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NSTPFHDLDAYLDLPRVSGLAVSPDGTRVVTTVSTLNAKRTEFVTALWELDPAGQQPARRLTRGLKGESA PVFTADGDVLFLAVRPTEDDEKPPAALWRLPAHGGEAHEMLSLPGGVSAAASARTADVTVVAAPLLPSAA DVEADRSLRKARKDNKVSAILHTGYPVRQWDHDLGPDLPHLFDADGARNLTERPGVALRESTFDVSPDGA FVVATWHVPAPGAATRSTLVRIDRETGARTTIAEDPQADLEHPVIAPDGGALAFTRETHSTPTEPPRITL CCMRFGNDDEQLGEWAEVATEWDRWPSSLAWSADASALIVTADDNGRGPVFSVHPDTGTVTRLTDDDHTY TDVCPAPGGIIYALRSSYAVPPHPVRIDPDGTVTELPCFDAPALPGSLTEITATAEDGTPVRSWLTLPES TDPAPLVLWVHGGPLGSWNTWHWRWNPWLLTAHGYAVLMPDPALSTGYGQDFIARGWGAWGEAPYTDLMA ATDAACEHPRVDASRTAAMGGSFGGYMANWVAGHTDRFDAIVTHASLWALDQFAPTTDGAYWWAREMTPE MMQRNSPHRFVDQINTPMLVIHGDKDYRVPIGEALRLWYELLTESALPADDNGDSPHRFLYYPAENHWVL TPQHAKLWYQVVTAFLDENLRNEPAQWPELLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4633 | - | - | 100% (663) | peptidase S9, prolyl oligopeptidase |
| M. smegmatis MC2 155 | MSMEG_5523 | - | 5e-21 | 31.54% (298) | peptidase |
| M. smegmatis MC2 155 | MSMEG_4719 | - | 1e-14 | 26.39% (288) | peptidase S9, prolyl oligopeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2627 | - | 0.0 | 68.67% (667) | peptidase S9 prolyl oligopeptidase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4725 | - | 4e-24 | 32.74% (394) | peptidase |
| M. marinum M | MMAR_0779 | - | 3e-09 | 25.90% (332) | peptidase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4519 | - | 5e-14 | 25.81% (372) | PUTATIVE peptidase S9, prolyl oligopeptidase active site domain |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3954 | - | 0.0 | 68.40% (674) | peptidase S9 prolyl oligopeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2627|M.gilvum_PYR-GCK ------------MTAAPD-PNPVSP--TPFHDLDEFLSLPRVSGLAVSRD
Mvan_3954|M.vanbaalenii_PYR-1 MKSCPAMCYEFRMSSAPEQPTPATPGTTAFHDLDEFLALPRVAGLAVSPD
MSMEG_4633|M.smegmatis_MC2_155 ------------MN------------STPFHDLDAYLDLPRVSGLAVSPD
MAB_4725|M.abscessus_ATCC_1997 ------------------------MGLPKLITVEEFFEPPVRTSASISPD
TH_4519|M.thermoresistible__bu ----------------------------------VAEQVRATYGASLSPD
MMAR_0779|M.marinum_M --------MAPKAPEAPQAPDAADTTTDPYLWLEDVTGEEALDWVRARNE
:
Mflv_2627|M.gilvum_PYR-GCK GARVVTTVAT-LNDTRTEFVSALWELDPVGREPARRITRGVTGESAPEFT
Mvan_3954|M.vanbaalenii_PYR-1 GTRVVTTVSR-LDDKRTEFVSALWELDPSGQQPARRLTFGAKGESAPEFT
MSMEG_4633|M.smegmatis_MC2_155 GTRVVTTVST-LNAKRTEFVTALWELDPAGQQPARRLTRGLKGESAPVFT
MAB_4725|M.abscessus_ATCC_1997 GTMIAYLAPR-KNR------LNVWVQG-IGSTEARCVTHDETRSVTGFFW
TH_4519|M.thermoresistible__bu ATAFAHLVDD-GGFPR----AVQRFLRGWRASSSRDVELPVVGPVRRVLH
MMAR_0779|M.marinum_M PTKAQFCGGESEDEFERMRTEALEVLDTDARIPYVRRRGDYLYDFWRDAN
: .
Mflv_2627|M.gilvum_PYR-GCK ADGDLLFLAARPTADDDKPP-KSLWCLPVAGGEAYEVCQMPGGVDGVASA
Mvan_3954|M.vanbaalenii_PYR-1 ADGDLLFLAARPTGDDDEPTRKALWRLPAAGGEAHEVATLPGGVDRVTSA
MSMEG_4633|M.smegmatis_MC2_155 ADGDVLFLAVRPTEDDEKPP-AALWRLPAHGGEAHEMLSLPGGVSAAASA
MAB_4725|M.abscessus_ATCC_1997 VDDPRWLLYVQDSGGDENWH-LYRVDLSTPDATAVDLTPFPGARLLGLER
TH_4519|M.thermoresistible__bu SPDGGWLACEVAPDGSDRSQ-IWVVTTDPDDRGAHRIDSWPPDAPEGAAE
MMAR_0779|M.marinum_M NPRGLWRRTTLESYRTDAPEWDVLIDVDELGRTDNKKWVWAGADVIEPEF
. : . .
Mflv_2627|M.gilvum_PYR-GCK --GGATV---------------VVSSMLPSAVDIDADERLRTARKDNKVS
Mvan_3954|M.vanbaalenii_PYR-1 REAATTL---------------ITSAMLASATDVDDDKRLRAARKDNKVS
MSMEG_4633|M.smegmatis_MC2_155 RTADVTV---------------VAAPLLPSAADVEADRSLRKARKDNKVS
MAB_4725|M.abscessus_ATCC_1997 PYGRSGK---------------VYIQLNHRRIDQIDLYELDIASGELTML
TH_4519|M.thermoresistible__bu LIAWDGN---------------RIAAILTGQDGVGSSCLIDPADGSTVVL
MMAR_0779|M.marinum_M TRALISLSPGGSDAVIVREFDMVTREFVADGFELPEAKSQVGWDDPDTIL
. : :
Mflv_2627|M.gilvum_PYR-GCK ALLHTGYPVRAWDHD---IGPARTHLFDADTKR--DVTPDPGDALRDSHF
Mvan_3954|M.vanbaalenii_PYR-1 AVLHAGYPVRYWDHD---LGPEQPHLFDITEERPRDLTPTPGQALREAHF
MSMEG_4633|M.smegmatis_MC2_155 AILHTGYPVRQWDHD---LGPDLPHLFDADGAR--NLTERPGVALRESTF
MAB_4725|M.abscessus_ATCC_1997 AENPGGVMAWFCGPNHEVFAQSLTPGGDIEFSRYESGALRPLCVYDGADY
TH_4519|M.thermoresistible__bu DRRSGGRLVDAWAGAALIRVGPRGYRELIMLHGNTEMALLPSDPGSTTDF
MMAR_0779|M.marinum_M VGTDFGPDSMTESGYPRIVKRWRRGTPLSDAEMIFQGAHTDVSAGGSTDR
* . : :
Mflv_2627|M.gilvum_PYR-GCK DVSPDGGFLVASWNVPAPG---AALRSTLVRIDVNTGDRAVIVDDPESDA
Mvan_3954|M.vanbaalenii_PYR-1 DLSRDGAFLVTTWQGPAPG---AALRTTLVHVDVATGRRTTIVDDRDADL
MSMEG_4633|M.smegmatis_MC2_155 DVSPDGAFVVATWHVPAPG---AATRSTLVRIDRETGARTTIAEDPQADL
MAB_4725|M.abscessus_ATCC_1997 PVGMNPTQMTPDGSGMWLGSSRDTDRTRLVRLDLATGAESTIDSHPAYDL
TH_4519|M.thermoresistible__bu GVILDDHSARRLRRGPDGE-----LTKLYQPAKRYPRESTEGYVRALIRS
MMAR_0779|M.marinum_M TPGFERTFVSRSLDFWNRQR-YELRGTELIPLDVPTDASSMSVHREWLLI
: . . . :
Mflv_2627|M.gilvum_PYR-GCK GFPAIAPDGTSVAYLRETL-STPHHAPRITLALLHFGEEP------RELT
Mvan_3954|M.vanbaalenii_PYR-1 GNPAVSPDGQSVAYTRETI-STPRKAPRITLCLLRFGEEP------VELT
MSMEG_4633|M.smegmatis_MC2_155 EHPVIAPDGGALAFTRETH-STPTEPPRITLCCMRFGNDDEQLGEWAEVA
MAB_4725|M.abscessus_ATCC_1997 AAALGLPP----TLIRHRK-SGELLAARYLGARQEI----------RVLD
TH_4519|M.thermoresistible__bu DNGAGYARLLEVTTTADGV-AYQVVAERPGHDLDEF-----------VVS
MMAR_0779|M.marinum_M ELRTDWSPKAGADDAAKTYRAGSLLAANYDDFLSGTSDLH------VVFE
. . : . . .
