For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VSARDGNTASEWVPTGSVTVRVPGKVNLYLDVGDRRQDGYHELTTVFHAVSLLDEVTVRTADTLSLEHVG EGADSLPTDERNLAWRAAELMAEHVGRAPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSLWELGVPRR DLHALAAQLGSDVPFALHGGTALGTGRGEELATVLTRNTFHWVLAFSPGGLSTAKVFAEIDRLRAEEDRT LPPRLESPEPVLAALASGDPAQLAPLLGNDLQPAALSLDPALRRTLRAGLDAGALAGLVSGSGPTCAFLC TSAGAAVDIGTDLAGAGVCRTVRVASGPVQGARVVPAPSTAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1934 | - | - | 100% (322) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. gilvum PYR-GCK | Mflv_2300 | - | 1e-06 | 27.17% (265) | homoserine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1038 | ispE | 1e-141 | 81.43% (307) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. tuberculosis H37Rv | Rv1011 | ispE | 1e-141 | 81.43% (307) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. leprae Br4923 | MLBr_00242 | - | 1e-130 | 75.81% (310) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. abscessus ATCC 19977 | MAB_1139 | - | 1e-131 | 75.00% (312) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. marinum M | MMAR_4477 | ispE | 1e-139 | 79.94% (309) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE |
| M. avium 104 | MAV_1149 | ispE | 1e-146 | 82.22% (315) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. smegmatis MC2 155 | MSMEG_5436 | ispE | 1e-150 | 83.18% (321) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. thermoresistible (build 8) | TH_2002 | thrB | 2e-05 | 25.96% (285) | PROBABLE HOMOSERINE KINASE THRB |
| M. ulcerans Agy99 | MUL_4649 | ispE | 1e-140 | 80.52% (308) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
| M. vanbaalenii PYR-1 | Mvan_4799 | - | 1e-174 | 95.03% (322) | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1934|M.gilvum_PYR-GCK --MSARDGNTASEWVPTGSVTVRVPGKVNLYLDVGDRRQDGYHELTTVFH
Mvan_4799|M.vanbaalenii_PYR-1 --MSARDGNTASEWVPTGSVTVRVPGKVNLYLDVGDRRDDGYHELTTVFH
MSMEG_5436|M.smegmatis_MC2_155 MAVPASDGSTASEWVTTGSVTVRVPGKVNLYLSVGDLRDDGYHDLTTVFH
MMAR_4477|M.marinum_M --------------MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFH
MUL_4649|M.ulcerans_Agy99 --------------MPTGSATVRVPGKVNLYLAVGDRRDDGYHELTTVFH
MLBr_00242|M.leprae_Br4923 --------------MPTGSVTVQVPGKINLYLAVGDCCDNGYHELVTVFH
Mb1038|M.bovis_AF2122/97 --------------MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFH
Rv1011|M.tuberculosis_H37Rv --------------MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFH
MAV_1149|M.avium_104 ----MSDGNTAAAWVPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTIFQ
MAB_1139|M.abscessus_ATCC_1997 ------MSETVSDWVPTGAVTVRAPGKVNLYLAVGDLRDDGYHELTTVFH
TH_2002|M.thermoresistible__bu ------VVLDAREDQGRRSMAATLPPGLTATSVVAASSANLGPGFDSFGL
: :. * :. *. : : :.
