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AVPASDGSTASEWVTTGSVTVRVPGKVNLYLSVGDLRDDGYHDLTTVFHAVSLLDEVTVRNADVLSLRMI GEGAESLPADERNLAWRAAELMAEHVGRAPDVEITIEKSIPVAGGMAGGSADAAGVLVAMNTLWELGVPR RDLHALAAQLGSDVPFALHGGTALGSGRGEDLATVLARNTFHWVLAFAHRGLSTPKVFGELDRLRADTTR GLPRTDEPEPVLAALASGDPAELAALLGNDLQPAALSLYPDLRRTLRAGVEAGALAGIVSGSGPTCAFLC ASAPAALDVGTQLSGAGVCRTVRVASGPVHGAHVVPAPSAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5436 | ispE | - | 100% (322) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. smegmatis MC2 155 | MSMEG_4955 | thrB | 4e-05 | 32.56% (86) | homoserine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1038 | ispE | 1e-134 | 79.08% (306) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. gilvum PYR-GCK | Mflv_1934 | - | 1e-150 | 83.18% (321) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. tuberculosis H37Rv | Rv1011 | ispE | 1e-134 | 79.08% (306) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. leprae Br4923 | MLBr_00242 | - | 1e-127 | 75.58% (303) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. abscessus ATCC 19977 | MAB_1139 | - | 1e-128 | 73.63% (311) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. marinum M | MMAR_4477 | ispE | 1e-134 | 79.02% (305) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE |
| M. avium 104 | MAV_1149 | ispE | 1e-138 | 79.05% (315) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4649 | ispE | 1e-135 | 79.34% (305) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. vanbaalenii PYR-1 | Mvan_4799 | - | 1e-151 | 84.01% (319) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1934|M.gilvum_PYR-GCK --MSARDGNTASEWVPTGSVTVRVPGKVNLYLDVGDRRQDGYHELTTVFH
Mvan_4799|M.vanbaalenii_PYR-1 --MSARDGNTASEWVPTGSVTVRVPGKVNLYLDVGDRRDDGYHELTTVFH
MSMEG_5436|M.smegmatis_MC2_155 MAVPASDGSTASEWVTTGSVTVRVPGKVNLYLSVGDLRDDGYHDLTTVFH
MMAR_4477|M.marinum_M --------------MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFH
MUL_4649|M.ulcerans_Agy99 --------------MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFH
MLBr_00242|M.leprae_Br4923 --------------MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFH
Mb1038|M.bovis_AF2122/97 --------------MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFH
Rv1011|M.tuberculosis_H37Rv --------------MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFH
MAV_1149|M.avium_104 ----MSDGNTAAAWVPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQ
MAB_1139|M.abscessus_ATCC_1997 ------MSETVSDWVPTGAVTVRAPGKVNLYLAVGDLRDDGYHELTTVFH
:.**:.**:.***:**** *** ::***:*.*:*:
Mflv_1934|M.gilvum_PYR-GCK AVSLLDEVTVRTADTLSLEHVGEGADSLPTDERNLAWRAAELMAEHVGRA
Mvan_4799|M.vanbaalenii_PYR-1 AVSLLDEVTVRTADILSLEMTGEGAESLPTDERNLAWRAAELMADHVGRS
MSMEG_5436|M.smegmatis_MC2_155 AVSLLDEVTVRNADVLSLRMIGEGAESLPADERNLAWRAAELMAEHVGRA
MMAR_4477|M.marinum_M AVSLVDEVTVRNADLLSLEVVGEGADRLPTDKRNLAWQAAELMAEHVGRA
MUL_4649|M.ulcerans_Agy99 AVSLVDEVTVRNADLLSLEVVGEGADKLPTDKRNLAWQAAELMAEHVGRA
MLBr_00242|M.leprae_Br4923 AVSLVDQVTVRNADVLSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGRA
Mb1038|M.bovis_AF2122/97 AVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRA
Rv1011|M.tuberculosis_H37Rv AVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRA
MAV_1149|M.avium_104 AVSLLDEVTVRNADVLSLDIVGEGADKLPTDERNLAWQAAELMAEHVGRA
MAB_1139|M.abscessus_ATCC_1997 AVSLADDVTVRDADVLSIDVVGQGEGTVPTDERNLAWQAAELFADHVGRA
**** *:**** ** **: *:* :*:*::*:**:****:*:****:
Mflv_1934|M.gilvum_PYR-GCK PDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSLWELGVPRRDLHALAAQ
Mvan_4799|M.vanbaalenii_PYR-1 PDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSLWELGVPRRDLHALAAQ
MSMEG_5436|M.smegmatis_MC2_155 PDVEITIEKSIPVAGGMAGGSADAAGVLVAMNTLWELGVPRRDLHALAAQ
MMAR_4477|M.marinum_M PDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNLPRRDLRMLAAR
MUL_4649|M.ulcerans_Agy99 PDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNLPRRDLRMLAAQ
MLBr_00242|M.leprae_Br4923 PDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELSLPRRDLCMLAAK
Mb1038|M.bovis_AF2122/97 PDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAAR
Rv1011|M.tuberculosis_H37Rv PDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAAR
MAV_1149|M.avium_104 PDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAAQ
MAB_1139|M.abscessus_ATCC_1997 PDVSIFINKDIPVAGGMAGGSADAAAVLVAMNELWHAGVPRRDLHHLAAQ
*** * *:* ***************.****** **. .:***** ***:
Mflv_1934|M.gilvum_PYR-GCK LGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLSTAKVFA
Mvan_4799|M.vanbaalenii_PYR-1 LGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLSTAKVFA
MSMEG_5436|M.smegmatis_MC2_155 LGSDVPFALHGGTALGSGRGEDLATVLARNTFHWVLAFAHRGLSTPKVFG
MMAR_4477|M.marinum_M LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFT
MUL_4649|M.ulcerans_Agy99 LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFARSGLSTPAVFT
MLBr_00242|M.leprae_Br4923 LGSDVPFALHGGTALGTGRGEELATVLSRATFHWVLAFADSSLLTPAVYT
Mb1038|M.bovis_AF2122/97 LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYN
Rv1011|M.tuberculosis_H37Rv LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYN
MAV_1149|M.avium_104 LGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADGELLTRKVFA
MAB_1139|M.abscessus_ATCC_1997 LGSDVPFALHGGTALGTGRGEQLATVLARNVFHWVFAFADGGLATPQVFK
****************:****:*****:* .****:**: * * *:
Mflv_1934|M.gilvum_PYR-GCK EIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSL
Mvan_4799|M.vanbaalenii_PYR-1 EIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSL
MSMEG_5436|M.smegmatis_MC2_155 ELDRLRADTTRGLP-RTDEPEPVLAALASGDPAELAALLGNDLQPAALSL
MMAR_4477|M.marinum_M ELDRLRDVGS---PPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSL
MUL_4649|M.ulcerans_Agy99 ELDRLRDVGS---PPRLAEPGPVLAALAAGDPEQLAPLLGNEMQAAAVSL
MLBr_00242|M.leprae_Br4923 EFDRLRDVGN---PPRLAEPGPVLAALVAADPEQLAPLLGNELQAAAVSL
Mb1038|M.bovis_AF2122/97 ELDRLREVGD---PPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSL
Rv1011|M.tuberculosis_H37Rv ELDRLREVGD---PPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSL
MAV_1149|M.avium_104 ELDRLRRAGD---PPRLPGPGPVLAALAAGDADQLAPLLGNEMQAAAVSL
MAB_1139|M.abscessus_ATCC_1997 EIDRLRENGD---PPRLAEADELLGALAAGDARRLAPLLGNELQAAAVSL
*:**** * * . :*.**.:.*. .**.****::*.**:**
Mflv_1934|M.gilvum_PYR-GCK DPALRRTLRAGLDAGALAGLVSGSGPTCAFLCTSAGAAVDIGTDLAGAGV
Mvan_4799|M.vanbaalenii_PYR-1 DSTLRRTLRAGVDAGALAGVVSGSGPTCAFLCGSAGAAVDVGTELAGAGV
MSMEG_5436|M.smegmatis_MC2_155 YPDLRRTLRAGVEAGALAGIVSGSGPTCAFLCASAPAALDVGTQLSGAGV
MMAR_4477|M.marinum_M DPALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGV
MUL_4649|M.ulcerans_Agy99 DPALRRALRAGVEAGALAGIVSGSGPTCAFLCRTAESALDVSAQLSGAGV
MLBr_00242|M.leprae_Br4923 DPALRCALRAGMEAGALAGIVSGSGPTCAFLCASATSAIDVGAQLAGAGV
Mb1038|M.bovis_AF2122/97 DPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGV
Rv1011|M.tuberculosis_H37Rv DPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGV
MAV_1149|M.avium_104 NPGLRRTLRAGVQAGALAGIVSGSGPTCAFLCPSAAAAVDVGTEVSGVGV
MAB_1139|M.abscessus_ATCC_1997 NPELRRTLRAGESAGALAGIVSGSGPTCAFLCTSADDAVQVSAELAGAGV
. * :**** .******:************ :* *:::.::::*.**
Mflv_1934|M.gilvum_PYR-GCK CRTVRVASGPVQGARVVPAPSTAG----
Mvan_4799|M.vanbaalenii_PYR-1 CRTVRVASGPVQGARVVPSPSNAG----
MSMEG_5436|M.smegmatis_MC2_155 CRTVRVASGPVHGAHVVPAPSAS-----
MMAR_4477|M.marinum_M CRTVRIATGPVPGARVVPTPGIAE----
MUL_4649|M.ulcerans_Agy99 CRTVRIATGPVPGARVVPTPGTPE----
MLBr_00242|M.leprae_Br4923 CRTVRVATGPVPGARVVHAPMSRGLNDM
Mb1038|M.bovis_AF2122/97 CRTVRVATGPVPGARVVSAPTEV-----
Rv1011|M.tuberculosis_H37Rv CRTVRVATGPVPGARVVSAPTEV-----
MAV_1149|M.avium_104 CRTVRVASGPVAGARVVPAPTEV-----
MAB_1139|M.abscessus_ATCC_1997 CRTVRVASGPVHGAQVIQGRSDG-----
*****:*:*** **:*: