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NVSPALLRRIDLRDTALSAARLRTALPRGGVDVDAVVPKVRPIVDAVAARGADAALEYGASFDGVRPDRV RVPSNKLTEALDTLDDDVRTALEVAIERTRIVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNA VYPSSVVMNVVPAQTAGVDSLVIASPPQKTNPDRFAGLPHPTILAAAALLGVDEVWAVGGAQAVALLAYG GTDTDGETELAPVDMITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHD EMAASVLVTDSTELADATDRELALQLETTVHRERVTAALRGRQSAIVLVDDVDAGVRTVNAYAAEHLEIQ TADAAQVANRIRSAGAIFVGPYSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALK DVSGYVITLANAENLPSHGEAVRRRFES*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3613 | hisD | - | 100% (449) | histidinol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1625 | hisD | 0.0 | 83.03% (442) | histidinol dehydrogenase |
| M. tuberculosis H37Rv | Rv1599 | hisD | 0.0 | 83.03% (442) | histidinol dehydrogenase |
| M. leprae Br4923 | MLBr_01257 | hisD | 0.0 | 80.81% (443) | histidinol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2670c | hisD | 0.0 | 78.75% (447) | histidinol dehydrogenase |
| M. marinum M | MMAR_2395 | hisD | 0.0 | 82.37% (448) | histidinol dehydrogenase HisD |
| M. avium 104 | MAV_3187 | hisD | 0.0 | 79.01% (467) | histidinol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3205 | hisD | 0.0 | 86.17% (441) | histidinol dehydrogenase |
| M. thermoresistible (build 8) | TH_1162 | hisD | 0.0 | 82.59% (448) | Probable histidinol dehydrogenase HisD (HDH) |
| M. ulcerans Agy99 | MUL_1572 | hisD | 0.0 | 81.70% (448) | histidinol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2804 | hisD | 0.0 | 89.96% (448) | histidinol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3613|M.gilvum_PYR-GCK ----MNVSPALLRRIDLRDTALSAARLRTALPRGGVDVDAVVPKVRPIVD
Mvan_2804|M.vanbaalenii_PYR-1 -MVSVSVSPGLLRRIDLRGTTLSAARLRSALPRGGVDVDTVVPKVRPIVD
MSMEG_3205|M.smegmatis_MC2_155 ---MNMMAKFQMSRIDLRNRVLSAAQLRSALPRGGVDVDAVVPKVRPIVD
MMAR_2395|M.marinum_M -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MUL_1572|M.ulcerans_Agy99 -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MLBr_01257|M.leprae_Br4923 -MS--ITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQ
Mb1625|M.bovis_AF2122/97 ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
Rv1599|M.tuberculosis_H37Rv ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
MAV_3187|M.avium_104 MDTVSPTPASPMARIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQ
TH_1162|M.thermoresistible__bu -MNVVNVSRPVLARIDLRGTNQSAGRLRTVLPRGVVDVESVLPKVRPIVE
MAB_2670c|M.abscessus_ATCC_199 ---MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVE
: :*:*. :. **:.**** .**::*:* * *:*
Mflv_3613|M.gilvum_PYR-GCK AVAARGADAALEYGASFDGVRPDRVRVPSNKLTEALDTLDDDVRTALEVA
Mvan_2804|M.vanbaalenii_PYR-1 AVAERGAAAALEYGAAFDGIRPDQVRVPAERLKAALAELDPDVRTALEVA
MSMEG_3205|M.smegmatis_MC2_155 AVAQRGAQAALEYGESFDGIRPETVRVPRELLSQALENLDADVRAALQVS
MMAR_2395|M.marinum_M AVAERGAQAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MUL_1572|M.ulcerans_Agy99 AVAERGARAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MLBr_01257|M.leprae_Br4923 AVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVM
Mb1625|M.bovis_AF2122/97 AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
Rv1599|M.tuberculosis_H37Rv AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
MAV_3187|M.avium_104 AVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVM
TH_1162|M.thermoresistible__bu AVAERGAEAALEYGRSFDGVRPAAVRVPAEALRTALVELDRDVRTALEVA
MAB_2670c|M.abscessus_ATCC_199 AVRDRGAEAALDFCAEFDGVRPGTVRVPAAELDRALADLDPAVRDALEVA
** ** ***:: ***:** :*** * ** *. * **.*
Mflv_3613|M.gilvum_PYR-GCK IERTRIVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYPSS
Mvan_2804|M.vanbaalenii_PYR-1 IERARAVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYPSS
MSMEG_3205|M.smegmatis_MC2_155 IDRARAVHADQRRTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYPSS
MMAR_2395|M.marinum_M IERTRAVHADQRRTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYPSS
MUL_1572|M.ulcerans_Agy99 IERTRAVHGDQRRTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYPSS
MLBr_01257|M.leprae_Br4923 IERTRVVHADQRRTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYPSS
Mb1625|M.bovis_AF2122/97 VERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSS
Rv1599|M.tuberculosis_H37Rv VERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSS
MAV_3187|M.avium_104 IDRARAVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSS
TH_1162|M.thermoresistible__bu IERARAVHADQRRTDTTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSS
MAB_2670c|M.abscessus_ATCC_199 ILRARAVHADQRRQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYPSS
: *:* **..*** *..*::. ********:*******************
Mflv_3613|M.gilvum_PYR-GCK VVMNVVPAQTAGVDSLVIASPPQKTNPDRFAGLPHPTILAAAALLGVDEV
Mvan_2804|M.vanbaalenii_PYR-1 VVMNVVPAQTAGVDSLVIASPPQAGNAEPFKGLPHPTILAAAALLGVDEV
MSMEG_3205|M.smegmatis_MC2_155 VVMNVVPAQTAGVDSMVIASPPQ----GQFGGRPHPTILAAAALLGVDEV
MMAR_2395|M.marinum_M VVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVDEV
MUL_1572|M.ulcerans_Agy99 VVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVDEV
MLBr_01257|M.leprae_Br4923 VVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVDEV
Mb1625|M.bovis_AF2122/97 VVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVDEV
Rv1599|M.tuberculosis_H37Rv VVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVDEV
MAV_3187|M.avium_104 VVMNVVPAQAAGVASLVVASPPQAQFDG----LPHPTILAAARLLGVDEV
TH_1162|M.thermoresistible__bu VVMNVVPAQIAGVESLVIASPPQAAHGG----LPHPTILAAAALLGVEEV
MAB_2670c|M.abscessus_ATCC_199 VVMNVVPAQTAGVGSLVIASPPQAQFGG----LPHPTILAAAQLLGVQEV
********* *** *:*:***** ********* ****:**
Mflv_3613|M.gilvum_PYR-GCK WAVGGAQAVALLAYGGTDTDGE------------------TELAPVDMIT
Mvan_2804|M.vanbaalenii_PYR-1 WAVGGAQAVALLAYGGVDTDG-------------------AELAPVDMIT
MSMEG_3205|M.smegmatis_MC2_155 WAVGGAQAVALLAYGGTDTDG-------------------AELAPVDMIT
MMAR_2395|M.marinum_M WAVGGAQAVALLAYGGTDV-------------------DGHELAPVDMIT
MUL_1572|M.ulcerans_Agy99 WAVGGAQVVALLAYGGTDV-------------------DGHELAPVDMIT
MLBr_01257|M.leprae_Br4923 WAVGGAQAVALLAYGGTDS-------------------DDCELAPVDMIT
Mb1625|M.bovis_AF2122/97 WAVGGAQAVALLAYGGTDT-------------------DGAALTPVDMIT
Rv1599|M.tuberculosis_H37Rv WAVGGAQAVALLAYGGTDT-------------------DGAALTPVDMIT
MAV_3187|M.avium_104 WAVGGAQAVALLAYGGTDTGAEWPGFSSDRARSASSPGADAELVPVDMIT
TH_1162|M.thermoresistible__bu WAVGGAQAVALLAHGGTDA-------------------DGAELLPVDMIT
MAB_2670c|M.abscessus_ATCC_199 WAVGGAQGVALLAHGGTDT-------------------DGAELAPVDMIT
******* *****:**.* * ******
Mflv_3613|M.gilvum_PYR-GCK GPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLISQA
Mvan_2804|M.vanbaalenii_PYR-1 GPGNIYVTAAKRICRSAVGIDAEAGPTEIAILADHTADPAHVVADLISQA
MSMEG_3205|M.smegmatis_MC2_155 GPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLISQA
MMAR_2395|M.marinum_M GPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLISQA
MUL_1572|M.ulcerans_Agy99 GPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLISQA
MLBr_01257|M.leprae_Br4923 GPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMISQA
Mb1625|M.bovis_AF2122/97 GPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQA
Rv1599|M.tuberculosis_H37Rv GPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQA
MAV_3187|M.avium_104 GPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLISQA
TH_1162|M.thermoresistible__bu GPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADHSANPAHLAADLISQA
MAB_2670c|M.abscessus_ATCC_199 GPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADETADPVHVAADLISQA
************:*** ****.************.:*:*.*:.**:****
Mflv_3613|M.gilvum_PYR-GCK EHDEMAASVLVTDSTELADATDRELALQLETTVHRERVTAALRGRQSAIV
Mvan_2804|M.vanbaalenii_PYR-1 EHDEMAASVLVTDSAELADATDRELAVQLETTVHRERVTAALGGQQSAIV
MSMEG_3205|M.smegmatis_MC2_155 EHDEMAASVLVTDSETLAEATDRELANQLATTKHVERVTAALSGKQSAIV
MMAR_2395|M.marinum_M EHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSAII
MUL_1572|M.ulcerans_Agy99 EHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSAII
MLBr_01257|M.leprae_Br4923 EHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSAII
Mb1625|M.bovis_AF2122/97 EHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIV
Rv1599|M.tuberculosis_H37Rv EHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIV
MAV_3187|M.avium_104 EHDEMAGSVLVTPSEELAAATDAELAAQLPTTVHRERVTAALGGRQSAII
TH_1162|M.thermoresistible__bu EHDEMAASVLVTADVGLADATDAAVAEQLATTVHRQRVETALRGPQSAIV
MAB_2670c|M.abscessus_ATCC_199 EHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQSGIV
*** :*.***** . ** *. : ** ** * :** :** * **.*:
Mflv_3613|M.gilvum_PYR-GCK LVDDVDAGVRTVNAYAAEHLEIQTADAAQVANRIRSAGAIFVGPYSPVSL
Mvan_2804|M.vanbaalenii_PYR-1 LVDDIEAGIRTVNAYAAEHLEIQTVDAAAVAGRIRSAGAIFVGPWSPVSL
MSMEG_3205|M.smegmatis_MC2_155 LVDDIDAGVRTVNAYAAEHLEIQTVDAPGVAGRIRSAGAIFVGAWSPVSL
MMAR_2395|M.marinum_M LVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPVSL
MUL_1572|M.ulcerans_Agy99 LVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPVSL
MLBr_01257|M.leprae_Br4923 LVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPVSL
Mb1625|M.bovis_AF2122/97 LVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSL
Rv1599|M.tuberculosis_H37Rv LVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSL
MAV_3187|M.avium_104 LVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPVSL
TH_1162|M.thermoresistible__bu LVDDLDAGIRTVNAYAAEHLEIQTADAAAVAARIRSAGAVFVGPYSPVSL
MAB_2670c|M.abscessus_ATCC_199 LVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPVSL
****::*.: .** ********:*.:. ** *:* ***:*:*.::****
Mflv_3613|M.gilvum_PYR-GCK GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVI
Mvan_2804|M.vanbaalenii_PYR-1 GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDYTEAALKDVSGYVI
MSMEG_3205|M.smegmatis_MC2_155 GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYDEAALKDVSGHVI
MMAR_2395|M.marinum_M GDYCAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVL
MUL_1572|M.ulcerans_Agy99 GDYCAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDYTEVALKDVSGHVL
MLBr_01257|M.leprae_Br4923 GDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNYTKTALKDISGHVI
Mb1625|M.bovis_AF2122/97 GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVI
Rv1599|M.tuberculosis_H37Rv GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVI
MAV_3187|M.avium_104 GDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVI
TH_1162|M.thermoresistible__bu GDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHAI
MAB_2670c|M.abscessus_ATCC_199 GDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHIVDYTEAALKEVAGHVI
*************** ****.************:*:* :.***:::*:.:
Mflv_3613|M.gilvum_PYR-GCK TLANAENLPSHGEAVRRRFES-
Mvan_2804|M.vanbaalenii_PYR-1 TLAKAENLPSHGEAVRRRFER-
MSMEG_3205|M.smegmatis_MC2_155 TLSKAEDLPAHGEAVRRRFER-
MMAR_2395|M.marinum_M TLAKAEDLPAHGEAVRRRFER-
MUL_1572|M.ulcerans_Agy99 TLAKAEDLPAHGEAVRRRFER-
MLBr_01257|M.leprae_Br4923 TLAKAEDLPAHGEAVRRRFAR-
Mb1625|M.bovis_AF2122/97 TLATAEDLPAHGEAVRRRFER-
Rv1599|M.tuberculosis_H37Rv TLATAEDLPAHGEAVRRRFER-
MAV_3187|M.avium_104 TLAQAEDLPAHGEAIRRRFER-
TH_1162|M.thermoresistible__bu TLAQAEDLPAHGEAIRRRFEQS
MAB_2670c|M.abscessus_ATCC_199 TLANAENLPAHGEAVRRRFERS
**: **:**:****:****