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VSSSIVGSAAQEVESDRVDRLIADEEQVFLRRQPRSAEFIARARAHLAGGATSNWQIAQPQAVWMSHGYG SKVYDVDGTEYVDMHGGYGAAIAGHGHPAIVAAVSEQVRRGTHFAQPTENAIWIAEELSRRFGLPLWRFA NSGTEATMDAVHLARAVTGRDLIIKVEGCYHGHHDSVQVSVLPEADEVGPRAHPVGVPGTSGIPEAIRNL VVVVPFNDPEAVARALTEHRGQVAAMILEPVMMNAGIIPPADGYLAEIRDLLHEAGSLLIYDEVKTGFTA GPGGITALSGVVPDIVCLAKALGGGIAVAAIGGTTQVMSAIADGRYEQVGTFNGNPLAMAATRATLSEVL TDESYAHLNRLAGDLRARLASVIAEHGVDWHVVSVGAKGCVTFRKEPVREYRDFLQIDDRLGHLHWLMQH NGGVFLPPWGKVEQWLLSVQHDTADVDRFVANFARLAAAVTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0661 | - | - | 100% (462) | glutamate-1-semialdehyde 2,1-aminomutase |
| M. smegmatis MC2 155 | MSMEG_0969 | hemL | 3e-58 | 34.79% (457) | glutamate-1-semialdehyde aminotransferase |
| M. smegmatis MC2 155 | MSMEG_3773 | argD | 2e-34 | 34.38% (317) | acetylornithine aminotransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0537 | hemL | 4e-54 | 34.56% (408) | glutamate-1-semialdehyde aminotransferase |
| M. gilvum PYR-GCK | Mflv_0054 | - | 3e-55 | 33.57% (420) | glutamate-1-semialdehyde aminotransferase |
| M. tuberculosis H37Rv | Rv0524 | hemL | 4e-54 | 34.56% (408) | glutamate-1-semialdehyde aminotransferase |
| M. leprae Br4923 | MLBr_02414 | hemL | 1e-59 | 35.96% (431) | glutamate-1-semialdehyde aminotransferase |
| M. abscessus ATCC 19977 | MAB_3978c | - | 2e-55 | 34.86% (436) | glutamate-1-semialdehyde aminotransferase |
| M. marinum M | MMAR_0870 | hemL | 2e-58 | 35.24% (437) | glutamate-1-semialdehyde 2,1-aminomutase, HemL |
| M. avium 104 | MAV_4621 | hemL | 2e-57 | 34.46% (444) | glutamate-1-semialdehyde aminotransferase |
| M. thermoresistible (build 8) | TH_4624 | - | 2e-56 | 35.14% (424) | PUTATIVE glutamate-1-semialdehyde 2,1-aminomutase |
| M. ulcerans Agy99 | MUL_0623 | hemL | 1e-58 | 35.76% (439) | glutamate-1-semialdehyde aminotransferase |
| M. vanbaalenii PYR-1 | Mvan_0864 | - | 2e-54 | 33.72% (436) | glutamate-1-semialdehyde aminotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0537|M.bovis_AF2122/97 --MGSTEQATSRVRGAARTSAQLFEAACSVIPGG------VNSPVRAFTA
Rv0524|M.tuberculosis_H37Rv --MGSTEQATSRVRGAARTSAQLFEAACSVIPGG------VNSPVRAFTA
MLBr_02414|M.leprae_Br4923 --MGSTDQATAPAGPAVSISAKLFEDACAVIPGG------VNSPVRAFSA
MMAR_0870|M.marinum_M --MGSTDQAVTSVR----RSAQLFTDACAVIPGG------VNSPVRAFTA
