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MPHIPAVRSFEESCELQTKLHHVVPGGAHTYSRGSDQYPEFMTPVLTHGHGCHVWDADGNEYIEYGMGLR SVTLGHGFRPVIEAVCSAIADGVNFSRPTTLELDAAEEFLDLIPAAEMVKFAKNGSDVTTAAVRLARAVT GRATVAACHQPFFSTDDWFIGTTEMSGGIPQSNRSTVLFEYNDLDSLASVLTTHDIACVILEAATSTTEP AAGFLEGVRRLCDKHGALLVIDEMITGFRWSEHGAQTVYGIEPDLSCWGKAMGNGFPISALAGKREFMEL GGLRTDRERVFLLSTTHGPERGSLAAFRAVVREYIENDPISRMEQAGRLLAAGVKAAVDEAGLADFVQVA GRPSCLTFITRDAGRVPSQAYRTLFLQELLKRGVLGQSFVTSAAHTDRDIEQTITAVSGALPAYKLAVER GSVDGLLEGRPVAPAIRQYAAPRRIESTAGLTQTSASQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5970 | - | - | 100% (458) | glutamate-1-semialdehyde 2,1-aminomutase |
| M. smegmatis MC2 155 | MSMEG_0969 | hemL | 2e-38 | 29.65% (452) | glutamate-1-semialdehyde aminotransferase |
| M. smegmatis MC2 155 | MSMEG_0661 | - | 9e-32 | 29.30% (355) | glutamate-1-semialdehyde 2,1-aminomutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0537 | hemL | 9e-34 | 31.39% (309) | glutamate-1-semialdehyde aminotransferase |
| M. gilvum PYR-GCK | Mflv_0054 | - | 1e-37 | 28.54% (431) | glutamate-1-semialdehyde aminotransferase |
| M. tuberculosis H37Rv | Rv0524 | hemL | 9e-34 | 31.39% (309) | glutamate-1-semialdehyde aminotransferase |
| M. leprae Br4923 | MLBr_02414 | hemL | 2e-35 | 29.31% (447) | glutamate-1-semialdehyde aminotransferase |
| M. abscessus ATCC 19977 | MAB_3978c | - | 5e-36 | 29.57% (416) | glutamate-1-semialdehyde aminotransferase |
| M. marinum M | MMAR_0870 | hemL | 1e-38 | 29.07% (454) | glutamate-1-semialdehyde 2,1-aminomutase, HemL |
| M. avium 104 | MAV_4621 | hemL | 8e-37 | 29.70% (431) | glutamate-1-semialdehyde aminotransferase |
| M. thermoresistible (build 8) | TH_4624 | - | 2e-38 | 29.25% (441) | PUTATIVE glutamate-1-semialdehyde 2,1-aminomutase |
| M. ulcerans Agy99 | MUL_0623 | hemL | 7e-39 | 29.89% (455) | glutamate-1-semialdehyde aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_0864 | - | 1e-38 | 29.79% (433) | glutamate-1-semialdehyde aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0537|M.bovis_AF2122/97 ---MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGG-T
Rv0524|M.tuberculosis_H37Rv ---MGSTEQATSRVRGAARTSAQLFEAACSVIPGGVNSPVRAFTAVGG-T
MLBr_02414|M.leprae_Br4923 ---MGSTDQATAPAGPAVSISAKLFEDACAVIPGGVNSPVRAFSAVGG-T
MMAR_0870|M.marinum_M ---MGSTDQAVT----SVRRSAQLFTDACAVIPGGVNSPVRAFTAVGG-T
MUL_0623|M.ulcerans_Agy99 ---MGSTDQAVT----SVRRSAQLFTDACAVIPGGVNSPVRAFTAVGG-T
MAV_4621|M.avium_104 ---MGSSDQATAHAR-AQAASARLFDDACAVIPGGVNSPVRAFTAVGG-T
Mflv_0054|M.gilvum_PYR-GCK ---MSTTE-----------ESAKLFADASSVIPGGVNSPVRAFNSVGG-T
Mvan_0864|M.vanbaalenii_PYR-1 ---MSSTD-----------LSAKLFADACSVIPGGVNSPVRAFSSVGG-T
TH_4624|M.thermoresistible__bu -VVMRVDHPAPG----TTRTSARLFADAATVIPGGVNSPVRAFAAVGG-T
MAB_3978c|M.abscessus_ATCC_199 MDDLASAETLDAVS-DETPNSARLFADASTVIPGGVNSPVRAFAAVGG-V
MSMEG_5970|M.smegmatis_MC2_155 ---MPHIPAVRS-----FEESCELQTKLHHVVPGGAHTYSRGSDQYPEFM
: *..* *:***.:: *.
