_Br4923 ALHAVGQVFEAMIRASGYIPQISVVVGFAA--GGAAYGPALTDVVIMAPE
Mvan_3758|M.vanbaalenii_PYR-1 ALHAVGLVFEAMIRASGYIPQISVVVGFAA--GGAAYGPALTDVIVMAPD
Mflv_1170|M.gilvum_PYR-GCK SLAWYAELGRRHELLRGLVPEISLIFGKCA--GGAVYSPIQTDLVVAVRD
TH_1608|M.thermoresistible__bu SLAWYAELGRRHELLSGLVPQISIILGKCA--GGAVYSPIQTDLIVAVRD
MAB_0181|M.abscessus_ATCC_1997 SLAWYAELGRRHELLRGTVPEISIILGKCA--GGAVYSPIQTDLLVAVRD
MSMEG_6632|M.smegmatis_MC2_155 GLNAVAEICSALLDLRPLAPVVGVVAGEVGSFGGVSIAAGLCTTLVVTPQ
.* . : * :.:: * . **. .. :: . :
Mb2271|M.bovis_AF2122/97 -SRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAD
Rv2247|M.tuberculosis_H37Rv -SRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAD
MMAR_3340|M.marinum_M -SRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAD
MUL_1302|M.ulcerans_Agy99 -SRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAD
MAV_2190|M.avium_104 -SRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAD
MLBr_01657|M.leprae_Br4923 -GRVFVTGPDVVRSVTG-------EDVDMASLGGPETHHKKSGVCHIVAN
Mvan_3758|M.vanbaalenii_PYR-1 -SKVFVTGPDVVRSVTG-------EDVDMVSLGGPEAHHKKSGVCHIVAD
Mflv_1170|M.gilvum_PYR-GCK QGYMFVTGPDVIKDVTG-------EDVTLDELGGADAQARY-GNIHQVVE
TH_1608|M.thermoresistible__bu QGYMFVTGPDVIKDVTG-------EEVTLDELGGADAQARY-GNIHTVVN
MAB_0181|M.abscessus_ATCC_1997 QGYMFITGPDVIKDVTG-------EDVSFDELGGADVQAQR-GNIHKVVE
MSMEG_6632|M.smegmatis_MC2_155 -GRIGLNGPAVIEQEAGAAEFDASDRALIWSIDGGEKRHADGLADVLVPD
. : :.** *:.. :* : . : .:.* : : * :
Mb2271|M.bovis_AF2122/97 DELDAYDRGRRLVGLFCQQGHFDRSKAEAG--------DTDIHALLPESS
Rv2247|M.tuberculosis_H37Rv DELDAYDRGRRLVGLFCQQGHFDRSKAEAG--------DTDIHALLPESS
MMAR_3340|M.marinum_M DELDAYERGRRLVGLFCQQGHFDRSKAEAG--------DTDIHALLPESA
MUL_1302|M.ulcerans_Agy99 DELDAYERGRRLVGLFCQQGHFDRSKAEAG--------DTDIHALLPESA
MAV_2190|M.avium_104 DELDAYERGRRLVGLFCQQGHFDRTKAEAG--------DTDIHALLPESA
MLBr_01657|M.leprae_Br4923 DELDAYERGRRLVGLFCQQGHFDRSKAEAG--------DTNIQALLPESS
Mvan_3758|M.vanbaalenii_PYR-1 DELDAYERGRRLVGLFCQQGHFDRSKAEAG--------DTDLKALLPESA
Mflv_1170|M.gilvum_PYR-GCK SEAAAFQYVRDYLSFLPANTFDDAPIVNPGLEPEITPHDLELDAIVPDSD
TH_1608|M.thermoresistible__bu SEKEAFQYVRDYLGFLPANTFDDAPIVNPGLEPEITPHDLELDSIVPDND
MAB_0181|M.abscessus_ATCC_1997 DEAAAFQYVRDYLSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSD
MSMEG_6632|M.smegmatis_MC2_155 DADALRAAVSAAVAAGPRAPGAHRSEQVHALG---ARLPTTPEPHNTSAP
. :. . . .. ..
Mb2271|M.bovis_AF2122/97 RRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNP
Rv2247|M.tuberculosis_H37Rv RRAYDVRPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNP
MMAR_3340|M.marinum_M RRAYDVHPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNP
MUL_1302|M.ulcerans_Agy99 RRAYDVHPIVTAILDADTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNP
MAV_2190|M.avium_104 RRAYDVRPIVTAILDDETPFDEFQANWAPSMVIGLGRLSGRTVGVLANNP
MLBr_01657|M.leprae_Br4923 RRAYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNP
Mvan_3758|M.vanbaalenii_PYR-1 RRAYDVHPLIEALLDEGVPFEEFQSRWAPSIVVGLGRLAGRTVGVIANNP
Mflv_1170|M.gilvum_PYR-GCK NQAYDMMEILLRIFDDGD-VFQVAEQAGPAIITAFARVDGRPVGVIANQP
TH_1608|M.thermoresistible__bu NTAYDMHEILLRIFDDGD-FLEVAGQAGQAIITGFARVDGRPVGVVANQP
MAB_0181|M.abscessus_ATCC_1997 NQGYDMMEILLRIFDDGD-IFEISEQRGPAMITAFARVDGHPVGVIANQP
MSMEG_6632|M.smegmatis_MC2_155 SRGRTWLTELAGTQPIPVIGSVIRADTGDRAYLAVVPDPENAYHRARHGE
. : . . .. .. :
Mb2271|M.bovis_AF2122/97 LRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVV
Rv2247|M.tuberculosis_H37Rv LRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVV
MMAR_3340|M.marinum_M LRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVV
MUL_1302|M.ulcerans_Agy99 LRLGGCLNSESAEKAARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVV
MAV_2190|M.avium_104 LRLGGCLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVV
MLBr_01657|M.leprae_Br4923 LRLGGCLNSESAEKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVV
Mvan_3758|M.vanbaalenii_PYR-1 LRLGGCLNSESAEKSARFVRLCDAFGIPLVVVVDVPGYLPGVDQEWGGVV
Mflv_1170|M.gilvum_PYR-GCK MYMSGAIDNEASDKAARFVRFCDSFNTPLVFVVDTPGFMPGVEQEKGGII
TH_1608|M.thermoresistible__bu MVLSGAIDNEASDKAARFVRFCDAFNTPLVFVVDTPGFLPGVEQEKNGII
MAB_0181|M.abscessus_ATCC_1997 LQMAGAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGII
MSMEG_6632|M.smegmatis_MC2_155 VGLAESLALAGAVDDVIRTDAGKNDKRAIVAVVDLPSQAYGRLEETVGLH
: :. .: .: . . . .:* :** *. * :* *:
Mb2271|M.bovis_AF2122/97 RRGAKLLHAFGEC---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
Rv2247|M.tuberculosis_H37Rv RRGAKLLHAFGEC---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
MMAR_3340|M.marinum_M RRGAKLLHAFGEC---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
MUL_1302|M.ulcerans_Agy99 RRGAKLLHAFGEC---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
MAV_2190|M.avium_104 RRGAKLLHAFGEA---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
MLBr_01657|M.leprae_Br4923 RRGAKLLHAFGEC---TVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWP
Mvan_3758|M.vanbaalenii_PYR-1 RRGAKLLHAFGES---SVPRVTLVTRKIYGGAYIAMNSRSLNATKVFAWP
