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TDAPPRAGAPLPSPEELLYRREQIVADVVRQGFIDDLHPLCGVIDLDTLDELMASLHAAYPADLPALHTI AAKAISLRPVLARFAAAGFGCEVASPGELELALAAGFPAERIVFDSPAKTPTEIARALELGVSFNVDNFE ELARIDAAVARNGRPRSVIGVRVNPQTGAGTIDAMSTATSTSKFGIGLADHRDEIIDAFATRPWLTQLHV HSGSQGMSLEHAAEGVRLTTDLAADIDARAGSRQIQRIDVGGGLPVNFRSDDVTPTFADHRAALQAAAPR LFDGTYTVVTEFGRALTAKAGTVVARVEYTKVTGGRPIAITHAGVQVATRSIFAPEAWPLRVEVYDAHGR RRDDPPRVQDVAGPACFTGDMLAVGRELPPVHAGDLVAVPDTGGYYFSTHFSYNALPRPAVYTVGTDQHG DRRWSLARRAQTIEQIVAEAGEPSLEPLTFRPPNRPSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6197 | - | - | 100% (459) | diaminopimelate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_4958 | lysA | 2e-25 | 30.20% (394) | diaminopimelate decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1325 | lysA | 1e-25 | 29.20% (387) | diaminopimelate decarboxylase LysA |
| M. gilvum PYR-GCK | Mflv_2297 | - | 3e-27 | 30.43% (391) | diaminopimelate decarboxylase |
| M. tuberculosis H37Rv | Rv1293 | lysA | 1e-25 | 29.20% (387) | diaminopimelate decarboxylase LysA |
| M. leprae Br4923 | MLBr_01128 | lysA | 6e-24 | 27.61% (402) | diaminopimelate decarboxylase |
| M. abscessus ATCC 19977 | MAB_1434 | - | 5e-31 | 32.14% (420) | diaminopimelate decarboxylase |
| M. marinum M | MMAR_4104 | lysA | 2e-25 | 28.20% (422) | diaminopimelate decarboxylase LysA |
| M. avium 104 | MAV_1508 | lysA | 1e-24 | 28.79% (389) | diaminopimelate decarboxylase |
| M. thermoresistible (build 8) | TH_2005 | lysA | 4e-29 | 31.44% (388) | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP |
| M. ulcerans Agy99 | MUL_3971 | lysA | 1e-25 | 28.20% (422) | diaminopimelate decarboxylase LysA |
| M. vanbaalenii PYR-1 | Mvan_4349 | - | 3e-25 | 29.72% (397) | diaminopimelate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4104|M.marinum_M MNVHPAGPRHAEESRHPESPQRPQSAEELLYLAPNVWPRNTTRDEQGCAR
MUL_3971|M.ulcerans_Agy99 MNVHPAGPRHAEESRHPESPQRPQSAEELLYLAPNVWPRNTARDEQGCAR
Mb1325|M.bovis_AF2122/97 -------------------------MNELLHLAPNVWPRNTTRDEVGVVC
Rv1293|M.tuberculosis_H37Rv -------------------------MNELLHLAPNVWPRNTTRDEVGVVC
MLBr_01128|M.leprae_Br4923 MNVHTAGPRHAEKTRHTATPQRVQPSDDLLRLASNVWPRNITRDETGVAC
MAV_1508|M.avium_104 MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVAT
TH_2005|M.thermoresistible__bu VIAHPAGPRHAEEIHHGETPPRPQSPDELLLLAPNVWPRNTVRESDGVVS
Mflv_2297|M.gilvum_PYR-GCK MIAHPAGPRHAEEVPSAAAPERPQSAADVSRLAPNVWPQNTVRGDDGAVS
Mvan_4349|M.vanbaalenii_PYR-1 MIAHPAGPRHAEEVHPVATPDRPRTAAEVLQLAPNVWPQNAVRGADGVVS
MAB_1434|M.abscessus_ATCC_1997 MSAHPAGPRHAEGEQHTAMSSAP--PANPTELASNVWPRNASRGADGEVT
MSMEG_6197|M.smegmatis_MC2_155 -------------------------MTDAPPRAGAPLPSPEELLYRREQI
: * *
MMAR_4104|M.marinum_M IAGVPLTELAREYGTPLFVIDEDDFRSRCQEIAAAFGGGH--NVNYAAKA
MUL_3971|M.ulcerans_Agy99 IAGVPLTELAREYGTPLFVIDEDDFRSRCQEIAAAFGGGH--NVNYAAKA
Mb1325|M.bovis_AF2122/97 IAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGA--NVHYAAKA
Rv1293|M.tuberculosis_H37Rv IAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGA--NVHYAAKA
MLBr_01128|M.leprae_Br4923 IAGNKLTDLAGEYGTPLFVIDEDDFRFRCREIAAAFGGGE--NVHYAAKA
MAV_1508|M.avium_104 IAGVAVTELAREYGTPLFVVDEDDFRSRCREIASAFGGGN--NVHYAAKA
TH_2005|M.thermoresistible__bu IAGVRVTDIADEYGTPTFVIDEDDFRSRCREMAAAFGGGE--NVHYAAKA
Mflv_2297|M.gilvum_PYR-GCK IAGVPVADIAAEFGTPVFVIDEADFRSRCRDISSAFGGGE--YVHYAAKA
Mvan_4349|M.vanbaalenii_PYR-1 IAGVSVADIAAEFGTPVFVIDEADFRARCRDIAAAFGGGE--HVRYAAKA
MAB_1434|M.abscessus_ATCC_1997 LAGLAVSELAEQYGTPLFVIDEDDFRSRCRDMAAAFGGAA--RVHYASKA
MSMEG_6197|M.smegmatis_MC2_155 VADVVRQGFIDDLHPLCGVIDLDTLDELMASLHAAYPADLPALHTIAAKA
:*. : : . *:* : . :*: . *:**
MMAR_4104|M.marinum_M FLCSEIARWVNEEGLSIDVSTGGELAVALHANFPPERITLHGNNKSVAEL
MUL_3971|M.ulcerans_Agy99 FLCSEIARWVNEEGLSIDVSTGGELAVALHANFPPERITLHGNNKSVAEL
Mb1325|M.bovis_AF2122/97 FLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSEL
Rv1293|M.tuberculosis_H37Rv FLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSEL
MLBr_01128|M.leprae_Br4923 FLCTEIARWIDEEGLSLDVCSGGELAVALHASFPPERISLHGNNKSVAEL
MAV_1508|M.avium_104 FLCSEVARWIDEEGLSLDVCTGGELAVALHADFPPERITFHGNNKSVAEL
TH_2005|M.thermoresistible__bu FLCTEIARWIDEEGLCLDVASGGELAVALHAGFPAERITLHGNNKSVEEL
Mflv_2297|M.gilvum_PYR-GCK FLCGEIARWVDEEGLSLDVATGGELAVALHAGFPAERITVHGNNKSVAEL
Mvan_4349|M.vanbaalenii_PYR-1 FLCTEVARWIDEEGLSLDVASGGELAVALHAGFPAERIALHGNNKSVAEL
MAB_1434|M.abscessus_ATCC_1997 FLCTEVARWIKDEGLGLDVCSAGELAVALRAEFPPERIALHGNNKSEAEL
MSMEG_6197|M.smegmatis_MC2_155 ISLRPVLARFAAAGFGCEVASPGELELALAAGFPAERIVFDSPAKTPTEI
: : . *: :*.: *** :** * **.*** ... *: *:
MMAR_4104|M.marinum_M TTAVKAGVGHIVLDSMIEIERLDAIAGEAGIVQDVF-VRLTVGVEAHTHE
MUL_3971|M.ulcerans_Agy99 TTAVKAGVGHIVLDSMIEIERLDAIAGEAGIVQDVF-VRLTVGVEAHTHE
Mb1325|M.bovis_AF2122/97 TAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVL-VRLTVGVEAHTHE
Rv1293|M.tuberculosis_H37Rv TAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVL-VRLTVGVEAHTHE
MLBr_01128|M.leprae_Br4923 KDAVKAGVGYIVLDSTTEIERLDAIAGEAGIVQDVL-VRLTVGVEAHTHE
MAV_1508|M.avium_104 TAAVKAGVGHVVLDSMTEIERLDAIAADAGIVQDVF-VRLTVGVEAHTHE
TH_2005|M.thermoresistible__bu TTAVEAGVGHVVLDSMIEIERLDRIAAAAGKVQDVL-VRVTVGVEAHTHE
Mflv_2297|M.gilvum_PYR-GCK TAAVKHGVGHVVVDSMIEIERLDRIAADNGVVQDVL-VRVTVGVEAHTHE
Mvan_4349|M.vanbaalenii_PYR-1 TAAVEAGIEHVVVDSMTEIDRLDKIAGEAGVVQDVL-IRVTVGVEAHTHE
MAB_1434|M.abscessus_ATCC_1997 AQAVQAGVGHIVVDSMIEIDRLDAIAGRAGVVQDVL-VRVTVGVEAHTHE
MSMEG_6197|M.smegmatis_MC2_155 ARALELGVS-FNVDNFEELARIDAAVARNGRPRSVIGVRVNPQTGAGTID
*:: *: . :*. *: *:* .. * :.*: :*:. . * * :
MMAR_4104|M.marinum_M FISTAHEDQKFGLSISSGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD
MUL_3971|M.ulcerans_Agy99 FISTAHEDQKFGLSISSGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD
Mb1325|M.bovis_AF2122/97 FISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD
Rv1293|M.tuberculosis_H37Rv FISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVD
MLBr_01128|M.leprae_Br4923 FIATAHEDQKFGLSVASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVA
MAV_1508|M.avium_104 FISTAHEDQKFGLSVASGSALAAVGRVFDTEHLRLVGLHSHIGSQIFDVA
TH_2005|M.thermoresistible__bu FISTAHEDQKFGLSLASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVA
Mflv_2297|M.gilvum_PYR-GCK FISTAHEDQKFGLSLASGAAMEAVRRVFEAGNLRLVGLHSHIGSQIFDVA
Mvan_4349|M.vanbaalenii_PYR-1 FISTAHEDQKFGLSLASGAAMTAVRRVFETDHLRLVGLHSHIGSQIFDVA
MAB_1434|M.abscessus_ATCC_1997 FISTAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQIFDVD
MSMEG_6197|M.smegmatis_MC2_155 AMSTATSTSKFGIGLAD--HRDEIIDAFATR-PWLTQLHVHSGSQGMSLE
::** . .***:.::. : .* : *. ** * *** :.:
MMAR_4104|M.marinum_M GFELAAHRVIGLLREVVAEFGSEKTAQLATVDLGGGLGISYLSSDDPPPV
MUL_3971|M.ulcerans_Agy99 GFELAAHRVIGLLREVVAEFGSEKTAQLAMVDLGGGLGISYLSSDDPPPV
Mb1325|M.bovis_AF2122/97 GFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPI
Rv1293|M.tuberculosis_H37Rv GFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPI
MLBr_01128|M.leprae_Br4923 GFELAAHRVIGLLCDIVGEFDPEKTAQLSIVDLGGGLGISYLPDDDPPPI
MAV_1508|M.avium_104 GFELAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPM
TH_2005|M.thermoresistible__bu GFELAAHRVIGLLHDVVEEFGVEKTAQISTVDLGGGLGISYLPDDDPPPV
Mflv_2297|M.gilvum_PYR-GCK GFEIAAHRVIGLLRDVVAEFGVEKTSQMDIVDLGGGLGISYLPDDNPPPM
Mvan_4349|M.vanbaalenii_PYR-1 GFELAAHRVIGLLRDAVAEFGVEKTSQMSIVDLGGGLGISYLPHDDPPPM
MAB_1434|M.abscessus_ATCC_1997 GFEVAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPI
MSMEG_6197|M.smegmatis_MC2_155 HAAEGVRLTTDLAADIDARAG---SRQIQRIDVGGGLPVNFRSDDVTPTF
..: . .* : . . : *: :*:**** :.: . * .*..
MMAR_4104|M.marinum_M GELADKLGAIVSNESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDV
MUL_3971|M.ulcerans_Agy99 GELADKLGAIVSNESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDV
Mb1325|M.bovis_AF2122/97 AELAAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDV
Rv1293|M.tuberculosis_H37Rv AELAAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDV
MLBr_01128|M.leprae_Br4923 FELAAKLGAIVSNESAAVGLPVPKLMVEPGRAIAGPGTITLYEVGTIKDV
MAV_1508|M.avium_104 GELAGKLSAIVQHESAAVGLPTPRLVVEPGRAIAGPGTITLYEVGTVKDV
TH_2005|M.thermoresistible__bu EELAAKLKAIVRSESAAVGLPTPRLVVEPGRAIAGPGTITLYRVGTVKDV
Mflv_2297|M.gilvum_PYR-GCK SELAAKLRAIVARESAAVGLPAPKLVVEPGRAIAGPGTITLYEVGTVKDV
Mvan_4349|M.vanbaalenii_PYR-1 GELADKLHAIVRHESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDV
MAB_1434|M.abscessus_ATCC_1997 EDLAAKLGVIVRTESALAGLPGPRLVIEPGRAIAGPGTVTLYRVGTTKDV
MSMEG_6197|M.smegmatis_MC2_155 ADHRAALQAAAPRLFDGT----YTVVTEFGRALTAKAGTVVARVEYTKVT
: * . . . :: * ***::. . .: .* * .
