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M. ulcerans Agy99 MUL_4095 (-)

annotation: 4-hydroxy-2-ketovalerate aldolase
coordinates: 4566403 - 4567446
length: 347

TGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELI
KLAAQTAKEAKIAFLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLETVGFLMMA
HTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAALVAELGEDAQVGFHGHENLGLGVANSV
EAVRAGAKQIDGSVRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNAL
IMGYSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQESGQVASRR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. ulcerans Agy99MUL_4095--100% (347)4-hydroxy-2-ketovalerate aldolase
M. ulcerans Agy99MUL_2435-1e-8649.55% (331) 4-hydroxy-2-ketovalerate aldolase
M. ulcerans Agy99MUL_2447-1e-0723.94% (284) hypothetical protein MUL_2447

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3564c-0.094.72% (341) 4-hydroxy-2-ketovalerate aldolase
M. gilvum PYR-GCKMflv_1522-0.093.77% (337) 4-hydroxy-2-ketovalerate aldolase
M. tuberculosis H37RvRv3534c-0.094.72% (341) 4-hydroxy-2-ketovalerate aldolase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0626-1e-17692.19% (333) 4-hydroxy-2-ketovalerate aldolase
M. marinum MMMAR_5021-0.099.42% (347) 4-hydroxy-2-oxovalerate aldolase
M. avium 104MAV_0627-0.093.29% (343) 4-hydroxy-2-ketovalerate aldolase
M. smegmatis MC2 155MSMEG_5937-1e-18093.47% (337) 4-hydroxy-2-ketovalerate aldolase
M. thermoresistible (build 8)TH_0371-1e-18093.15% (336) PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA)
M. vanbaalenii PYR-1Mvan_5234-0.093.51% (339) 4-hydroxy-2-ketovalerate aldolase

CLUSTAL 2.0.9 multiple sequence alignment


MUL_4095|M.ulcerans_Agy99           ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
MMAR_5021|M.marinum_M               ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
Mb3564c|M.bovis_AF2122/97           ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV
Rv3534c|M.tuberculosis_H37Rv        ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV
MAV_0627|M.avium_104                ---------MTT-DIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIV
TH_0371|M.thermoresistible__bu      ---------MTT-DIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIV
Mflv_1522|M.gilvum_PYR-GCK          ---------MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIV
Mvan_5234|M.vanbaalenii_PYR-1       ---------MSTDEIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVQAIV
MSMEG_5937|M.smegmatis_MC2_155      ---------MS--DIFFNPIWDVRMTDTSLRDGSHHKRHQFTGEEVRSIV
MAB_0626|M.abscessus_ATCC_1997      MGSDTSTQLLGTDGIFFDAAWDVRVTDTSLRDGSHHKRHQFTADEVRAIV
                                                    :   ****:****************  :** :**

MUL_4095|M.ulcerans_Agy99           AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELIKLAAQTAKEAKIA
MMAR_5021|M.marinum_M               AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTAKEAKIA
Mb3564c|M.bovis_AF2122/97           AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA
Rv3534c|M.tuberculosis_H37Rv        AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA
MAV_0627|M.avium_104                AALDVAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIA
TH_0371|M.thermoresistible__bu      AALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
Mflv_1522|M.gilvum_PYR-GCK          AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
Mvan_5234|M.vanbaalenii_PYR-1       AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
MSMEG_5937|M.smegmatis_MC2_155      AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKIAAETAKESKIA
MAB_0626|M.abscessus_ATCC_1997      AALDGAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTATNAKIA
                                    **** **************************.******:** **.:::**

MUL_4095|M.ulcerans_Agy99           FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLET
MMAR_5021|M.marinum_M               FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
Mb3564c|M.bovis_AF2122/97           FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET
Rv3534c|M.tuberculosis_H37Rv        FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET
MAV_0627|M.avium_104                FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
TH_0371|M.thermoresistible__bu      FLMLPGVGTKDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
Mflv_1522|M.gilvum_PYR-GCK          FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
Mvan_5234|M.vanbaalenii_PYR-1       FLMLPGVGTKEDIKEAQSNGGSICRIATHCTEADVSIQHFGLARELGLET
MSMEG_5937|M.smegmatis_MC2_155      FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
MAB_0626|M.abscessus_ATCC_1997      FLMLPGVGTKEDIIEAQGNGGSICRIATHCTEADVSIQHFGLARERGLET
                                    **********:** **:.*********************:***** ****

MUL_4095|M.ulcerans_Agy99           VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
MMAR_5021|M.marinum_M               VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
Mb3564c|M.bovis_AF2122/97           VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA
Rv3534c|M.tuberculosis_H37Rv        VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA
MAV_0627|M.avium_104                VGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
TH_0371|M.thermoresistible__bu      VGFLMMAHTIPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
Mflv_1522|M.gilvum_PYR-GCK          VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSA
Mvan_5234|M.vanbaalenii_PYR-1       VGFLMMSHTIPPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVAA
MSMEG_5937|M.smegmatis_MC2_155      VGFLMMAHTISPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVQA
MAB_0626|M.abscessus_ATCC_1997      VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
                                    ******:***.***** ************************:** *** *

MUL_4095|M.ulcerans_Agy99           LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
MMAR_5021|M.marinum_M               LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
Mb3564c|M.bovis_AF2122/97           LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN
Rv3534c|M.tuberculosis_H37Rv        LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN
MAV_0627|M.avium_104                LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
TH_0371|M.thermoresistible__bu      LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
Mflv_1522|M.gilvum_PYR-GCK          LVAELGDDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN
Mvan_5234|M.vanbaalenii_PYR-1       LVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN
MSMEG_5937|M.smegmatis_MC2_155      LVAELGSDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
MAB_0626|M.abscessus_ATCC_1997      VVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSTRRFGAGAGN
                                    :*****.*******************: ************ *********

MUL_4095|M.ulcerans_Agy99           APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MMAR_5021|M.marinum_M               APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
Mb3564c|M.bovis_AF2122/97           APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
Rv3534c|M.tuberculosis_H37Rv        APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MAV_0627|M.avium_104                APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
TH_0371|M.thermoresistible__bu      APVEALIGVFDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMG
Mflv_1522|M.gilvum_PYR-GCK          APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
Mvan_5234|M.vanbaalenii_PYR-1       APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MSMEG_5937|M.smegmatis_MC2_155      APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MAB_0626|M.abscessus_ATCC_1997      APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
                                    ************:****************:** ****:************

MUL_4095|M.ulcerans_Agy99           YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MMAR_5021|M.marinum_M               YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mb3564c|M.bovis_AF2122/97           YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI
Rv3534c|M.tuberculosis_H37Rv        YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI
MAV_0627|M.avium_104                YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
TH_0371|M.thermoresistible__bu      YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mflv_1522|M.gilvum_PYR-GCK          YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mvan_5234|M.vanbaalenii_PYR-1       YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MSMEG_5937|M.smegmatis_MC2_155      YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MAB_0626|M.abscessus_ATCC_1997      YSGVYSSFLKHAIRQGERYGVPAHQLLHRAGERKLIGGQEDQLIDIALEI
                                    ************:**.*******  ******:******************

MUL_4095|M.ulcerans_Agy99           KREQESGQVASRR
MMAR_5021|M.marinum_M               KREQESGQVASRR
Mb3564c|M.bovis_AF2122/97           KRELDSGAAVTH-
Rv3534c|M.tuberculosis_H37Rv        KRELDSGAAVTH-
MAV_0627|M.avium_104                KREQESGAAAAR-
TH_0371|M.thermoresistible__bu      KRELEEQAGSTA-
Mflv_1522|M.gilvum_PYR-GCK          KREQEAEATRA--
Mvan_5234|M.vanbaalenii_PYR-1       KREQETAKS----
MSMEG_5937|M.smegmatis_MC2_155      KREQEAAASK---
MAB_0626|M.abscessus_ATCC_1997      QRENAANGQ----
                                    :**