Mflv_1934|M.gilvum_PYR-GCK AVSLLDEVTVRTADT-LSLEHVGEGADSLPTDERNLAWRAAELMAEHVGR
Mvan_4799|M.vanbaalenii_PYR-1 AVSLLDEVTVRTADI-LSLEMTGEGAESLPTDERNLAWRAAELMADHVGR
MSMEG_5436|M.smegmatis_MC2_155 AVSLLDEVTVRNADV-LSLRMIGEGAESLPADERNLAWRAAELMAEHVGR
MMAR_4477|M.marinum_M AVSLVDEVTVRNADL-LSLEVVGEGADRLPTDKRNLAWQAAELMAEHVGR
MUL_4649|M.ulcerans_Agy99 AVSLVDEVTVRNADL-LSLEVVGEGADKLPTDKRNLAWQAAELMAEHVGR
MLBr_00242|M.leprae_Br4923 AVSLVDQVTVRNADV-LSLGLVGEGANHVPTDEHNIAWRAAELMAEHVGR
Mb1038|M.bovis_AF2122/97 AVSLVDEVTVRNADV-LSLELVGEGADQLPTDERNLAWQAAELMAEHVGR
Rv1011|M.tuberculosis_H37Rv AVSLVDEVTVRNADV-LSLELVGEGADQLPTDERNLAWQAAELMAEHVGR
MAV_1149|M.avium_104 AVSLLDEVTVRNADV-LSLDIVGEGADKLPTDERNLAWQAAELMAEHVGR
MAB_1139|M.abscessus_ATCC_1997 AVSLADDVTVRDADV-LSIDVVGQGEGTVPTDERNLAWQAAELFADHVGR
TH_2002|M.thermoresistible__bu ALNAYDEIIVETTQSGLTVEVEGEGADQVPLDASHLVVRAIHTGLQAAGF
*:. *:: *. :: *:: *:* :* * ::. :* . : .*
Mflv_1934|M.gilvum_PYR-GCK -APDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSLWELG----VPRRDL
Mvan_4799|M.vanbaalenii_PYR-1 -SPDVAISIEKTIPVAGGMAGGSADAAAVLVAMNSLWELG----VPRRDL
MSMEG_5436|M.smegmatis_MC2_155 -APDVEITIEKSIPVAGGMAGGSADAAGVLVAMNTLWELG----VPRRDL
MMAR_4477|M.marinum_M -APDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSLWELN----LPRRDL
MUL_4649|M.ulcerans_Agy99 -APDVSIFIDKSIPVAGGMAGGSADAAAVLVAMNSLWELN----LPRRDL
MLBr_00242|M.leprae_Br4923 -APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELS----LPRRDL
Mb1038|M.bovis_AF2122/97 -APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELN----VPRRDL
Rv1011|M.tuberculosis_H37Rv -APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELN----VPRRDL
MAV_1149|M.avium_104 -APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELN----VPRRDL
MAB_1139|M.abscessus_ATCC_1997 -APDVSIFINKDIPVAGGMAGGSADAAAVLVAMNELWHAG----VPRRDL
TH_2002|M.thermoresistible__bu NVPGLRVHCRNEIPHSRGLGSSAAAVVGGLAAVNGLVAQVGSTPLTEAQL
*.: : : ** : *:...:* ... *.*:* * :.. :*
Mflv_1934|M.gilvum_PYR-GCK HALAAQLG---SDVPFALHGGTALG-------TGRGEELATVLTRNTFHW
Mvan_4799|M.vanbaalenii_PYR-1 HALAAQLG---SDVPFALHGGTALG-------TGRGEELATVLTRNTFHW
MSMEG_5436|M.smegmatis_MC2_155 HALAAQLG---SDVPFALHGGTALG-------SGRGEDLATVLARNTFHW
MMAR_4477|M.marinum_M RMLAARLG---SDVPFALHGGTALG-------TGRGEELATVLSRNTFHW
MUL_4649|M.ulcerans_Agy99 RMLAAQLG---SDVPFALHGGTALG-------TGRGEELATVLSRNTFHW
MLBr_00242|M.leprae_Br4923 CMLAAKLG---SDVPFALHGGTALG-------TGRGEELATVLSRATFHW
Mb1038|M.bovis_AF2122/97 RMLAARLG---SDVPFALHGGTALG-------TGRGEELATVLSRNTFHW
Rv1011|M.tuberculosis_H37Rv RMLAARLG---SDVPFALHGGTALG-------TGRGEELATVLSRNTFHW
MAV_1149|M.avium_104 RMLAAQLG---SDVPFALHGGTALG-------TGRGEELATVLSRNTFHW
MAB_1139|M.abscessus_ATCC_1997 HHLAAQLG---SDVPFALHGGTALG-------TGRGEQLATVLARNVFHW
TH_2002|M.thermoresistible__bu VQLASEFEGHPDNAAAAVLGGMVVSWTDWSGPSPRYAAVTLPLHRDIHLF
**:.: .:.. *: ** .:. : * :: * * . :
Mflv_1934|M.gilvum_PYR-GCK VLAFSPGGLSTAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQ
Mvan_4799|M.vanbaalenii_PYR-1 VLAFSPGGLSTAKVFAEIDRLRAEEDRTLPPRLESPEPVLAALASGDPAQ
MSMEG_5436|M.smegmatis_MC2_155 VLAFAHRGLSTPKVFGELDRLRADTTRGLP-RTDEPEPVLAALASGDPAE
MMAR_4477|M.marinum_M VLAFARSGLSTPAVFTELDRLRDVGS---PPRLAEPGPVLAALAAGDPEQ
MUL_4649|M.ulcerans_Agy99 VLAFARSGLSTPAVFTELDRLRDVGS---PPRLAEPGPVLAALAAGDPEQ
MLBr_00242|M.leprae_Br4923 VLAFADSSLLTPAVYTEFDRLRDVGN---PPRLAEPGPVLAALVAADPEQ
Mb1038|M.bovis_AF2122/97 VLAFADSGLLTSAVYNELDRLREVGD---PPRLGEPGPVLAALAAGDPDQ
Rv1011|M.tuberculosis_H37Rv VLAFADSGLLTSAVYNELDRLREVGD---PPRLGEPGPVLAALAAGDPDQ
MAV_1149|M.avium_104 VLAFADGELLTRKVFAELDRLRRAGD---PPRLPGPGPVLAALAAGDADQ
MAB_1139|M.abscessus_ATCC_1997 VFAFADGGLATPQVFKEIDRLRENGD---PPRLAEADELLGALAAGDARR
TH_2002|M.thermoresistible__bu SAIPEQRSSTAETRVLLPDRVDHTDARFNVSRAALLVVALTSRPDLLMDA
: **: * * :
Mflv_1934|M.gilvum_PYR-GCK LAPLLGNDLQPAALSLDPALRRTLRAGLDAGALAGLVSGSGP-TCAFLCT
Mvan_4799|M.vanbaalenii_PYR-1 LAPLLGNDLQPAALSLDSTLRRTLRAGVDAGALAGVVSGSGP-TCAFLCG
MSMEG_5436|M.smegmatis_MC2_155 LAALLGNDLQPAALSLYPDLRRTLRAGVEAGALAGIVSGSGP-TCAFLCA
MMAR_4477|M.marinum_M LAPLLGNEMQAAAVSLDPALRRALRAGVEAGALAGIVSGSGP-TCAFLCR
MUL_4649|M.ulcerans_Agy99 LAPLLGNEMQAAAVSLDPALRRALRAGVEAGALAGIVSGSGP-TCAFLCR
MLBr_00242|M.leprae_Br4923 LAPLLGNELQAAAVSLDPALRCALRAGMEAGALAGIVSGSGP-TCAFLCA
Mb1038|M.bovis_AF2122/97 LAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGP-TCAFLCT
Rv1011|M.tuberculosis_H37Rv LAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGP-TCAFLCT
MAV_1149|M.avium_104 LAPLLGNEMQAAAVSLNPGLRRTLRAGVQAGALAGIVSGSGP-TCAFLCP
MAB_1139|M.abscessus_ATCC_1997 LAPLLGNELQAAAVSLNPELRRTLRAGESAGALAGIVSGSGP-TCAFLCT
TH_2002|M.thermoresistible__bu TEDVLHQPQRAAAMPASAEYLRLLRR----CGIAAVLSGAGPTVLALSCQ
:* : :.**:. . ** .:*.::**:** . *: *
Mflv_1934|M.gilvum_PYR-GCK SAGAAVDIGTDLAGAGVCRTVRVASGPVQGARVVPAPSTAG----
Mvan_4799|M.vanbaalenii_PYR-1 SAGAAVDVGTELAGAGVCRTVRVASGPVQGARVVPSPSNAG----
MSMEG_5436|M.smegmatis_MC2_155 SAPAALDVGTQLSGAGVCRTVRVASGPVHGAHVVPAPSAS-----
MMAR_4477|M.marinum_M TAESALDVSAQLSGAGVCRTVRIATGPVPGARVVPTPGIAE----
MUL_4649|M.ulcerans_Agy99 TAESALDVSAQLSGAGVCRTVRIATGPVPGARVVPTPGTPE----
MLBr_00242|M.leprae_Br4923 SATSAIDVGAQLAGAGVCRTVRVATGPVPGARVVHAPMSRGLNDM
Mb1038|M.bovis_AF2122/97 SASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV-----
Rv1011|M.tuberculosis_H37Rv SASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV-----
MAV_1149|M.avium_104 SAAAAVDVGTEVSGVGVCRTVRVASGPVAGARVVPAPTEV-----
MAB_1139|M.abscessus_ATCC_1997 SADDAVQVSAELAGAGVCRTVRVASGPVHGAQVIQGRSDG-----
TH_2002|M.thermoresistible__bu PELPQEAVEYGTANGFTIREMKVGDGVRWSSGVAVRS--------
. : :. . * :::. * .: *