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PPLPPAPGLDAPLPPLPPEPAMASPRPWWVALPPSPPAPAYDANPPLPPAPAVAFAVEATLVMIASPPAP PLPGFELPFPPFPPAPPVTVPRPADWAEPPLPPRPTLSWPKLELPPAPPVAAAAATAGAAGGGGRRRGVG DGGVAPVSAVAAVAVASAAVGDATDAAGDAAQPGGGGVTARAAVPSAAGRVKASAAPGAALAAGHIRCRF GVVDGRVTAVAADATGAAFSGAPISSGATDRRRGRARRAGDGGVAAGTTVTGAGRVGVTVAVTAVAAGAA QC*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5381 | - | - | 100% (283) | hypothetical protein MSMEG_5381 |
M. smegmatis MC2 155 | MSMEG_5700 | - | 7e-15 | 34.60% (211) | secreted protein |
M. smegmatis MC2 155 | MSMEG_5583 | - | 2e-11 | 32.35% (170) | HNH endonuclease |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3906 | - | 7e-11 | 36.15% (130) | hypothetical protein Mb3906 |
M. gilvum PYR-GCK | Mflv_3843 | - | 5e-22 | 37.66% (231) | hypothetical protein Mflv_3843 |
M. tuberculosis H37Rv | Rv3879c | - | 4e-11 | 28.09% (267) | hypothetical protein Rv3879c |
M. leprae Br4923 | MLBr_00048 | - | 2e-07 | 29.33% (208) | hypothetical protein MLBr_00048 |
M. abscessus ATCC 19977 | MAB_3131c | - | 8e-12 | 30.74% (231) | translation initiation factor IF-2 (InfB) |
M. marinum M | MMAR_5451 | - | 6e-15 | 40.28% (144) | hypothetical protein MMAR_5451 |
M. avium 104 | MAV_4827 | - | 5e-13 | 27.52% (298) | hypothetical protein MAV_4827 |
M. thermoresistible (build 8) | TH_4426 | - | 6e-08 | 27.36% (201) | PUTATIVE AAA ATPase |
M. ulcerans Agy99 | MUL_2122 | infB | 6e-11 | 32.59% (224) | translation initiation factor IF-2 |
M. vanbaalenii PYR-1 | Mvan_2552 | - | 4e-22 | 34.56% (217) | hypothetical protein Mvan_2552 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_3843|M.gilvum_PYR-GCK MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTR Mvan_2552|M.vanbaalenii_PYR-1 MSRTKKSIVVVMMGSAGLFLSAPLLGPSANATPTRGGVPCVGILQQVISR MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 ----------MAADYDKLFRPHEGMEAPDDMAAQP------------FFD MLBr_00048|M.leprae_Br4923 ----------MAADYDKLFRLDDGAYASPDQAAEQ------------LFD MMAR_5451|M.marinum_M ----------MPADYDELFQPAEGSGPPDDETGQT------------FFD MAB_3131c|M.abscessus_ATCC_199 -----------MAGKARVHELAKELGVTSKEVLAR------------LSD MUL_2122|M.ulcerans_Agy99 -----------MAGKARVHELAKELGVTSKEVLAR------------LSE MAV_4827|M.avium_104 --------MNIVLGVSMAPSSIQMVVLEGEYADG---------------- Rv3879c|M.tuberculosis_H37Rv ----------MSITRPTGSYARQMLDPGG--------------------- TH_4426|M.thermoresistible__bu ----------VVRPAHPLYCAAVRAELTEPEVRGVR-------------- Mflv_3843|M.gilvum_PYR-GCK PGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGRPPASVV Mvan_2552|M.vanbaalenii_PYR-1 PGDIPQALTETARSFTNPGQPAPPVVRPPASSSSSVGTPPVPPTPPGSVV MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 PSASFPP------------------------------------------A MLBr_00048|M.leprae_Br4923 DAPLYPP------------------------------------------P MMAR_5451|M.marinum_M PGTAYPPPVKPNGDGHSAPKDWSRAFPPAEDESPSDSAEPAAGPAKSPLP MAB_3131c|M.abscessus_ATCC_199 QGEFVKSASSTVEAPVARRLRESFGGG-DKPAPAASNG----AAAEAAAP MUL_2122|M.ulcerans_Agy99 QGEFVKSASSTVEAPVARRLRESFGGGKSAPAKGSDTG----AAKGVAKA MAV_4827|M.avium_104 -----------------------------------------------ATV Rv3879c|M.tuberculosis_H37Rv ------------------------------------------------WV TH_4426|M.thermoresistible__bu -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK TPSSGATPPVPPSPG--------TPASTSTRGGTPPVPPAPPAPAGTPAS Mvan_2552|M.vanbaalenii_PYR-1 RPSSGATPPVPPTPG--------TPASTTTGVGTPPVPPTPPGSTVRPAA MSMEG_5381|M.smegmatis_MC2_155 ------MPPLPPAPG--------LDAP------LPPLPPEPAMASPRPWW Mb3906|M.bovis_AF2122/97 PASANLPKPNGQTP---------PPTSDDLSERFVSAPPPP--------- MLBr_00048|M.leprae_Br4923 IIPTCTTTPNGEVA---------SPMPD-----WSEQLPPN--------- MMAR_5451|M.marinum_M PMPIGGPAPTPPEP---------PPAPPELPPAPPEPPPARPEAPPQAPT MAB_3131c|M.abscessus_ATCC_199 PKKAG---PKPGAP---------KPAPKKVAEPVVEAPVAPEPPAAPAAP MUL_2122|M.ulcerans_Agy99 PQKVSGASPAAKAPDRSLDAALDKAVGNGAPAPVPAPAPAPTPAPAPAQP MAV_4827|M.avium_104 EEDAIDVTGADDAAT--------ASAPDRVISAILGTREGAADAGLQLSS Rv3879c|M.tuberculosis_H37Rv EADEDTFYDRAQEYS---------QVLQRVTDVLDTCRQQKGHVFEGGLW TH_4426|M.thermoresistible__bu TELAGAAAPTDVVGR-------LRWTLHALDSDAPPAAQQLTVAAEDALR Mflv_3843|M.gilvum_PYR-GCK GATP----------PAPPVPGVPAVTSTGGGTPPVPPVP----------- Mvan_2552|M.vanbaalenii_PYR-1 GATP----------PAPPVPGVPAGTPIGGGTPPLPPVP----------- MSMEG_5381|M.smegmatis_MC2_155 VALP----------PSPPAPAYDANPPL----PPAPAVA----------- Mb3906|M.bovis_AF2122/97 --------------PPPPPPPPPTPMPIAAGEPPSPEP------------ MLBr_00048|M.leprae_Br4923 --------------PPAASKSPLPPMPIGSSVQPPP-------------- MMAR_5451|M.marinum_M AEAEPPDEAIPVSGPPPGGKSPLPPMPIGGPPPASPEPP----------- MAB_3131c|M.abscessus_ATCC_199 AAP-----------APKPSPAARPAAAEAAAPAPAPAP------------ MUL_2122|M.ulcerans_Agy99 ADSGV---------APPAATPAAPAASAAPAPPKAPLPGQRPAPTPGKPA MAV_4827|M.avium_104 IGVT---------WTDQLEAAALRDALAARRIDNVMLVS----------- Rv3879c|M.tuberculosis_H37Rv SGGAAN--------AANGALGANINQLMTLQDYLATVITWHR-------- TH_4426|M.thermoresistible__bu LGDLG----LCERFGRAAVGAAGSGAGLAARLPLAYALAFQG-------- Mflv_3843|M.gilvum_PYR-GCK --------------------------------GAPVGAPVANPGLPTPPV Mvan_2552|M.vanbaalenii_PYR-1 --------------------------------GAPAGTPVANVAPPSPPV MSMEG_5381|M.smegmatis_MC2_155 --------------------------------FAVEATLVMIASPPAPPL Mb3906|M.bovis_AF2122/97 --------------------------------------AASKPPTPPMPI MLBr_00048|M.leprae_Br4923 --------------------------------------ASSESPRAPMPV MMAR_5451|M.marinum_M -AAPPEPTAPAEPPQPPEAAAQPPQAVEEQAHATAEPPAAPNPPRPPMPI MAB_3131c|M.abscessus_ATCC_199 ---APRPGATPGPKPG-----APRVPRVGNNPFSSAQPAERPAPRPQAPR MUL_2122|M.ulcerans_Agy99 APQAPHPGMAPGARPGPVPKQGVRTPRVGNNPFSSAQPVDRPIPRPQAPR MAV_4827|M.avium_104 --------------------------------------AFLAAAALAQNV Rv3879c|M.tuberculosis_H37Rv ---------------------------------HIAGLIEQAKSDIGNNV TH_4426|M.thermoresistible__bu ----------------------------RGREADEVLAAVDSTGLTEHEL Mflv_3843|M.gilvum_PYR-GCK PGAPVFGDGGAVLPPLPPAPAGPAGGPAGLVAPPAPPVPGGPAAVPAGVA Mvan_2552|M.vanbaalenii_PYR-1 PGVPVIGDGGAALPPLPPVPGGPAAVPAGVVTPPAPPIPGGPAAMPAGVA MSMEG_5381|M.smegmatis_MC2_155 PGFELP------FPPFPPAPPVTVPRPADWAEPPLPPRP---TLSWPKLE Mb3906|M.bovis_AF2122/97 AGPEPA-------------------------PPKPPTPPMPIAGPEPAPP MLBr_00048|M.leprae_Br4923 SAP----------------------------PRSPAASLMPISEPPQWPP MMAR_5451|M.marinum_M GGPPPTPPAAPEPQQDIAEEPAPAAAEAPAAPPKSPLPPMPVSGPPPEPP MAB_3131c|M.abscessus_ATCC_199 PGAPRP-----GGASPSNMPPRPSPGSMGPRPPRPGGGPRPGGGPRPGG- MUL_2122|M.ulcerans_Agy99 PGAPRPGAPRPGGASSGNMPPRPGGASGGPRPPRTG-APRPGGG-RPGGP MAV_4827|M.avium_104 GGAMGYER-----------------------TAVLLVEPDTATLAVVETS Rv3879c|M.tuberculosis_H37Rv DGAQREIDILENDPSLDADERHTAINSLVTATHGANVSLVAETAERVLES TH_4426|M.thermoresistible__bu MAWALPRAANQFWMLSQPERAVAFLRTVRERVSSPTAATTLDALSATFAM . Mflv_3843|M.gilvum_PYR-GCK LPPAPPGAPGAPVFGEAGAAPSGAAAPVAPAAGSGGAGGAGGGSGIGGPG Mvan_2552|M.vanbaalenii_PYR-1 APPAP-APPGAPIFGEAGAVPPPGVGGAPLDGASGVAAPGGPGGGAGAPG MSMEG_5381|M.smegmatis_MC2_155 LPPAP--------------------PVAAAAATAGAAGGGGRRRGVG--D Mb3906|M.bovis_AF2122/97 KPP----------------------------------------TPPMPIA MLBr_00048|M.leprae_Br4923 -------------------------------------------------- MMAR_5451|M.marinum_M ELPPAPPE----PTASAEPPQPPQSVEEQAHATAEPPAAPKPTRPPMPIG MAB_3131c|M.abscessus_ATCC_199 AGRPGGGGGGNYRGGGTGTGAPAGGPPGAGGGFRGRPGGGGGGGRPGQRG MUL_2122|M.ulcerans_Agy99 GGGRSDGGGGNYRGGGGGVGAAPGG------GFRGRPGGGGGGGRPGQRG MAV_4827|M.avium_104 DGSIP-------------------------DVYKQQIRAESYGDAAGQLS Rv3879c|M.tuberculosis_H37Rv KNWKP---------------------------------PKNALEDLLQQK TH_4426|M.thermoresistible__bu NAGRP--------------------QQALQTATEVLASPTADGTAIGWAG Mflv_3843|M.gilvum_PYR-GCK GGGAPVEGTGGAVPAGAPLAAAGGEVPPPAPPIPGAPVIGEAGVVPPPAP Mvan_2552|M.vanbaalenii_PYR-1 APVAAAAGNAGPPAPGAPVGDQAGVVAPPAPPAPGAPVGDQAGLVAPPGP MSMEG_5381|M.smegmatis_MC2_155 GGVAPVSAVAAVAVASAAVGDATDAAGDAAQPGGGG-----------VTA Mb3906|M.bovis_AF2122/97 GPAPTPTESQLAP------------------------PRPPTPQTPTGAP MLBr_00048|M.leprae_Br4923 AEAPEHQFAKAEP------------------------PSVPIPINEP-SP MMAR_5451|M.marinum_M GPPPTPEPQQGAPQPHQDIAEEPNPAAAEAPAAPPKSPRPPMPVNGP-AP MAB_3131c|M.abscessus_ATCC_199 GAAGAFGRPGGAPKRGRKSKRAKRAEYENMQAPVVGGVRLPHGNGEVIRL MUL_2122|M.ulcerans_Agy99 GAAGAFGRPGGAPRRGRKSKRAKRAEYENMQAPVVGGVRLPHGNGETIRL MAV_4827|M.avium_104 AMVAGLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVSVAEEPETAL Rv3879c|M.tuberculosis_H37Rv SPPPPDVPTLVVPSPGTPGTPGTPITPGTPITPGTPITPIPGAPVTPITP TH_4426|M.thermoresistible__bu AAAALSAARMGRFTEVDALAERAMSAGHPGLLRFTSGFGQTTARQLTGAP . Mflv_3843|M.gilvum_PYR-GCK PAPAPPAGGLGGAVPPPVPGAPGVPVVDEAGVVTPPAPGGPGVPTGGEGG Mvan_2552|M.vanbaalenii_PYR-1 PAPGVPVVDQAGVVAPPGPPAPGVPVVDEAGVVTPPGPGAPGVPVVGEAG MSMEG_5381|M.smegmatis_MC2_155 RAAVPSAAGRVKASAAPGAALAAGHIRCRFGVVD---------------- Mb3906|M.bovis_AF2122/97 QQPESPAPHVPSHGPHQPRRTAPAPPWAKMPIG--EPP-PAP---SRPSA MLBr_00048|M.leprae_Br4923 AKPATPMPMTPIDGSQRTPVTSPEPSLAEFEAQ--PPATPKPSLLPRPMS MMAR_5451|M.marinum_M TRPEPPLPPGPPRRRAQPPTAPPNQPGQPKPISGHPPPPPRPAAFAPPAR MAB_3131c|M.abscessus_ATCC_199 ARGASLSDFAEKIDANPASLVQALFNLGEMVTATQSVGDETLELLGGEMN MUL_2122|M.ulcerans_Agy99 ARGASLSDFADKINANPAALVQALFNLGEMVTATQSVGDETLELLGSEMN MAV_4827|M.avium_104 ARGAALAAANAPLFASSTAALAYAQDPGTGAVDQYSLPDYLYVPVDPEPG Rv3879c|M.tuberculosis_H37Rv TPGTPVTPVTPGKPVTPVTPVKPGTPGEPTPITPVTPPVAPATPATPATP TH_4426|M.thermoresistible__bu DQALALARRLTEIAQLQQPGRAIGELLIAEVLITRGDLDEAVALLRAAVK Mflv_3843|M.gilvum_PYR-GCK VV--------------TPPAPGAPGVPVVDEAGVVTPPAPGGPGVPTGGE Mvan_2552|M.vanbaalenii_PYR-1 VV--------------TPPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVDE MSMEG_5381|M.smegmatis_MC2_155 ---------------------GRVTAVAADATGAAFSGAPISSGATDRRR Mb3906|M.bovis_AF2122/97 ---------------------SPAEPPTRP-----APQHSRRARRGHRYR MLBr_00048|M.leprae_Br4923 ---------------------SPPEAPRPS-----ANQHSRHARRGHHHR MMAR_5451|M.marinum_M GATPNRHESAEPPPPRRVRIGGPPQPPGPPEAESEAPRHSRHARRTHRYR MAB_3131c|M.abscessus_ATCC_199 ----------------YVVQVVSPEDEDRELLESFDLTYGEDEGGEEDLR MUL_2122|M.ulcerans_Agy99 ----------------YNVQVVSPEDEDRELLESFDLTYGEDSGDESELQ MAV_4827|M.avium_104 DD-------------------ELAYSAVGEEDAESPTVVIEKLFLPEDSE Rv3879c|M.tuberculosis_H37Rv VT-------------------PAPAPHPQPAPAPAPSPGPQPVTPATPGP TH_4426|M.thermoresistible__bu VLTP------------TGYSWAPLAAMLLARALGEQGAAPEAAIALSRAE Mflv_3843|M.gilvum_PYR-GCK GGVVTPPAPGAPGAPVVDEAGVVTPPAPGGPGVPA-----VGDTAVVTPP Mvan_2552|M.vanbaalenii_PYR-1 AGVVTPPGPGAPGVPVVDEAGVVTPPAPGAPGVPV-----DGGAELVTPP MSMEG_5381|M.smegmatis_MC2_155 GRARRAGDGGVAAGTTVTGAGRVG------------------VTVAVTAV Mb3906|M.bovis_AF2122/97 TDT-------ERNVGKVATGPSIQARLRAEEASGA-----QLAPGTEPSP MLBr_00048|M.leprae_Br4923 DET-------QQANPASATEPMIAPRARTAELRQA-----P--------- MMAR_5451|M.marinum_M PEP-------ETDDLEATAVRPLPTREPMRRNGPA-----ADES-STASF MAB_3131c|M.abscessus_ATCC_199 TRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGG-----ITQHIGAYQV MUL_2122|M.ulcerans_Agy99 TRPPVVTVMGHVDHGKTRLLDTIRKANVREGEAGG-----ITQHIGAYQV MAV_4827|M.avium_104 PRR-------RPVLLVGSGLAVVGISAVLALEIAL-----AIGIRTTGTV Rv3879c|M.tuberculosis_H37Rv SGPATPGTPGGEPAPHVKPAALAEQPGVPGQHAGG-----GTQSGPAHAD TH_4426|M.thermoresistible__bu SRHGLKSMLFAPELALARAWTRAARGDRHGAVXXXXACWWWRWWDXXTPP Mflv_3843|M.gilvum_PYR-GCK APGAPGTPAVNSVETFSPPAPPAATPPSSGSVETFSPPAPPAPGTGTNST Mvan_2552|M.vanbaalenii_PYR-1 GPGAPGTPTVSSVETFSPPAPPAPGTPSSGSIETFSPPAPPTPGTPANSS MSMEG_5381|M.smegmatis_MC2_155 AAGAAQC------------------------------------------- Mb3906|M.bovis_AF2122/97 APLGQPRSYLAPPTRPAPTEP-PPSPSPQRNSGRRAERRVHPDLAAQHAA MLBr_00048|M.leprae_Br4923 ---------------HAAAEP-APTQHLTR-----------PDGLVSHRT MMAR_5451|M.marinum_M AWLQQSQPTLDRPSGPMPAAPGAPVESAPG----------RADGRRARRR MAB_3131c|M.abscessus_ATCC_199 AVEHDGTERPITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQT MUL_2122|M.ulcerans_Agy99 SVDHDGTERLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQT MAV_4827|M.avium_104 ALQPTPNQHLIVPTEQAPAPPPVQASAPQPKISVPEPVAAPKPLSPPVAA Rv3879c|M.tuberculosis_H37Rv ESAASVTPAAASGVPGARAAAAAPSGTAVGAGARSSVGTAAASGAGSHAA TH_4426|M.thermoresistible__bu GPPAPPAGGGGGGDVETPPGPPAPPAEVEERDDAEIPPGPPSPPAGGGGG Mflv_3843|M.gilvum_PYR-GCK VEISTPPPPGTPGLPSEGSTTYTTPPTPEITLNPANSGIDIATPPAPGLP Mvan_2552|M.vanbaalenii_PYR-1 VEIVTPPPPGVPGVPGEGSTTYTTPPTPEITLNPANSSIDVATPPGPGVP MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 AQPDSITAATTGGRRRKRAAPDLDATQKSLRPAAKGPKVKKVKPQK---- MLBr_00048|M.leprae_Br4923 ALHDSTATSAIG-------------VQTGRSTGAK--------------- MMAR_5451|M.marinum_M AESRTSAASTPSPLVPTRAQPPGPTRAQPPRTAAPAQPATEPLPDAGAPA MAB_3131c|M.abscessus_ATCC_199 VEAINHAQAADVPIVVAVNKIDKEGADPAKIRAQLTEYNLVAEDFGGDTM MUL_2122|M.ulcerans_Agy99 VEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVAEDFGGDTM MAV_4827|M.avium_104 PLPAAPPPAAPP-----------LPEAPPIPAAPPVVPVPVVVPPVPVPV Rv3879c|M.tuberculosis_H37Rv TGRAPVATSDKAAAPSTRAASARTAPPARPPSTDHIDKPDRSESADDGTP TH_4426|M.thermoresistible__bu GEIAPPPTPGEPGAVIDQSSQNVTVPAPPTPGSETSTALEVFSPPVP--- Mflv_3843|M.gilvum_PYR-GCK GAPLEATANITTPGTPGVPGAPVNSSIDVATPGEVGVPAAPIERSMTVTT Mvan_2552|M.vanbaalenii_PYR-1 GVPVEASANVSTPPVPGVPGAPVNSSVEVATPAEVGVPGTPIERSTTLTT MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 PKATKPPKVVSQRGWRHWVHALTRINLGLSPDEKYELDLHARVR------ MLBr_00048|M.leprae_Br4923 ----KPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVR------ MMAR_5451|M.marinum_M EQSKKPNKPVPQRGWRRWVYAVTRINFGLSPDEKYELDLRTRIG------ MAB_3131c|M.abscessus_ATCC_199 FVDISARQGTNIEQLLEAVLLTADAALDLRANPDMEAQGVAIEA------ MUL_2122|M.ulcerans_Agy99 FVDISAKQGTNIEALEEAVLLTADAALDLRANPDMEAQGVAIEA------ MAV_4827|M.avium_104 PVRIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGG------ Rv3879c|M.tuberculosis_H37Rv VSMIPVSAARAARDAATAAASARQRGRGDALRLARRIAAALNAS------ TH_4426|M.thermoresistible__bu ----PGEVSGGGSNMLELPGFPGGTIGGPEIAHNVEVTGPPAEAS----- Mflv_3843|M.gilvum_PYR-GCK PDTPGAPGAPANAAVDVATPPAPGVPGAPVVGEAGVTTPGAPGAPGAPAN Mvan_2552|M.vanbaalenii_PYR-1 PPTPGVPGTPVNSSVEVATPPAPGAPGVPVVDEAGVVTPPGPGAPGVPVV MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 ----RNPRGSYQIAVVGLKGGAGKTTLTAALGSTLAQVR---------AD MLBr_00048|M.leprae_Br4923 ----RPPRGSYQIGILGLKGGAGKTTVTVTLGSMFARVR---------ND MMAR_5451|M.marinum_M ----RKPRGSYQIAILGLKGGAGKTTTTVTLGTTLTHVR---------GD MAB_3131c|M.abscessus_ATCC_199 ----HLDRGRGPVATVLIQRGTLRVGDSIVAGDAYGRVRRMVDEHGEDVE MUL_2122|M.ulcerans_Agy99 ----HLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGEDVE MAV_4827|M.avium_104 ----TVPQSPPQHQTPPGEGTPPKPDGPGNYGGGHVPTPG---------- Rv3879c|M.tuberculosis_H37Rv ----DNNAGDYGFFWITAVTTDGSIVVANSYGLAYIPDG----------- TH_4426|M.thermoresistible__bu -----VPGVDASVATEAGTPPVPPGPTAPIEHAAETSVPAEVEIPGAEID Mflv_3843|M.gilvum_PYR-GCK AAVDVATPPAPGVPGAPVVGEAAVTTPGAPGVPGVPAGGDAGVVTPPAPG Mvan_2552|M.vanbaalenii_PYR-1 GEAGVVTPPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVGEAGVVTPPGPG MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 RILALDADPGAGNLADRVGRQSGATIADVLAEKELSHYNDIRAHTSVNAV MLBr_00048|M.leprae_Br4923 RILVVDADTSCGNLADRAGRFSEANIADLLADKDVKSYNDIRTHTSVNAV MMAR_5451|M.marinum_M RILVLDADPGAGNLAERSGRSSPSSIADLLADPRLSHYNDVRAHTSVNAA MAB_3131c|M.abscessus_ATCC_199 EALPSRPVQVIGFTSVPGAGDNLLVVDEDRIARQIADRRSARKRNALAAR MUL_2122|M.ulcerans_Agy99 EALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAAR MAV_4827|M.avium_104 --AGGSGGSGGGHVPTPGAGGSGGSGGGHVPTPGTGGPGGTGGSGGGHVP Rv3879c|M.tuberculosis_H37Rv MELPNKVYLASADHAIPVDEIARCATYPVLAVQAWAAFHDMTLRAVIGTA TH_4426|M.thermoresistible__bu HRAEVATPPVDGPPVEVENSVEVATPPHXXGPGAVVDXX----XXRRPGA Mflv_3843|M.gilvum_PYR-GCK VPGAPVVGEAGVTTPGAPGVPGVPAGGDAGVVTPPAPGVPGAPAATEAGL Mvan_2552|M.vanbaalenii_PYR-1 APGVPVVDEAGVVTPPGPGAPGVPVVGEAGVVTPPGPGAPGVPVVDEAGV MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 NLEVLPAPEYSSAQRALSDADWHFIADPASRFYNLVLADCGAGFFDPLTR MLBr_00048|M.leprae_Br4923 NLEVLPAAEYSTAQHALSGEDWNFAAATVSKYYNVMLADCGVGLFDPVTR MMAR_5451|M.marinum_M NLEILPTAEYTSAQRGLSGEDLRSAVDTVSKFYNLVLADCGAGLFDPVTL MAB_3131c|M.abscessus_ATCC_199 SRKRISLDDLDAALKETSQLNLILKGDNAGTVEALEEALLGIAIDDEVQL MUL_2122|M.ulcerans_Agy99 SRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIEVDDEVAL MAV_4827|M.avium_104 TPGAGTPGGSGGGHLPFPGAGSTPGGSGGGHLPTPGAGTPGGGLGGFGGG Rv3879c|M.tuberculosis_H37Rv EQLASSDPGVAKIVLEPDDIPESGKMTGRSRLEVVDP-SAAAQLADTTDQ TH_4426|M.thermoresistible__bu DPRPXPLPVAAQLHPRPVGCDGPRRPHRGGVVTASRQPRRLTGRVDAPHL Mflv_3843|M.gilvum_PYR-GCK ATPPGPGAPGAPVVGDAGVATPPGPGVPGAPIVDEAGLATPPAP-----V Mvan_2552|M.vanbaalenii_PYR-1 VTPPGPGAPGVPVVDEAGVVTPPGPGAPGVPVVDEAGVVTPPAPPAAAPG MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 GVLSTVSG-----------------------VVVVASVSIDGAQQASVAL MLBr_00048|M.leprae_Br4923 GVLSTASG-----------------------VVIVTSTSVDAARQAAIAL MMAR_5451|M.marinum_M GVLDTASA-----------------------IVILTNVSIDSARQAAIAL MAB_3131c|M.abscessus_ATCC_199 RVIDRGVG-----------------------GVTETNVNLASASDAIIIG MUL_2122|M.ulcerans_Agy99 RVIDRGVG-----------------------GITETNVNLASASDAIIIG MAV_4827|M.avium_104 HAPAPGGG-------------------------LGGGGGHAPAPGGGLGG Rv3879c|M.tuberculosis_H37Rv RLLDLLPP---------------------------APVDVNPPGDERHML TH_4426|M.thermoresistible__bu HRHRGQPG--------------------------DAQHQHGHHRRQRERG Mflv_3843|M.gilvum_PYR-GCK APVEGAGGAVPPAGPPPAPVFGDAGAPVEAAAGGAPVEAAAGVTGGGSVA Mvan_2552|M.vanbaalenii_PYR-1 APIDAAAASVAPSGPPAAPVLGEAGVVAPPAP-----------PGGGAPG MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 