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M. smegmatis MC2 155 MSMEG_6117 (-)

TAHGTTPVVTEMTVIQVAGHDSMLLNLSGAHGPYFTRNLVKLTDSDGNTGVGEVPGGEAIRRTLTDATPL
VVGRSIGEYHATLAAIRGAFADRDSGGRGAQTFDLRVTVHAVTAVESALLDLMGKHLGVPVAALLGDGQQ
RNRVQALGYLFFVGDRNRTDLPYRAPDDEPAGADEWQRIRHDEALSPEAVVRLAEAARARYGFRDFKLKG
GVLPAAEEAKAVTALAERFPDARITLDPNGGWLLRDAIVTCRQLTDVLAYAEDPVGPEGTFSGREVMAEF
KRATGLPTATNMIATDWRELGHAIRAGAVDIPLADPHFWTMSGSVRVAAICDAWGLTWGSHSNNHFDVSL
AMFTHVAAAAPGDITAIDTHWIWQDGQRITKQPFEIVDGYLDVPTAPGLGVELDDDRVAAAHELYLAEGL
GARDDSVAMQYLIPGWTFDPKRPALQRK*

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_6117	-	-	100% (449)	glucarate dehydratase
M. smegmatis MC2 155	MSMEG_6132	-	7e-61	36.11% (432)	glucarate dehydratase
M. smegmatis MC2 155	MSMEG_6871	-	4e-29	28.28% (389)	isomerase

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	-	-	-	-	-
M. gilvum PYR-GCK	Mflv_1357	-	5e-15	27.91% (387)	mandelate racemase/muconate lactonizing protein
M. tuberculosis H37Rv	-	-	-	-	-
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	-	-	-	-	-
M. marinum M	-	-	-	-	-
M. avium 104	-	-	-	-	-
M. thermoresistible (build 8)	-	-	-	-	-
M. ulcerans Agy99	-	-	-	-	-
M. vanbaalenii PYR-1	Mvan_1017	-	0.0	82.13% (442)	glucarate dehydratase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_6117|M.smegmatis_MC2_155      MTAHGTTPVVTEMTVIQVAGHDSMLLNLSGAHGPYFTRNLVKLTDSDGNT
Mvan_1017|M.vanbaalenii_PYR-1       ----MRTPVITDVTVVPIAGHDSMLLNLSGAHGPFFTRNLVIVEDSEGNT
Mflv_1357|M.gilvum_PYR-GCK          -------MKITAVDAIPFAIPYTKPLKFASGEVHTAEHVLVRVHTDEGVV
                                             :* : .: .*   :  *:::...     : ** :  .:* .

MSMEG_6117|M.smegmatis_MC2_155      GVGEVPGGEAIRRTLTDATPLVVGRSIGEYHATLAAIRGAFADRDSGGRG
Mvan_1017|M.vanbaalenii_PYR-1       GVGEVPGGEPIRRTLQDARGIVTGRSIGDYHAVLNEMRRTFADRDAGGRG
Mflv_1357|M.gilvum_PYR-GCK          GVAEAPPRPFTYGETQDGILAVIRQIFAPQIVGLTLTEREVVN----ARL
                                    **.*.*          *.   *  : :.   . *   .  ..:    .* 

MSMEG_6117|M.smegmatis_MC2_155      AQTFDLRVTVHAVTAVESALLDLMGKHLGVPVAALLGDGQQRNRVQALGY
Mvan_1017|M.vanbaalenii_PYR-1       AQTFDLRVTVHAVTAIESALMDLLGQHLEVPVAALLGDGQQRSRVQALGY
Mflv_1357|M.gilvum_PYR-GCK          ARTVGN---PTAKAAVDMAIWDALGRSLDLSVSALLGG------------
                                    *:*..      * :*:: *: * :*: * :.*:****.            

MSMEG_6117|M.smegmatis_MC2_155      LFFVGDRNRTDLPYRAPDDEPAGADEWQRIRHDEALSPEAVVRLAEAARA
Mvan_1017|M.vanbaalenii_PYR-1       LFFVGDRTRTDLAYRSPSDEEPGADDWFTVRHEEAMTPDAVVRLAEAARA
Mflv_1357|M.gilvum_PYR-GCK          ---YGDHMRVSHMLG-------------------FDTPDTMVAEAERIRD
                                        **: *..                         :*:::*  **  * 

MSMEG_6117|M.smegmatis_MC2_155      RYGFRDFKLKGGVLPAAEEAKAVTALAERFPD-ARITLDPNGGWLLRDAI
Mvan_1017|M.vanbaalenii_PYR-1       RYGFADFKLKGGVLPAADEAKAVIALAERFPD-SRITLDPNGGWLLADAI
Mflv_1357|M.gilvum_PYR-GCK          EYGISTFKVKVGRRPVTLDTAVVRALRERFGDTVELYVDGNRGWTASESL
                                    .**:  **:* *  *.: :: .* ** *** *  .: :* * **   :::

MSMEG_6117|M.smegmatis_MC2_155      VTCRQLTDVLAYAEDPVGPEGTFSGREVMAEFKRATGLPTATNMIATDWR
Mvan_1017|M.vanbaalenii_PYR-1       RTCRELKDVLAYAEDPVGPEDGFSGREVMAEFKRATGLPTATNMIATDWR
Mflv_1357|M.gilvum_PYR-GCK          RALKDMADLDLLFAEELCPADDVLGRRWLVEHT---EIPFIADESVPTPA
                                     : ::: *:     : : * . . **. :.*..    :*  ::  ..   

MSMEG_6117|M.smegmatis_MC2_155      ELGHAIRAGAVDIPLADPHFWTMSGSVRVAAICDAWGLTWGSHSNNHFDV
Mvan_1017|M.vanbaalenii_PYR-1       EMGHAIRSGAVDIPLADPHFWTMTGSVRVAQLCDAWGLTWGSHSNNHFDV
Mflv_1357|M.gilvum_PYR-GCK          DVTREVLGGSATAISIKTARTGFTGSRRVHHLAEGLGLEVVMG--NQIDG
                                    :: : : .*:.     ..    ::** **  :.:. **       *::* 

MSMEG_6117|M.smegmatis_MC2_155      SLAMFTHVAAAAPGDITAIDT---HWIWQDGQRITKQPFEIVDGYLDVPT
Mvan_1017|M.vanbaalenii_PYR-1       SLAMFTHVAAAAPGDITAIDT---HWIWQDGQAITTNPYPIVDGYLSVPD
Mflv_1357|M.gilvum_PYR-GCK          QLGTACAVAFGAAFELTSRRAGELSNFLDMSDDLLTHPLRIRDGRLHVPP
                                    .*.    ** .*. ::*:  :     : : .: : .:*  * ** * ** 

MSMEG_6117|M.smegmatis_MC2_155      APGLGVELDDDRVAAAHELYLAEGLGARDDSVAMQYLIPGWTFDPKRPAL
Mvan_1017|M.vanbaalenii_PYR-1       APGLGVTLDEPAVQAAHALYQREGLGGRDDAVAMQYLIPGWTFDGKRPAL
Mflv_1357|M.gilvum_PYR-GCK          GPGLGIEIDPDKLDHYRTDH------------------------------
                                    .****: :*   :   :  :                              

MSMEG_6117|M.smegmatis_MC2_155      QRK
Mvan_1017|M.vanbaalenii_PYR-1       DRG
Mflv_1357|M.gilvum_PYR-GCK          ---