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VLVAGQDDARGTGRAVVEELLKAPGTLLVSHTFDGHVVVRTVSSSVDSSQWVLELVHGCVSCTVRDDLLI LLRRLHRRADVTRIVVQMMPWLEPEPVRWAIDNVHVRVGPGYIDGPAARDVEVAAVVTCVDTAAWLEQAL GEDELADGRTAAQVVVGQAEVADVLVLGEPEATTLAVLRRLAPRARITVGPDRLELALAHLEPDTPRGRA LSPRDSLLAGQPPLTADGEVRIVEFTARRPFHPVRLHAAIDLLLDGVVRTRGRAWLANRDAEVMWIESAG GGLRVSTAGKWLAAMNSSELAYTDPQWRALAAIDWDPSFGDRHVSLVMLVCGARTDDILDALRGALLTDA EFARRQEWRHYPDPFGDWHQEPCDADQAAHAAQFSDARHHPDPQTGEQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6069 | - | - | 100% (399) | CobW/P47K domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6048 | - | 3e-25 | 30.52% (344) | cobalamin synthesis protein/P47K |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0109 | - | 1e-134 | 62.09% (393) | hypothetical protein Mb0109 |
| M. gilvum PYR-GCK | Mflv_1313 | - | 1e-107 | 56.12% (376) | cobalamin synthesis CobW domain-containing protein |
| M. tuberculosis H37Rv | Rv0106 | - | 1e-134 | 62.09% (393) | hypothetical protein Rv0106 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0335 | - | 1e-138 | 62.20% (381) | cobalamin synthesis protein |
| M. marinum M | MMAR_0293 | - | 1e-133 | 61.44% (389) | hypothetical protein MMAR_0293 |
| M. avium 104 | MAV_4874 | - | 1e-130 | 62.04% (382) | CobW/P47K domain-containing protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4830 | - | 1e-132 | 61.18% (389) | hypothetical protein MUL_4830 |
| M. vanbaalenii PYR-1 | Mvan_5332 | - | 1e-119 | 55.42% (397) | cobalamin synthesis CobW domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0109|M.bovis_AF2122/97 -MRTPVILVAGQDHTD----EVTGALLRRTGTVVVEHRFDGHVVRRMTAT
Rv0106|M.tuberculosis_H37Rv -MRTPVILVAGQDHTD----EVTGALLRRTGTVVVEHRFDGHVVRRMTAT
MMAR_0293|M.marinum_M -MRTPVVLVAGQGDTD----DVTGLLLRRPGTVVVEHRFDGHVVRRNIIT
MUL_4830|M.ulcerans_Agy99 -MRTPVVLVAGQGDTD----DVTGLLLRRPGTVVVEHRFDGHVVRRNIIT
MAB_0335|M.abscessus_ATCC_1997 -MRTPVLLVSGQTDTD----AVTQVLARDPGTVVVTHRFDGHIVMRSVAG
MAV_4874|M.avium_104 ----------------------MGALLRTSGTLVVEHRFDGHVVRRTTAV
Mvan_5332|M.vanbaalenii_PYR-1 MNRTPVLLVSGQELTD----QISEALLHKSGTLVVRHRFDGQVVLRSVCI
MSMEG_6069|M.smegmatis_MC2_155 ------MLVAGQDDARGTGRAVVEELLKAPGTLLVSHTFDGHVVVRTVSS
Mflv_1313|M.gilvum_PYR-GCK -MRTPVVVVTGQSDTG----DIGDLLLADGATALVEHHVEGHVVHRTTTV
* .* :* * .:*::* *
Mb0109|M.bovis_AF2122/97 LSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAP
Rv0106|M.tuberculosis_H37Rv LSRGELITTEDALEFAHGCVSCTIRDDLLVLLRRLHRRDNVGRIVVHLAP
MMAR_0293|M.marinum_M FRRGELSTAEEVLELAHGCVSCTIRNDLLILLRRLHRRDGVDRIVVHLAP
MUL_4830|M.ulcerans_Agy99 FRRGELSTAEEALELAHGCVSCTIRNDLLILLRRLHRRDGVDRIVVHLAP
MAB_0335|M.abscessus_ATCC_1997 IRG----VTETVLELAHGCVSCTIRDDLLVLLRKLHRRDDVGRIVLHLEP
MAV_4874|M.avium_104 LTDGVLTSTECGLELAHGCVSCTIRNDLLVLLRQLHRRDDVDRIVVHLAP
Mvan_5332|M.vanbaalenii_PYR-1 RRGDEPHTSQWPIELMNCCVDCTIRSDLLVLLRRLHRRDDVSRIVVHLPP
MSMEG_6069|M.smegmatis_MC2_155 SVD----SSQWVLELVHGCVSCTVRDDLLILLRRLHRRADVTRIVVQMMP
Mflv_1313|M.gilvum_PYR-GCK LRRGVVVKAVSVVEMTNGCPSCAVREDLVDHLCRLHLRPDVARIAVLLSP
: :*: : * .*::*.**: * :** * .* **.: : *
Mb0109|M.bovis_AF2122/97 WLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSL
Rv0106|M.tuberculosis_H37Rv WLEPQPICWAIDHVRVCVGHGYPDGPAALDVRVAAVVTCVDCVRWLPQSL
MMAR_0293|M.marinum_M WLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAVVTCVDSANWLAQSL
MUL_4830|M.ulcerans_Agy99 WLEPEPICWAINHVRVRVGPGYPDAPAGRDVRIGAVVTCVDSANWLAQSL
MAB_0335|M.abscessus_ATCC_1997 WLEADPICWAINTVPVRVGPGFVDGPAARDVQIAGVVSCVDSANWLEQAL
MAV_4874|M.avium_104 WLEPEPICLAINHVRVRVAPGGVDGPAALDVSIAAVVTCVDSSTWLSQAL
Mvan_5332|M.vanbaalenii_PYR-1 WLEPEPLCWDINNVDVVVGPGYIDGPAARDVRIEAVITTVATGQWLTDAL
MSMEG_6069|M.smegmatis_MC2_155 WLEPEPVRWAIDNVHVRVGPGYIDGPAARDVEVAAVVTCVDTAAWLEQAL
Mflv_1313|M.gilvum_PYR-GCK WMEPEPVCVALTRS-----------TAARHVAVSAVVATVDTSVWLHQAL
*:*.:*: : .*. .* : .*:: * ** ::*
Mb0109|M.bovis_AF2122/97 GEDELPDGRTVAQVTVGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGG
Rv0106|M.tuberculosis_H37Rv GEDELPDGRTVAQVTVGQAEFADLLVLTHPEPVAVAVLRRLAPRARITGG
MMAR_0293|M.marinum_M GDEELADGRTFAQVTVGQAEFADVLVLNRPDPVTLAVLPRLAPRARITVG
MUL_4830|M.ulcerans_Agy99 GDEELADGRTFAQVTVGQAEFADVLVLNRPDPVTLAVLPRLAPRARITVG
MAB_0335|M.abscessus_ATCC_1997 GDDELADGRTVAQVVIGQAEFADVLLVRNPEPEVLSVLRRLAPRARITAR
MAV_4874|M.avium_104 GEDELDDGRTHAQVVIGQAEFADVVVLDHPNPFLAAVLRRLAPRARVRVG
Mvan_5332|M.vanbaalenii_PYR-1 GADVLDDGRTVAQVVVGQAEFADVLLLSAPDRTTQAVLHRLAPRAQIITG
MSMEG_6069|M.smegmatis_MC2_155 GEDELADGRTAAQVVVGQAEVADVLVLGEPEATTLAVLRRLAPRARITVG
Mflv_1313|M.gilvum_PYR-GCK GDDELDDGRTVAQVVVGQVEFADVVVLTEAHRDTLAVVRRLAPAARITVG
* : * **** ***.:**.*.**:::: .. :*: **** *::
Mb0109|M.bovis_AF2122/97 VDRVELALAHLDDNSRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRP
Rv0106|M.tuberculosis_H37Rv VDRVELALAHLDDNSRRGRTDTPHTPLLAGLPPLAADGEVAIVEFSARRP
MMAR_0293|M.marinum_M LDRVELALANLDDYSRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRP
MUL_4830|M.ulcerans_Agy99 LDRVELALANLDDYSRRGRSDHPHASLLGGRPPLGTDGGVGIVEFNARRP
MAB_0335|M.abscessus_ATCC_1997 VGRVEQALDHLEEDARCGRADNPHGALLAGQPSLAADGRVELVEFNARRP
MAV_4874|M.avium_104 ADGIDDALNNLYRDARRGRVDDPHGPLLAGQPPLDARGPIRLVEFNSRRP
Mvan_5332|M.vanbaalenii_PYR-1 TEQLGSALDALSDSARRGADHDPHEPLLSGEPPLVAEHGVKLVEFQAIRP
MSMEG_6069|M.smegmatis_MC2_155 PDRLELALAHLEPDTPRGRALSPRDSLLAGQPPLTADGEVRIVEFTARRP
Mflv_1313|M.gilvum_PYR-GCK VSRFTLALANLDADARRGRGNDPHGSLLAGQPPLEPAGRVRLVEFAARRP
. ** * : * *: .**.* *.* . : :*** : **
Mb0109|M.bovis_AF2122/97 FHPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGK
Rv0106|M.tuberculosis_H37Rv FHPQRLHAAVDLLLDGVVRTRGRLWLANRPDQVMWLESAGGGLRVASAGK
MMAR_0293|M.marinum_M FRPERLHDAVDHLLDGVIRTRGRLWLANRPDQVMWLESAGGGLRVASAGK
MUL_4830|M.ulcerans_Agy99 FRPERLHDAVDHLLDGVIRTRGRLWLANRPDQVMWLESAGGGLRVAWAGK
MAB_0335|M.abscessus_ATCC_1997 FHPLRLHAAIDMLLDGVIRTRGRLWLATQGEQAMWLESAGGGLRVSAAGK
MAV_4874|M.avium_104 FHPGRLHACLDLLLDGVIRTRGRLWLASRADRAMWLESAGAGLRVSSAGK
Mvan_5332|M.vanbaalenii_PYR-1 FHPLRLHRAIDDLLDGVVRLRGRAWLASQPDVVLWIESAGGGLRVGHAGE
MSMEG_6069|M.smegmatis_MC2_155 FHPVRLHAAIDLLLDGVVRTRGRAWLANRDAEVMWIESAGGGLRVSTAGK
Mflv_1313|M.gilvum_PYR-GCK FHPSRLHAAVDLLLEGVVRSRGRLWLAHLPDMAVGLDSAGGGLLVTRAGK
*:* *** .:* **:**:* *** *** .: ::***.** * **:
Mb0109|M.bovis_AF2122/97 WLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVN
Rv0106|M.tuberculosis_H37Rv WLAAMAASEVAYVDLERRLFADLMWVYPFGDRHTAMTVLVCGADPTDIVN
MMAR_0293|M.marinum_M WLAAMSPAEVDHADPERRLFAELMWEYRFGDRHTAMTVLACGADRAEITR
MUL_4830|M.ulcerans_Agy99 WLAAMSPAEVDHADPERRLFAEMMWEYRFGDRHTAMTVLACGADRAEITR
MAB_0335|M.abscessus_ATCC_1997 WLAAMDSVEVQRVDPERRAFADLMWDYQFGDRHNAMTVLVCGADSREVLD
MAV_4874|M.avium_104 WLAAMTGPERDGIDAQRRVLAALGWDDRHGDRHTAMAILVCGADPAEILD
Mvan_5332|M.vanbaalenii_PYR-1 WLAASAIDEPADPDPERAVLASLRWDEQFGDRHISLTALICGADPEAVTA
MSMEG_6069|M.smegmatis_MC2_155 WLAAMNSSELAYTDPQWRALAAIDWDPSFGDRHVSLVMLVCGARTDDILD
Mflv_1313|M.gilvum_PYR-GCK WLAAMTSRELAYVGAERRAMADMMWDDRYGDRHTSMTVLVCGADPAEIVS
**** * . : :* : * .**** ::. * *** :
Mb0109|M.bovis_AF2122/97 ALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAG--EFSAHRN
Rv0106|M.tuberculosis_H37Rv ALNAALLSDDEMASPQRWQSYVDPFGDWHDDPCHEMPDAAG--EFSAHRN
MMAR_0293|M.marinum_M VLTGALLTDREMARPQDWPAYDDPFGDWHEDPCHETPDESG--QFSGHLN
MUL_4830|M.ulcerans_Agy99 VLTGALLTDREMARPQDWPAYDDPFGDWHEDPCHETPDESG--QFSGHLN
MAB_0335|M.abscessus_ATCC_1997 ALRGALLTDDEMASPADWDEFDDPFGDWHEDPCEHLSEAEAFLAYGDHNT
MAV_4874|M.avium_104 ALQAALLTDEELERPGEWQGYDDPFGDWHEEPCVGLEAADN--AAQGARQ
Mvan_5332|M.vanbaalenii_PYR-1 SLSAALLTDDELSRPDLWAHWEDPFGEWHEDPCEGLDKADG-AATRDRPD
MSMEG_6069|M.smegmatis_MC2_155 ALRGALLTDAEFARRQEWRHYPDPFGDWHQEPCDADQAAHA-AQFSDARH
Mflv_1313|M.gilvum_PYR-GCK ALRGALLTDAEMGRPQDWPRFDDPFGDWHPQEARLA--------------
* .***:* *: * : ****:** : .
Mb0109|M.bovis_AF2122/97 SGESR-----
Rv0106|M.tuberculosis_H37Rv SGESR-----
MMAR_0293|M.marinum_M KGELE-----
MUL_4830|M.ulcerans_Agy99 KGELE-----
MAB_0335|M.abscessus_ATCC_1997 EGNH------
MAV_4874|M.avium_104 DPDPS-----
Mvan_5332|M.vanbaalenii_PYR-1 EGDPTGFSRS
MSMEG_6069|M.smegmatis_MC2_155 HPDPQTGEQS
Mflv_1313|M.gilvum_PYR-GCK ----------