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VDMIRQEFDVVVIGGGVGGVAAARKLAAAGLTVAIIEDRLVGGECHYFGCNPSKTLIRPIEVFNLARAVP GVRETIGKEIVYTPRVFDKRDAIIEYLSDHDRTTSLQQAGAAVFHGSGRLSGPRTVRVTHTDRHAGHTDS VLTALHAVVLATGTRPNIPAVPGLAQARPWTNRDLTTMTHVPGRTLVVGGGPMSVEFSTILAGLGSEVTH LVRGNSLLGGCEPEAREMVTQSLRDNGVTFHFGTQLSGVARPVPAGPVTVTFKNRTAEVDEIVLAAGRHT NTDDLGLDTVGLRSGEIVAVNDNLQAVGVPGGWLYALGDTTGRARLSHISTYHGRLAADIIVARAAGHHH LLDELSARDAHSQAQVIFTDPQLVRVGRSEHQARAEGLAVRTRTAHYPEAVTHFALNRDEFVGWAKLVID DEHNTLLGATFVGPQFSELVQAATLAIVAKLPISLLRHAVAPHPTINQAWDPLLAQETELVQHLRTCEPT THRVAL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4422 | - | - | 100% (496) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4023 | - | 3e-84 | 40.72% (474) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0903 | lpdA | 4e-44 | 28.96% (473) | dihydrolipoamide dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0819c | - | 6e-49 | 41.77% (249) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3059 | - | 2e-44 | 28.57% (476) | mercuric reductase |
| M. tuberculosis H37Rv | Rv0794c | - | 1e-91 | 40.34% (476) | oxidoreductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 1e-36 | 27.37% (475) | dihydrolipoamide dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3014 | - | 3e-47 | 29.34% (484) | mercuric reductase |
| M. marinum M | MMAR_4894 | lpdB | 9e-92 | 42.41% (474) | dihydrolipoamide dehydrogenase, LpdB |
| M. avium 104 | MAV_2396 | - | 2e-39 | 27.59% (482) | mercuric reductase |
| M. thermoresistible (build 8) | TH_4200 | - | 4e-43 | 29.05% (475) | PUTATIVE dihydrolipoamide dehydrogenase |
| M. ulcerans Agy99 | MUL_0404 | lpdB | 1e-90 | 41.77% (474) | dihydrolipoamide dehydrogenase, LpdB |
| M. vanbaalenii PYR-1 | Mvan_3468 | - | 1e-40 | 27.04% (466) | mercuric reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3059|M.gilvum_PYR-GCK -------------------------MSETATQKFDAIIIGAGQAGPPLAA
Mvan_3468|M.vanbaalenii_PYR-1 ----------------------------MSAQHFDAIIVGAGQAGPPLAG
MAV_2396|M.avium_104 -----------------------------MTKHFDAIIVGAGQAGPPLAG
MAB_3014|M.abscessus_ATCC_1997 -----------------------------MSTHFDAVVVGAGQAGPSLAA
MLBr_02387|M.leprae_Br4923 ------------------------------MTHYDVVVLGAGPGGYVAAI
TH_4200|M.thermoresistible__bu ---------------------------VEAVSHYDVVVLGAGPGGYVAAI
Mb0819c|M.bovis_AF2122/97 ------------MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVAD
Rv0794c|M.tuberculosis_H37Rv ------------MTAAQQDQAPMATPGCREGETYDVVVLGAGPVGQNVAD
MMAR_4894|M.marinum_M ----------------MTEDERARIPAGEPDLSFDVIVLGAGPVGENAAD
MUL_0404|M.ulcerans_Agy99 MRGVASQRESTEGSAAVTEDERARIPAGEPDLSFDVIVLGAGPVGQNAAD
MSMEG_4422|M.smegmatis_MC2_155 ----------------------MDMIR----QEFDVVVIGGGVGGVAAAR
:*.:::*.* * *
Mflv_3059|M.gilvum_PYR-GCK RLTAAGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRGADFGI
Mvan_3468|M.vanbaalenii_PYR-1 RLTAAGQTVAVIERKLVGGTCVNYGCIPTKTLVASAHAAHLARRGNDFGV
MAV_2396|M.avium_104 RLTAAGQRVAIIERKLIGGTCVNTGCIPTKTLVASAHAAHLARRGADYGV
MAB_3014|M.abscessus_ATCC_1997 RLRGAGLTVAIVERHLFGGTCVNTGCRPTKALVASAHAAHMAREAARWGV
MLBr_02387|M.leprae_Br4923 RAAQLGLSTAVVEPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFG
TH_4200|M.thermoresistible__bu RAAQLGQKTAIIEPRYWGGVCLNVGCIPSKALLRNAELASIFTRDAKLFG
Mb0819c|M.bovis_AF2122/97 RARAGGLRVAVVERELVGGECSYWACVPSKALLRPVIAISDARRVDGARE
Rv0794c|M.tuberculosis_H37Rv RARAGGLRVAVVERELVGGECSYWACVPSKALLRPVIAISDARRVDGARE
MMAR_4894|M.marinum_M RCQAAGLHVAVIERDLVGGECSYWACVPSKALLRPVVAVADARRVDGARE
MUL_0404|M.ulcerans_Agy99 RYQAAGLHVAVIERDLVGGECSYWACVPSKALLRPVIAVADARLVDGARE
MSMEG_4422|M.smegmatis_MC2_155 KLAAAGLTVAIIEDRLVGGECHYFGCNPSKTLIRPIEVFNLARAVPGVRE
: * .*::* ** * .* *:*.*:
Mflv_3059|M.gilvum_PYR-GCK GTS-EVTVDMAAVKARKDRISGGDREGLESWLDGMDGATLIRGHARFESP
Mvan_3468|M.vanbaalenii_PYR-1 AAA-GVTVDMAAVKARKDRISVGDREGLESWLAGMKGCTLIRGHARFENP
MAV_2396|M.avium_104 GTG-AISVDMAKVKARKDEIMLGDRKGVEDWLAGMAGCTVVRGHARFRDP
MAB_3014|M.abscessus_ATCC_1997 VVDGSVSMDMVRVRERKDAVILPSRNGGQTWLKDLG-CAIYHEHASFLSP
MLBr_02387|M.leprae_Br4923 ISG-DASFDYGIAYDRSRKVSEGRVAG-VHFLMKKNKITEIHGYGRFTDA
TH_4200|M.thermoresistible__bu IQG-EVTFDYGAAFDRSRKVADGRVSG-VHFLMKKNKITEIHGYGRFTDA
Mb0819c|M.bovis_AF2122/97 AVDGSIN-TAGVFGRRNRYVAHWDDTGQADWVSGIG-ATLIRGDGRLDGP
Rv0794c|M.tuberculosis_H37Rv AVDGSIN-TAGVFGRRNRYVAHWDDTGQADWVSGIG-ATLIRGDGRLDGP
MMAR_4894|M.marinum_M AISDSIS-AAAVFDRRDRYVSNWDDGDQADWVSGIG-ATLIRGHGRLAGP
MUL_0404|M.ulcerans_Agy99 AISGSIS-AAAVFDRRDRYVSNWDDGGQADWVSGIG-ATLIRGHGRLAGP
MSMEG_4422|M.smegmatis_MC2_155 TIGKEIVYTPRVFDKRDAIIEYLSDHDRTTSLQQAG-AAVFHGSGRLSGP
*. : . : : : . : ..
