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VTLTTPHPRPEQSESAAQSSLLAGFTPFPAERAQAYRAAGYWRDQLLDSVLRTAARTWPDHIAVIDADHR HTYAELDRLADRAAAGIAGLGIRPGDRVLVQLPNTAEFAVALFGLLRAGAVPVMCLPGHRLAELTHFAEV SSAVALVVADTAGGFDHRDLARELVRSHPDVRHVLVDGDAAEFLSWAEVTRAAPGPVPEIAPDPAAPALL LVSGGTTGAPKLIPRTHQDYVYNATASAELCRLTADDVYLVALPAAHNFPLACPGLLGAMTVGATTVFTT DPSPEAAFAAIDEHGVTATALVPALAKLWAQACAWEPLAPKTLRLLQVGGAKLAAPDAALVRGALTPGLQ QVFGMAEGLLNYTRIGDPPEVLENTQGRPLSPDDEIRIVDEVGNEVPPGAEGELLVRGPYTLNGYFNAEA ANERSFSPDGFYRSGDRVRRFADGPLAGYLEVTGRIKDVIVRGGENVSALDLEEHLLTHPSVWAAAAVAL PDEFLGEKICAVVVFNGPPVSLAELHAHLEQRGVAAHSRPDALVPMPSLPTTAVGKIDKKAIVRQLGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4516 | - | - | 100% (558) | 2,3-dihydroxybenzoate-AMP ligase |
| M. smegmatis MC2 155 | MSMEG_4112 | - | 3e-62 | 32.35% (541) | cyclohexanecarboxylate-CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 2e-42 | 29.59% (507) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2405 | mbtA | 0.0 | 69.19% (555) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. gilvum PYR-GCK | Mflv_2691 | - | 0.0 | 65.34% (554) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2384 | mbtA | 0.0 | 69.19% (555) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 2e-37 | 32.84% (402) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2247c | - | 0.0 | 63.47% (553) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. marinum M | MMAR_3698 | mbtA | 0.0 | 66.91% (550) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. avium 104 | MAV_2008 | - | 0.0 | 68.33% (540) | 2,3-dihydroxybenzoate-AMP ligase |
| M. thermoresistible (build 8) | TH_2907 | - | 0.0 | 65.45% (547) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3641 | mbtA | 0.0 | 67.84% (538) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. vanbaalenii PYR-1 | Mvan_3850 | - | 0.0 | 66.42% (539) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2405|M.bovis_AF2122/97 -----MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTV
Rv2384|M.tuberculosis_H37Rv -----MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTV
MAV_2008|M.avium_104 -----MSPNTT-----PPAGVLDGFVPFPAERAAAYRAAGLWTGRALDTI
MMAR_3698|M.marinum_M -----MPVTSA---QPPRPGPVAGFIPYPPERVASYRAAGYWTGRSIGSL
MUL_3641|M.ulcerans_Agy99 ---------------------MAGFIPYPPERVASYRAAGYWTGRSIGSL
Mflv_2691|M.gilvum_PYR-GCK ---MTTGFPIEYGHGLTNGDLKHGFVPFPEDRAEAYRRAGYWTGRPLDSI
Mvan_3850|M.vanbaalenii_PYR-1 ---MNTGLPADQGN-----DLTRGFVPFPPDRAEVYRRAGYWTGRPLDSI
TH_2907|M.thermoresistible__bu ---MTTEFQPVESDLTS--DFRTGFVPFPPDRVEEYRRAGYWTGRRLDSI
MSMEG_4516|M.smegmatis_MC2_155 MTLTTPHPRPEQSESAAQSSLLAGFTPFPAERAQAYRAAGYWRDQLLDSV
MAB_2247c|M.abscessus_ATCC_199 ----MTQPRSTTTASSAATPALDGFVPFPSVRADEYRRAGYWTGNTVESL
MLBr_01051|M.leprae_Br4923 --------------------------------------------MLLASL
: ::
Mb2405|M.bovis_AF2122/97 LSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPG
Rv2384|M.tuberculosis_H37Rv LSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPG
MAV_2008|M.avium_104 LTDAARRWPDRTAVLDAS---GGTGFSYAGLDEQANRAAAGLADAGIAPG
MMAR_3698|M.marinum_M LRQAAARWPDRVGVVDAG-----ASHTFCELDKLADRAAAGFVSLGIAPG
MUL_3641|M.ulcerans_Agy99 LRQAAARWPDRVGVVDAG-----ASHTFCELDKLADRVAAGFVSLGIAPG
Mflv_2691|M.gilvum_PYR-GCK LTDAASRWPDKPAIIDAT-----RSYTFAELDAAADRAAAGLADLGIRPG
Mvan_3850|M.vanbaalenii_PYR-1 LTEAAATWPDKPAVIDSA-----QTYTFRELDAAADRVAAGLAALGIRPG
TH_2907|M.thermoresistible__bu LSDAAAAQPDKAAVIDPD-----RSHTFAELDALADRVAAGLADLGIAPG
MSMEG_4516|M.smegmatis_MC2_155 LRTAARTWPDHIAVIDAD-----HRHTYAELDRLADRAAAGIAGLGIRPG
MAB_2247c|M.abscessus_ATCC_199 LRVSAARRPCHPAVIDEH-----RALSYRELDEAADNAAHAFLRLGIAPG
MLBr_01051|M.leprae_Br4923 NPSVVTATDIADAVCVDG----------VVLSRSGLVGAATSVAERVGGA
. .: *. . * : .
