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MINHLKKATPTEVDANRDTAVKETVAKVISDVATRGDEAVREYSAKFDNWSPESFALGADEIERIVARVP EQALEDIRAVQARVRDFAQRQRDAILDFEAETEPGVFLGQRNIPVAAAGAYVPGGRYPLVASAHMTVVTA KVAGVERVTACTPPIHGEIPAATVAALHLAGADEINILGGTQAVAAMALGTETIGKVDLLAGPGNAYVAE AKRQLFGQVGIDLFAGPTEVLVIADEFADPFVVAVDLLSQAEHGPDSPAVLITTSRALAERVGELIERLL PGMPTRDFAEPAWRDHGEIVVVDDVEEAFALGDRYAFEHVQVLTADPRQALTGMTNYGALFLGEGTCVSY GDKVIGTNHTLPTRGAARYTGGLWVGKYLKTVTYQEVRSAEASAALGRLCGRAARVESFEGHARSGDIRA MKFGDDTFSWVPADAAVRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2012 | hisD | - | 100% (439) | histidinol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5656 | hisD | 9e-99 | 47.26% (438) | histidinol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3205 | hisD | 2e-54 | 36.17% (412) | histidinol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1625 | hisD | 2e-57 | 36.05% (405) | histidinol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3613 | hisD | 6e-56 | 35.59% (413) | histidinol dehydrogenase |
| M. tuberculosis H37Rv | Rv1599 | hisD | 2e-57 | 36.05% (405) | histidinol dehydrogenase |
| M. leprae Br4923 | MLBr_01257 | hisD | 3e-53 | 35.11% (376) | histidinol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2670c | hisD | 5e-57 | 35.36% (427) | histidinol dehydrogenase |
| M. marinum M | MMAR_2395 | hisD | 2e-56 | 35.44% (412) | histidinol dehydrogenase HisD |
| M. avium 104 | MAV_3187 | hisD | 1e-51 | 32.70% (419) | histidinol dehydrogenase |
| M. thermoresistible (build 8) | TH_1162 | hisD | 1e-56 | 36.63% (415) | Probable histidinol dehydrogenase HisD (HDH) |
| M. ulcerans Agy99 | MUL_1572 | hisD | 1e-55 | 35.66% (415) | histidinol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2804 | hisD | 6e-54 | 35.02% (414) | histidinol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1625|M.bovis_AF2122/97 ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
Rv1599|M.tuberculosis_H37Rv ----------MLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVA
MMAR_2395|M.marinum_M -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MUL_1572|M.ulcerans_Agy99 -MVGVSTPRSLLARVDLRGAELTAAGLRAALPRGGADVEAVLPKVRPIVA
MLBr_01257|M.leprae_Br4923 -MS--ITPPFLLACIDLRGAELTATQLRATLPRGGADVEAVLPTVWPIVQ
MAV_3187|M.avium_104 MDTVSPTPASPMARIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQ
Mflv_3613|M.gilvum_PYR-GCK ----MNVSPALLRRIDLRDTALSAARLRTALPRGGVDVDAVVPKVRPIVD
Mvan_2804|M.vanbaalenii_PYR-1 -MVSVSVSPGLLRRIDLRGTTLSAARLRSALPRGGVDVDTVVPKVRPIVD
TH_1162|M.thermoresistible__bu -MNVVNVSRPVLARIDLRGTNQSAGRLRTVLPRGVVDVESVLPKVRPIVE
MAB_2670c|M.abscessus_ATCC_199 ---MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVE
MSMEG_2012|M.smegmatis_MC2_155 --------------------MINHLKKATPTEVDANRDTAVKETVAKVIS
. : . :* * ::
Mb1625|M.bovis_AF2122/97 AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
Rv1599|M.tuberculosis_H37Rv AVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVM
MMAR_2395|M.marinum_M AVAERGAQAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MUL_1572|M.ulcerans_Agy99 AVAERGARAALEFCESFDGVRPAAVRVPQAALAAALDELSPDVRDALQVM
MLBr_01257|M.leprae_Br4923 AVAECGADAALEFGALFDGVRPPTVRVPDAALDAALAGLDPDVRDALQVM
MAV_3187|M.avium_104 AVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVM
Mflv_3613|M.gilvum_PYR-GCK AVAARGADAALEYGASFDGVRPDRVRVPSNKLTEALDTLDDDVRTALEVA
Mvan_2804|M.vanbaalenii_PYR-1 AVAERGAAAALEYGAAFDGIRPDQVRVPAERLKAALAELDPDVRTALEVA
TH_1162|M.thermoresistible__bu AVAERGAEAALEYGRSFDGVRPAAVRVPAEALRTALVELDRDVRTALEVA
MAB_2670c|M.abscessus_ATCC_199 AVRDRGAEAALDFCAEFDGVRPGTVRVPAAELDRALADLDPAVRDALEVA
MSMEG_2012|M.smegmatis_MC2_155 DVATRGDEAVREYSAKFDNWSPESFALGADEIERIVARVPEQALEDIRAV
* * *. :: **. * . : : : : . :..
Mb1625|M.bovis_AF2122/97 VERTRAVHSGQR--RTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
Rv1599|M.tuberculosis_H37Rv VERTRAVHSGQR--RTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
MMAR_2395|M.marinum_M IERTRAVHADQR--RTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYP
MUL_1572|M.ulcerans_Agy99 IERTRAVHGDQR--RTDVVTTLGPGATVTERWIPVERVGLYVPGGNAVYP
MLBr_01257|M.leprae_Br4923 IERTRVVHADQR--RTDVTTALGPGATVTERWVPVERVGLYVPGGNAVYP
MAV_3187|M.avium_104 IDRARAVHADQR--RTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
Mflv_3613|M.gilvum_PYR-GCK IERTRIVHADQR--RTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYP
Mvan_2804|M.vanbaalenii_PYR-1 IERARAVHADQR--RTDTTTTLAPGATVTERWVPVERVGLYVPGGNAVYP
TH_1162|M.thermoresistible__bu IERARAVHADQR--RTDTTTTLGPGATVTERWVPVERVGLYVPGGNAVYP
MAB_2670c|M.abscessus_ATCC_199 ILRARAVHADQR--RQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYP
MSMEG_2012|M.smegmatis_MC2_155 QARVRDFAQRQRDAILDFEAETEPGVFLGQRNIPVAAAGAYVPGGRYPLV
*.* . ** * : *. : :* :** .* *****.
Mb1625|M.bovis_AF2122/97 SSVVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVD
Rv1599|M.tuberculosis_H37Rv SSVVMNVVPAQAAGVDSLVVASPPQAQWDG----MPHPTILAAARLLGVD
MMAR_2395|M.marinum_M SSVVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVD
MUL_1572|M.ulcerans_Agy99 SSVVMNVVPAQAAGVDSLVVASPPQASHGG----LPHPTILAAARLLGVD
MLBr_01257|M.leprae_Br4923 SSVVMNVVPAQTAGVDSLVVASPPQFTSGGRFHGLPHPTILAAARLLGVD
MAV_3187|M.avium_104 SSVVMNVVPAQAAGVASLVVASPPQAQFDG----LPHPTILAAARLLGVD
Mflv_3613|M.gilvum_PYR-GCK SSVVMNVVPAQTAGVDSLVIASPPQKTNPDRFAGLPHPTILAAAALLGVD
Mvan_2804|M.vanbaalenii_PYR-1 SSVVMNVVPAQTAGVDSLVIASPPQAGNAEPFKGLPHPTILAAAALLGVD
TH_1162|M.thermoresistible__bu SSVVMNVVPAQIAGVESLVIASPPQAAHG----GLPHPTILAAAALLGVE
MAB_2670c|M.abscessus_ATCC_199 SSVVMNVVPAQTAGVGSLVIASPPQAQFGG----LPHPTILAAAQLLGVQ
MSMEG_2012|M.smegmatis_MC2_155 ASAHMTVVTAKVAGVERVTACTPPIHGEIP-------AATVAALHLAGAD
:*. *.**.*: *** :. .:** .: :** * *.:
Mb1625|M.bovis_AF2122/97 EVWAVGGAQAVALLAYGGTDT-------------------DGAALTPVDM
Rv1599|M.tuberculosis_H37Rv EVWAVGGAQAVALLAYGGTDT-------------------DGAALTPVDM
MMAR_2395|M.marinum_M EVWAVGGAQAVALLAYGGTDV-------------------DGHELAPVDM
MUL_1572|M.ulcerans_Agy99 EVWAVGGAQVVALLAYGGTDV-------------------DGHELAPVDM
MLBr_01257|M.leprae_Br4923 EVWAVGGAQAVALLAYGGTDS-------------------DDCELAPVDM