Mflv_3059|M.gilvum_PYR-GCK NTVRVDGTLLGAER-------IFLN---VGGRAVVPDIPG-LADVDYLTN
Mvan_3468|M.vanbaalenii_PYR-1 HTLRVDDQLLEADR-------IFLN---VGGRAVAPDMPG-LADVDYLTN
MAV_2396|M.avium_104 HTLQVGEDLLRAER-------IFLN---VGGRAVVPDIPG-LAEVDFLTN
MAB_3014|M.abscessus_ATCC_1997 TELSVGDEIISAER-------IFLN---VGGRAVVPDWPG-VDDVPLFTN
MLBr_02387|M.leprae_Br4923 NTLSVELSEGVPETP----LKVTFNNVIIATGSKTRLVPGTLLSTNVITY
TH_4200|M.thermoresistible__bu HTIEVELNEGGTEQ-------VTFDNAIIATGSSTKLVPGTSLSENVVTY
Mb0819c|M.bovis_AF2122/97 RRVVVTKSSGES----VALTARHAVVICTGSRPALPDLPG-ITEARPWTN
Rv0794c|M.tuberculosis_H37Rv RRVVVTKSSGES----VALTARHAVVICTGSRPALPDLPG-ITEARPWTN
MMAR_4894|M.marinum_M RRVSVSDHDGQT----LMIAARHAVVVCTGSRPTLPDLPG-ITEAWPWTN
MUL_0404|M.ulcerans_Agy99 RRISVSDHDGQT----LMIAARHAVVVCTGSRPTLPDLPG-ITEAWPWTN
MSMEG_4422|M.smegmatis_MC2_155 RTVRVTHTDRHAGHTDSVLTALHAVVLATGTRPNIPAVPG-LAQARPWTN
: * . . . ** . *
Mflv_3059|M.gilvum_PYR-GCK VGILDLGVVPEHLVIIGGSYIALEFAQMYRRFGAEVTVVEKGPRLTARED
Mvan_3468|M.vanbaalenii_PYR-1 VGILDLDEVPEHLVVIGGSYIALEFAQMYRRFGAAVTVIERGPRLTARED
MAV_2396|M.avium_104 VSILELDRLPTHLVIVGGSYIALEFAQMYRRFGAAVTVVERGPRLASRED
MAB_3014|M.abscessus_ATCC_1997 SSLIEYDGIPEHLVVIGGSYVGLEFAQIYRRFGSQVTVVHRGPRLVERED
MLBr_02387|M.leprae_Br4923 EEQILTRELPDSIVIVGAGAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED
TH_4200|M.thermoresistible__bu EKLIMTRELPGSIVIAGAGAIGMEFGYIMANYGVDVTVVEFLPRVLPNED
Mb0819c|M.bovis_AF2122/97 RQATDNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRME
Rv0794c|M.tuberculosis_H37Rv RQATDNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRME
MMAR_4894|M.marinum_M RQATEASSVPRRLAIVGAGGVGVEMATAWQGLGSSVILLAR-SRLLSRME
MUL_0404|M.ulcerans_Agy99 RQATEASSAPRRLAIVGAGGVGVEMETAWQGLGSSVTLLAR-SRLLSRME
MSMEG_4422|M.smegmatis_MC2_155 RDLTTMTHVPGRTLVVGGGPMSVEFSTILAGLGSEVTHLVRGNSLLGGCE
* : *.. :.:*: * * : :
Mflv_3059|M.gilvum_PYR-GCK EDVSAVIKDILEAEGIRVELGADAISVAKRRNG--IAVTP--RDGAAPID
Mvan_3468|M.vanbaalenii_PYR-1 EDVSAAIKEILEAEGIDVVVGADAISFAKQADG--FTVTP--RAGAEPIG
MAV_2396|M.avium_104 EDVSAAVQEILRAEGIDIVVNADDVRIAKTGNG--FELTS--RDGAPPIR
MAB_3014|M.abscessus_ATCC_1997 PDASAIIQEVLEREGITFRLNASCINLARHDEG--VAVGVDCTDGAPKVV
MLBr_02387|M.leprae_Br4923 AEVSKEIEKQFKKMGIKILTGTKVESISDNGS--HVLVAVSKDGQFQELK
TH_4200|M.thermoresistible__bu PEVSREIEKQFKKLGVKIHTGTKVESITDNGAGGSVVVKVSKDGESSELK
Mb0819c|M.bovis_AF2122/97 PFVGELIGRGLADAGVDVRVGVSVRALGRPNP------------------
Rv0794c|M.tuberculosis_H37Rv PFVGELIGRGLADAGVDVRVGVSVRALGRPNPTGPVVLEL---DDGTELR
MMAR_4894|M.marinum_M PFVGDFVGRGLTRSGVDVRVGISVRALHRPHPDAPVTLEL---DDDTRLE
MUL_0404|M.ulcerans_Agy99 PFVGDFVGRGLTRAGVDVRVGISVRALHRPHPDAPVTLEI---DDDTRLE
MSMEG_4422|M.smegmatis_MC2_155 PEAREMVTQSLRDNGVTFHFGTQLSGVARPVPAGPVTVTF---KNRT-AE
. : : *: . . . .