Mflv_2627|M.gilvum_PYR-GCK AHWDRWPTSVTWSADGSTLLVTADDDGRGPIFAVDPQTGAVRTLVSDDYT
Mvan_3954|M.vanbaalenii_PYR-1 TGWDRWPTSVTWSADGSSVIITADDHGRGPIFAVDPDTGAVRTLVADDFT
MSMEG_4633|M.smegmatis_MC2_155 TEWDRWPSSLAWSADASALIVTADDNGRGPVFSVHPDTGTVTRLTDDDHT
MAB_4725|M.abscessus_ATCC_1997 PDFGPVLEKLQELSDGDLAEVSSDEDGRRWVVSFTHDR------------
TH_4519|M.thermoresistible__bu DDLSTVALLWNIDGASELQILQYADNTLSEPIPLPGMVAG----------
MMAR_0779|M.marinum_M PDEHTCLYHYAWVRDRLLMVSLADVASQVEIVTPGSWRREPIAGIPASTN
..
Mflv_2627|M.gilvum_PYR-GCK YTDVRAAPGGVIFALRSSYAAPQHPVRIDPDGTITVLDCVPLPSL-----
Mvan_3954|M.vanbaalenii_PYR-1 YSDVRPAPGGVLFALRSSYAAPQHPVRIDADGTVTVLDCVALPDL-----
MSMEG_4633|M.smegmatis_MC2_155 YTDVCPAPGGIIYALRSSYAVPPHPVRIDPDGTVTELPCFDAPAL-----
MAB_4725|M.abscessus_ATCC_1997 -------DPGVTYFYDHATGESHQLFRPYP---------HLDPAD-----
TH_4519|M.thermoresistible__bu --ELSISAGGSMVAMTVESPWLPPTVELVDPRTRQWELIDREPSTGPV--
MMAR_0779|M.marinum_M TVIVAADDTGDEFFVDSSGFDAPSRLLRGTAGSATTQLEQIKSAPTFFDA
* . .
Mflv_2627|M.gilvum_PYR-GCK -PGTLTEIEATAADGQRVRSWLVLP-EGDHP----------APLLLWIHG
Mvan_3954|M.vanbaalenii_PYR-1 -PGTLTEVTATTADGRTVRSWMVLP-HGEAAGSYSSRERSSAPLLLWIHG
MSMEG_4633|M.smegmatis_MC2_155 -PGSLTEITATAEDGTPVRSWLTLP-ESTDP----------APLVLWVHG
MAB_4725|M.abscessus_ATCC_1997 -LAPVVPVTITARDGLTLNSYLTLP-VGTEP--------EGLPLVLVVHG
TH_4519|M.thermoresistible__bu -TGTPTLERLTARDGLELTGWLYRPPTGVQP----------VGAMIFLHG
MMAR_0779|M.marinum_M QNISVSQHFATSEDGTSIPYFLVRPTGSDGP----------GPTLLYGYG
. *: ** : :: * . . :: :*
Mflv_2627|M.gilvum_PYR-GCK GPLASWNAWHWRWNPWLMAAGGYAVLLPDPALSTGYGQEFIERGWGAWGF
Mvan_3954|M.vanbaalenii_PYR-1 GPLASWNAWHWRWNPWVMAARGYAVLLPDPALSTGYGQEFIQRGWGSWGF
MSMEG_4633|M.smegmatis_MC2_155 GPLGSWNTWHWRWNPWLLTAHGYAVLMPDPALSTGYGQDFIARGWGAWGE
MAB_4725|M.abscessus_ATCC_1997 GPWH-RDSWGFDPTVQLLANRGYAVLQVNFRGSTGYGKAFTKAAIGEFAG
TH_4519|M.thermoresistible__bu GPEGQSRPGYNEYFPPLLDR-GITVFTPNVRGSGGFGRSFVHADDKENRF
MMAR_0779|M.marinum_M GFETSNTPGYSGVMGRLWLARGGTYVLANIRGGGEYGPGWHTQAMREGRH
* . : * : . : . :* :
