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TQREFDLVLYGATGFAGKLTAQYLAGAAGDARIALAGRSAEKLQAARDSIGGAAADWPLVIADADNPSTL ADMAARTRVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGETMFIRDSIDRYHQQAVDTGARIVHSCGFD SVPSDLTVFALHRRATADGAGELVDTDLVLRSFAGGVSGGTAASMIEVLRTSSTDPAARAAMTDPYTLSP DRSREPELGDQPDVRWRRGSEIAPELAGYWTGAFAMAGPNTRIVRRSNALLDYAYGRRFAYAEQMSCGRS PAAPIAAALVTASNAATMGLGGRFFDKIPSGLLERVLPKPGTGPSEQTRERGHYRVETYTTTTSGARYVA TMAQQGDPGYKATAVLLGECGLALATDRDKLSGLHGVLTPAAAMGDALLTRLPAAGVVLETTKLD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4632 | - | - | 100% (416) | saccharopine dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2476c | - | 1e-166 | 69.81% (414) | hypothetical protein Mb2476c |
| M. gilvum PYR-GCK | Mflv_2628 | - | 1e-177 | 73.85% (413) | saccharopine dehydrogenase |
| M. tuberculosis H37Rv | Rv2449c | - | 1e-166 | 69.81% (414) | hypothetical protein Rv2449c |
| M. leprae Br4923 | MLBr_00129 | - | 1e-146 | 63.29% (414) | hypothetical protein MLBr_00129 |
| M. abscessus ATCC 19977 | MAB_4339c | - | 1e-149 | 66.51% (415) | hypothetical protein MAB_4339c |
| M. marinum M | MMAR_3775 | - | 1e-172 | 72.22% (414) | hypothetical protein MMAR_3775 |
| M. avium 104 | MAV_1723 | - | 1e-173 | 72.71% (414) | saccharopine dehydrogenase |
| M. thermoresistible (build 8) | TH_0608 | - | 0.0 | 76.76% (413) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3722 | - | 1e-172 | 71.74% (414) | hypothetical protein MUL_3722 |
| M. vanbaalenii PYR-1 | Mvan_3953 | - | 1e-177 | 73.61% (413) | saccharopine dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2628|M.gilvum_PYR-GCK MDMSE-NDREHDIVLYGATGFVGKLTAQYLAS--AGTGARIALAGRSTDR
Mvan_3953|M.vanbaalenii_PYR-1 MSANEAHDREHDIVVYGATGFVGKLTAQYLAA--AGAGARIALAGRSTDR
TH_0608|M.thermoresistible__bu MTAAQ---REFDIVLYGATGFVGKLTARYLAS--AGVGARIALAGRSEQK
MSMEG_4632|M.smegmatis_MC2_155 MTQ-----REFDLVLYGATGFAGKLTAQYLAG--AAGDARIALAGRSAEK
Mb2476c|M.bovis_AF2122/97 MTATP---REFDIVLYGATGFVGKLTAEYLAR--AGGDARIALAGRSTQR
Rv2449c|M.tuberculosis_H37Rv MTATP---REFDIVLYGATGFVGKLTAEYLAR--AGGDARIALAGRSTQR
MAV_1723|M.avium_104 MTATP---REFDIVLYGATGFVGKLTAEYLAG--AAPDKRIALAGRSTEK
MMAR_3775|M.marinum_M MSETP---REFDIILYGATGFVGKLTAQYLAR--AGGDARIALAGRSTDR
MUL_3722|M.ulcerans_Agy99 MSETP---REFDIILYGATGFVGKLTAQYLAR--AGGDARIALAGRSTDR
MAB_4339c|M.abscessus_ATCC_199 MS------REHDIVLYGATGYVGKLTALYLAGRVEATGARIALAGRSTEK
