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TGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELI KLAAQTAKEAKIAFLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLETVGFLMMA HTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAALVAELGEDAQVGFHGHENLGLGVANSV EAVRAGAKQIDGSVRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNAL IMGYSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQESGQVASRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. ulcerans Agy99 | MUL_4095 | - | - | 100% (347) | 4-hydroxy-2-ketovalerate aldolase |
M. ulcerans Agy99 | MUL_2435 | - | 1e-86 | 49.55% (331) | 4-hydroxy-2-ketovalerate aldolase |
M. ulcerans Agy99 | MUL_2447 | - | 1e-07 | 23.94% (284) | hypothetical protein MUL_2447 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3564c | - | 0.0 | 94.72% (341) | 4-hydroxy-2-ketovalerate aldolase |
M. gilvum PYR-GCK | Mflv_1522 | - | 0.0 | 93.77% (337) | 4-hydroxy-2-ketovalerate aldolase |
M. tuberculosis H37Rv | Rv3534c | - | 0.0 | 94.72% (341) | 4-hydroxy-2-ketovalerate aldolase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_0626 | - | 1e-176 | 92.19% (333) | 4-hydroxy-2-ketovalerate aldolase |
M. marinum M | MMAR_5021 | - | 0.0 | 99.42% (347) | 4-hydroxy-2-oxovalerate aldolase |
M. avium 104 | MAV_0627 | - | 0.0 | 93.29% (343) | 4-hydroxy-2-ketovalerate aldolase |
M. smegmatis MC2 155 | MSMEG_5937 | - | 1e-180 | 93.47% (337) | 4-hydroxy-2-ketovalerate aldolase |
M. thermoresistible (build 8) | TH_0371 | - | 1e-180 | 93.15% (336) | PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) |
M. vanbaalenii PYR-1 | Mvan_5234 | - | 0.0 | 93.51% (339) | 4-hydroxy-2-ketovalerate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment MUL_4095|M.ulcerans_Agy99 ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV MMAR_5021|M.marinum_M ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV Mb3564c|M.bovis_AF2122/97 ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV Rv3534c|M.tuberculosis_H37Rv ----------------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIV MAV_0627|M.avium_104 ---------MTT-DIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIV TH_0371|M.thermoresistible__bu ---------MTT-DIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIV Mflv_1522|M.gilvum_PYR-GCK ---------MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIV Mvan_5234|M.vanbaalenii_PYR-1 ---------MSTDEIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVQAIV MSMEG_5937|M.smegmatis_MC2_155 ---------MS--DIFFNPIWDVRMTDTSLRDGSHHKRHQFTGEEVRSIV MAB_0626|M.abscessus_ATCC_1997 MGSDTSTQLLGTDGIFFDAAWDVRVTDTSLRDGSHHKRHQFTADEVRAIV : ****:**************** :** :** MUL_4095|M.ulcerans_Agy99 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELIKLAAQTAKEAKIA MMAR_5021|M.marinum_M AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTAKEAKIA Mb3564c|M.bovis_AF2122/97 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA Rv3534c|M.tuberculosis_H37Rv AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIA MAV_0627|M.avium_104 AALDVAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIA TH_0371|M.thermoresistible__bu AALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA Mflv_1522|M.gilvum_PYR-GCK AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA Mvan_5234|M.vanbaalenii_PYR-1 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA MSMEG_5937|M.smegmatis_MC2_155 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKIAAETAKESKIA MAB_0626|M.abscessus_ATCC_1997 AALDGAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTATNAKIA **** **************************.******:** **.:::** MUL_4095|M.ulcerans_Agy99 FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLET MMAR_5021|M.marinum_M FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET Mb3564c|M.bovis_AF2122/97 FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET Rv3534c|M.tuberculosis_H37Rv FLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLET MAV_0627|M.avium_104 FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET TH_0371|M.thermoresistible__bu FLMLPGVGTKDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET Mflv_1522|M.gilvum_PYR-GCK FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET Mvan_5234|M.vanbaalenii_PYR-1 FLMLPGVGTKEDIKEAQSNGGSICRIATHCTEADVSIQHFGLARELGLET MSMEG_5937|M.smegmatis_MC2_155 FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET MAB_0626|M.abscessus_ATCC_1997 FLMLPGVGTKEDIIEAQGNGGSICRIATHCTEADVSIQHFGLARERGLET **********:** **:.