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TQTLPVGLSATSVVAASSANLGPGFDSLGIALSLYDEIVVETVESGLTVHVEGEGAGQVPLDQTHLVVRA INKGLQAAGFSAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAVNGLVTQAGSEPMDDARLIQLSSEFEGH PDNAAAAVLGGAVVSWTEQAGAFGGEPRYSAVPVRLHPDIRLFPAVPQQRSSTAETRVLLPEQVSHVDAR FNLSRAALLVVALSERPDLLMAATEDVLHQPQRAAAMPASAEYLAILRRCGIAAVLSGAGPSVLGLSAQS GLPAEALEYGTAHGFTVTEMSVGAGVRWTAGAVVRN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4955 | thrB | - | 100% (317) | homoserine kinase |
| M. smegmatis MC2 155 | MSMEG_5436 | ispE | 4e-05 | 32.56% (86) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1328 | thrB | 1e-126 | 75.24% (311) | homoserine kinase |
| M. gilvum PYR-GCK | Mflv_2300 | - | 1e-128 | 72.56% (317) | homoserine kinase |
| M. tuberculosis H37Rv | Rv1296 | thrB | 1e-126 | 75.24% (311) | homoserine kinase |
| M. leprae Br4923 | MLBr_01131 | thrB | 1e-120 | 71.52% (309) | homoserine kinase |
| M. abscessus ATCC 19977 | MAB_1437 | - | 1e-108 | 65.15% (307) | homoserine kinase |
| M. marinum M | MMAR_4101 | thrB | 1e-125 | 74.04% (312) | homoserine kinase ThrB |
| M. avium 104 | MAV_1511 | thrB | 1e-124 | 72.35% (311) | homoserine kinase |
| M. thermoresistible (build 8) | TH_2002 | thrB | 1e-134 | 76.43% (314) | PROBABLE HOMOSERINE KINASE THRB |
| M. ulcerans Agy99 | MUL_3968 | thrB | 1e-125 | 73.72% (312) | homoserine kinase |
| M. vanbaalenii PYR-1 | Mvan_4346 | - | 1e-135 | 77.53% (316) | homoserine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2300|M.gilvum_PYR-GCK ------------MVTRTLPPGVSATAEVAASSANLGPGFDSLGLAVGLYD
Mvan_4346|M.vanbaalenii_PYR-1 -------------MTRTLPPGLTATAVVAASSANLGPGFDSMGLAIGLYD
Mb1328|M.bovis_AF2122/97 -----------MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYD
Rv1296|M.tuberculosis_H37Rv -----------MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYD
MLBr_01131|M.leprae_Br4923 ------------MVTWMLPAGLVASAVVAASSANLGPGFDSIGLALSLCD
MAV_1511|M.avium_104 ----------------MLPAGLVASAVVSASSANLGPGFDSIGLALSLID
MMAR_4101|M.marinum_M -------------MTQVLPSGLVASAVVAASSANLGPGFDSLGLALSLYD
MUL_3968|M.ulcerans_Agy99 -------------MTQVLPSGLVASAVVAASSANLGPGFDSLGLALSLYD
TH_2002|M.thermoresistible__bu VVLDAREDQGRRSMAATLPPGLTATSVVAASSANLGPGFDSFGLALNAYD
MSMEG_4955|M.smegmatis_MC2_155 -------------MTQTLPVGLSATSVVAASSANLGPGFDSLGIALSLYD
MAB_1437|M.abscessus_ATCC_1997 -------------MSEVLPAGLATTVLVPASSANLGPGFDSLGIALSLYD
** *: :: *.************.*:*:. *
Mflv_2300|M.gilvum_PYR-GCK EISVETTESGLVVEVEGEGAGQVPLDESHLVVRAIQRGLRENGIDAPGLI
Mvan_4346|M.vanbaalenii_PYR-1 EIVVETTESGLVVEVEGEGSGQVPLDGSHLVVRAIERGLRETGVSAPGLI
