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VNVHTAGPRHAEKTRHTATPQRVQPSDDLLRLASNVWPRNITRDETGVACIAGNKLTDLAGEYGTPLFVI DEDDFRFRCREIAAAFGGGENVHYAAKAFLCTEIARWIDEEGLSLDVCSGGELAVALHASFPPERISLHG NNKSVAELKDAVKAGVGYIVLDSTTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIATAHEDQKFGL SVASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVAGFELAAHRVIGLLCDIVGEFDPEKTAQLSIVDL GGGLGISYLPDDDPPPIFELAAKLGAIVSNESAAVGLPVPKLMVEPGRAIAGPGTITLYEVGTIKDVDVS ATAHRRYVSIDGGMSDNIRTALYDAQYDVRLVSRTSDAPAAPASIVGKHCESGDIVVRDTWVPDDLKPGD LVGVAATGAYCYSLSSRYNMLGRPAVVAVCAGQARLILRRETVDDLLSLEVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01128 | lysA | - | 100% (472) | diaminopimelate decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1325 | lysA | 0.0 | 86.77% (446) | diaminopimelate decarboxylase LysA |
| M. gilvum PYR-GCK | Mflv_2297 | - | 0.0 | 75.42% (472) | diaminopimelate decarboxylase |
| M. tuberculosis H37Rv | Rv1293 | lysA | 0.0 | 86.77% (446) | diaminopimelate decarboxylase LysA |
| M. abscessus ATCC 19977 | MAB_1434 | - | 0.0 | 71.97% (471) | diaminopimelate decarboxylase |
| M. marinum M | MMAR_4104 | lysA | 0.0 | 84.11% (472) | diaminopimelate decarboxylase LysA |
| M. avium 104 | MAV_1508 | lysA | 0.0 | 82.20% (472) | diaminopimelate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_4958 | lysA | 0.0 | 78.60% (472) | diaminopimelate decarboxylase |
| M. thermoresistible (build 8) | TH_2005 | lysA | 0.0 | 80.30% (472) | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP |
| M. ulcerans Agy99 | MUL_3971 | lysA | 0.0 | 83.90% (472) | diaminopimelate decarboxylase LysA |
| M. vanbaalenii PYR-1 | Mvan_4349 | - | 0.0 | 76.65% (471) | diaminopimelate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2297|M.gilvum_PYR-GCK MIAHPAGPRHAEEVPSAAAPERPQSAADVSRLAPNVWPQNTVRGDDGAVS
Mvan_4349|M.vanbaalenii_PYR-1 MIAHPAGPRHAEEVHPVATPDRPRTAAEVLQLAPNVWPQNAVRGADGVVS
Mb1325|M.bovis_AF2122/97 -------------------------MNELLHLAPNVWPRNTTRDEVGVVC
Rv1293|M.tuberculosis_H37Rv -------------------------MNELLHLAPNVWPRNTTRDEVGVVC
MLBr_01128|M.leprae_Br4923 MNVHTAGPRHAEKTRHTATPQRVQPSDDLLRLASNVWPRNITRDETGVAC
MMAR_4104|M.marinum_M MNVHPAGPRHAEESRHPESPQRPQSAEELLYLAPNVWPRNTTRDEQGCAR
MUL_3971|M.ulcerans_Agy99 MNVHPAGPRHAEESRHPESPQRPQSAEELLYLAPNVWPRNTARDEQGCAR
MAV_1508|M.avium_104 MNVHPAGPRHAEETRHPESPPRPQSPEELLLLAPNVWPRNATRNEAGVAT
TH_2005|M.thermoresistible__bu VIAHPAGPRHAEEIHHGETPPRPQSPDELLLLAPNVWPRNTVRESDGVVS
MSMEG_4958|M.smegmatis_MC2_155 MNAHPAGPRHAEELHHADVPDKPQSPDEIMLLAPNVWPRNLVRGADGVVT
MAB_1434|M.abscessus_ATCC_1997 MSAHPAGPRHAEGEQHTAMSSAP--PANPTELASNVWPRNASRGADGEVT
: **.****:* * * .