MLBr_00129|M.leprae_Br4923 MSPDK---REFDIVLYGATGFSGKLTAEHLAL--SESTARIALAGRSSER
* **.*:::*****: ***** :** ******** ::
Mflv_2628|M.gilvum_PYR-GCK LLAVRDSLGEQAKDWPLIVADASQPSTINAMAASTRVVVTTVGPYLRYGL
Mvan_3953|M.vanbaalenii_PYR-1 LLAVRESLGEAAQDWPLLVADASQPSTLNAMAASTRVVITTVGPYLRYGL
TH_0608|M.thermoresistible__bu LAAVRESLGEAAASWPLLTADADQPATLDELASRTQVVVTTVGPYTKYGM
MSMEG_4632|M.smegmatis_MC2_155 LQAARDSIGGAAADWPLVIADADNPSTLADMAARTRVVVTTVGPYTRYGL
Mb2476c|M.bovis_AF2122/97 VLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGL
Rv2449c|M.tuberculosis_H37Rv VLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGL
MAV_1723|M.avium_104 LHAVRDSLGDAAQSWPVLQADASSPATLNEMAARTQVVITTVGPYTRYGL
MMAR_3775|M.marinum_M LLAVRQTLGEAAQSWPVVSADAGAPATLKEMAARTRVVVTTVGPYMRYGL
MUL_3722|M.ulcerans_Agy99 LLAVRQTLGEAAQSWPVVSADAGAPATLKEMAARTRVVVTTVGPYMRYGL
MAB_4339c|M.abscessus_ATCC_199 LAAVRDACGPAARDWPLIEADTTRPATLAAMAASTQVVLTTVGPYTKYGL
MLBr_00129|M.leprae_Br4923 LRNVRALLGPNAQDWPLIVADASQPSTLEAMAGRAQVVLTTVGPYTRYGL
: .* * * **:: **: *:*: :*. ::**:****** :**:
Mflv_2628|M.gilvum_PYR-GCK PLVAACAAAGTDYADLTGETLFVRRAIDLHHKQAVDTGARIVHACGFDSI
Mvan_3953|M.vanbaalenii_PYR-1 PLVAACAAAGTDYADLTGETLFVRECIDLYHKQAADTGARIVHACGFDSI
TH_0608|M.thermoresistible__bu PLVAACAVAGTDYADLTGETMFIRRAIDLYHKQAADNGARIVHSCGFDSI
MSMEG_4632|M.smegmatis_MC2_155 PLVAACAAAGTDYADLTGETMFIRDSIDRYHQQAVDTGARIVHSCGFDSV
Mb2476c|M.bovis_AF2122/97 PLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSV
Rv2449c|M.tuberculosis_H37Rv PLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSV
MAV_1723|M.avium_104 PLVAACAAAGTDYADLTGEAMFVRDSIDSYHKQAADTGARIVHACGFDSV
MMAR_3775|M.marinum_M PLVAACAAAGTDYADLTGEPPFVRESIDLYHKQAADTGARIVHACGFDSI
MUL_3722|M.ulcerans_Agy99 PLVAACAAAGTDYADLTGEPPFVRESIDLYHKQAADTGARIVHACGFDSI
MAB_4339c|M.abscessus_ATCC_199 PLVAACAEAGTDYADLTGEVNFVRESIDVYGKQAADTGARIVHCCGFDSI
MLBr_00129|M.leprae_Br4923 PLVAACARTGTDYADLTGELMFCRNSIDLHHKQAAATGARIILACGFDSV
******* :********** * * .** : :**. .****: .*****:
Mflv_2628|M.gilvum_PYR-GCK PSDMTVFALYRQAERDGTGQLGDTNFVARSFAG-GVSGGTIASMTELARE
Mvan_3953|M.vanbaalenii_PYR-1 PSDMTVFALYRAAERDRTGELGDTNFVVRSFAG-GVSGGTVASMTELARQ
TH_0608|M.thermoresistible__bu PSDITVYALYRRAVEDGTGELGDTNLVVRRFAG-GVSGGTAASMLEVMRT
MSMEG_4632|M.smegmatis_MC2_155 PSDLTVFALHRRATADGAGELVDTDLVLRSFAG-GVSGGTAASMIEVLRT
Mb2476c|M.bovis_AF2122/97 PSDLSVYALYHAAREDGAGELTDTNCVVRSFKG-GFSGGTIASMLEVLST
