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QITTDEARTLGPFTWLKKPAVDGPPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWSGPLEIGAD ELRKSGDALPADLREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLL ASAFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGLIGDGPVDM LVGAGNAFVTEAKRQLFGRVGIDLLAGPSEVAVLADETADPEWVAADLLGQAEHGPNSPAALITTSETLG RRVIEAIDRQLETLATREVAGPAWRDFGSVLVASDAEQAAAIADVLGPEHLEVQTADDDYFLKRLRNYGS LFLGRWSTVAYSDKGIAGTNHVLPTGKTARYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGL AAHEATATIRIEEIGRDSAVFDGTPAASRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5656 | hisD | - | 100% (451) | histidinol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2012 | hisD | 9e-99 | 47.26% (438) | histidinol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3205 | hisD | 3e-62 | 38.80% (415) | histidinol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1625 | hisD | 2e-61 | 37.07% (410) | histidinol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3613 | hisD | 8e-61 | 37.35% (415) | histidinol dehydrogenase |
| M. tuberculosis H37Rv | Rv1599 | hisD | 2e-61 | 37.07% (410) | histidinol dehydrogenase |
| M. leprae Br4923 | MLBr_01257 | hisD | 1e-57 | 36.57% (391) | histidinol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2670c | hisD | 2e-58 | 37.23% (411) | histidinol dehydrogenase |
| M. marinum M | MMAR_2395 | hisD | 5e-62 | 36.59% (410) | histidinol dehydrogenase HisD |
| M. avium 104 | MAV_3187 | hisD | 8e-57 | 34.88% (430) | histidinol dehydrogenase |
| M. thermoresistible (build 8) | TH_1162 | hisD | 1e-59 | 36.50% (411) | Probable histidinol dehydrogenase HisD (HDH) |
| M. ulcerans Agy99 | MUL_1572 | hisD | 3e-61 | 36.34% (410) | histidinol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2804 | hisD | 1e-59 | 36.47% (414) | histidinol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1625|M.bovis_AF2122/97 ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
Rv1599|M.tuberculosis_H37Rv ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
MMAR_2395|M.marinum_M -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MUL_1572|M.ulcerans_Agy99 -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MLBr_01257|M.leprae_Br4923 -MS--ITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQ
MAV_3187|M.avium_104 MDTVSPTPASPMARIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQ
Mflv_3613|M.gilvum_PYR-GCK ----MNVSPALLRRIDLRDTALSAARLRTALPRGGVDVDAVVPKVRPIVD
Mvan_2804|M.vanbaalenii_PYR-1 -MVSVSVSPGLLRRIDLRGTTLSAARLRSALPRGGVDVDTVVPKVRPIVD
TH_1162|M.thermoresistible__bu -MNVVNVSRPVLARIDLRGTNQSAGRLRTVLPRGVVDVESVLPKVRPIVE
MAB_2670c|M.abscessus_ATCC_199 ---MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVE
MSMEG_5656|M.smegmatis_MC2_155 -MQITTDEARTLGPFTWLKKPAVDGPPAQRDPK-------VVERVSQMLL
: . *: *: * ::
Mb1625|M.bovis_AF2122/97 AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
Rv1599|M.tuberculosis_H37Rv AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
MMAR_2395|M.marinum_M AVAERGAQAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MUL_1572|M.ulcerans_Agy99 AVAERGARAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MLBr_01257|M.leprae_Br4923 AVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVM
MAV_3187|M.avium_104 AVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVM
Mflv_3613|M.gilvum_PYR-GCK AVAARGADAALEYGASFDGVRPDRVRVPSNKLTEALDTLDDDVRTALEVA
Mvan_2804|M.vanbaalenii_PYR-1 AVAERGAAAALEYGAAFDGIRPDQVRVPAERLKAALAELDPDVRTALEVA
TH_1162|M.thermoresistible__bu AVAERGAEAALEYGRSFDGVRPAAVRVPAEALRTALVELDRDVRTALEVA
MAB_2670c|M.abscessus_ATCC_199 AVRDRGAEAALDFCAEFDGVRPGTVRVPAAELDRALADLDPAVRDALEVA
MSMEG_5656|M.smegmatis_MC2_155 DIERRGLDAVRAYARELDGWS-GPLEIGADELRKSGDALPADLREALELG
: * *. : :** :.: * : * : **.:
Mb1625|M.bovis_AF2122/97 VERTR--AVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
Rv1599|M.tuberculosis_H37Rv VERTR--AVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
MMAR_2395|M.marinum_M IERTR--AVHADQRRTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYP
MUL_1572|M.ulcerans_Agy99 IERTR--AVHGDQRRTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYP
MLBr_01257|M.leprae_Br4923 IERTR--VVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYP
MAV_3187|M.avium_104 IDRAR--AVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
Mflv_3613|M.gilvum_PYR-GCK IERTR--IVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYP
Mvan_2804|M.vanbaalenii_PYR-1 IERAR--AVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYP
TH_1162|M.thermoresistible__bu IERAR--AVHADQRRTDTTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
MAB_2670c|M.abscessus_ATCC_199 ILRAR--AVHADQRRQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYP
MSMEG_5656|M.smegmatis_MC2_155 YERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLL
*:. * * * :. *.* :::**:*** *:*.*.
Mb1625|M.bovis_AF2122/97 SSVVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVD
Rv1599|M.tuberculosis_H37Rv SSVVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVD
MMAR_2395|M.marinum_M SSVVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVD
MUL_1572|M.ulcerans_Agy99 SSVVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVD
MLBr_01257|M.leprae_Br4923 SSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVD
MAV_3187|M.avium_104 SSVVMNVVPAQAAGVASLVVASPPQAQFDG----LPHPTILAAARLLGVD
Mflv_3613|M.gilvum_PYR-GCK SSVVMNVVPAQTAGVDSLVIASPPQKTNPDRFAGLPHPTILAAAALLGVD
Mvan_2804|M.vanbaalenii_PYR-1 SSVVMNVVPAQTAGVDSLVIASPPQAGNAEPFKGLPHPTILAAAALLGVD
TH_1162|M.thermoresistible__bu SSVVMNVVPAQIAGVESLVIASPPQAAHG----GLPHPTILAAAALLGVE
MAB_2670c|M.abscessus_ATCC_199 SSVVMNVVPAQTAGVGSLVIASPPQAQFGG----LPHPTILAAAQLLGVQ
MSMEG_5656|M.smegmatis_MC2_155 ASAFMTVGVAKAAGVPTVLACTPPSGEHG------AHPAVLYGAYLSRAD
:*..*.* *: *** ::: .:**. .**::* .* * .:
Mb1625|M.bovis_AF2122/97 EVWAVGGAQAVALLAYGGTDT-------------------DGAALTPVDM
Rv1599|M.tuberculosis_H37Rv EVWAVGGAQAVALLAYGGTDT-------------------DGAALTPVDM
MMAR_2395|M.marinum_M EVWAVGGAQAVALLAYGGTDV-------------------DGHELAPVDM
MUL_1572|M.ulcerans_Agy99 EVWAVGGAQVVALLAYGGTDV-------------------DGHELAPVDM
MLBr_01257|M.leprae_Br4923 EVWAVGGAQAVALLAYGGTDS-------------------DDCELAPVDM
MAV_3187|M.avium_104 EVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRARSASSPGADAELVPVDM
Mflv_3613|M.gilvum_PYR-GCK EVWAVGGAQAVALLAYGGTDTDGE------------------TELAPVDM
Mvan_2804|M.vanbaalenii_PYR-1 EVWAVGGAQAVALLAYGGVDTDG-------------------AELAPVDM
TH_1162|M.thermoresistible__bu EVWAVGGAQAVALLAHGGTDADG-------------------AELLPVDM
MAB_2670c|M.abscessus_ATCC_199 EVWAVGGAQGVALLAHGGTDTDG-------------------AELAPVDM
MSMEG_5656|M.smegmatis_MC2_155 SVFAVGGVQALGAMAFGLIGD------------------------GPVDM
.*:****.* :. :*.* . ****
Mb1625|M.bovis_AF2122/97 ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLIS
Rv1599|M.tuberculosis_H37Rv ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLIS
MMAR_2395|M.marinum_M ITGPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLIS
MUL_1572|M.ulcerans_Agy99 ITGPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLIS
MLBr_01257|M.leprae_Br4923 ITGPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMIS
MAV_3187|M.avium_104 ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLIS
Mflv_3613|M.gilvum_PYR-GCK ITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLIS
Mvan_2804|M.vanbaalenii_PYR-1 ITGPGNIYVTAAKRICRSAVGIDAEAGPTEIAILADHTADPAHVVADLIS
TH_1162|M.thermoresistible__bu ITGPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADHSANPAHLAADLIS
MAB_2670c|M.abscessus_ATCC_199 ITGPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADETADPVHVAADLIS
MSMEG_5656|M.smegmatis_MC2_155 LVGAGNAFVTEAKRQLFGRVGIDLLAGPSEVAVLADETADPEWVAADLLG
:.*.** :** *** . **** ***:*:*:***.:*:* :.**::.