Mb2405|M.bovis_AF2122/97 DRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATG
Rv2384|M.tuberculosis_H37Rv DRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATG
MAV_2008|M.avium_104 DRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAALSQATA
MMAR_3698|M.marinum_M DRVLLQLPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVG
MUL_3641|M.ulcerans_Agy99 DRVLLQLPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVG
Mflv_2691|M.gilvum_PYR-GCK ERVLLQLPNSCQFAVALFALLRAGVVPVMCLTGHRTAELGHFADVSGAVA
Mvan_3850|M.vanbaalenii_PYR-1 DRVLLQLPNSCQFAIALFGLLRAAAVPVMCLPGHRTAELGHFAEVSGAVA
TH_2907|M.thermoresistible__bu DRVLLQMPNDTRFAVAFFGLLRAGAIPVMCLPGHRSAEMSHFAEVSGAVG
MSMEG_4516|M.smegmatis_MC2_155 DRVLVQLPNTAEFAVALFGLLRAGAVPVMCLPGHRLAELTHFAEVSSAVA
MAB_2247c|M.abscessus_ATCC_199 DRVLLQLPNRASFAVALFGLMRAGAIPVMCLPGHRAAELSHFIEVADAVG
MLBr_01051|M.leprae_Br4923 RLVAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQA
* : . .:*: . : *.. * .. .* *: : * .
Mb2405|M.bovis_AF2122/97 LVVADVASGFDYRPMARELVADHPTLRHVIVDGDPGP----FVSWAQLCA
Rv2384|M.tuberculosis_H37Rv LVVADVASGFDYRPMARELVADHPTLRHVIVDGDPGP----FVSWAQLCA
MAV_2008|M.avium_104 LLIADTAAGFDYRTMAAGLVEEHEALAHVIVDGDPGP----FLSWAQLCE
MMAR_3698|M.marinum_M LIVAQHAGGFDYRSMAERLVAAHPQLRHVIIDGESGP----FLPWSSLSE
MUL_3641|M.ulcerans_Agy99 LIVAQHAGGFDYRSMAERLVAAHPQLRHVIIDGESGP----FLPWSSLSE
Mflv_2691|M.gilvum_PYR-GCK VIVPDRAGGFDYRDMAASLAAQRPALRHVIVDGEPGD----QVSWQSILD
Mvan_3850|M.vanbaalenii_PYR-1 LIVPDEAGGFDYRDMAGRLAAEHPSLQHVIVDGENGP----FVAWSSIRD
TH_2907|M.thermoresistible__bu LIIPERANGFDYRELARALTASRPRLRHVIVDGATDPSGDGFVPWSALAE
MSMEG_4516|M.smegmatis_MC2_155 LVVADTAGGFDHRDLARELVRSHPDVRHVLVDGDAAE----FLSWAEVTR
MAB_2247c|M.abscessus_ATCC_199 LVIPDSAGGFDYRALAVALSQRHPRLRTVVVEGDAGP----FASWTSLLK
MLBr_01051|M.leprae_Br4923 WLGPGPS-----------ADSAPDGLPHIPVQLDARS-------WN----
: . : : : :: *
Mb2405|M.bovis_AF2122/97 QAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALC
Rv2384|M.tuberculosis_H37Rv QAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAALC
MAV_2008|M.avium_104 RAPAGRPATPVDPGSPALLLVSGGTTGTPKLIPRTHDDYVFNANASAELC
MMAR_3698|M.marinum_M GA---TPDIDVDTTSPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLC
MUL_3641|M.ulcerans_Agy99 GA---TPDIDVDTTSPALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLC
Mflv_2691|M.gilvum_PYR-GCK FAGPRLGRTPVDPSLPALLLVSGGTTGLPKLIARTHDDYVYNAHACAQAC
Mvan_3850|M.vanbaalenii_PYR-1 FDGPAVERAAVDPGLPALLLVSGGTTGLPKLIARTHDDYVYNAVASAQAC
TH_2907|M.thermoresistible__bu FAGPAVPRPPVDTTAPALLLVSGGTTGLPKLIPRTHDDYVYTAVASARAY
MSMEG_4516|M.smegmatis_MC2_155 AAPGPVPEIAPDPAAPALLLVSGGTTGAPKLIPRTHQDYVYNATASAELC
MAB_2247c|M.abscessus_ATCC_199 SVEPQGPLPTVQTDTPALLLVSGGTTAAPKLIPRTHEDYVYNATQAARVC
MLBr_01051|M.leprae_Br4923 ------RYPEPSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAW
.. .*::: :.***. ** : :: . *
Mb2405|M.bovis_AF2122/97 RLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAI
Rv2384|M.tuberculosis_H37Rv RLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAI
MAV_2008|M.avium_104 GLTRDDVYLAVLSAGHNFPLACPGLLGAMTVGATTVFGTDPSPEAAFATI
MMAR_3698|M.marinum_M RLTADDVYLVSLPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTLI
MUL_3641|M.ulcerans_Agy99 RLTADDVYLVSLPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTLI
Mflv_2691|M.gilvum_PYR-GCK EMTGEDAYLVALPAGHNFPLACPGLLGSMTVGAPTVFTADPSPENAFALI
Mvan_3850|M.vanbaalenii_PYR-1 EMTAEDAYLVALPAGHNFPLACPGMLGSMTVGAPTVFTADPSPENAFALI
TH_2907|M.thermoresistible__bu EMTSDDVYLVVLPAAHNFPLACPGMLGAMTVGASTVFTADPSPEAAFPLI
MSMEG_4516|M.smegmatis_MC2_155 RLTADDVYLVALPAAHNFPLACPGLLGAMTVGATTVFTTDPSPEAAFAAI
MAB_2247c|M.abscessus_ATCC_199 GLTQDDVYLVALPAGHNFPLACPGLLGAISTGATTVFLSDPSPESAFATI
MLBr_01051|M.leprae_Br4923 QWTADDVLVHGLPLFHVHGLVLG-LLGSLRIGNRFVHTGKPTPTAYAQAC
: :*. : *. * . *. :**:: * *. .*:*
Mb2405|M.bovis_AF2122/97 ERHGVTVTALVPALAKLWAQSCEWEPVT--PKSLRLLQVGGSKLEPEDAR
Rv2384|M.tuberculosis_H37Rv ERHGVTVTALVPALAKLWAQSCEWEPVT--PKSLRLLQVGGSKLEPEDAR
MAV_2008|M.avium_104 ARHGVTVTALVPALAKLWAHACEWEDNP--PKSLRLLQVGGAKLEADDAR
MMAR_3698|M.marinum_M ERHGVTVTALVPALAKLWTQACDWEPVT--PKSLRLLQVGGSRLEPEDAR
MUL_3641|M.ulcerans_Agy99 ERHGVTVTALVPALAKLWTQACDWEPVI--PKSLRLLQVGGSRLEPEDAR
Mflv_2691|M.gilvum_PYR-GCK DKHRITVTGLVNALAKLWAQACDWEPVL--PTSLRFVQVGGSRMSPEEAR
Mvan_3850|M.vanbaalenii_PYR-1 DKFRITVTGLVNALAKLWAQACEWEPVL--PTSLRFVQVGGSRMSPEEAR
TH_2907|M.thermoresistible__bu NRHRVTVTGLVNALAKLWAQACEWEPEL--PESLRVVQVGGSRMSPQEAQ
MSMEG_4516|M.smegmatis_MC2_155 DEHGVTATALVPALAKLWAQACAWEPLA--PKTLRLLQVGGAKLAAPDAA
MAB_2247c|M.abscessus_ATCC_199 ARHRVSVTAVVPSLAQLWAQATAWEPVL--PETLRLLQVGGAKLGADDAR
MLBr_01051|M.leprae_Br4923 SEAGG---SLYFGVPTVWSRLVADEAVARALRPARLLVSGSASLPVPVFD