Mb1328|M.bovis_AF2122/97 EIIVETTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLA
Rv1296|M.tuberculosis_H37Rv EIIVETTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLA
MLBr_01131|M.leprae_Br4923 EIVVETTDSGLVVVVDGEGADQVPMGPEHLVVRAVRRGLQAVGVSAAGLV
MAV_1511|M.avium_104 EITVETTDSGLVVQVEGEGADQVPLGPEHLVVRAVECGLRAVGVRAAGLV
MMAR_4101|M.marinum_M EIVLETTDSGLEVVVEGEGSGQVPLNSEHLVVRAIQHGLRAVGVSAAGLI
MUL_3968|M.ulcerans_Agy99 EIVLETTDSGLEVVVEGEGAGQVPLNSEHLVVRAIQHGLRAVGVPATGLI
TH_2002|M.thermoresistible__bu EIIVETTQSGLTVEVEGEGADQVPLDASHLVVRAIHTGLQAAGFNVPGLR
MSMEG_4955|M.smegmatis_MC2_155 EIVVETVESGLTVHVEGEGAGQVPLDQTHLVVRAINKGLQAAGFSAPGLV
MAB_1437|M.abscessus_ATCC_1997 EIEVNTTESGLKVAVEGQGAGEVPLDGSHLVVRAIERGLAAGGAAAPGLI
** ::*.:*** * *:*:*..:**:. ******:. ** * ..**
Mflv_2300|M.gilvum_PYR-GCK VRCRNRIPHSRGLGSSAAAVVGGLAAASGLAMQADSTPMSAERLVQVSSE
Mvan_4346|M.vanbaalenii_PYR-1 VRCRNDIPHSRGLGSSAAAVVGGLAAANGLAAQTDSTLMSPERLVQVSSE
Mb1328|M.bovis_AF2122/97 VRCRNAIPHSRGLGSSAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASE
Rv1296|M.tuberculosis_H37Rv VRCRNAIPHSRGLGSSAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASE
MLBr_01131|M.leprae_Br4923 VRCRNAIPHSRGLGSSAAAVVGGLAVVNGFVAQIDSTPLSNAQLIQLASE
MAV_1511|M.avium_104 VRCRNAIPHSRGLGSSAAAVVGGLAAANGLVAQANCQPLSDAALIQLSSE
MMAR_4101|M.marinum_M VRCRNDIPHSRGLGSSASAVVGGLAAVNGLVSQAGWAPLSDQQLIQLSSE
MUL_3968|M.ulcerans_Agy99 VRCRNDIPHSRGLGSSASAVVGGLAAVNGLVSQAGWVPLSDQQLIQLSSE
TH_2002|M.thermoresistible__bu VHCRNEIPHSRGLGSSAAAVVGGLAAVNGLVAQVGSTPLTEAQLVQLASE
MSMEG_4955|M.smegmatis_MC2_155 VRCRNDIPHSRGLGSSAAAVVGGLAAVNGLVTQAGSEPMDDARLIQLSSE
MAB_1437|M.abscessus_ATCC_1997 VQCHNKIPHSRGLGSSAAAAVAGLGVANGLLAKAGRAVLSDDVLVQLASE
*:*:* ***********:*.*.**....*: : . *:*::**
Mflv_2300|M.gilvum_PYR-GCK FEGHPDNAAAAVLGGAVVSWTEDR---GDGPRYAAVQIRLHPAITVFAAI
Mvan_4346|M.vanbaalenii_PYR-1 FEGHPDNAAAAVLGGAVVAWTAAG---AGDPRYAAAPIRLHPDIAIFAAV
Mb1328|M.bovis_AF2122/97 FEGHPDNAAAAVLGGAVVSWTDHS---GDRPNYSAVSLRLHPDIRLFTAI
Rv1296|M.tuberculosis_H37Rv FEGHPDNAAAAVLGGAVVSWTDHS---GDRPNYSAVSLRLHPDIRLFTAI
MLBr_01131|M.leprae_Br4923 FEGHPDNAAAAVLGGAVVSWVDRS---YDQPDYCAVPLRLHPDIHLFAAI
MAV_1511|M.avium_104 FEGHPDNAAAAVFGGAIVSWIDRG---GQHPRYAAAPLRLHPDIHLYCAI
MMAR_4101|M.marinum_M FEGHPDNAAAAVLGGAVVSWIERC---GDRADYSAVQLDLHPDIHLFSAI
MUL_3968|M.ulcerans_Agy99 FEGHPDNAAAAVLGGAVVSWIERC---GDRADYSAVQLDLHPDIHLFSAI
TH_2002|M.thermoresistible__bu FEGHPDNAAAAVLGGMVVSWTDWS---GPSPRYAAVTLPLHRDIHLFSAI
MSMEG_4955|M.smegmatis_MC2_155 FEGHPDNAAAAVLGGAVVSWTEQAGAFGGEPRYSAVPVRLHPDIRLFPAV
MAB_1437|M.abscessus_ATCC_1997 FEGHPDNAAASVLGGAVVSWSETS---GATPIYAATRLDVHPDIKIVAAI