Mflv_3059|M.gilvum_PYR-GCK ASHLLVAVGRVPNTDDLGLEAAGVETDKRGYVVVDDQLRTSAEN---IWA
Mvan_3468|M.vanbaalenii_PYR-1 GSHLLVAVGRRPNTDDLNLEAAGVQTDSRGYIVVDDQLRTSADN---IWA
MAV_2396|M.avium_104 GSHLLLAVGRRPNTDDLDLAVAGVRTDARGYILVDDQLKTNVEH---IWA
MAB_3014|M.abscessus_ATCC_1997 GSHVLVAVGRRPNTDDLGLENAGVATDARGYITVDDQLRTSTPG---IWA
MLBr_02387|M.leprae_Br4923 ADKVLQAIGFAPNVDGYGLDKVGVALTADKAVDIDDYMQTNVSH---IYA
TH_4200|M.thermoresistible__bu ADKVLQAIGFAPNVDGYGLDRAGVRLDDRQAIAIDDYMRTSVPH---IYA
Mb0819c|M.bovis_AF2122/97 ---------------------LAQWSSS--WTTVPSCGSTR-------YS
Rv0794c|M.tuberculosis_H37Rv VDEVLFATGRAPRTDDIGLETIGLTPGS--WLDVDDTCRVRAVDDGWLYA
MMAR_4894|M.marinum_M VDEVLFATGRAPRTDDIGLQTVGLAPGN--WLDVDDTCRVNAVDGGWLYA
MUL_0404|M.ulcerans_Agy99 VDEVLFATGRAPRTDDIGLQTVGLAPGN--WLDVDDTCRVNAVDGGWLYA
MSMEG_4422|M.smegmatis_MC2_155 VDEIVLAAGRHTNTDDLGLDTVGLRSGE--IVAVNDNLQAVGVPGGWLYA
. : . . ::
Mflv_3059|M.gilvum_PYR-GCK MGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRVSD-------------RI
Mvan_3468|M.vanbaalenii_PYR-1 MGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRVSD-------------RV
MAV_2396|M.avium_104 MGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRVSD-------------RI
MAB_3014|M.abscessus_ATCC_1997 LGDCNGRGAFTHTSYNDFEIVAANLLDDDPRRVTD-------------RL
MLBr_02387|M.leprae_Br4923 IGDVTGKLQLAHVAEAQGVVAAEAIAGAETLALSDY------------RM
TH_4200|M.thermoresistible__bu IGDVTAKLQLAHVAEAMGVVAAETIAGVETLPLGDY------------RM
Mb0819c|M.bovis_AF2122/97 S-------------------------PPAEHREPTTSAWRQ---------
Rv0794c|M.tuberculosis_H37Rv AGDVNHRALLTHQGKYQARIAGTAIGARAAGRPLDTTSWGMHATTADHHA
MMAR_4894|M.marinum_M AGDVNHRALLTHQGKYQARIAGSAIGARAAGDSLDTAPWGAHATTADHHA
MUL_0404|M.ulcerans_Agy99 AGDVNHRALLTHQGKYQARIAGSAIGARAAGDSLDTAPWGAHATTADHHA
MSMEG_4422|M.smegmatis_MC2_155 LGDTTGRARLSHISTYHGRLAADIIVARAAGHHHLLDELSAR----DAHS
Mflv_3059|M.gilvum_PYR-GCK TTYALYIDPPLGRAGMTADEVRRTGR--KALVGKRPMTRVGRAVEKGETQ
Mvan_3468|M.vanbaalenii_PYR-1 TTYALYIDPPLGRAGMTVEEVRRSGR--KALVGKRPMTRVGRAVEKGETQ
MAV_2396|M.avium_104 TTYALYIDPPLGRAGMTVAQVRASGR--RALVGKRPMTRVGRAVEKGETQ
MAB_3014|M.abscessus_ATCC_1997 PCYALYTDPPLGRVGMTEAQARASGR--SLLVGRKPMSHVGRALEKGETD