Mb1625|M.bovis_AF2122/97 QAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSA
Rv1599|M.tuberculosis_H37Rv QAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSA
MMAR_2395|M.marinum_M QAEHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSA
MUL_1572|M.ulcerans_Agy99 QAEHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSA
MLBr_01257|M.leprae_Br4923 QAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSA
MAV_3187|M.avium_104 QAEHDEMAGSVLVTPSEELAAATDAELAAQLPTTVHRERVTAALGGRQSA
Mflv_3613|M.gilvum_PYR-GCK QAEHDEMAASVLVTDSTELADATDRELALQLETTVHRERVTAALRGRQSA
Mvan_2804|M.vanbaalenii_PYR-1 QAEHDEMAASVLVTDSAELADATDRELAVQLETTVHRERVTAALGGQQSA
TH_1162|M.thermoresistible__bu QAEHDEMAASVLVTADVGLADATDAAVAEQLATTVHRQRVETALRGPQSA
MAB_2670c|M.abscessus_ATCC_199 QAEHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQSG
MSMEG_5656|M.smegmatis_MC2_155 QAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWR-DFGS
****. : :.*:* . *. . ** * . : . .* ..
Mb1625|M.bovis_AF2122/97 IVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPV
Rv1599|M.tuberculosis_H37Rv IVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPV
MMAR_2395|M.marinum_M IILVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPV
MUL_1572|M.ulcerans_Agy99 IILVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPV
MLBr_01257|M.leprae_Br4923 IILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPV
MAV_3187|M.avium_104 IILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPV
Mflv_3613|M.gilvum_PYR-GCK IVLVDDVDAGVRTVNAYAAEHLEIQTADAAQVANRIRSAGAIFVGPYSPV
Mvan_2804|M.vanbaalenii_PYR-1 IVLVDDIEAGIRTVNAYAAEHLEIQTVDAAAVAGRIRSAGAIFVGPWSPV
TH_1162|M.thermoresistible__bu IVLVDDLDAGIRTVNAYAAEHLEIQTADAAAVAARIRSAGAVFVGPYSPV
MAB_2670c|M.abscessus_ATCC_199 IVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPV
MSMEG_5656|M.smegmatis_MC2_155 VLVASDAEQAAAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTV
:::..* : . .: ..****::*.: . *:* *::*:* ::.*
Mb1625|M.bovis_AF2122/97 SLGDY-CAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSG
Rv1599|M.tuberculosis_H37Rv SLGDY-CAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSG
MMAR_2395|M.marinum_M SLGDY-CAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDYTEAALKDVSG
MUL_1572|M.ulcerans_Agy99 SLGDY-CAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDYTEVALKDVSG
MLBr_01257|M.leprae_Br4923 SLGDY-CAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTALKDISG
MAV_3187|M.avium_104 SLGDY-CAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSG
Mflv_3613|M.gilvum_PYR-GCK SLGDY-CAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSG
Mvan_2804|M.vanbaalenii_PYR-1 SLGDY-CAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSG
TH_1162|M.thermoresistible__bu SLGDY-CAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVEYTEAALKDVSG
MAB_2670c|M.abscessus_ATCC_199 SLGDY-CAGSNHVLPTAGCARHSSGLSVQTFLRGIHIVDYTEAALKEVAG
MSMEG_5656|M.smegmatis_MC2_155 AYSDKGIAGTNHVLPTGKTARYNAGLSVSRFVKPLTYQRAAREATAALAP
: .* **:******. **:..****. *:: : :. * ::
Mb1625|M.bovis_AF2122/97 HVITLATAEDLPAHGEAVRRRFER-----------------
Rv1599|M.tuberculosis_H37Rv HVITLATAEDLPAHGEAVRRRFER-----------------
MMAR_2395|M.marinum_M HVLTLAKAEDLPAHGEAVRRRFER-----------------
MUL_1572|M.ulcerans_Agy99 HVLTLAKAEDLPAHGEAVRRRFER-----------------
MLBr_01257|M.leprae_Br4923 HVITLAKAEDLPAHGEAVRRRFAR-----------------
MAV_3187|M.avium_104 HVITLAQAEDLPAHGEAIRRRFER-----------------
Mflv_3613|M.gilvum_PYR-GCK YVITLANAENLPSHGEAVRRRFES-----------------
Mvan_2804|M.vanbaalenii_PYR-1 YVITLAKAENLPSHGEAVRRRFER-----------------
TH_1162|M.thermoresistible__bu HAITLAQAEDLPAHGEAIRRRFEQS----------------
MAB_2670c|M.abscessus_ATCC_199 HVITLANAENLPAHGEAVRRRFERS----------------
MSMEG_5656|M.smegmatis_MC2_155 AVERISAFEGLAAHEATATIRIEEIGRDSAVFDGTPAASRR
. :: *.*.:* : *: