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MTEPQFDAVIVGGGHNGLVAAAYLARAGRRVRVLERLDHVGGAAVSAHAFDGVDARLSRYSYLVSLLPRS IVDDLGARVRLARRRYSSYTPDPATGGRTGLLVGPESTFAAIGAADDAERFAEFYRRWSLVTTRVWPTLL QPLRTRAQMREHVLAGQGPEAAAAWEDLTTRPIGDVITASVRNDLVRGVMATDALIGTFAATDDPALIQN VCFLYHLIGGGTGDWDVPIGGMGAVTGALAASAAGFGAEIVTGAEVYAITPDGEVRYRHGGTAHRISAHR VLANVTPVVLAKLLGEPAPQTAQGSQAKVNLMLRRLPRLRDDTVTAEQAFGGTFHINETLRQLDSAHAAA AGGRVPDPLPCEIYCHSLTDPSILSDDLRASGAQTLTVFGLHTPHSLAANDPDRMRDRLTSAVLNSLNSV LAEPIQDVLMEDSAGRLCIEAKTTVDLERSLGMTAGNIFHDALRWPFVDDDEPLDTPAQRWGVATGHERI LLCGSGSRRGGAVSGVGGHNAAMAVLERV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5667 | - | - | 100% (519) | phytoene dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0664 | - | 1e-35 | 27.80% (554) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2377 | - | 2e-12 | 28.08% (527) | P49 protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0921c | - | 0.0 | 67.63% (519) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1732 | - | 0.0 | 73.24% (512) | hypothetical protein Mflv_1732 |
| M. tuberculosis H37Rv | Rv0897c | - | 0.0 | 67.63% (519) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0948c | - | 1e-178 | 62.38% (513) | hypothetical protein MAB_0948c |
| M. marinum M | MMAR_4639 | - | 0.0 | 70.10% (515) | oxidoreductase |
| M. avium 104 | MAV_1019 | - | 0.0 | 70.78% (510) | phytoene dehydrogenase |
| M. thermoresistible (build 8) | TH_0456 | - | 0.0 | 75.00% (488) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_0254 | - | 0.0 | 69.51% (515) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5019 | - | 0.0 | 73.60% (519) | hypothetical protein Mvan_5019 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0921c|M.bovis_AF2122/97 --MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLRVRLLERLAQTGGAAVS
Rv0897c|M.tuberculosis_H37Rv --MSDHDRDFDVVVVGGGHNGLVAAAYLARAGLRVRLLERLAQTGGAAVS
MMAR_4639|M.marinum_M ------MKEFDVVVVGGGHNGLVAAAYLARAGLRVRVLERLGHVGGAAVS
MUL_0254|M.ulcerans_Agy99 ------MKEFDVVVVGGGHNGLVAAAYLARAGLRVRVLERLGYVGGAAVS
MAV_1019|M.avium_104 ------------MVIGGGHNGLVAAAYLARAGLRVRLLERLGQVGGAAVS
MSMEG_5667|M.smegmatis_MC2_155 ----MTEPQFDAVIVGGGHNGLVAAAYLARAGRRVRVLERLDHVGGAAVS