DWLRNNG-YQDLASRACVVIN----------------------------- MLBr_00048|M.leprae_Br4923 DWLRHNG-YQDLLSRACVVIN----------------------------- MMAR_5451|M.marinum_M DWLRKHG-YQDLASRACVAIN----------------------------- MAB_3131c|M.abscessus_ATCC_199 FNVRAEGKATELANREGVDIRYYS-------------------------- MUL_2122|M.ulcerans_Agy99 FNVRAEGKATELANREGVEIRYYS-------------------------- MAV_4827|M.avium_104 FGGGHSGGGLGGLGGGHK-------------------------------- Rv3879c|M.tuberculosis_H37Rv WFELMKPMTSTATGREAAHLRAFR-------------------------- TH_4426|M.thermoresistible__bu FHGDRATITHTLVFNAR--------------------------------- Mflv_3843|M.gilvum_PYR-GCK GAGAGGGAGGAAGGAGVEGASGAVGAAGGPGAGAAPAAAGGAAPGGAPGG Mvan_2552|M.vanbaalenii_PYR-1 GGAPGAGVG---TGAPIEGAAGAGGVPAAPLAANAGAAT---PPAAATGG MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00048|M.leprae_Br4923 -------------------------------------------------- MMAR_5451|M.marinum_M -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_2122|M.ulcerans_Agy99 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PVAGGGPVGGPGALPAPGAPIVGEAGVVSPPAPGVPGGAAAVPAGAVTPP Mvan_2552|M.vanbaalenii_PYR-1 ----------------AGAPIDAAAGAAAPPAP----------------P MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00048|M.leprae_Br4923 -------------------------------------------------- MMAR_5451|M.marinum_M -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_2122|M.ulcerans_Agy99 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK APGVPGAPVFGEAGVVTPPAPGVPGGAAAVPAGVVTPPAPGVPGGAAAVP Mvan_2552|M.vanbaalenii_PYR-1 AP---GAPIFGEAGVAAPPLPPAPGGAGAVPAGVVTPPVPGVPGGAGAVP MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 --------------------HIMPGEPNVAVKDLVRHFEQQVQPGRVVVM MLBr_00048|M.leprae_Br4923 --------------------HVMPKEPNIASKDLVQQFEQQIQPGRVVVL MMAR_5451|M.marinum_M --------------------HVAVGETNVSEQQLVRDFEQQLQPGRVVVL MAB_3131c|M.abscessus_ATCC_199 ------------------VIYQAIDEIESALKGMLKPVYEEVELGRAEIR MUL_2122|M.ulcerans_Agy99 ------------------VIYQAIDEIEKALRGMLKPIYEEVELGRAEIR MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv --------------------AYAAHSQEIALHQAHTATDAAVQR------ TH_4426|M.thermoresistible__bu ---------------------LMMLVSALTIESPVTTAYRMAPNAAAAIV Mflv_3843|M.gilvum_PYR-GCK AGAVTPPAPGVPGAPVFGDAGVATPPVPGVPGGGTTVPAASVTPPAPGVP Mvan_2552|M.vanbaalenii_PYR-1 AGAVTPPTP----------------PVPGSSSGG---------------- MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 PWDRH--------------------------------------------- MLBr_00048|M.leprae_Br4923 PWDKH--------------------------------------------- MMAR_5451|M.marinum_M PWDRH--------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 AMFRS--------------------------------------------- MUL_2122|M.ulcerans_Agy99 ALFRS--------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv -------------------------------------------------- TH_4426|M.thermoresistible__bu