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SDIFFNPIWDVRMTDTSLRDGSHHKRHQFTGEEVRSIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTP EQELIKIAAETAKESKIAFLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVG FLMMAHTISPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVQALVAELGSDAQVGFHGHENLGLG VANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLL DRNALIMGYSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQEAAASK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5937 | - | - | 100% (349) | 4-hydroxy-2-ketovalerate aldolase |
| M. smegmatis MC2 155 | MSMEG_4150 | - | 1e-86 | 48.49% (332) | 4-hydroxy-2-ketovalerate aldolase |
| M. smegmatis MC2 155 | MSMEG_2024 | - | 7e-08 | 25.95% (262) | hydroxymethylglutaryl-CoA lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3564c | - | 1e-178 | 90.88% (340) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_1522 | - | 0.0 | 95.97% (347) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv3534c | - | 1e-178 | 90.88% (340) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0626 | - | 1e-180 | 91.52% (342) | 4-hydroxy-2-ketovalerate aldolase |
| M. marinum M | MMAR_5021 | - | 0.0 | 94.07% (337) | 4-hydroxy-2-oxovalerate aldolase |
| M. avium 104 | MAV_0627 | - | 0.0 | 95.10% (347) | 4-hydroxy-2-ketovalerate aldolase |
| M. thermoresistible (build 8) | TH_0371 | - | 0.0 | 94.80% (346) | PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) |
| M. ulcerans Agy99 | MUL_4095 | - | 1e-180 | 93.47% (337) | 4-hydroxy-2-ketovalerate aldolase |
| M. vanbaalenii PYR-1 | Mvan_5234 | - | 0.0 | 95.38% (346) | 4-hydroxy-2-ketovalerate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3564c|M.bovis_AF2122/97 ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV
Rv3534c|M.tuberculosis_H37Rv ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV
MMAR_5021|M.marinum_M ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
MUL_4095|M.ulcerans_Agy99 ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
Mflv_1522|M.gilvum_PYR-GCK ---------MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIV
Mvan_5234|M.vanbaalenii_PYR-1 ---------MSTDEIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVQAIV
MSMEG_5937|M.smegmatis_MC2_155 ---------MS--DIFFNPIWDVRMTDTSLRDGSHHKRHQFTGEEVRSIV
MAV_0627|M.avium_104 ---------MTT-DIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIV
TH_0371|M.thermoresistible__bu ---------MTT-DIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIV
MAB_0626|M.abscessus_ATCC_1997 MGSDTSTQLLGTDGIFFDAAWDVRVTDTSLRDGSHHKRHQFTADEVRAIV
: ****:**************** :** :**
Mb3564c|M.bovis_AF2122/97 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA
Rv3534c|M.tuberculosis_H37Rv AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA
MMAR_5021|M.marinum_M AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTAKEAKIA
MUL_4095|M.ulcerans_Agy99 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELIKLAAQTAKEAKIA
Mflv_1522|M.gilvum_PYR-GCK AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
Mvan_5234|M.vanbaalenii_PYR-1 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
MSMEG_5937|M.smegmatis_MC2_155 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKIAAETAKESKIA
MAV_0627|M.avium_104 AALDVAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIA
TH_0371|M.thermoresistible__bu AALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
MAB_0626|M.abscessus_ATCC_1997 AALDGAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTATNAKIA
**** **************************.******:** **.:::**
Mb3564c|M.bovis_AF2122/97 FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET
Rv3534c|M.tuberculosis_H37Rv FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET
MMAR_5021|M.marinum_M FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
MUL_4095|M.ulcerans_Agy99 FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLET
Mflv_1522|M.gilvum_PYR-GCK FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
Mvan_5234|M.vanbaalenii_PYR-1 FLMLPGVGTKEDIKEAQSNGGSICRIATHCTEADVSIQHFGLARELGLET
MSMEG_5937|M.smegmatis_MC2_155 FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
MAV_0627|M.avium_104 FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
TH_0371|M.thermoresistible__bu FLMLPGVGTKDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
MAB_0626|M.abscessus_ATCC_1997 FLMLPGVGTKEDIIEAQGNGGSICRIATHCTEADVSIQHFGLARERGLET
**********:** **:.*********************:***** ****
Mb3564c|M.bovis_AF2122/97 VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA
Rv3534c|M.tuberculosis_H37Rv VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA
MMAR_5021|M.marinum_M VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
MUL_4095|M.ulcerans_Agy99 VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
Mflv_1522|M.gilvum_PYR-GCK VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSA
Mvan_5234|M.vanbaalenii_PYR-1 VGFLMMSHTIPPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVAA
MSMEG_5937|M.smegmatis_MC2_155 VGFLMMAHTISPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVQA
MAV_0627|M.avium_104 VGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
TH_0371|M.thermoresistible__bu VGFLMMAHTIPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
MAB_0626|M.abscessus_ATCC_1997 VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
******:***.***** ************************:** *** *
Mb3564c|M.bovis_AF2122/97 LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN
Rv3534c|M.tuberculosis_H37Rv LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN
MMAR_5021|M.marinum_M LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
MUL_4095|M.ulcerans_Agy99 LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
Mflv_1522|M.gilvum_PYR-GCK LVAELGDDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN
Mvan_5234|M.vanbaalenii_PYR-1 LVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN
MSMEG_5937|M.smegmatis_MC2_155 LVAELGSDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
MAV_0627|M.avium_104 LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
TH_0371|M.thermoresistible__bu LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
MAB_0626|M.abscessus_ATCC_1997 VVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSTRRFGAGAGN
:*****.*******************: ************ *********
Mb3564c|M.bovis_AF2122/97 APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
Rv3534c|M.tuberculosis_H37Rv APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MMAR_5021|M.marinum_M APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MUL_4095|M.ulcerans_Agy99 APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
Mflv_1522|M.gilvum_PYR-GCK APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
Mvan_5234|M.vanbaalenii_PYR-1 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MSMEG_5937|M.smegmatis_MC2_155 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MAV_0627|M.avium_104 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
TH_0371|M.thermoresistible__bu APVEALIGVFDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMG
MAB_0626|M.abscessus_ATCC_1997 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
************:****************:** ****:************
Mb3564c|M.bovis_AF2122/97 YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI
Rv3534c|M.tuberculosis_H37Rv YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI
MMAR_5021|M.marinum_M YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MUL_4095|M.ulcerans_Agy99 YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mflv_1522|M.gilvum_PYR-GCK YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mvan_5234|M.vanbaalenii_PYR-1 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MSMEG_5937|M.smegmatis_MC2_155 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MAV_0627|M.avium_104 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
TH_0371|M.thermoresistible__bu YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MAB_0626|M.abscessus_ATCC_1997 YSGVYSSFLKHAIRQGERYGVPAHQLLHRAGERKLIGGQEDQLIDIALEI
************:**.******* ******:******************
Mb3564c|M.bovis_AF2122/97 KRELDSGAAVTH-
Rv3534c|M.tuberculosis_H37Rv KRELDSGAAVTH-
MMAR_5021|M.marinum_M KREQESGQVASRR
MUL_4095|M.ulcerans_Agy99 KREQESGQVASRR
Mflv_1522|M.gilvum_PYR-GCK KREQEAEATRA--
Mvan_5234|M.vanbaalenii_PYR-1 KREQETAKS----
MSMEG_5937|M.smegmatis_MC2_155 KREQEAAASK---
MAV_0627|M.avium_104 KREQESGAAAAR-
TH_0371|M.thermoresistible__bu KRELEEQAGSTA-
MAB_0626|M.abscessus_ATCC_1997 QRENAANGQ----
:**