Mflv_2297|M.gilvum_PYR-GCK IAGVPVADIAAEFGTPVFVIDEADFRSRCRDISSAFGGGEYVHYAAKAFL
Mvan_4349|M.vanbaalenii_PYR-1 IAGVSVADIAAEFGTPVFVIDEADFRARCRDIAAAFGGGEHVRYAAKAFL
Mb1325|M.bovis_AF2122/97 IAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFL
Rv1293|M.tuberculosis_H37Rv IAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFL
MLBr_01128|M.leprae_Br4923 IAGNKLTDLAGEYGTPLFVIDEDDFRFRCREIAAAFGGGENVHYAAKAFL
MMAR_4104|M.marinum_M IAGVPLTELAREYGTPLFVIDEDDFRSRCQEIAAAFGGGHNVNYAAKAFL
MUL_3971|M.ulcerans_Agy99 IAGVPLTELAREYGTPLFVIDEDDFRSRCQEIAAAFGGGHNVNYAAKAFL
MAV_1508|M.avium_104 IAGVAVTELAREYGTPLFVVDEDDFRSRCREIASAFGGGNNVHYAAKAFL
TH_2005|M.thermoresistible__bu IAGVRVTDIADEYGTPTFVIDEDDFRSRCREMAAAFGGGENVHYAAKAFL
MSMEG_4958|M.smegmatis_MC2_155 IAGVPVTDLAAKFGTPLFVIDEDDFRTRCRDIAAAFGGGQYVHYAAKAFL
MAB_1434|M.abscessus_ATCC_1997 LAGLAVSELAEQYGTPLFVIDEDDFRSRCRDMAAAFGGAARVHYASKAFL
:** ::::* ::*** **:** *** **:: ::***.. *.**:****
Mflv_2297|M.gilvum_PYR-GCK CGEIARWVDEEGLSLDVATGGELAVALHAGFPAERITVHGNNKSVAELTA
Mvan_4349|M.vanbaalenii_PYR-1 CTEVARWIDEEGLSLDVASGGELAVALHAGFPAERIALHGNNKSVAELTA
Mb1325|M.bovis_AF2122/97 CSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTA
Rv1293|M.tuberculosis_H37Rv CSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTA
MLBr_01128|M.leprae_Br4923 CTEIARWIDEEGLSLDVCSGGELAVALHASFPPERISLHGNNKSVAELKD
MMAR_4104|M.marinum_M CSEIARWVNEEGLSIDVSTGGELAVALHANFPPERITLHGNNKSVAELTT
MUL_3971|M.ulcerans_Agy99 CSEIARWVNEEGLSIDVSTGGELAVALHANFPPERITLHGNNKSVAELTT
MAV_1508|M.avium_104 CSEVARWIDEEGLSLDVCTGGELAVALHADFPPERITFHGNNKSVAELTA
TH_2005|M.thermoresistible__bu CTEIARWIDEEGLCLDVASGGELAVALHAGFPAERITLHGNNKSVEELTT
MSMEG_4958|M.smegmatis_MC2_155 CSEIARWVDEEGLSLDVATGGELAVALHAGFPASRITVHGNNKSVAELTA
MAB_1434|M.abscessus_ATCC_1997 CTEVARWIKDEGLGLDVCSAGELAVALRAEFPPERIALHGNNKSEAELAQ
* *:***:.:*** :**.:.*******:* **..**:.****** **
Mflv_2297|M.gilvum_PYR-GCK AVKHGVGHVVVDSMIEIERLDRIAADNGVVQDVLVRVTVGVEAHTHEFIS
Mvan_4349|M.vanbaalenii_PYR-1 AVEAGIEHVVVDSMTEIDRLDKIAGEAGVVQDVLIRVTVGVEAHTHEFIS
Mb1325|M.bovis_AF2122/97 AVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIS
Rv1293|M.tuberculosis_H37Rv AVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIS
MLBr_01128|M.leprae_Br4923 AVKAGVGYIVLDSTTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFIA
MMAR_4104|M.marinum_M AVKAGVGHIVLDSMIEIERLDAIAGEAGIVQDVFVRLTVGVEAHTHEFIS
MUL_3971|M.ulcerans_Agy99 AVKAGVGHIVLDSMIEIERLDAIAGEAGIVQDVFVRLTVGVEAHTHEFIS
MAV_1508|M.avium_104 AVKAGVGHVVLDSMTEIERLDAIAADAGIVQDVFVRLTVGVEAHTHEFIS
TH_2005|M.thermoresistible__bu AVEAGVGHVVLDSMIEIERLDRIAAAAGKVQDVLVRVTVGVEAHTHEFIS
MSMEG_4958|M.smegmatis_MC2_155 AVQAGVGHVVLDSEIEIERLDQIAGAAGVVQDVLVRVTVGVEAHTHEFIS
MAB_1434|M.abscessus_ATCC_1997 AVQAGVGHIVVDSMIEIDRLDAIAGRAGVVQDVLVRVTVGVEAHTHEFIS