**********:*:** :*:* . *.*. : :* * : *:
Mflv_2300|M.gilvum_PYR-GCK PQVRSSTAETRVLLPEHVSHADASFNVSRAALLIVALTERPDLLLAATED
Mvan_4346|M.vanbaalenii_PYR-1 PQVRSSTAETRVLLPEHVRHTDARFNLSRAALLVVALTERPDLLMEATED
Mb1328|M.bovis_AF2122/97 PEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVALTERPDLLMAATED
Rv1296|M.tuberculosis_H37Rv PEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVALTERPDLLMAATED
MLBr_01131|M.leprae_Br4923 PEERSSTAESRVLLPARVSHDDARFNVSRAALLVVALTERPDLLMAATED
MAV_1511|M.avium_104 PQERSLTAETRVLLPAQVSHEDARFNVSRAALLVVALTERPDLLMAATED
MMAR_4101|M.marinum_M PEVRSSTAETRVLLPDLVSHDDARFNISRAALLVVALTQRPDLLMAATED
MUL_3968|M.ulcerans_Agy99 PEVRSSTAETRVLLPDLVSHDDARFNISRAALLVVALTQRPDLLMAATED
TH_2002|M.thermoresistible__bu PEQRSSTAETRVLLPDRVDHTDARFNVSRAALLVVALTSRPDLLMDATED
MSMEG_4955|M.smegmatis_MC2_155 PQQRSSTAETRVLLPEQVSHVDARFNLSRAALLVVALSERPDLLMAATED
MAB_1437|M.abscessus_ATCC_1997 PEEQSSTAHTRVLLPQAVTHVDARFNISRVALLTVALTARPDLLMTATED
*: :* **.:***** * * ** **:**.*** ***: *****: ****
Mflv_2300|M.gilvum_PYR-GCK ALHQSQRAPAMPASAEYLAVLRRCGVAGVLSGAGPSVLALSTEAELPVEA
Mvan_4346|M.vanbaalenii_PYR-1 VLHQPQRAAAMPASAEYLAMLRRCGVPAVLSGAGPAVLALSTETELPAEA
Mb1328|M.bovis_AF2122/97 LLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSELPTDA
Rv1296|M.tuberculosis_H37Rv LLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSELPTDA
MLBr_01131|M.leprae_Br4923 VLHQPHRASAMSASAEYLRLLRRHNVAATLSGAGPSLIALSTQSELPREA
MAV_1511|M.avium_104 VLHQPQRAPAMPASAEYLRLLRRHNVAATLSGAGPSLIALTTASALPPEV
MMAR_4101|M.marinum_M VLHQPQRASAMPASAEYLQLLRRHKVAATLSGAGPALIALSTDPDLPPEA
MUL_3968|M.ulcerans_Agy99 VLHQPQRASAMPASAEYLQLLRRHKVAATLSGAGPALIALTTNPDLPPEA
TH_2002|M.thermoresistible__bu VLHQPQRAAAMPASAEYLRLLRRCGIAAVLSGAGPTVLALSCQPELPQEA
MSMEG_4955|M.smegmatis_MC2_155 VLHQPQRAAAMPASAEYLAILRRCGIAAVLSGAGPSVLGLSAQSGLPAEA
MAB_1437|M.abscessus_ATCC_1997 RLHQPQRASAMPASADVLAYLRSQGVAAVLSGAGPAVLALTT-VDLPDSA
***.:**.**.***: * ** :...******:::.*: ** ..
Mflv_2300|M.gilvum_PYR-GCK AEFGNRNGFEIVRMSVGHGVTWSSGVAAKS
Mvan_4346|M.vanbaalenii_PYR-1 LRYGADHGFAVKRMSVGHGVSWTSGVAVRT
Mb1328|M.bovis_AF2122/97 VEFGAAKGFAVTELTVGEAVRWSPTVRVPG
Rv1296|M.tuberculosis_H37Rv VEFGAAKGFAVTELTVGEAVRWSPTVRVPG
MLBr_01131|M.leprae_Br4923 AEYGAANGFIIIKMTAGDEVCWRPEVTVPG
MAV_1511|M.avium_104 TEYGAANGFTLAEMTAGQGVRWSPGVTVVG
MMAR_4101|M.marinum_M VEYGAANGFTITAMTAGDRVRWKPGVAFSD
MUL_3968|M.ulcerans_Agy99 VEYGAANGFTITAMTAGDRVRWKPGVAFSD
TH_2002|M.thermoresistible__bu VEYGTANGFTIREMKVGDGVRWSSGVAVRS
MSMEG_4955|M.smegmatis_MC2_155 LEYGTAHGFTVTEMSVGAGVRWTAGAVVRN
MAB_1437|M.abscessus_ATCC_1997 VKYAEDQGFSLVAMAV------SAGVSVR-
.:. :** : : . . .