TH_0456|M.thermoresistible__bu ----------------------------------VLVLERLDHVGGAAVS
Mflv_1732|M.gilvum_PYR-GCK MRTTTGTEHRDAVIVGGGHNGLVAAAYLARAGRRVLVLERLDQVGGAAVS
Mvan_5019|M.vanbaalenii_PYR-1 ----MSEGRVDTVIVGGGHNGLVAAAYLAKAGRSVRVLERLGHVGGAAVS
MAB_0948c|M.abscessus_ATCC_199 -MGLSESDRYDTVIVGGGHNALTAAAYLARAGQRVMLLERLDVFGGAAIS
* :**** ****:*
Mb0921c|M.bovis_AF2122/97 IQAFDGVEVALSRYSYLVSLLPSRIVADLGAPVRLARRPFSSYTPAPATA
Rv0897c|M.tuberculosis_H37Rv IQAFDGVEVALSRYSYLVSLLPSRIVADLGAPVRLARRPFSSYTPAPATA
MMAR_4639|M.marinum_M IQAFDGVEVRLSRYSYLVSLLPPQIIKDLGAPVRLARRQFSSYTPQPDTH
MUL_0254|M.ulcerans_Agy99 IQAFDGVEVRLSRYSYLVSLLPPQIIKDLGAPVRLARRQFSSYTPQPDTH
MAV_1019|M.avium_104 AHAFDGVGVRVSRYSYLVSLLPPRIIDDLGARVRLARRRFSSYTPDPATG
MSMEG_5667|M.smegmatis_MC2_155 AHAFDGVDARLSRYSYLVSLLPRSIVDDLGARVRLARRRYSSYTPDPATG
TH_0456|M.thermoresistible__bu AHAFDGVDARLSRYSYLVSLLPRRIVDDLGARVRLARRRYSSYTPDPETG
Mflv_1732|M.gilvum_PYR-GCK AHPFDGVDARLSRYSYLVSLLPRRIVDDLGARVQLARRRWSSYTPNPADG
Mvan_5019|M.vanbaalenii_PYR-1 LYPFDGIDARLSRYSYLVSLLPRRIVDDLGARIRLARRRYSSYTPDPSDG
MAB_0948c|M.abscessus_ATCC_199 APAFEGVEARLSRYSYLVSLMPRQIIDDLGLDVRLARRKYASYTPDPMNG
.*:*: . :*********:* *: *** ::**** ::**** *
Mb0921c|M.bovis_AF2122/97 GRSGLLIGPTGEPRAAHLAAIGAAPDAHGFAAFYRRCRLVTARLWPTLIE
Rv0897c|M.tuberculosis_H37Rv GRSGLLIGPTGEPRAAHLAAIGAAPDAHGFAAFYRRCRLVTARLWPTLIE
MMAR_4639|M.marinum_M GRSGLLIGTAGD---DTFAAVGAAGDEPGFAAFYRRCRLVTERLWPTLLE
MUL_0254|M.ulcerans_Agy99 GRSGLLIGTAGD---DTFAAVGAAGDEPGFAAFYRRCRLVTERLWPTLLE
MAV_1019|M.avium_104 GARGLLIGAPGN----PFAAVGAAGDAPGFAAFYRRCRLVTERLWPTLLE
MSMEG_5667|M.smegmatis_MC2_155 GRTGLLVGPEST-----FAAIGAADDAERFAEFYRRWSLVTTRVWPTLLQ
TH_0456|M.thermoresistible__bu GRTGLLIGPETT-----FAAVGAADDEARFADFHRRSRMLTERLWPTMLQ
Mflv_1732|M.gilvum_PYR-GCK GRTGLLIGPEST-----FAAVGAAADEAGFAEFYRRCATVTTRLWPTLTE
Mvan_5019|M.vanbaalenii_PYR-1 GRSGLLIGPEST-----FGAVGAAADEAGFGEFYRQCATVTSALWPTLTE
MAB_0948c|M.abscessus_ATCC_199 GQRGFLAG------------------PNDFAEFGALCDSVTRPMWDSMLQ
* *:* * *. * :* :* :: :
Mb0921c|M.bovis_AF2122/97 PLRTREQARRDIVEYGGHEAAAAWQAMVDEPIGHAIAGAVANDLLRGVIA
Rv0897c|M.tuberculosis_H37Rv PLRTREQARRDIVEYGGHEAAAAWQAMVDEPIGHAIAGAVANDLLRGVIA
MMAR_4639|M.marinum_M PLRTRDQARRTVVDCGDPEALGAWHAMIDEPIGRAITAAVHDDLVRGVIA
MUL_0254|M.ulcerans_Agy99 PLRTRDQARRTVVDYGAPEALGAWHAMIEEPIGRAITAAVHDDLVRGVIA
MAV_1019|M.avium_104 PLRSRRHARRHVVDGGGAGAQAAWRALVEEPIGAAIADAVGNDLVRGVIA
MSMEG_5667|M.smegmatis_MC2_155 PLRTRAQMREHVLAGQGPEAAAAWEDLTTRPIGDVITASVRNDLVRGVMA
TH_0456|M.thermoresistible__bu PLRRRGDLRRQITAG-APDLDAVWRAMVDEPIGAAITAAVRSDLVRGVIA
Mflv_1732|M.gilvum_PYR-GCK PLQTRTALRRTVCSA---GGEAAWQAMIERPVGEAITDAVADDLVRGVMA
Mvan_5019|M.vanbaalenii_PYR-1 PLRTRSEAHRAVVGA---GGRDAWQWMIERPLAEAITSAVGDDLVRGVMA
MAB_0948c|M.abscessus_ATCC_199 PLRRRGAVR-----------TGAWEQLIETPIGEVIRAATPDDVRRGVLL
**: * : .*. : *:. .* :. .*: ***:
Mb0921c|M.bovis_AF2122/97 TDALIGTFARMHEPSLMQNICFLYHLVGGGTGVWHVPIGGMGSVTSALAT
Rv0897c|M.tuberculosis_H37Rv TDALIGTFARMHEPSLMQNICFLYHLVGGGTGVWHVPIGGMGSVTSALAT
MMAR_4639|M.marinum_M TDALIGTFAGLDEPSLAQNICFLYHLLGGGTGDWDVPIGGMGSVTAGLAA
MUL_0254|M.ulcerans_Agy99 TDALIGTFAGLDEPSLTQNICFLYHLLGGGTGDWDVPIGGMGSVTAGLAA
MAV_1019|M.avium_104 TDALIGTFARLDDPSLTQNVCFLYHVLGGGTGDWDVPVGGMGALTTALAT
MSMEG_5667|M.smegmatis_MC2_155 TDALIGTFAATDDPALIQNVCFLYHLIGGGTGDWDVPIGGMGAVTGALAA
TH_0456|M.thermoresistible__bu TDALIGTFARLDDPSLIQNRCFLYHLIG---GDWAVPVGGMGAVSGALAA
Mflv_1732|M.gilvum_PYR-GCK TDALIGTFADMHDQSLIQNRCLLYHLIGGGNGDWDVPIGGMGAVSGALAA
Mvan_5019|M.vanbaalenii_PYR-1 TDALIGTFARLDEESLVQNRCFLYHLIGGGTGDWDVPIGGMGAVSEAMAA
MAB_0948c|M.abscessus_ATCC_199 TDALIGTFASADDLSLQQNICFLYHQMN----PWDVPIGGMGAVTGSLEA
********* .: :* ** *:*** :. * **:****::: .: :
Mb0921c|M.bovis_AF2122/97 AAARHGAEIVTGADVFALDPDGTVRYHSDGSDGAEHLVRGRFVLVGVTPA
Rv0897c|M.tuberculosis_H37Rv AAARHGAEIVTGADVFALDPDGTVRYHSDGSDGAEHLVRGRFVLVGVTPA
MMAR_4639|M.marinum_M AATGYGAEIVTGAEAVAVTPNGDVRYR-AGDD--EHLIRGRFVLAGVTPA
MUL_0254|M.ulcerans_Agy99 AATGYGAEIVTGAEAVAVTPNGDVRYR-AGDD--EHLVRGRFVLAGVTPA
MAV_1019|M.avium_104 AAVRHGAEILTGAEVFAVDPSGEVRYR-SGDD--EHVVRARFVLAGVTPT
MSMEG_5667|M.smegmatis_MC2_155 SAAGFGAEIVTGAEVYAITPDGEVRYRHGGTA---HRISAHRVLANVTPV
TH_0456|M.thermoresistible__bu AAAGFGAEILTGAQVSAITPDGEVRYHRDGAD---RWAHGEVVLANVAPA
Mflv_1732|M.gilvum_PYR-GCK AATGFGAEILTGAEVYAIDADGMVHYRRTDGE---YRVSADHVLANVTPA
Mvan_5019|M.vanbaalenii_PYR-1 AATGFGAEIVTGADVYAIDPEGQVRYRCADDE---HVVAARHILANVTPA
MAB_0948c|M.abscessus_ATCC_199 SARRHGAELLSGAEVLSISPDAEVRYRSDGGE---HTVAGDRVLSGVSPT
:* .***:::**:. :: ... *:*: . . :* .*:*.