**: *: ::*:** **:*** **. * ****::*:************:
Mflv_2297|M.gilvum_PYR-GCK TAHEDQKFGLSLASGAAMEAVRRVFEAGNLRLVGLHSHIGSQIFDVAGFE
Mvan_4349|M.vanbaalenii_PYR-1 TAHEDQKFGLSLASGAAMTAVRRVFETDHLRLVGLHSHIGSQIFDVAGFE
Mb1325|M.bovis_AF2122/97 TAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFE
Rv1293|M.tuberculosis_H37Rv TAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFE
MLBr_01128|M.leprae_Br4923 TAHEDQKFGLSVASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVAGFE
MMAR_4104|M.marinum_M TAHEDQKFGLSISSGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFE
MUL_3971|M.ulcerans_Agy99 TAHEDQKFGLSISSGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFE
MAV_1508|M.avium_104 TAHEDQKFGLSVASGSALAAVGRVFDTEHLRLVGLHSHIGSQIFDVAGFE
TH_2005|M.thermoresistible__bu TAHEDQKFGLSLASGAAMAAVRRVFATDNLRLVGLHSHIGSQIFDVAGFE
MSMEG_4958|M.smegmatis_MC2_155 TAHEDQKFGLSLATGAAMNAIRRVFATDNLRLVGLHSHIGSQIFDVAGFE
MAB_1434|M.abscessus_ATCC_1997 TAHEDQKFGLSLAGGQALEAVRRVFATDNLRLVGLHSHIGSQIFDVDGFE
***********:: * *: *: *** : :***************** ***
Mflv_2297|M.gilvum_PYR-GCK IAAHRVIGLLRDVVAEFGVEKTSQMDIVDLGGGLGISYLPDDNPPPMSEL
Mvan_4349|M.vanbaalenii_PYR-1 LAAHRVIGLLRDAVAEFGVEKTSQMSIVDLGGGLGISYLPHDDPPPMGEL
Mb1325|M.bovis_AF2122/97 LAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAEL
Rv1293|M.tuberculosis_H37Rv LAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAEL
MLBr_01128|M.leprae_Br4923 LAAHRVIGLLCDIVGEFDPEKTAQLSIVDLGGGLGISYLPDDDPPPIFEL
MMAR_4104|M.marinum_M LAAHRVIGLLREVVAEFGSEKTAQLATVDLGGGLGISYLSSDDPPPVGEL
MUL_3971|M.ulcerans_Agy99 LAAHRVIGLLREVVAEFGSEKTAQLAMVDLGGGLGISYLSSDDPPPVGEL
MAV_1508|M.avium_104 LAARRVIGLLHDAVEQFGVEKTAQIATVDLGGGLGISYLAADDPPPMGEL
TH_2005|M.thermoresistible__bu LAAHRVIGLLHDVVEEFGVEKTAQISTVDLGGGLGISYLPDDDPPPVEEL
MSMEG_4958|M.smegmatis_MC2_155 IAAHRVIGLLRDVVAEFGVEKTSQMSIVDLGGGLGISYLPHDDPPPMKEL
MAB_1434|M.abscessus_ATCC_1997 VAAHRVIGLLRDVVAEFGTDKTAQLNIIDLGGGLGISYVPSDDPPPIEDL
:**:****** : * :*. :**:*: :**********:. *:***: :*
Mflv_2297|M.gilvum_PYR-GCK AAKLRAIVARESAAVGLPAPKLVVEPGRAIAGPGTITLYEVGTVKDVAVS
Mvan_4349|M.vanbaalenii_PYR-1 ADKLHAIVRHESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDVAIS
Mb1325|M.bovis_AF2122/97 AAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVS
Rv1293|M.tuberculosis_H37Rv AAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVS
MLBr_01128|M.leprae_Br4923 AAKLGAIVSNESAAVGLPVPKLMVEPGRAIAGPGTITLYEVGTIKDVDVS
MMAR_4104|M.marinum_M ADKLGAIVSNESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDVDVS
MUL_3971|M.ulcerans_Agy99 ADKLGAIVSNESAAVGLPAPRLVVEPGRAIAGPGTITLYEVGTVKDVDVS
MAV_1508|M.avium_104 AGKLSAIVQHESAAVGLPTPRLVVEPGRAIAGPGTITLYEVGTVKDVDVS
TH_2005|M.thermoresistible__bu AAKLKAIVRSESAAVGLPTPRLVVEPGRAIAGPGTITLYRVGTVKDVAIS
MSMEG_4958|M.smegmatis_MC2_155 ADKLLEIVRTESAAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVAVS
MAB_1434|M.abscessus_ATCC_1997 AAKLGVIVRTESALAGLPGPRLVIEPGRAIAGPGTVTLYRVGTTKDVILS
* ** ** **: .*** *:*::***********:***.*** *** :*
Mflv_2297|M.gilvum_PYR-GCK PTSHRRYVSVDGGMSDNIRTSLYGAEYDVRLLSRVSDATPTLSRVVGKHC
Mvan_4349|M.vanbaalenii_PYR-1 SDRNRRYVSVDGGMSDNIRTSLYDAEYDVRLVSRTSNAEPTLSRVVGKHC
Mb1325|M.bovis_AF2122/97 ATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHC
Rv1293|M.tuberculosis_H37Rv ATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHC
MLBr_01128|M.leprae_Br4923 ATAHRRYVSIDGGMSDNIRTALYDAQYDVRLVSRTSDAPAAPASIVGKHC
MMAR_4104|M.marinum_M ATANRRYVSVDGGMSDNIRTALYDAQYDVRLVSRVSDAPATLARVVGKHC
MUL_3971|M.ulcerans_Agy99 ATANRRYVSVDGGMSDNIRTALYDAQYDVRLVSRVSDAPAMLARVVGKHC
MAV_1508|M.avium_104 ATAHRRYVSVDGGMSDNIRTALYDAQYDARLVSRVSDAPAELARIVGKHC
TH_2005|M.thermoresistible__bu PTAYRRYVSVDGGMSDNIRTALYGAQYDARLVSRRTDAEPALGRIVGKHC
MSMEG_4958|M.smegmatis_MC2_155 QTAHRRYVSVDGGMSDNIRTSLYAAQYDARLVSRVSDAPPALARIVGKHC
MAB_1434|M.abscessus_ATCC_1997 -NGQRRYVSVDGGMSDNIRTSLYQAEYHPQLVSRDSDVAPVLSRVVGKHC
*****:**********:** *:*. :*:** ::. . . :*****
Mflv_2297|M.gilvum_PYR-GCK ESGDIVVRDAWLSEDVRPGDLLGVAATGAYCYSMSSRYNLIGRPAVVAVR
Mvan_4349|M.vanbaalenii_PYR-1 ESGDIVVRDAWIPDDVGPGDLLGVAATGAYCYSMSSRYNLIGRPAVVAVR
Mb1325|M.bovis_AF2122/97 ESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVH
Rv1293|M.tuberculosis_H37Rv ESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVH
MLBr_01128|M.leprae_Br4923 ESGDIVVRDTWVPDDLKPGDLVGVAATGAYCYSLSSRYNMLGRPAVVAVC
MMAR_4104|M.marinum_M ESGDIIVRDTWVPDDLQPGDLVAVAATGAYCYSLSSRYNMIGRPAVVAVR
MUL_3971|M.ulcerans_Agy99 ESGDIIVRDTWVPDDLQPGDLVAVAATGAYCYSLSSRYNMIGRPAVVAVR
MAV_1508|M.avium_104 ESGDIVVRDTWVPGDLRPGDLIGVAATGAYCYSLSSRYNMVCRPAVVAVR
TH_2005|M.thermoresistible__bu ESGDIVVRDVWVPGDVQPGDLIGVAATGAYCYSMSSRYNLIGRPAVVVVR
MSMEG_4958|M.smegmatis_MC2_155 ESGDIVVRDTWVSDDIAPGDLIGVAATGAYCYSMSSRYNLLCRPAVVAVA
MAB_1434|M.abscessus_ATCC_1997 ESGDIVVRDAWLPEDVAPGDLLAVAATGAYCYSMSSRYNLLTRPAVIAVK
*****:***.*:. *: ****:.**********:*****:: ****:.*
Mflv_2297|M.gilvum_PYR-GCK DGRARLILRRETVEDLLSLEVR----
Mvan_4349|M.vanbaalenii_PYR-1 DGRARLILRRETFDDLLSLEVSEVKR
Mb1325|M.bovis_AF2122/97 AGNARLVLRRETVDDLLSLEVR----
Rv1293|M.tuberculosis_H37Rv AGNARLVLRRETVDDLLSLEVR----
MLBr_01128|M.leprae_Br4923 AGQARLILRRETVDDLLSLEVR----
MMAR_4104|M.marinum_M AGKARLVLRRETVDDLLSLEVR----
MUL_3971|M.ulcerans_Agy99 AGKARLVLRRETVDDLLSLEVR----
MAV_1508|M.avium_104 DGRARLVLRRETVDDLLSLEVR----
TH_2005|M.thermoresistible__bu DGRARLILRRETVDDLLSLEVR----
MSMEG_4958|M.smegmatis_MC2_155 DGQARLVLRRETVEDLLSLEVKGQ--
MAB_1434|M.abscessus_ATCC_1997 DGRARLILRRETVEDLVSLEVSE---
*.***:*****.:**:****