Rv2449c|M.tuberculosis_H37Rv PSDLSVYALYHAAREDGAGELTDTNCVVRSFKG-GFSGGTIASMLEVLST
MAV_1723|M.avium_104 PSDLSVYALYRAARDDGAGELVDTDLVVRSFSG-GVSGGTVASMLEVLDT
MMAR_3775|M.marinum_M PSDLTVYALYRAVRDDGAGELGRTDFVVRSFAG-GVSGGTVASMLEILRA
MUL_3722|M.ulcerans_Agy99 PSDLTVYALYRAVRDDGAGELGRTDFVVRSFAG-GVSGGTVASMLEILRA
MAB_4339c|M.abscessus_ATCC_199 PSDLSVYALYRRAQEDGTGELLDTTYVLSKFRG-GVSGGTAASMVEVMEA
MLBr_00129|M.leprae_Br4923 PSDLNVYQLYRRVIEDRTGELCDTDLVLRSFSQRWVSGGSVAAYSEAMLT
***:.*: *:: . * :*:* * * * .***: *: *
Mflv_2628|M.gilvum_PYR-GCK ASLDPEARRLLNDPYTLTPDRGAEPELGPQPDARWRRGREIAPELDGYWV
Mvan_3953|M.vanbaalenii_PYR-1 ASQDPEARRLLNDPYTLTPDRAAEPELGAQPDARWRRGREIAPELDGYWV
TH_0608|M.thermoresistible__bu ASEDPEARRLMTDPYTLSPDRAAEPELGGQPDIRWRRGGEIAPELEGYWT
MSMEG_4632|M.smegmatis_MC2_155 SSTDPAARAAMTDPYTLSPDRSREPELGDQPDVRWRRGSEIAPELAGYWT
Mb2476c|M.bovis_AF2122/97 ASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAGVWT
Rv2449c|M.tuberculosis_H37Rv ASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAGVWT
MAV_1723|M.avium_104 ASRDPEARRQLADPYTLSSDRGAEPDVGPQPDLPCRRGRQIAPELAGVWT
MMAR_3775|M.marinum_M VSADPDLRRQFTDPYTLSTDRAAEPELGPQPDLPWRRGGRIAPELTGLWT
MUL_3722|M.ulcerans_Agy99 VSAAPDLRRQFTDPYTLSTDRAAEPELGPQPDLPWRRGGRIAPELTGLWT
MAB_4339c|M.abscessus_ATCC_199 SAEDPEVRRNAQDPYSLSPDRPAEPEVGRQREFQTLRGESVAPELTGKWL
MLBr_00129|M.leprae_Br4923 TSNDPEALRLVTDPYTLTTDRDAEPDLGPQPDFPRHRGSDLAPELAGFWT
: * *** *:.** **::* * : ** :**** * *
Mflv_2628|M.gilvum_PYR-GCK GAFAMALPNTRVVRRSNALLDYAYGRRFEYAELMSTGRSIGAPVLAAVAT
Mvan_3953|M.vanbaalenii_PYR-1 GAFAMALPNTRVVRRSNALLGYAYGRRFEYAEQMSTGRSVGAPLVAAMAT
TH_0608|M.thermoresistible__bu GAFVMAVANTRIVRRTNALLDYAYGRRFEYAEQMSLGKSIAAPVAAALAT
MSMEG_4632|M.smegmatis_MC2_155 GAFAMAGPNTRIVRRSNALLDYAYGRRFAYAEQMSCGRSPAAPIAAALVT
Mb2476c|M.bovis_AF2122/97 AGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGG
Rv2449c|M.tuberculosis_H37Rv AGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGG
MAV_1723|M.avium_104 AGFVMAPYNTRIVRRSNALLDWAYGRSLRYSESMSLGSSPLAPVASAVVG
MMAR_3775|M.marinum_M AGFMMAPTNTRIVRRSNALLDWAYGRRFQYTEHMSLGSSAVAPVASAMIS
MUL_3722|M.ulcerans_Agy99 AGFMMAPTNTRIVRRSNALLDWAYGKRFQYTEHMSLGSSAVAPVASAMIS
MAB_4339c|M.abscessus_ATCC_199 GAFFMGPVNTRIVRRSNALLDWAYGTRMRYREAMSLGSSVVAPVAAAAVT
MLBr_00129|M.leprae_Br4923 GGFVQAQFNTRIVRRSNALQNWSYGRQFRYSETMSLGKSWAAPVASAAVT
..* . ***:***:*** .::** : * * ** * : **: :.