. .: .:. :*:: * . *.: *.: :
Mb2405|M.bovis_AF2122/97 RVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIV
Rv2384|M.tuberculosis_H37Rv RVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIV
MAV_2008|M.avium_104 VIRSALTPGLQQVFGMAEGLLNYTRLDDPPEITEHTQGRPLSTADEVRVV
MMAR_3698|M.marinum_M QAREALTPGLQQVFGMAEGLLNFTRLEDPPDLLEHTQGRPLCSADELRIV
MUL_3641|M.ulcerans_Agy99 QAREALTPGLQQVFGMAEGLLNFTRLEDPPDLLEHTQGRPLCSADELRIV
Mflv_2691|M.gilvum_PYR-GCK FILDRLTPGMSQIFGMAEGMLNFTRPGDPEDVVVHTQGRPMSPHDEMRVV
Mvan_3850|M.vanbaalenii_PYR-1 FILERLTPGMSQIFGMAEGMLNFTRPGDPEDVVVHTQGRPMSPHDEVRVV
TH_2907|M.thermoresistible__bu FILDRLTPGMSQIFGMAEGMLNFTRPGDPIDVVVHTQGRPMSPHDEMRVV
MSMEG_4516|M.smegmatis_MC2_155 LVRGALTPGLQQVFGMAEGLLNYTRIGDPPEVLENTQGRPLSPDDEIRIV
MAB_2247c|M.abscessus_ATCC_199 AVRESLTQGLQQVFGMAEGLLCLTQPGDPTDILDNSQGRPMCDADEVRIV
MLBr_01051|M.leprae_Br4923 RLAHLTGHRPIERYGSTESLITLSTLADG-ERRAGWVGLPLAG-VQTRLV
: :* :*.:: : * : * *:. : *:*
Mb2405|M.bovis_AF2122/97 NADGEPVGPGEE--GELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDL
Rv2384|M.tuberculosis_H37Rv NADGEPVGPGEE--GELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDL
MAV_2008|M.avium_104 DAAGNPVAPGQE--GELLVRGPYTFNGYFRAERDNQRCFDAQGFFRSGDL
MMAR_3698|M.marinum_M DGAGAPVAPGAE--GELLVRGPYTINGYFCADRDNERCFDPAGFYRSGDL
MUL_3641|M.ulcerans_Agy99 DGAGAPVAPGAE--GELLVRGPYTINGYFCADRDNERCFDPAGFYRSGDL
Mflv_2691|M.gilvum_PYR-GCK DEDGVEVAPGEE--GELLVRGPYTLNGYYRADDANARSFTPDGFYRTGDR
Mvan_3850|M.vanbaalenii_PYR-1 DESGDGVPPGEE--GELLVRGPYTLYGYYRDDDANARSFSPDGFYRTGDR
TH_2907|M.thermoresistible__bu DESGAEVAPGEE--GELLVRGPNTLNGYYRDDEANARSFSPDGFYRTGDR
MSMEG_4516|M.smegmatis_MC2_155 DEVGNEVPPGAE--GELLVRGPYTLNGYFNAEAANERSFSPDGFYRSGDR
MAB_2247c|M.abscessus_ATCC_199 DEDGADVPAGET--GELLVRGPYTLNGYYRADADNMRSFTVDGFYRSGDR
MLBr_01051|M.leprae_Br4923 DESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDV
: * * . *.* **.* : ** . ..* *::*:**
Mb2405|M.bovis_AF2122/97 VRRRDDG----NLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAA
Rv2384|M.tuberculosis_H37Rv VRRRDDG----NLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAAA
MAV_2008|M.avium_104 VRVRDDG----YLVVTGRVKDVICRGGETISAADLEEQMLSHPAIFSAAA
MMAR_3698|M.marinum_M VRLRDDG----YLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAA
MUL_3641|M.ulcerans_Agy99 VRLRDDG----YLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAAA
Mflv_2691|M.gilvum_PYR-GCK VRIFTDGPRAGYVEVTGRVKDVIHRGGETVSATDLEDHLHTHPSVYAAAA
Mvan_3850|M.vanbaalenii_PYR-1 VRIFADGPRAGYVEVVGRIKDVIHRGGETVSATDLEDHLHTHPAIYAAAA
TH_2907|M.thermoresistible__bu VRIFADGPRAGHVEVTGRVKDVIHRGGETVSATDLEDHLLTHPAIYAAAA
MSMEG_4516|M.smegmatis_MC2_155 VRRFADGPLAGYLEVTGRIKDVIVRGGENVSALDLEEHLLTHPSVWAAAA
MAB_2247c|M.abscessus_ATCC_199 VRALPGG----YLEVTGRIKDVILRGGESIAALDLESHLQTHPAVYAAAA
MLBr_01051|M.leprae_Br4923 AVVDSGG---MHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAV
. .* * . *:* * :.* ::* : ** : .*.
Mb2405|M.bovis_AF2122/97 VGLPDQYLGEKICAAVVFAGAP---ITLAELNGYLDRRGVAAHTRPDQLV
Rv2384|M.tuberculosis_H37Rv VGLPDQYLGEKICAAVVFAGAP---ITLAELNGYLDRRGVAAHTRPDQLV
MAV_2008|M.avium_104 VPLPDPYLGEKICAAVVFEGPA---LSLAELNGYLDERGVAAHARPDVLA
MMAR_3698|M.marinum_M VPLPDPDMGELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRLV
MUL_3641|M.ulcerans_Agy99 VPLPDPDMGELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRLV
Mflv_2691|M.gilvum_PYR-GCK VALPDEYLGEKICAAVVFTGPP---LTLADLNAFLDERGASTHARPDVLV
Mvan_3850|M.vanbaalenii_PYR-1 VALPDEYLGEKICAAVVFRGKP---ITLAELNAFLDERGASKHARPDVLM
TH_2907|M.thermoresistible__bu VPLPDEFLGEKICAAVVFRGAP---VSLTELNGYLDERGVATHARPDVLV
MSMEG_4516|M.smegmatis_MC2_155 VALPDEFLGEKICAVVVFNGPP---VSLAELHAHLEQRGVAAHSRPDALV
MAB_2247c|M.abscessus_ATCC_199 VGLPDQYLGEIVCAAIVFKGKP---VAAAELNQHLQARGAATHSRVDKLV
MLBr_01051|M.leprae_Br4923 VGLPDEDLGQRIVAFVVGAEAL----DADELINYVAQQ-LSIHKRPREVR
* *** :*: : * :* * .: : : * * :
Mb2405|M.bovis_AF2122/97 AMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
Rv2384|M.tuberculosis_H37Rv AMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
MAV_2008|M.avium_104 AMPSLPTTPIGKIDKKAIANQVSARNRRP------
MMAR_3698|M.marinum_M AMPSLPTTPVGKIDKKAIASQILTTTAT-------
MUL_3641|M.ulcerans_Agy99 AMPSLPTTPVGKIDKKAIASQILTTTAT-------
Mflv_2691|M.gilvum_PYR-GCK PVPSLPTTAVGKVDKKALVAQLTANS---------
Mvan_3850|M.vanbaalenii_PYR-1 PVRSLPTTAVGKVDKKQLGAQLTS-----------
TH_2907|M.thermoresistible__bu ALPSLPMTAVGKVDKKKVVEQVLSQ----------
MSMEG_4516|M.smegmatis_MC2_155 PMPSLPTTAVGKIDKKAIVRQLGG-----------
MAB_2247c|M.abscessus_ATCC_199 AVSALPLTAVGKIDKRALLASLTG-----------
MLBr_01051|M.leprae_Br4923 FVDALPRNAMGKVLKKQLLFEG-------------
: :** ..:**: *: : .