MLBr_02387|M.leprae_Br4923 MPRATFCQPNVASFGLTEQQARDGGY--DVVVAKFPFTANAKAHGMGDPS
TH_4200|M.thermoresistible__bu MPRATFCQPQVASFGLTEEQAREEGY--DVKVAKFPFTANGKAHGMGAPS
Mb0819c|M.bovis_AF2122/97 --------------------------------------------------
Rv0794c|M.tuberculosis_H37Rv VPQAFFTDPEAAAVGLTADQAAQAGHRIKAIDVEIGDVVMGAKLFADGYT
MMAR_4894|M.marinum_M VPQAFFTDPEAAAVGLTAEQAARAGHRIKTIDVDIGDVVTGAKLFADGYA
MUL_0404|M.ulcerans_Agy99 VPQAFFTDPEAAAVGLTTEQAARAGHRIKTIDVEIGDVVTGAKLFADGYA
MSMEG_4422|M.smegmatis_MC2_155 QAQVIFTDPQLVRVGRSEHQARAEGLAVRTRTAHYPEAVTHFALNRDEFV
Mflv_3059|M.gilvum_PYR-GCK GFMKVVVDAETEEILGASILGVGGDEVVHLILDVMTAKLPYTAISRTMHI
Mvan_3468|M.vanbaalenii_PYR-1 GFMKVVVDAETDEILGAAILGVGGDEVVHLILDVMTAKLPYTAISRTMHI
MAV_2396|M.avium_104 GFMKVVVDADTREILGAAILGVGGDEAIHGILDVMSAKAPYTTLSRTMHI
MAB_3014|M.abscessus_ATCC_1997 GYMQVLVDADSDLILGATILGVGGDEVVHCLLDTMQYGIPARQLQRTVHI
MLBr_02387|M.leprae_Br4923 GFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTATELVRNVHT
TH_4200|M.thermoresistible__bu GFVKLIADAKYGELLGGHMVGHDVSELLPELTLAQKWDLTAHELARNVHT
Mb0819c|M.bovis_AF2122/97 --------------------------------------------------
Rv0794c|M.tuberculosis_H37Rv GRARMVVDVDRGHLLGVTMVGPGAAELLHSATVAVAGQVPIDRLWHAVPC
MMAR_4894|M.marinum_M GRARMVVDVDRGCLLGVTIVGPGAAELLHAATIAIAGQVPIDRLWHAVPC
MUL_0404|M.ulcerans_Agy99 GRARMVVDVDRGCLLGVTIVGPRAAELLHAATIAIAGQVPIDRLWHTVPC
MSMEG_4422|M.smegmatis_MC2_155 GWAKLVIDDEHNTLLGATFVGPQFSELVQAATLAIVAKLPISLLRHAVAP
Mflv_3059|M.gilvum_PYR-GCK HPTVSELVPTLLQDLHPLT---------------
Mvan_3468|M.vanbaalenii_PYR-1 HPTVSELIPTVLQELKPLA---------------
MAV_2396|M.avium_104 HPTVSELIPTMLQQMSPLA---------------
MAB_3014|M.abscessus_ATCC_1997 HPTVAEFLPTILGELQPLI---------------
MLBr_02387|M.leprae_Br4923 HPTLSEALQECFHGLIGHMINF------------
TH_4200|M.thermoresistible__bu HPTLSEAMQECFHGLVGHMINF------------
Mb0819c|M.bovis_AF2122/97 ----------------------------------
Rv0794c|M.tuberculosis_H37Rv FPTISELWLRLLESYRDSFYLLV-----------
MMAR_4894|M.marinum_M FPTISELWLRLLEAYRDSFFVLV-----------
MUL_0404|M.ulcerans_Agy99 FPTISELWLRLLEAYRDSFFVLV-----------
MSMEG_4422|M.smegmatis_MC2_155 HPTINQAWDPLLAQETELVQHLRTCEPTTHRVAL