Mb0921c|M.bovis_AF2122/97 VLASLLGEPVAALAPGAQVKVNMVVRRLPRLRDDSVTPQQAFAGTFHVNE
Rv0897c|M.tuberculosis_H37Rv VLASLLGEPVAALAPGAQVKVNMVVRRLPRLRDDSVTPQQAFAGTFHVNE
MMAR_4639|M.marinum_M VLAKLLGDTEPTLAPGAQVKVNMVLRRLPRLRDAGVTPEQAFAGTFHANE
MUL_0254|M.ulcerans_Agy99 VLAKLLGDTEPSFAPGAQVKVNMVLRRLPRLRDAVVTPEQAFAGTFHANE
MAV_1019|M.avium_104 VLAGLLGEHPAPAAAGAQVKVNMALRRLPRLADGGVTPEQAFAGTFHVNE
MSMEG_5667|M.smegmatis_MC2_155 VLAKLLGEPAPQTAQGSQAKVNLMLRRLPRLRDDTVTAEQAFGGTFHINE
TH_0456|M.thermoresistible__bu ELARLTGSAPPEVTPGAQVKVNLMLRRLPRLRDETVTAEQAFGGTFHVNE
Mflv_1732|M.gilvum_PYR-GCK VLAGLMGEEEPAIAPGAQVKVNLMLRRLPRLRDEKVSAEQAFGGTFHINE
Mvan_5019|M.vanbaalenii_PYR-1 VLARLLGEAEPELAPGAQVKVNLMLTRLPRLRDESVTPEQAFGGTFHINE
MAB_0948c|M.abscessus_ATCC_199 VLAGLLGETPPAGQPGAQVKVNLLLRRLPRLRDENVTPEQAFGGTFHVNE
** * *. . *:*.***: : ***** * *:.:***.**** **
Mb0921c|M.bovis_AF2122/97 TWSQLDAAYSQAASGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTV
Rv0897c|M.tuberculosis_H37Rv TWSQLDAAYSQAASGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTV
MMAR_4639|M.marinum_M TWTQLEAAHQRAAAGHLPDPLPCEAYCHSLSDPSILSPALRDSGAQTMTV
MUL_0254|M.ulcerans_Agy99 TWTQLEAAHQRAAAGHLPDPLPCEAYCHSLSDPSILSPALRDVGAQTMTV
MAV_1019|M.avium_104 TWTQLDTAYARAAAGQVPNPLPCEAYCHSLADPSILSDDLRAAGAHTMTV
MSMEG_5667|M.smegmatis_MC2_155 TLRQLDSAHAAAAGGRVPDPLPCEIYCHSLTDPSILSDDLRASGAQTLTV
TH_0456|M.thermoresistible__bu GFGRLQAAYDEAAAGQVPAPLPCEVYAHSLTDPSILGDGLRAAGAHTMTV
Mflv_1732|M.gilvum_PYR-GCK NFGQLRDAYRQAEAGSVPEPVPCEIYCHTLADPSILSESLRVAGAHTLTV
Mvan_5019|M.vanbaalenii_PYR-1 TYRQLDAAYRQAAAGSVPDPLPCEIYCHTLADPTILSDSLRAAGAHTLTV
MAB_0948c|M.abscessus_ATCC_199 TYTQLEYAYQQASHGRIPDPLPCEIYCHSLADPSILSPELRASGAHTLTV
:* *: * * :* *:*** *.*:*:**:**. ** **:*:**
Mb0921c|M.bovis_AF2122/97 FGLHTPHSVFG--DTEGLAERLTAAVLASLNSVLAEPIQDVLWTDAQSKP
Rv0897c|M.tuberculosis_H37Rv FGLHTPHSVFG--DTEGLAERLTAAVLASLNSVLAEPIQDVLWTDAQSKP
MMAR_4639|M.marinum_M FGLHTPHSVFGNADPDVLRDQLTAAVLASLNSVLAEPIQDVLLTDADGRP
MUL_0254|M.ulcerans_Agy99 FGLHTPHSVFGNADPDVLRDQLTAAVLASLNSVLAEPIQDVLLTDADGRP
MAV_1019|M.avium_104 FGLHTPHALARGADPDTLRGRLTDRVLASLNSVLAEPIQELLLTDARGRP