Mflv_1170|M.gilvum_PYR-GCK KRGGRFLNAVVEA---SVAKVTITIRKSYGGAYAVMGSKQLTSDFNFAWP
TH_1608|M.thermoresistible__bu KRGGRFLYAVVEA---DVPKVTITVRKSYGGAYAVMGSKQLTSDFNFLWP
MAB_0181|M.abscessus_ATCC_1997 KKGGRFFNAVVEA---DVPKVTIITRKAYGGGYAVMGSKQLSADLNYVWP
MSMEG_6632|M.smegmatis_MC2_155 QTIAAAVDAYHRARTAGHPVVALVVGEALSGGFLAHG-LQAQRIVALDDP
: . . * .. . *:: : .*.: . . . *
Mb2271|M.bovis_AF2122/97 DAEVAVMGAKAAVGILHKKKLAAAPE--------------HEREALHDQL
Rv2247|M.tuberculosis_H37Rv DAEVAVMGAKAAVGILHKKKLAAAPE--------------HEREALHDQL
MMAR_3340|M.marinum_M DAEVAVMGAKAAVGILHKKKLAAAAE--------------HEREALHDEL
MUL_1302|M.ulcerans_Agy99 DAEVAVMGAKAAVGILHKKKLAAAAE--------------HEREALHDEL
MAV_2190|M.avium_104 DAEVAVMGAKAAVGILHKKKLAAAPE--------------HEREALHDQL
MLBr_01657|M.leprae_Br4923 DAEVAVMGAKAAVGILHKRKLAAAPN--------------DEREALHDDL
Mvan_3758|M.vanbaalenii_PYR-1 EAEVAVMGAKAAVGILHKKKLAAAPD--------------HERESLHEAL
Mflv_1170|M.gilvum_PYR-GCK TARIAVIGADGAAQLLVKR-FPDPTA--------------PEVQKIKADF
TH_1608|M.thermoresistible__bu TARIAVIGAEGAAQLIMKR-FPDPNA--------------PEVQEIRRQF
MAB_0181|M.abscessus_ATCC_1997 TARIAVIGAEGAAQLLVKR-FPDPTA--------------PEVQKIRADF
MSMEG_6632|M.smegmatis_MC2_155 GVRIHAMHEEAAARITLRTVDELEALGKTVLPLSFDVRDWARLGFCDGLL
..: .: ..*. : : . :
Mb2271|M.bovis_AF2122/97 AAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARR------
Rv2247|M.tuberculosis_H37Rv AAEHERIAGGVDSALDIGVVDEKIDPAHTRSKLTEALAQAPARR------
MMAR_3340|M.marinum_M AAEHERIAGGVDSAIDIGVVDEKIDPAHTRSRLTEALAQAPARR------
MUL_1302|M.ulcerans_Agy99 AAEHERIAGGVDSAIDIGVVDEKIDPAHTRSRLTEVLAQAPARR------
MAV_2190|M.avium_104 AAEHEKIAGGVDSAIEIGVVDEKIDPAHTRSKLTEALAQAPARR------
MLBr_01657|M.leprae_Br4923 AAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRR------
Mvan_3758|M.vanbaalenii_PYR-1 ALEHERIAGGVDSAIEIGVVDEKIDPSHTRSKLTQALAEAPMRR------
Mflv_1170|M.gilvum_PYR-GCK IEGYNANLAVPWIAAERGFIDGVIEPHETRLLLRKCLHLLADKQ-INRVH
TH_1608|M.thermoresistible__bu IEGYNRDMATPYVAAERGYVDAVIEPHETRLKLRSAMRLLRDKQ-IQRVQ
MAB_0181|M.abscessus_ATCC_1997 IEGYNKNLATPWIAAERGYIDGVIEPHQTRLLLRKSLKLLRDKQKHDRMQ
MSMEG_6632|M.smegmatis_MC2_155 HVTDADTPTEDDIATVRAAVDTQIAAARTGPRDLSNRLDSPAAEQTRQAS
* . :* * . .* . .
Mb2271|M.bovis_AF2122/97 GRHKNIPL-------
Rv2247|M.tuberculosis_H37Rv GRHKNIPL-------
MMAR_3340|M.marinum_M GRHKNIPL-------
MUL_1302|M.ulcerans_Agy99 GRHKNIPL-------
MAV_2190|M.avium_104 GRHKNIPL-------
MLBr_01657|M.leprae_Br4923 GRHKNIPL-------
Mvan_3758|M.vanbaalenii_PYR-1 GRHKNIPL-------
Mflv_1170|M.gilvum_PYR-GCK RKHGLTPI-------
TH_1608|M.thermoresistible__bu RKHGLIPI-------
MAB_0181|M.abscessus_ATCC_1997 RKHGLTPI-------
MSMEG_6632|M.smegmatis_MC2_155 RRVRTTMFTQWYSQA
: :