MUL_0623|M.ulcerans_Agy99 --MGSTDQAVTSVR----RSAQLFTDACAVIPGG------VNSPVRAFTA
MAV_4621|M.avium_104 --MGSSDQATAHAR-AQAASARLFDDACAVIPGG------VNSPVRAFTA
Mflv_0054|M.gilvum_PYR-GCK ---------MSTTE----ESAKLFADASSVIPGG------VNSPVRAFNS
Mvan_0864|M.vanbaalenii_PYR-1 ---------MSSTD----LSAKLFADACSVIPGG------VNSPVRAFSS
TH_4624|M.thermoresistible__bu VVMRVDHPAPGTTR----TSARLFADAATVIPGG------VNSPVRAFAA
MAB_3978c|M.abscessus_ATCC_199 MDDLASAETLDAVSDETPNSARLFADASTVIPGG------VNSPVRAFAA
MSMEG_0661|M.smegmatis_MC2_155 --MSSSIVGSAAQEVESDRVDRLIADEEQVFLRRQPRSAEFIARARAHLA
:*: *: . : .**. :
Mb0537|M.bovis_AF2122/97 VGGTP---------RFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHP
Rv0524|M.tuberculosis_H37Rv VGGTP---------RFITEAHGCWLIDADGNRYVDLVCSWGPMILGHAHP
MLBr_02414|M.leprae_Br4923 VGGTP---------LFITEARGCWLTDADGRRYVDLVCSWGPMILGHAHP
MMAR_0870|M.marinum_M VGGTP---------RFITEAHGCWLTDADGNRYADLVCSWGPMILGHAHP
MUL_0623|M.ulcerans_Agy99 VGGTP---------RFITEAHGCWLTDADGNRYADLVCSWGPMILGHAHP
MAV_4621|M.avium_104 VGGTP---------PFITAARGCRLTDADGNHYVDLVCSWGPMILGHAHP
Mflv_0054|M.gilvum_PYR-GCK VGGTP---------RFITSAKGCRLTDVDGNQYVDLVCSWGPMILGHAHP
Mvan_0864|M.vanbaalenii_PYR-1 VGGTP---------RFITSANGCWLTDADGNRYVDLVCSWGPMILGHAHP
TH_4624|M.thermoresistible__bu VGGTP---------RFITSARGCWLTDADGNRYVDLVCSWGPMILGHAHP
MAB_3978c|M.abscessus_ATCC_199 VGGVP---------RFVRSGAGCWLTDVDDNRYVDLVCSWGPLILGHAHP
MSMEG_0661|M.smegmatis_MC2_155 GGATSNWQIAQPQAVWMSHGYGSKVYDVDGTEYVDMHGGYGAAIAGHGHP
*... :: . *. : *.*. .*.*: .:*. * **.**
Mb0537|M.bovis_AF2122/97 AVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEAT
Rv0524|M.tuberculosis_H37Rv AVVEAVAKAAARGLSFGAPTPAETQLAGEIIGRVAPVERIRLVNSGTEAT
MLBr_02414|M.leprae_Br4923 AVVDAVATVAASGLSFGAPTPAETQLAAEIIGRMAPVERIRLVNSGTEAT
MMAR_0870|M.marinum_M AVVEAVSRAATNGLSFGAPTPTETELAAEMIGRVAPVERLRLVNSGTEAT
MUL_0623|M.ulcerans_Agy99 AVVEAVSRAAANGLSFGAPTPTETELAAEMIGRVAPVERLRLVNSGTEAT
MAV_4621|M.avium_104 AVVEAVAKAAASGLSFGAPTPAESELAAEMIARVAPVERIRLVNSGTEAT
Mflv_0054|M.gilvum_PYR-GCK AVVEAVQRVAAHGLSFGAPTPSESELAREIIDRVAPVERVRLVNSGTEAT
Mvan_0864|M.vanbaalenii_PYR-1 AVVEAVQRAAADGLSFGAPTPSEAELAREIIDRVAPVELIRLVNSGTEAT
TH_4624|M.thermoresistible__bu AVVEAVQRAAADGLSFGAPTPAETELVREIIDRVPPVQRLRLVNSGTEAT
MAB_3978c|M.abscessus_ATCC_199 AVVEAVQRAAKDGLSYGAPVEGEIELAREIIDRVQPVEKVRLVNSGTEAT
MSMEG_0661|M.smegmatis_MC2_155 AIVAAVSEQVRRGTHFAQPTENAIWIAEELSRRFG-LPLWRFANSGTEAT