MSMEG_5667|M.smegmatis_MC2_155 FGLHTPHSLAAN-DPDRMRDRLTSAVLNSLNSVLAEPIQDVLMEDSAGRL
TH_0456|M.thermoresistible__bu FGLHTPHRLAAA-DPDRVRDRLTSAVLTSLNSVLAEPIQDVIAEDAAGRL
Mflv_1732|M.gilvum_PYR-GCK FGLHTPHTLAHGQDGGRYRDTLTAAVLDSLDTVLAEPIRDVVWLDAAGRP
Mvan_5019|M.vanbaalenii_PYR-1 FGLHTPHSLADSATPDRLRDTLTSAVLTSLNSVLAEPIQDVIMQDSSGRL
MAB_0948c|M.abscessus_ATCC_199 FGLHTPHGLGAS------AEQLQQAVLASLSSVLAEPITDVVATDTHGRP
******* : * ** **.:****** ::: *: .:
Mb0921c|M.bovis_AF2122/97 CIETTTTLDLQRTLGMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDH
Rv0897c|M.tuberculosis_H37Rv CIETTTTLDLQRTLGMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDH
MMAR_4639|M.marinum_M CIETTTTADLQHTLHMTAGNIFHGALSWPFAENDDTLATPAQQWGVATDH
MUL_0254|M.ulcerans_Agy99 CIETTTTADLQHTLHMTAGNIFHGALSWPFAENDDTLATPAQQWGVATNH
MAV_1019|M.avium_104 CIETTTTADLERTLNMSGGNIFHGGLDWPFADDDDPLDTPGRQWGVATAH
MSMEG_5667|M.smegmatis_MC2_155 CIEAKTTVDLERSLGMTAGNIFHDALRWPFVDDDEPLDTPAQRWGVATGH
TH_0456|M.thermoresistible__bu CIETKTTADLEHSLHMTAGNIFHGALRWPFAEDDDPLDTPAQRWGVATGH
Mflv_1732|M.gilvum_PYR-GCK CIETKTTLDLDATLGMTNGHIFHGALQWPFAEDDEPLSTPAQRWGVDTPH
Mvan_5019|M.vanbaalenii_PYR-1 CIEAKTTSDLDDALGMTDGNIFHGALSWPFVEDDEPLATPAQRWGVATAH
MAB_0948c|M.abscessus_ATCC_199 CIETKTTIDLESALGMTAGNIFHGGLQWPFAEDDDPLETAAQRWGVATNH
***:.** **: :* *: *:***..* ***.::*:.* *..::*** * *
Mb0921c|M.bovis_AF2122/97 ERIMLCGSGARRGGAVSGIGGHNAAMAVLACLASRRKSP
Rv0897c|M.tuberculosis_H37Rv ERIMLCGSGARRGGAVSGIGGHNAAMAVLACLASRRKSP
MMAR_4639|M.marinum_M DRIMLCGSGARRGGAVSGIGGHNAAMAVLAYLRQDR---
MUL_0254|M.ulcerans_Agy99 DRIMLCGSGARRGGAVSGIGGHNAAMAVLAYLRQDR---
MAV_1019|M.avium_104 ERIMLCGSGARRGGAVSGIGGHNAAMAVLSSLSSR----
MSMEG_5667|M.smegmatis_MC2_155 ERILLCGSGSRRGGAVSGVGGHNAAMAVLERV-------
TH_0456|M.thermoresistible__bu DRILLCGSGSRRGGGVSGIGGHNAAMAVLQR--------
Mflv_1732|M.gilvum_PYR-GCK ERILLCGSGSRRGGAVSGIGGHNAAMAVLES--------
Mvan_5019|M.vanbaalenii_PYR-1 DRILLCGSGSRRGGAVSGIGGHNAAMAVLER--------
MAB_0948c|M.abscessus_ATCC_199 DRILLCGSGSRRGGGVSGLGGYHAARAVLETH-------
:**:*****:****.***:**::** ***