Mflv_2627|M.gilvum_PYR-GCK APYTDLMAATDAACAHPRIDETRTAVMGGSFGGYMANWIAGHT-DRFAAI
Mvan_3954|M.vanbaalenii_PYR-1 APYTDLMAATDAACAHPRVDETRTAAMGGSFGGYMANWIAGHT-DRFAAI
MSMEG_4633|M.smegmatis_MC2_155 APYTDLMAATDAACEHPRVDASRTAAMGGSFGGYMANWVAGHT-DRFDAI
MAB_4725|M.abscessus_ATCC_1997 KMHDDLIDAVDWAVEQGYADPGRIAIFGGSYGGYSALVGVTFTPDVFAAA
TH_4519|M.thermoresistible__bu RAIDDVADCVHYLVRNGLAPADRIACAGWSYGGYLTQAALAFHPDLFAAG
MMAR_0779|M.marinum_M KVAEDFVAVADDLVRRGITTVDQLGAQGGSNGGLLMGIMVTKYPEKFGAL
*. .. . : . * * ** : * *
Mflv_2627|M.gilvum_PYR-GCK VTHAGLWALDQFGATTD-------GSYWWSREMTPKMAS------ANSPH
Mvan_3954|M.vanbaalenii_PYR-1 VTHASLWALDQFGATTD-------GGYWWAREMTPEMAA------ANSPH
MSMEG_4633|M.smegmatis_MC2_155 VTHASLWALDQFAPTTD-------GAYWWAREMTPEMMQ------RNSPH
MAB_4725|M.abscessus_ATCC_1997 VDYVGISNLANFMRTLPPFVRPNLANNWYRYVGDPAVPEQEADMLARSPI
TH_4519|M.thermoresistible__bu ISVCGMSDLTTWYQTTEP----WIAQSSYTEYGHPVADR--DLLERLSPL
MMAR_0779|M.marinum_M VCNVPLLDMKRYHLLLAG-------ASWVAEYGDPDNPDDWAFISEYSPY
: : : : * **
Mflv_2627|M.gilvum_PYR-GCK L--FVSDIRTPMLVIHGDKDYRVPIGEALRLWYDLLSRSGLPAADSGPEA
Mvan_3954|M.vanbaalenii_PYR-1 L--FVSQIATPMLVIHGDKDYRVPIGEALRLWYELLSSSALPAADDG---
MSMEG_4633|M.smegmatis_MC2_155 R--FVDQINTPMLVIHGDKDYRVPIGEALRLWYELLTESALPADDNG---
MAB_4725|M.abscessus_ATCC_1997 S--RVDRIRTPLLVAQGANDVRVVQAESDNIVAALRARG-----------
TH_4519|M.thermoresistible__bu T--HAAAVTAPLLLVHGASDTNVPPSESIQMHTALERLG-----------
MMAR_0779|M.marinum_M QNISADRTYPPILITTSTRDDRVHPGHARKMTAALQASG-----------
. .*:*: . * .* ..: .: * .
Mflv_2627|M.gilvum_PYR-GCK GTTQHRFLYFPSENHWILSPQHAKLWYQVVLGFLNLHVLGQDADVPELLG
Mvan_3954|M.vanbaalenii_PYR-1 -STEHRFLYFPSENHWVLSPQHAKIWYQVVLAFLAHHVLGQDSELPEMLG
MSMEG_4633|M.smegmatis_MC2_155 -DSPHRFLYYPAENHWVLTPQHAKLWYQVVTAFLDENLRNEPAQWPELLG
MAB_4725|M.abscessus_ATCC_1997 --VEVEYMVKADEGHGFLNPENQIDLHRATERFLAQHVGGRQVS------
TH_4519|M.thermoresistible__bu --RPVKLLMFDDDGHEIVRRENRATLVEAMSHWLMSAFAERRREAS----
MMAR_0779|M.marinum_M --HRVWYYENIEGGHGGAADNEQLAFKSALSYSFLWRMLGSRK-------
.* :. . : .