MAV_3187|M.avium_104 EVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRARSASSPGADAELVPVDM
Mflv_3613|M.gilvum_PYR-GCK EVWAVGGAQAVALLAYGGTDTDGE------------------TELAPVDM
Mvan_2804|M.vanbaalenii_PYR-1 EVWAVGGAQAVALLAYGGVDTDG-------------------AELAPVDM
TH_1162|M.thermoresistible__bu EVWAVGGAQAVALLAHGGTDADG-------------------AELLPVDM
MAB_2670c|M.abscessus_ATCC_199 EVWAVGGAQGVALLAHGGTDTDG-------------------AELAPVDM
MSMEG_2012|M.smegmatis_MC2_155 EINILGGTQAVAAMALG------------------------TETIGKVDL
*: :**:* ** :* * : **:
Mb1625|M.bovis_AF2122/97 ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLIS
Rv1599|M.tuberculosis_H37Rv ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLIS
MMAR_2395|M.marinum_M ITGPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLIS
MUL_1572|M.ulcerans_Agy99 ITGPGNIYVTAAKRLCRSQVGIDAEAGPTEIAILADHTADPAHVAADLIS
MLBr_01257|M.leprae_Br4923 ITGPGNIYVTAAKRLCRSRVGIDGEAGPTEIAILADHTADPAHVAADMIS
MAV_3187|M.avium_104 ITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLIS
Mflv_3613|M.gilvum_PYR-GCK ITGPGNIYVTAAKRICRSQVGIDAEAGPTEIAILADHTADPVHVAADLIS
Mvan_2804|M.vanbaalenii_PYR-1 ITGPGNIYVTAAKRICRSAVGIDAEAGPTEIAILADHTADPAHVVADLIS
TH_1162|M.thermoresistible__bu ITGPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADHSANPAHLAADLIS
MAB_2670c|M.abscessus_ATCC_199 ITGPGNIYVTAAKRLCRSLVGIDAEAGPTEIAILADETADPVHVAADLIS
MSMEG_2012|M.smegmatis_MC2_155 LAGPGNAYVAEAKRQLFGQVGIDLFAGPTEVLVIADEFADPFVVAVDLLS
::**** **: *** . **** *****: ::**. *:* :..*::*
Mb1625|M.bovis_AF2122/97 QAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSA
Rv1599|M.tuberculosis_H37Rv QAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSA
MMAR_2395|M.marinum_M QAEHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSA
MUL_1572|M.ulcerans_Agy99 QAEHDEMAASVLVTPSEHLADATDAELAAQLATTVHHERVTTALGGRQSA
MLBr_01257|M.leprae_Br4923 QAEHDEMAASVLVTPSTDLADATDAELAAQLRTTVHRKRVVAALGGRQSA
MAV_3187|M.avium_104 QAEHDEMAGSVLVTPSEELAAATDAELAAQLPTTVHRERVTAALGGRQSA
Mflv_3613|M.gilvum_PYR-GCK QAEHDEMAASVLVTDSTELADATDRELALQLETTVHRERVTAALRGRQSA
Mvan_2804|M.vanbaalenii_PYR-1 QAEHDEMAASVLVTDSAELADATDRELAVQLETTVHRERVTAALGGQQSA
TH_1162|M.thermoresistible__bu QAEHDEMAASVLVTADVGLADATDAAVAEQLATTVHRQRVETALRGPQSA
MAB_2670c|M.abscessus_ATCC_199 QAEHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQSG
MSMEG_2012|M.smegmatis_MC2_155 QAEHGPDSPAVLITTSRALAERVGELIERLLPGMPTRDFAEPAWR-DHGE
****. : :**:* . ** . * . . .* :.
Mb1625|M.bovis_AF2122/97 IVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPV
Rv1599|M.tuberculosis_H37Rv IVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPV
MMAR_2395|M.marinum_M IILVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPV
MUL_1572|M.ulcerans_Agy99 IILVDDLDAGVKVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWAPV
MLBr_01257|M.leprae_Br4923 IILVDDLEAGVKVVNLYAAEHLEIQTAEASRVASRIRCAGAIFVGPWAPV
MAV_3187|M.avium_104 IILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPV
Mflv_3613|M.gilvum_PYR-GCK IVLVDDVDAGVRTVNAYAAEHLEIQTADAAQVANRIRSAGAIFVGPYSPV
Mvan_2804|M.vanbaalenii_PYR-1 IVLVDDIEAGIRTVNAYAAEHLEIQTVDAAAVAGRIRSAGAIFVGPWSPV
TH_1162|M.thermoresistible__bu IVLVDDLDAGIRTVNAYAAEHLEIQTADAAAVAARIRSAGAVFVGPYSPV
MAB_2670c|M.abscessus_ATCC_199 IVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPV
MSMEG_2012|M.smegmatis_MC2_155 IVVVDDVEEAFALGDRYAFEHVQVLTADPRQALTGMTNYGALFLGEGTCV
*::***:: .. : ** **::: *.:. . : **:*:* : *
Mb1625|M.bovis_AF2122/97 SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEY----TEAALKD
Rv1599|M.tuberculosis_H37Rv SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEY----TEAALKD
MMAR_2395|M.marinum_M SLGDYCAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDY----TEAALKD
MUL_1572|M.ulcerans_Agy99 SLGDYCAGSNHVLPTAGFARHSSGLSVQTFLRGIHVVDY----TEVALKD
MLBr_01257|M.leprae_Br4923 SLGDYCAGSNHVLPTAGFARHSGGLSVQTFLRGIHVVNY----TKTALKD
MAV_3187|M.avium_104 SLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDY----TEAALKD
Mflv_3613|M.gilvum_PYR-GCK SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDY----TEAALKD
Mvan_2804|M.vanbaalenii_PYR-1 SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVDY----TEAALKD
TH_1162|M.thermoresistible__bu SLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVEY----TEAALKD
MAB_2670c|M.abscessus_ATCC_199 SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHIVDY----TEAALKE
MSMEG_2012|M.smegmatis_MC2_155 SYGDKVIGTNHTLPTRGAARYTGGLWVGKYLKTVTYQEVRSAEASAALGR
* ** *:**.*** * **::.** * .:*: : : :..**
Mb1625|M.bovis_AF2122/97 VSGHVITLATAEDLPAHGEAVRRRFER--------------
Rv1599|M.tuberculosis_H37Rv VSGHVITLATAEDLPAHGEAVRRRFER--------------
MMAR_2395|M.marinum_M VSGHVLTLAKAEDLPAHGEAVRRRFER--------------
MUL_1572|M.ulcerans_Agy99 VSGHVLTLAKAEDLPAHGEAVRRRFER--------------
MLBr_01257|M.leprae_Br4923 ISGHVITLAKAEDLPAHGEAVRRRFAR--------------
MAV_3187|M.avium_104 VSGHVITLAQAEDLPAHGEAIRRRFER--------------
Mflv_3613|M.gilvum_PYR-GCK VSGYVITLANAENLPSHGEAVRRRFES--------------
Mvan_2804|M.vanbaalenii_PYR-1 VSGYVITLAKAENLPSHGEAVRRRFER--------------
TH_1162|M.thermoresistible__bu VSGHAITLAQAEDLPAHGEAIRRRFEQS-------------
MAB_2670c|M.abscessus_ATCC_199 VAGHVITLANAENLPAHGEAVRRRFERS-------------
MSMEG_2012|M.smegmatis_MC2_155 LCGRAARVESFEGHARSGDIRAMKFGDDTFSWVPADAAVRR
:.* . : *. . *: :*