Mb0537|M.bovis_AF2122/97 PRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARG
Rv0524|M.tuberculosis_H37Rv PRFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHPAVVEAVAKAAARG
MLBr_02414|M.leprae_Br4923 PLFITEARGCWLTDADGRRYVDLVCSWGPMILGHAHPAVVDAVATVAASG
MMAR_0870|M.marinum_M PRFITEAHGCWLTDADGNRYADLVCSWGPMILGHAHPAVVEAVSRAATNG
MUL_0623|M.ulcerans_Agy99 PRFITEAHGCWLTDADGNRYADLVCSWGPMILGHAHPAVVEAVSRAAANG
MAV_4621|M.avium_104 PPFITAARGCRLTDADGNHYVDLVCSWGPMILGHAHPAVVEAVAKAAASG
Mflv_0054|M.gilvum_PYR-GCK PRFITSAKGCRLTDVDGNQYVDLVCSWGPMILGHAHPAVVEAVQRVAAHG
Mvan_0864|M.vanbaalenii_PYR-1 PRFITSANGCWLTDADGNRYVDLVCSWGPMILGHAHPAVVEAVQRAAADG
TH_4624|M.thermoresistible__bu PRFITSARGCWLTDADGNRYVDLVCSWGPMILGHAHPAVVEAVQRAAADG
MAB_3978c|M.abscessus_ATCC_199 PRFVRSGAGCWLTDVDDNRYVDLVCSWGPLILGHAHPAVVEAVQRAAKDG
MSMEG_5970|M.smegmatis_MC2_155 TPVLTHGHGCHVWDADGNEYIEYGMGLRSVTLGHGFRPVIEAVCSAIADG
. .: . ** : *.*...* : . .: ***.. .*::** . *
Mb0537|M.bovis_AF2122/97 LSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGR
Rv0524|M.tuberculosis_H37Rv LSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEATMSAVRLARGFTGR
MLBr_02414|M.leprae_Br4923 LSFGAPTPAETQLAAEIIGRMAPVERIRLVNSGTEATMSAVRLARGFTGR
MMAR_0870|M.marinum_M LSFGAPTPTETELAAEMIGRVAPVERLRLVNSGTEATMSAVRLARGFTGR
MUL_0623|M.ulcerans_Agy99 LSFGAPTPTETELAAEMIGRVAPVERLRLVNSGTEATMSAVRLARGFTGR
MAV_4621|M.avium_104 LSFGAPTPAESELAAEMIARVAPVERIRLVNSGTEATMSAVRLARGFTGR
Mflv_0054|M.gilvum_PYR-GCK LSFGAPTPSESELAREIIDRVAPVERVRLVNSGTEATMSAIRLARGFTGR
Mvan_0864|M.vanbaalenii_PYR-1 LSFGAPTPSEAELAREIIDRVAPVELIRLVNSGTEATMSAIRLARGFTGR
TH_4624|M.thermoresistible__bu LSFGAPTPAETELVREIIDRVPPVQRLRLVNSGTEATMSAIRLARGFTGR
MAB_3978c|M.abscessus_ATCC_199 LSYGAPVEGEIELAREIIDRVQPVEKVRLVNSGTEATMSAVRLARGFTGR
MSMEG_5970|M.smegmatis_MC2_155 VNFSRPTTLELDAAEEFLDLIPAAEMVKFAKNGSDVTTAAVRLARAVTGR
:.:. *. * : . *:: : ..: :::.:.*::.* :*:****..***
Mb0537|M.bovis_AF2122/97 AKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPS
Rv0524|M.tuberculosis_H37Rv AKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRPASPRSQSSRGLPS
MLBr_02414|M.leprae_Br4923 TKIIKFSGCYHGHVDALLADAGSGVATL------------------SLPS
MMAR_0870|M.marinum_M SKIIKFSGCYHGHVDALLADAGSGVATLG------------------LPS
MUL_0623|M.ulcerans_Agy99 SKIIKFSGCYHGHVDALLADAGSGVATLG------------------LPS
MAV_4621|M.avium_104 AKIVKFSGCYHGHVDALLADAGSGVATLG------------------LPS
Mflv_0054|M.gilvum_PYR-GCK AKIVKFSGCYHGHSDALLADAGSGVATLG------------------LPS
Mvan_0864|M.vanbaalenii_PYR-1 AKIVKFSGCYHGHSDALLADAGSGVATLG------------------LPS
TH_4624|M.thermoresistible__bu AKIVKFAGCYHGHSDALLADAGSGVATLG------------------LPS
MAB_3978c|M.abscessus_ATCC_199 PKIVKFAGCYHGHADALLADAGSGLATFG------------------LPS
MSMEG_5970|M.smegmatis_MC2_155 ATVAACHQPFFSTDDWFIGTT----------------------------E
..: :.. * ::. : .
Mb0537|M.bovis_AF2122/97 SPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVP
Rv0524|M.tuberculosis_H37Rv SPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAVITEASPGNMGVVP
MLBr_02414|M.leprae_Br4923 SPGVTGAAAADTIVLPYNDIEAVRQTFARLGDQIAAVITEASPGNMGVVP
MMAR_0870|M.marinum_M SPGVTGAAAADTIVLPYNDLEAVRQTFAQHGEQIAAVITEASPGNMGVVP
MUL_0623|M.ulcerans_Agy99 SPGVTGAAAADTIVLPYNDLEAVRQTFAQHGEQIAAVITEASPGNMGVVP
MAV_4621|M.avium_104 SPGVTGATAADTIVLPYNDIDAVRQAFAEFGDQIAAVITEASPGNMGVVP
Mflv_0054|M.gilvum_PYR-GCK SPGVTGAAAADTLVLPYNNVAAVEEIFAQFGDEIACVITEASPGNMGTVP
Mvan_0864|M.vanbaalenii_PYR-1 SPGVTGAAAADTIVLPYNNVPAVEEVFGRFGDEIACVITEASPGNMGTVP
TH_4624|M.thermoresistible__bu SPGVTGAATADTIVLPYNDVTAVEQTFDRLGAEIAAVITEAAPGNMGAVP
MAB_3978c|M.abscessus_ATCC_199 SPGVTGASAADTIVLPYNDIGAVAQVFAEQGDHIAAVITEAAAGNMGTVA
MSMEG_5970|M.smegmatis_MC2_155 MSGGIPQSNRSTVLFEYNDLDSLASVLTT--HDIACVILEAATS---TTE
.* : .*::: **:: :: . : .**.** **:.. ..