*********************:***** **** MUL_4095|M.ulcerans_Agy99 VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA MMAR_5021|M.marinum_M VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA Mb3564c|M.bovis_AF2122/97 VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA Rv3534c|M.tuberculosis_H37Rv VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSA MAV_0627|M.avium_104 VGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA TH_0371|M.thermoresistible__bu VGFLMMAHTIPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA Mflv_1522|M.gilvum_PYR-GCK VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSA Mvan_5234|M.vanbaalenii_PYR-1 VGFLMMSHTIPPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVAA MSMEG_5937|M.smegmatis_MC2_155 VGFLMMAHTISPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVQA MAB_0626|M.abscessus_ATCC_1997 VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLDGVADRVAA ******:***.***** ************************:** *** * MUL_4095|M.ulcerans_Agy99 LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN MMAR_5021|M.marinum_M LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN Mb3564c|M.bovis_AF2122/97 LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN Rv3534c|M.tuberculosis_H37Rv LVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGN MAV_0627|M.avium_104 LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN TH_0371|M.thermoresistible__bu LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN Mflv_1522|M.gilvum_PYR-GCK LVAELGDDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN Mvan_5234|M.vanbaalenii_PYR-1 LVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN MSMEG_5937|M.smegmatis_MC2_155 LVAELGSDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN MAB_0626|M.abscessus_ATCC_1997 VVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSTRRFGAGAGN :*****.*******************: ************ ********* MUL_4095|M.ulcerans_Agy99 APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG MMAR_5021|M.marinum_M APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG Mb3564c|M.bovis_AF2122/97 APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG Rv3534c|M.tuberculosis_H37Rv APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG MAV_0627|M.avium_104 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG TH_0371|M.thermoresistible__bu APVEALIGVFDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMG Mflv_1522|M.gilvum_PYR-GCK APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG Mvan_5234|M.vanbaalenii_PYR-1 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG MSMEG_5937|M.smegmatis_MC2_155 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG MAB_0626|M.abscessus_ATCC_1997 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG ************:****************:** ****:************ MUL_4095|M.ulcerans_Agy99 YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI MMAR_5021|M.marinum_M YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI Mb3564c|M.bovis_AF2122/97 YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI Rv3534c|M.tuberculosis_H37Rv YSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEI MAV_0627|M.avium_104 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI TH_0371|M.thermoresistible__bu YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI Mflv_1522|M.gilvum_PYR-GCK YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI Mvan_5234|M.vanbaalenii_PYR-1 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI MSMEG_5937|M.smegmatis_MC2_155 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI MAB_0626|M.abscessus_ATCC_1997 YSGVYSSFLKHAIRQGERYGVPAHQLLHRAGERKLIGGQEDQLIDIALEI ************:**.******* ******:****************** MUL_4095|M.ulcerans_Agy99 KREQESGQVASRR MMAR_5021|M.marinum_M KREQESGQVASRR Mb3564c|M.bovis_AF2122/97 KRELDSGAAVTH- Rv3534c|M.tuberculosis_H37Rv KRELDSGAAVTH- MAV_0627|M.avium_104 KREQESGAAAAR- TH_0371|M.thermoresistible__bu KRELEEQAGSTA- Mflv_1522|M.gilvum_PYR-GCK KREQEAEATRA-- Mvan_5234|M.vanbaalenii_PYR-1 KREQETAKS---- MSMEG_5937|M.smegmatis_MC2_155 KREQEAAASK--- MAB_0626|M.abscessus_ATCC_1997 QRENAANGQ---- :**