Mflv_2628|M.gilvum_PYR-GCK AGNAATMQLGSRFLNRVPRAALERVLPKPGTGPNEQTRERGHYTVETYTT
Mvan_3953|M.vanbaalenii_PYR-1 AGNVATMELSSRFLDRVPRGALERILPKVGTGPSEQTRERGHYTVETYTT
TH_0608|M.thermoresistible__bu AGNAAAFGLGSRFFHRVPDRLIEKVMPKPGTGPSERTRERGHYTVETYTT
MSMEG_4632|M.smegmatis_MC2_155 ASNAATMGLGGRFFDKIPSGLLERVLPKPGTGPSEQTRERGHYRVETYTT
Mb2476c|M.bovis_AF2122/97 GVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTT
Rv2449c|M.tuberculosis_H37Rv GVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTT
MAV_1723|M.avium_104 GTAAATFGLGSRYFRFLPRRLVERIVPKPGTGPSPSARERGYYRIETYTT
MMAR_3775|M.marinum_M GVGNAMTGLGSRYFRLLPQRLVERIAPKPGTGPSAATRERGYYRIETYTT
MUL_3722|M.ulcerans_Agy99 GVGNAMTGLGSRYFRLLPQRLVERIAPKPGTGPSAATRERGYYRIETYTT
MAB_4339c|M.abscessus_ATCC_199 GALTVGFGLGTRVP--LPKFIAQRVLPKPGTGPSERTRERGHYRVETYTT
MLBr_00129|M.leprae_Br4923 SVVAGAVGLGNKYFNRLPRRVVERVTPKSGTGPSRKTQARGHYTFETYTT
. *. : :* ::: ** ****. :: **:* .*****
Mflv_2628|M.gilvum_PYR-GCK TSTGARYVARMSQNGDPGYKATAVLLGESGLALALDRDKLSDLRGILTPA
Mvan_3953|M.vanbaalenii_PYR-1 TSTGARYLARMSQQGDPGYKATSVLLGESGLALALDRDKLSDLRGILTPA
TH_0608|M.thermoresistible__bu TTTGARYVARMSQQGDPGYQATSVLLGESGLALALDRDKLSDLRGVLTPA
MSMEG_4632|M.smegmatis_MC2_155 TTSGARYVATMAQQGDPGYKATAVLLGECGLALATDRDKLSGLHGVLTPA
Mb2476c|M.bovis_AF2122/97 TTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPA
Rv2449c|M.tuberculosis_H37Rv TTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPA
MAV_1723|M.avium_104 TTSGARYVARMEQRGDPGYKATSVLLGESGLALAFDRDKLPQLYGVLTPA
MMAR_3775|M.marinum_M TTSGDRYVARMEQGGDPGYKATSVLLGECGLALAFDRDQLSGLHGVLTPA
MUL_3722|M.ulcerans_Agy99 TTSGDRYVARMEQDGDPGYKATSVLLGECGLALAFDRDQLSGLHGVLTPA
MAB_4339c|M.abscessus_ATCC_199 TTEGVRYRAIIAQEGDPGYKATAVLLGESGLTLALDRTELPDRLGVLTPA
MLBr_00129|M.leprae_Br4923 TTTGARYMATFAHNVD-AYKSTAGLLAASGLTLALDRDRLSELRGVLTPA
*: * ** * : : * .*::*: **. .**:** ** .*. *:****
Mflv_2628|M.gilvum_PYR-GCK AAMGDALLARCPGA-DVSLDVSRLN-
Mvan_3953|M.vanbaalenii_PYR-1 AAMGDALLARFPAA-GVSLDVSRLN-
TH_0608|M.thermoresistible__bu AAMGDVLLTRLPAA-GVTLTVERLA-
MSMEG_4632|M.smegmatis_MC2_155 AAMGDALLTRLPAA-GVVLETTKLD-
Mb2476c|M.bovis_AF2122/97 AAMGDALLERLPAA-GVSLQTTRLAS
Rv2449c|M.tuberculosis_H37Rv AAMGDALLERLPAA-GVSLQTTRLAS
MAV_1723|M.avium_104 AAMGDALLDRFPGA-GVSLQVDRLAG
MMAR_3775|M.marinum_M AAMGDALLARLPAA-GVALATERLT-
MUL_3722|M.ulcerans_Agy99 AAMGDALLARLPAA-GVALATERLT-
MAB_4339c|M.abscessus_ATCC_199 AAMGDPLLERLRAARGVTVEVERL--
MLBr_00129|M.leprae_Br4923 AAMGEALLTRLPSA-GVVIGTTRLS-
****: ** * .* .* : . :*