Mb0537|M.bovis_AF2122/97 PGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFG
Rv0524|M.tuberculosis_H37Rv PGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWYGIDPVPADLFAFG
MLBr_02414|M.leprae_Br4923 PAPGYNAALRAITAEHGALLIIDEVMTGFRVSRSGWYGLDPVAADLFIFG
MMAR_0870|M.marinum_M PGRGYNAALRAVTAEHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFG
MUL_0623|M.ulcerans_Agy99 PGRGYNAALRAVTAEHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFG
MAV_4621|M.avium_104 PAPGFNAALRALTAEHGALLIVDEVMTGFRVSRSGWYGIDPVDADLFTFG
Mflv_0054|M.gilvum_PYR-GCK PLPGFNAALRRITAAHGALLIVDEVMTGFRVSRSGWYGLDPVDADLFTFG
Mvan_0864|M.vanbaalenii_PYR-1 PLPGFNAELRRITAAHGALLILDEVMTGFRVSRAGWYGVDPVEADLFTFG
TH_4624|M.thermoresistible__bu PQPGFNAALRRITAEHGALLISDEVMTGFRVSRSGWYGLESVEADLFTFG
MAB_3978c|M.abscessus_ATCC_199 PGPDFNAGLRRITENHGALLIMDEVMTGFRVSRSGWYGIDQVAGDLVTFG
MSMEG_5970|M.smegmatis_MC2_155 PAAGFLEGVRRLCDKHGALLVIDEMITGFRWSEHGAQTVYGIEPDLSCWG
* .: :* : *****: **::**** *. * : : ** :*
Mb0537|M.bovis_AF2122/97 KVMSGGMPAAAFGGRAEVMQR---LAPLGPVYQAGTLSGNPVAVAAGLAT
Rv0524|M.tuberculosis_H37Rv KVMSGGMPAAAFGGRAEVMQR---LAPLGPVYQAGTLSGNPVAVAAGLAT
MLBr_02414|M.leprae_Br4923 KVMSGGMPAAAFGGRAEVMER---LAPLGPVYQAGTLSGNPVAMAAGLAT
MMAR_0870|M.marinum_M KVMSGGLPAAAFGGRAEVMER---LAPLGPVYQAGTLSGNPVAMAAGLAT
MUL_0623|M.ulcerans_Agy99 KVMSGGLPAAAFGGRAEVMER---LAPLGPVYQAGTLSGNPVAMAAGLAT
MAV_4621|M.avium_104 KVMSGGLPAAAFGGRAEVMER---LAPLGPVYQAGTLSGNPVAVAAGLAT
Mflv_0054|M.gilvum_PYR-GCK KVMSGGLPAAAFGGTAEVMGR---LAPLGPVYQAGTLSGNPVAMAAGLAT
Mvan_0864|M.vanbaalenii_PYR-1 KVMSGGLPAAAFGGRAEVMNR---LAPLGPVYQAGTLSGNPVAMAAGLAT
TH_4624|M.thermoresistible__bu KVMSGGLPAAAFGGRAEVMER---LAPLGPVYQAGTLSGNPVAMAAGLAT
MAB_3978c|M.abscessus_ATCC_199 KVMSGGMPAAAFGGRADIMDR---LAPLGPVYQAGTLSGNPVAVAAGLAS
MSMEG_5970|M.smegmatis_MC2_155 KAMGNGFPISALAGKREFMELGGLRTDRERVFLLSTTHGPERGSLAAFRA
*.*..*:* :*:.* :.* : *: .* * . *.: :
Mb0537|M.bovis_AF2122/97 LR--AADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAG-----NML
Rv0524|M.tuberculosis_H37Rv LR--AADDAVYTALDANADRLAGLLSEALTDAVVPHQISRAG-----NML
MLBr_02414|M.leprae_Br4923 LR--AAADAVYATLDRNADRLVAMLSEALTDAGVPHQIPRAG-----NMF
MMAR_0870|M.marinum_M LR--AADDGVYAALDANADRLARLLAGALTDAGVAHQIPRAG-----NML
MUL_0623|M.ulcerans_Agy99 LR--TADDGVYAALDANADRLARLLAGALTDAGVAHQIPRAG-----NML
MAV_4621|M.avium_104 LR--HADAAAYAALDANADRLARLLSDALTNAGVPHQIPRAG-----NML
Mflv_0054|M.gilvum_PYR-GCK LR--AADDAAYAKLDANADRLVGLIGDALTEAGVTHQIPRAG-----NMF
Mvan_0864|M.vanbaalenii_PYR-1 LR--AADDAAYATLDVNADRLAGLIGDALTEAGVAHQIPRAG-----NMF
TH_4624|M.thermoresistible__bu LR--AADDAAYATLDANADRLTGLLTSALAEAGVPHQVSRAG-----NML
MAB_3978c|M.abscessus_ATCC_199 LR--AADAKAYETLDRNADALIALLTASLDAEGVAHHIGRAG-----NMF
MSMEG_5970|M.smegmatis_MC2_155 VVREYIENDPISRMEQAGRLLAAGVKAAVDEAGLADFVQVAGRPSCLTFI
: :: . * : :: :.. : ** .::
Mb0537|M.bovis_AF2122/97 SVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSA-
Rv0524|M.tuberculosis_H37Rv SVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCSAFEAWFVSA-
MLBr_02414|M.leprae_Br4923 SVFFSEAPVTDFASACNSQVWRYPAFFHALLDAGVYPPCSTFEAWFVSA-
MMAR_0870|M.marinum_M SVFFSETPVTDFAAARNSQSWRFAPFFHALLDAGVYPPCSAFEAWFVSA-
MUL_0623|M.ulcerans_Agy99 SVFFSETPVTDFAAARNSQTWRFAPFFHALLDAGVYPPCSAFEAWFVSA-
MAV_4621|M.avium_104 SVFFTDTPVTDFASARATQTWRYPPFFHALLDAGVYPPCSAFETWFVST-
Mflv_0054|M.gilvum_PYR-GCK SVFFGGDPVTDFASAKATETWRFPAFFHALLDAGIYPPPSAYEAWFVST-
Mvan_0864|M.vanbaalenii_PYR-1 SVFFGAEPVTDFAAARATETWRFPAFFHGLLDAGVYPPPSAYECWFVST-
TH_4624|M.thermoresistible__bu SVFFTDKPVTDYDTARASETWRFPPFFHALLERGVYAPPSAFEAWFVST-
MAB_3978c|M.abscessus_ATCC_199 SVFFGTEPVRDFQSAKATETWRYPAFFHGLLSRGVYPPASAFETWFVST-
MSMEG_5970|M.smegmatis_MC2_155 TRDAGRVPSQAYRTLFLQELLKRGVLGQSFVTSAAHTDRDIEQTITAVSG
: * : : : : : :.:: . :. . : . :
Mb0537|M.bovis_AF2122/97 -------ALDDAAFGRIANALP--AAARAAAQERPA-------------
Rv0524|M.tuberculosis_H37Rv -------ALDDAAFGRIANALP--AAARAAAQERPA-------------
MLBr_02414|M.leprae_Br4923 -------ALDDAAFGRIVDALPGAAAAAVAARHRES-------------
MMAR_0870|M.marinum_M -------ALDDTAFERIADALP--TAARAAANATPESRP----------
MUL_0623|M.ulcerans_Agy99 -------ALDDTAFERIADALP--TAARAAANATPESRP----------
MAV_4621|M.avium_104 -------ALDDDAFDRIAAALP--AAARAAAGADEGNS-----------
Mflv_0054|M.gilvum_PYR-GCK -------ALDDEAFDRIADALP--GAARAAAQAAA--------------
Mvan_0864|M.vanbaalenii_PYR-1 -------ALDDDAFDKIAAALP--GAARAAAQATA--------------
TH_4624|M.thermoresistible__bu -------ALDDEAFDKIADALP--AAARAAGRAEPEARPA---------
MAB_3978c|M.abscessus_ATCC_199 -------ALDDEAFDRIADALP--AAARAAAAAEEN-------------
MSMEG_5970|M.smegmatis_MC2_155 ALPAYKLAVERGSVDGLLEGRPVAPAIRQYAAPRRIESTAGLTQTSASQ
*:: :. : . * * .