MMAR_4104|M.marinum_M DVSATANRRYVSVDGGMSDNIRTALYDAQYDVRLVS-RVSDAPATLARVV
MUL_3971|M.ulcerans_Agy99 DVSATANRRYVSVDGGMSDNIRTALYDAQYDVRLVS-RVSDAPAMLARVV
Mb1325|M.bovis_AF2122/97 DVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVS-RVSDAPPVPARLV
Rv1293|M.tuberculosis_H37Rv DVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVS-RVSDAPPVPARLV
MLBr_01128|M.leprae_Br4923 DVSATAHRRYVSIDGGMSDNIRTALYDAQYDVRLVS-RTSDAPAAPASIV
MAV_1508|M.avium_104 DVSATAHRRYVSVDGGMSDNIRTALYDAQYDARLVS-RVSDAPAELARIV
TH_2005|M.thermoresistible__bu AISPTAYRRYVSVDGGMSDNIRTALYGAQYDARLVS-RRTDAEPALGRIV
Mflv_2297|M.gilvum_PYR-GCK AVSPTSHRRYVSVDGGMSDNIRTSLYGAEYDVRLLS-RVSDATPTLSRVV
Mvan_4349|M.vanbaalenii_PYR-1 AISSDRNRRYVSVDGGMSDNIRTSLYDAEYDVRLVS-RTSNAEPTLSRVV
MAB_1434|M.abscessus_ATCC_1997 ILS-NGQRRYVSVDGGMSDNIRTSLYQAEYHPQLVS-RDSDVAPVLSRVV
MSMEG_6197|M.smegmatis_MC2_155 GGRPIAIT-HAGVQVATRSIFAPEAWPLRVEVYDAHGRRRDDPPRVQDVA
:..:: . . : . : . . * : . :.
MMAR_4104|M.marinum_M GKHCESGDIIVRDTWVPDDLQPGDLVAVAATGAYCYSLSSRYNMIGRPAV
MUL_3971|M.ulcerans_Agy99 GKHCESGDIIVRDTWVPDDLQPGDLVAVAATGAYCYSLSSRYNMIGRPAV
Mb1325|M.bovis_AF2122/97 GKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAV
Rv1293|M.tuberculosis_H37Rv GKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAV
MLBr_01128|M.leprae_Br4923 GKHCESGDIVVRDTWVPDDLKPGDLVGVAATGAYCYSLSSRYNMLGRPAV
MAV_1508|M.avium_104 GKHCESGDIVVRDTWVPGDLRPGDLIGVAATGAYCYSLSSRYNMVCRPAV
TH_2005|M.thermoresistible__bu GKHCESGDIVVRDVWVPGDVQPGDLIGVAATGAYCYSMSSRYNLIGRPAV
Mflv_2297|M.gilvum_PYR-GCK GKHCESGDIVVRDAWLSEDVRPGDLLGVAATGAYCYSMSSRYNLIGRPAV
Mvan_4349|M.vanbaalenii_PYR-1 GKHCESGDIVVRDAWIPDDVGPGDLLGVAATGAYCYSMSSRYNLIGRPAV
MAB_1434|M.abscessus_ATCC_1997 GKHCESGDIVVRDAWLPEDVAPGDLLAVAATGAYCYSMSSRYNLLTRPAV
MSMEG_6197|M.smegmatis_MC2_155 GPACFTGDMLAVGRELP-PVHAGDLVAVPDTGGYYFSTHFSYNALPRPAV
* * :**::. . :. : .***:.*. **.* :* ** : ****
MMAR_4104|M.marinum_M VAVR-----AGKARLVLRRETVDDLLSLEVR----------------
MUL_3971|M.ulcerans_Agy99 VAVR-----AGKARLVLRRETVDDLLSLEVR----------------
Mb1325|M.bovis_AF2122/97 VAVH-----AGNARLVLRRETVDDLLSLEVR----------------
Rv1293|M.tuberculosis_H37Rv VAVH-----AGNARLVLRRETVDDLLSLEVR----------------
MLBr_01128|M.leprae_Br4923 VAVC-----AGQARLILRRETVDDLLSLEVR----------------
MAV_1508|M.avium_104 VAVR-----DGRARLVLRRETVDDLLSLEVR----------------
TH_2005|M.thermoresistible__bu VVVR-----DGRARLILRRETVDDLLSLEVR----------------
Mflv_2297|M.gilvum_PYR-GCK VAVR-----DGRARLILRRETVEDLLSLEVR----------------
Mvan_4349|M.vanbaalenii_PYR-1 VAVR-----DGRARLILRRETFDDLLSLEVSEVKR------------
MAB_1434|M.abscessus_ATCC_1997 IAVK-----DGRARLILRRETVEDLVSLEVSE---------------
MSMEG_6197|M.smegmatis_MC2_155 YTVGTDQHGDRRWSLARRAQTIEQIVAEAGEPSLEPLTFRPPNRPSD
.* . * * :*.:::::