*:* ** . * :. *. :. *: *. : *:.*******
Mb0537|M.bovis_AF2122/97 MSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRP
Rv0524|M.tuberculosis_H37Rv MSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLGLCDDPQRP
MLBr_02414|M.leprae_Br4923 MSAVRLARGFTGRTKIIKFSGCYHGHVDALLADAGSGVATL---------
MMAR_0870|M.marinum_M MSAVRLARGFTGRSKIIKFSGCYHGHVDALLADAGSGVATLG--------
MUL_0623|M.ulcerans_Agy99 MSAVRLARGFTGRSKIIKFSGCYHGHVDALLADAGSGVATLG--------
MAV_4621|M.avium_104 MSAVRLARGFTGRAKIVKFSGCYHGHVDALLADAGSGVATLG--------
Mflv_0054|M.gilvum_PYR-GCK MSAIRLARGFTGRAKIVKFSGCYHGHSDALLADAGSGVATLG--------
Mvan_0864|M.vanbaalenii_PYR-1 MSAIRLARGFTGRAKIVKFSGCYHGHSDALLADAGSGVATLG--------
TH_4624|M.thermoresistible__bu MSAIRLARGFTGRAKIVKFAGCYHGHSDALLADAGSGVATLG--------
MAB_3978c|M.abscessus_ATCC_199 MSAVRLARGFTGRPKIVKFAGCYHGHADALLADAGSGLATFG--------
MSMEG_0661|M.smegmatis_MC2_155 MDAVHLARAVTGRDLIIKVEGCYHGHHDSVQVSVLPEADEVG--------
*.*::***..*** *:*. ****** *:: ... . .
Mb0537|M.bovis_AF2122/97 ASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAV
Rv0524|M.tuberculosis_H37Rv ASPRSQSSRGLPSSPGVTGAAAADTIVLPYNDIDAVQQTFARFGEQIAAV
MLBr_02414|M.leprae_Br4923 ---------SLPSSPGVTGAAAADTIVLPYNDIEAVRQTFARLGDQIAAV
MMAR_0870|M.marinum_M ----------LPSSPGVTGAAAADTIVLPYNDLEAVRQTFAQHGEQIAAV
MUL_0623|M.ulcerans_Agy99 ----------LPSSPGVTGAAAADTIVLPYNDLEAVRQTFAQHGEQIAAV
MAV_4621|M.avium_104 ----------LPSSPGVTGATAADTIVLPYNDIDAVRQAFAEFGDQIAAV
Mflv_0054|M.gilvum_PYR-GCK ----------LPSSPGVTGAAAADTLVLPYNNVAAVEEIFAQFGDEIACV
Mvan_0864|M.vanbaalenii_PYR-1 ----------LPSSPGVTGAAAADTIVLPYNNVPAVEEVFGRFGDEIACV
TH_4624|M.thermoresistible__bu ----------LPSSPGVTGAATADTIVLPYNDVTAVEQTFDRLGAEIAAV
MAB_3978c|M.abscessus_ATCC_199 ----------LPSSPGVTGASAADTIVLPYNDIGAVAQVFAEQGDHIAAV
MSMEG_0661|M.smegmatis_MC2_155 ---PRAHPVGVPGTSGIPEAIRNLVVVVPFNDPEAVARALTEHRGQVAAM
:*.:.*:. * .:*:*:*: ** . : . .:*.:
Mb0537|M.bovis_AF2122/97 ITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWY
Rv0524|M.tuberculosis_H37Rv ITEASPGNMGVVPPGPGFNAALRAITAEHGALLILDEVMTGFRVSRSGWY
MLBr_02414|M.leprae_Br4923 ITEASPGNMGVVPPAPGYNAALRAITAEHGALLIIDEVMTGFRVSRSGWY
MMAR_0870|M.marinum_M ITEASPGNMGVVPPGRGYNAALRAVTAEHGALLIVDEVMTGFRVSRSGWY
MUL_0623|M.ulcerans_Agy99 ITEASPGNMGVVPPGRGYNAALRAVTAEHGALLIVDEVMTGFRVSRSGWY
MAV_4621|M.avium_104 ITEASPGNMGVVPPAPGFNAALRALTAEHGALLIVDEVMTGFRVSRSGWY