PTAYS--------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GGASTVPGNAGTPSTPGLPPGSTDTYINYPAPPVPPTPPNSTGVSAGTPG Mvan_2552|M.vanbaalenii_PYR-1 -------------------------FVNYPAPPVPPTPPNSAGVNTGTPG MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00048|M.leprae_Br4923 -------------------------------------------------- MMAR_5451|M.marinum_M -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 -------------------------------------------------- MUL_2122|M.ulcerans_Agy99 -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK SPAPGTPGSTLTLTDLLTPPGIARTLQNTASSVMGATPPGTPPVPGGSGS Mvan_2552|M.vanbaalenii_PYR-1 SPIPGTPGSTLTISDLLTPPGVARTVQNTASSVMSIAPPGTPPVPGGAGS MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 -IAAGTEISLDLLDPIYKR----KVLELAAALSDDFERAGRR-------- MLBr_00048|M.leprae_Br4923 -IAAGTEIRLDRLDPLYRR----RILELAAALSDDFERAGRH-------- MMAR_5451|M.marinum_M -IAAGTEIHLDQLGPVYRR----RVLELAAALSDDFERAGRR-------- MAB_3131c|M.abscessus_ATCC_199 -SKVGNIAGCLVTSGIIRRNAKARLLRDNIVVAETVTISSLRREKDDVVE MUL_2122|M.ulcerans_Agy99 -SKVGLIAGCMISSGVVRRNAKARLLRDNIVVVENLSIRSLRREKDDVTE MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv ----------VAVADWLYWQYVTGLLDRALAAAC---------------- TH_4426|M.thermoresistible__bu ------------------------TVDIPASSTINIVVLA---------- Mflv_3843|M.gilvum_PYR-GCK VSLAVPGTPSPIAPLAATGLSNLVSPPSLTIPSIPGLPVPLPNTVPVPSD Mvan_2552|M.vanbaalenii_PYR-1 VSVGVPAPPSPLTPLAATGLSNLVSPPSLTIPSIPGLPVPLPNEVPVPSD MSMEG_5381|M.smegmatis_MC2_155 -------------------------------------------------- Mb3906|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00048|M.leprae_Br4923 -------------------------------------------------- MMAR_5451|M.marinum_M -------------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 VRDGYECGLTLTYNDIKEGDVIEAYELREKERV----------------- MUL_2122|M.ulcerans_Agy99 VREGFECGMTLGYSDLKEGDFIESYELVQKDRS----------------- MAV_4827|M.avium_104 -------------------------------------------------- Rv3879c|M.tuberculosis_H37Rv -------------------------------------------------- TH_4426|M.thermoresistible__bu -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK LLCVGTDWSASQGDSAATPPAAEVPR-VVTGAAPTGDRRDRWGNR Mvan_2552|M.vanbaalenii_PYR-1 LLCVGTDWSATQGDSATTPVNAEIPRALVTGAAPVGDRRDRWDTR MSMEG_5381|M.smegmatis_MC2_155 --------------------------------------------- Mb3906|M.bovis_AF2122/97 --------------------------------------------- MLBr_00048|M.leprae_Br4923 --------------------------------------------- MMAR_5451|M.marinum_M --------------------------------------------- MAB_3131c|M.abscessus_ATCC_199 --------------------------------------------- MUL_2122|M.ulcerans_Agy99 --------------------------------------------- MAV_4827|M.avium_104 --------------------------------------------- Rv3879c|M.tuberculosis_H37Rv --------------------------------------------- TH_4426|M.thermoresistible__bu ---------------------------------------------