Mflv_0054|M.gilvum_PYR-GCK ITEASPGNMGTVPPLPGFNAALRRITAAHGALLIVDEVMTGFRVSRSGWY
Mvan_0864|M.vanbaalenii_PYR-1 ITEASPGNMGTVPPLPGFNAELRRITAAHGALLILDEVMTGFRVSRAGWY
TH_4624|M.thermoresistible__bu ITEAAPGNMGAVPPQPGFNAALRRITAEHGALLISDEVMTGFRVSRSGWY
MAB_3978c|M.abscessus_ATCC_199 ITEAAAGNMGTVAPGPDFNAGLRRITENHGALLIMDEVMTGFRVSRSGWY
MSMEG_0661|M.smegmatis_MC2_155 ILEPVMMNAGIIPPADGYLAEIRDLLHEAGSLLIYDEVKTGFTAGPGGIT
* *. * * :.* .: * :* : *:*** *** *** .. .*
Mb0537|M.bovis_AF2122/97 GIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGN
Rv0524|M.tuberculosis_H37Rv GIDPVPADLFAFGKVMSGGMPAAAFGGRAEVMQRLAPLGPVYQAGTLSGN
MLBr_02414|M.leprae_Br4923 GLDPVAADLFIFGKVMSGGMPAAAFGGRAEVMERLAPLGPVYQAGTLSGN
MMAR_0870|M.marinum_M GIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGN
MUL_0623|M.ulcerans_Agy99 GIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGN
MAV_4621|M.avium_104 GIDPVDADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGN
Mflv_0054|M.gilvum_PYR-GCK GLDPVDADLFTFGKVMSGGLPAAAFGGTAEVMGRLAPLGPVYQAGTLSGN
Mvan_0864|M.vanbaalenii_PYR-1 GVDPVEADLFTFGKVMSGGLPAAAFGGRAEVMNRLAPLGPVYQAGTLSGN
TH_4624|M.thermoresistible__bu GLESVEADLFTFGKVMSGGLPAAAFGGRAEVMERLAPLGPVYQAGTLSGN
MAB_3978c|M.abscessus_ATCC_199 GIDQVAGDLVTFGKVMSGGMPAAAFGGRADIMDRLAPLGPVYQAGTLSGN
MSMEG_0661|M.smegmatis_MC2_155 ALSGVVPDIVCLAKALGGGIAVAAIGGTTQVMSAIADG-RYEQVGTFNGN
.:. * *:. :.*.:.**:..**:** :::* :* *.**:.**
Mb0537|M.bovis_AF2122/97 PVAVAAGLATL-RAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRA
Rv0524|M.tuberculosis_H37Rv PVAVAAGLATL-RAADDAVYTALDANADRLAGLLSEALTDAVVPHQISRA
MLBr_02414|M.leprae_Br4923 PVAMAAGLATL-RAAADAVYATLDRNADRLVAMLSEALTDAGVPHQIPRA
MMAR_0870|M.marinum_M PVAMAAGLATL-RAADDGVYAALDANADRLARLLAGALTDAGVAHQIPRA
MUL_0623|M.ulcerans_Agy99 PVAMAAGLATL-RTADDGVYAALDANADRLARLLAGALTDAGVAHQIPRA
MAV_4621|M.avium_104 PVAVAAGLATL-RHADAAAYAALDANADRLARLLSDALTNAGVPHQIPRA
Mflv_0054|M.gilvum_PYR-GCK PVAMAAGLATL-RAADDAAYAKLDANADRLVGLIGDALTEAGVTHQIPRA
Mvan_0864|M.vanbaalenii_PYR-1 PVAMAAGLATL-RAADDAAYATLDVNADRLAGLIGDALTEAGVAHQIPRA
TH_4624|M.thermoresistible__bu PVAMAAGLATL-RAADDAAYATLDANADRLTGLLTSALAEAGVPHQVSRA
MAB_3978c|M.abscessus_ATCC_199 PVAVAAGLASL-RAADAKAYETLDRNADALIALLTASLDAEGVAHHIGRA
MSMEG_0661|M.smegmatis_MC2_155 PLAMAATRATLSEVLTDESYAHLNRLAGDLRARLASVIAEHGVDWHVVSV
*:*:** *:* . * *: *. * : : * :: .
Mb0537|M.bovis_AF2122/97 GNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCS-AFEAW
Rv0524|M.tuberculosis_H37Rv GNMLSVFFGETPVTDFASARASQTWRYPAFFHAMLDAGVYPPCS-AFEAW
MLBr_02414|M.leprae_Br4923 GNMFSVFFSEAPVTDFASACNSQVWRYPAFFHALLDAGVYPPCS-TFEAW
MMAR_0870|M.marinum_M GNMLSVFFSETPVTDFAAARNSQSWRFAPFFHALLDAGVYPPCS-AFEAW
MUL_0623|M.ulcerans_Agy99 GNMLSVFFSETPVTDFAAARNSQTWRFAPFFHALLDAGVYPPCS-AFEAW
MAV_4621|M.avium_104 GNMLSVFFTDTPVTDFASARATQTWRYPPFFHALLDAGVYPPCS-AFETW
Mflv_0054|M.gilvum_PYR-GCK GNMFSVFFGGDPVTDFASAKATETWRFPAFFHALLDAGIYPPPS-AYEAW
Mvan_0864|M.vanbaalenii_PYR-1 GNMFSVFFGAEPVTDFAAARATETWRFPAFFHGLLDAGVYPPPS-AYECW
TH_4624|M.thermoresistible__bu GNMLSVFFTDKPVTDYDTARASETWRFPPFFHALLERGVYAPPS-AFEAW
MAB_3978c|M.abscessus_ATCC_199 GNMFSVFFGTEPVRDFQSAKATETWRYPAFFHGLLSRGVYPPAS-AFETW
MSMEG_0661|M.smegmatis_MC2_155 GAKGCVTFRKEPVREYRDFLQIDDRLGHLHWLMQHNGGVFLPPWGKVEQW
* .* * ** :: : .: . *:: * * *
Mb0537|M.bovis_AF2122/97 FVSAALDDAAFGRIANALP--AAARAAAQERPA----
Rv0524|M.tuberculosis_H37Rv FVSAALDDAAFGRIANALP--AAARAAAQERPA----
MLBr_02414|M.leprae_Br4923 FVSAALDDAAFGRIVDALPGAAAAAVAARHRES----
MMAR_0870|M.marinum_M FVSAALDDTAFERIADALP--TAARAAANATPESRP-
MUL_0623|M.ulcerans_Agy99 FVSAALDDTAFERIADALP--TAARAAANATPESRP-
MAV_4621|M.avium_104 FVSTALDDDAFDRIAAALP--AAARAAAGADEGNS--
Mflv_0054|M.gilvum_PYR-GCK FVSTALDDEAFDRIADALP--GAARAAAQAAA-----
Mvan_0864|M.vanbaalenii_PYR-1 FVSTALDDDAFDKIAAALP--GAARAAAQATA-----
TH_4624|M.thermoresistible__bu FVSTALDDEAFDKIADALP--AAARAAGRAEPEARPA
MAB_3978c|M.abscessus_ATCC_199 FVSTALDDEAFDRIADALP--AAARAAAAAEEN----
MSMEG_0661|M.smegmatis_MC2_155 LLSVQHDTADVDRFVANFARLAAAVTR----------
::*. * . ::. :. ** .