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DETDSTESSRWPSRVLCALATLEGLGQHPTDAATLKEAVAARYAAEFVERDRQYENNLPFWHNRVDDAVR QLRRRRLLTAKNKGRPQEIAFTESGRQAAERACAQDAGDAERAEKTVPAGRALTPRPARDERPRRDPVLA GVVTPPLRERMAEVPDERPIPIMIELNLGFQPTAQAARDRVRSLWGLVGAAGEPGDLADQFMVGDLTAAQ IKQLVSADAVPQIWPGRAIYRIWPDFDVQPLIDASSRTVKAVAAQRSFDSFGDGIVWAVVDSGIEKRHPH FAAHQNLDHPSVADLHRDFTGGAAPLTDTDGHGTHVAGIIAGGLVGWTGKVVVAEKRLNAPEGGDAIMQP REVDPDRLAGMAPRAKLVSLKVLGPGDHVSRVSRVMAALAYVRELNAGSERVPRIHGVNLSLGYPFDAEW YACGQSPLCVEVDKTVRSGVVVVVAAGNSGYVSLNVASSKDSMKFTADMTINDPGNTESAITVGSTHRSS PHTFGVSYFSSRGPTGDGRAKPDLVAPGERITSAAAGTRRSTVTNQIDVPDGVPVYIEESGTSMAAPHVS GAVAAFLSVQREFVSRPEAVKRIFTESATSLGRDRSFQGSGLVDLLRALQSV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4203 | - | - | 100% (613) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. smegmatis MC2 155 | MSMEG_0624 | - | 8e-13 | 25.82% (364) | subtilase family protein |
| M. smegmatis MC2 155 | MSMEG_1533 | - | 4e-09 | 26.39% (360) | subtilase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0299 | - | 4e-16 | 26.99% (389) | protease precursor |
| M. gilvum PYR-GCK | Mflv_4961 | - | 7e-07 | 27.15% (361) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. tuberculosis H37Rv | Rv0291 | mycP3 | 4e-16 | 26.99% (389) | membrane-anchored mycosin |
| M. leprae Br4923 | MLBr_02528 | - | 3e-13 | 26.03% (388) | putative protease |
| M. abscessus ATCC 19977 | MAB_3910 | - | 2e-97 | 46.50% (514) | Serine peptidase |
| M. marinum M | MMAR_0550 | mycP3 | 2e-13 | 27.95% (365) | membrane-anchored mycosin MycP3 |
| M. avium 104 | MAV_4862 | - | 2e-11 | 28.69% (366) | subtilase family protein |
| M. thermoresistible (build 8) | TH_3348 | - | 6e-07 | 25.14% (358) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_1213 | mycP3 | 4e-13 | 27.67% (365) | membrane-anchored mycosin MycP3 |
| M. vanbaalenii PYR-1 | Mvan_0421 | - | 6e-10 | 27.22% (371) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0299|M.bovis_AF2122/97 --------------------------------------------------
Rv0291|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0550|M.marinum_M --------------------------------------------------
MUL_1213|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02528|M.leprae_Br4923 --------------------------------------------------
MAV_4862|M.avium_104 --------------------------------------------------
Mvan_0421|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3348|M.thermoresistible__bu --------------------------------------------------
Mflv_4961|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4203|M.smegmatis_MC2_155 MDETDSTESSRWPSRVLCALATLEGLGQHPTDAATLKEAVAARYAAEFVE
MAB_3910|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0299|M.bovis_AF2122/97 ------------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAA
Rv0291|M.tuberculosis_H37Rv ------------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAA
MMAR_0550|M.marinum_M ------------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDS
MUL_1213|M.ulcerans_Agy99 ------------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDS
MLBr_02528|M.leprae_Br4923 --------MMRSELRIGLAGIATTLVVFQATLLRGCPWALAISPPVVDPG
MAV_4862|M.avium_104 ------------MIRPASACLAAVLALLPATATWASPPALAISPPTVDPG
Mvan_0421|M.vanbaalenii_PYR-1 -------------MRAHPWALAAAVALLAAS----APPAGAITPPEVDPA
TH_3348|M.thermoresistible__bu ---------------LGVLITALLLAVVT------APPAGAIEPPVIDPA
Mflv_4961|M.gilvum_PYR-GCK ------------MTRTWRVAAVTAIALMHT-----TPTAAAIGPPPVDTL
MSMEG_4203|M.smegmatis_MC2_155 RDRQYENNLPFWHNRVDDAVRQLRRRRLLTAKNKGRPQEIAFTESGRQAA
MAB_3910|M.abscessus_ATCC_1997 --------------MSDPAPRGPKRPSVISP--------MVLAPAG-TTE
.: .
Mb0299|M.bovis_AF2122/97 AQPPSGDPGPVAPME-----------------------------------
Rv0291|M.tuberculosis_H37Rv AQPPSGDPGPVAPME-----------------------------------
MMAR_0550|M.marinum_M VQPPSGTPGPVQTME-----------------------------------
MUL_1213|M.ulcerans_Agy99 VQPPSGTPGPVQTME-----------------------------------
MLBr_02528|M.leprae_Br4923 VPPPNGAPGPVQIMQ-----------------------------------
MAV_4862|M.avium_104 VPPPSGAPGPGQPME-----------------------------------
Mvan_0421|M.vanbaalenii_PYR-1 VPPPGGSVGPVGAMA-----------------------------------
TH_3348|M.thermoresistible__bu AVPPD-ETGPDNPME-----------------------------------
Mflv_4961|M.gilvum_PYR-GCK RLPTADPPAPAQPTV-----------------------------------
MSMEG_4203|M.smegmatis_MC2_155 ERACAQDAGDAERAEKTVPAGRALTPRPARDERPRRDPVLAGVVTPPLRE
MAB_3910|M.abscessus_ATCC_1997 AKALATDAADHER-------------------------------------
. .
Mb0299|M.bovis_AF2122/97 -------QRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVA
Rv0291|M.tuberculosis_H37Rv -------QRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEGQLVA
MMAR_0550|M.marinum_M -------QRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEGQLVA
MUL_1213|M.ulcerans_Agy99 -------QRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEGQLVA
MLBr_02528|M.leprae_Br4923 -------QRGSCITSGVIPGTDLGIVTSSQSMLNLPAAWQFSRGEGQLVA
MAV_4862|M.avium_104 -------QRAPCTTSGVIPGSEPAAVTPSQSALNLPAAWRFSRGDGQLVA
Mvan_0421|M.vanbaalenii_PYR-1 -------QRNPCVISTALPGTDPGAATPDRTALRLSEAWTHSRGEGQTVA
TH_3348|M.thermoresistible__bu -------QRRVCAAPTVYPDSNFADRPWASDYLRLTEAHKFATGAGITVA
Mflv_4961|M.gilvum_PYR-GCK -------QFTDCVAAPPAAGSAPGQLAG----MDLPTVWALTRGAGQTVA
MSMEG_4203|M.smegmatis_MC2_155 RMAEVPDERPIPIMIELNLGFQPTAQAARDRVRSLWGLVGAAGEPGDLAD
MAB_3910|M.abscessus_ATCC_1997 --------RLVLIELRLDGGMDPNEVRADFLRLFRRALGGVPPAPTPIAG
. . .
Mb0299|M.bovis_AF2122/97 IIDTGVQPGPRLPNVDAGGDFVEST--------------DGLTDCDGHGT
Rv0291|M.tuberculosis_H37Rv IIDTGVQPGPRLPNVDAGGDFVEST--------------DGLTDCDGHGT
MMAR_0550|M.marinum_M ILDTGVQPGPRLPNVDAGGDFVDST--------------DGLTDCDGRGT
MUL_1213|M.ulcerans_Agy99 ILDTGVQPGPRLPNVDAGGDFVDST--------------DGLTDCDGRGT
MLBr_02528|M.leprae_Br4923 IVDTGVRPGPRLPNVEAGGDYVESS--------------DGLTDCDGHGT
MAV_4862|M.avium_104 VLDTGVRPGPRLPNVEPGGDFVETT--------------DGLTDCDGHGT
Mvan_0421|M.vanbaalenii_PYR-1 VLDTGVKPGPRLPDVEAGGDYVASG--------------DGLTDCDGQGT
TH_3348|M.thermoresistible__bu VIDTGVNGSPRVP-AEPGGDFVDAAG-------------NGMSDCDAHGT
Mflv_4961|M.gilvum_PYR-GCK VIDTGTARHRRLPHLVPGGDYVSHR--------------DGTDDCDGHGT
MSMEG_4203|M.smegmatis_MC2_155 QFMVGDLTAAQIKQLVSADAVP-----QIWPGRAIYRIWPDFDVQPLIDA
MAB_3910|M.abscessus_ATCC_1997 HYVRCSLTADEVKLLVNGGSKSGGTKSAQRALQLIYRVWPDLRVKPHLDK
.: .. . .
Mb0299|M.bovis_AF2122/97 LVAGIVAGQP---GNDGFSGVAPAARLLSIRAMSTKFS----PRTSGGDP
Rv0291|M.tuberculosis_H37Rv LVAGIVAGQP---GNDGFSGVAPAARLLSIRAMSTKFS----PRTSGGDP
MMAR_0550|M.marinum_M LVAGIVAGQP---GNDGFSGVAPAARLLSIRVTSDKFS----ARSSGGDP
MUL_1213|M.ulcerans_Agy99 LVAGIVAGQP---GNDGFSGVAPAARLLSIRVTSDKFS----ARSSGGDP
MLBr_02528|M.leprae_Br4923 LVAGIVAGQPAPSGEDGFSGVAPAARLLSIRVTSAKFS----LRSLGGDP
MAV_4862|M.avium_104 LLAGLVAGQP--SPDDGFAGVAPAARVVSIRTTSAKFS----PRTPGGDP
Mvan_0421|M.vanbaalenii_PYR-1 LVAGLIAGQP---GADGFSGVAPAARILSIRVSSPRYA----PRDAGEDP
TH_3348|M.thermoresistible__bu LTASVIAGRG--APTDGFIGVAPDARILSLRHTSAAFQPVG-ARTDPNNP
Mflv_4961|M.gilvum_PYR-GCK LVAGIIGASPDAADPGGFTGIAPDVSLLSIRQSSNKFR-------AVDDP
MSMEG_4203|M.smegmatis_MC2_155 SSRTVKAVAAQRSFDSFGDGIVWAVVDSGIEKRHPHFAAHQNLDHPSVAD
MAB_3910|M.abscessus_ATCC_1997 SVATIKADAALRTYGSGGSGIVWGVLDSGIEASHPHFAKNGNLTGDAVSS
: . . *:. . .:. :
Mb0299|M.bovis_AF2122/97 QLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALGAAI
Rv0291|M.tuberculosis_H37Rv QLAQATLDVAVLAGAIVHAADLGAKVINVSTITCLPADRMVDQAALGAAI
MMAR_0550|M.marinum_M SVERATIDVAALGRAIVHAADRGARVINISSITCLPADRQVDQAALGAAI
MUL_1213|M.ulcerans_Agy99 SVERATIDVAALGRAIVHAADRGARVINISSITCLPADRQVDQAALGAAI
MLBr_02528|M.leprae_Br4923 QLKQASLEVTRLSRAIVHAADLGARVINISAITCLPADRSIDQSGLGAAI
MAV_4862|M.avium_104 LLARAAAEVGTLARAIVHAADLGARVIDIGSATCLPVDRPVDQAALGAAV
Mvan_0421|M.vanbaalenii_PYR-1 AVTRAMLETEAMAGAIVRAADLGARVINISAVTCVPVGENFDQSGLGAAL
TH_3348|M.thermoresistible__bu NTTQTAGSLRSLARAIVHAANLGAQVINISEAACYKVTRPIDETGVGAAV
Mflv_4961|M.gilvum_PYR-GCK -GGSGVGDVETLAAAVRTAADLGATVINISTVACLPVAAGLDDRTLGAAL
MSMEG_4203|M.smegmatis_MC2_155 LHRDFTG----GAAPLTDTDGHGTHVAGIIAGGLVGWTGKVVVAEKRLNA
MAB_3910|M.abscessus_ATCC_1997 LHKDFSLSQHPSTGPLVDMQGHGTHVAGIIAGECPDPT-NVVIASTQPTA
.: . *: * .: .
Mb0299|M.bovis_AF2122/97 R------------------YAAVDKDAVIVAAAGNTGASGSVS--ASCDS
Rv0291|M.tuberculosis_H37Rv R------------------YAAVDKDAVIVAAAGNTGASGSVS--ASCDS
MMAR_0550|M.marinum_M R------------------YAAVDKDVVIVAAAGNSGAGGSGSG-GTCES
MUL_1213|M.ulcerans_Agy99 R------------------YAAVDKDVVIVAAAGNSGAGGSGSG-GTCES
MLBr_02528|M.leprae_Br4923 R------------------YAAVDKDALLVAPAGNAGSTGTVGGNMNCES
MAV_4862|M.avium_104 R------------------YAAVDKDAVIVAAAGDSGPTGSFAGGTSCES
Mvan_0421|M.vanbaalenii_PYR-1 R------------------YAAVDRDVVIVAAAGEGGAAG------GCDS
TH_3348|M.thermoresistible__bu N------------------YAVHVKNAVVIAAAGNTG--------QDCTQ
Mflv_4961|M.gilvum_PYR-GCK S------------------YAVEAKNVVVVTAAGNVGGPG------QCQD
MSMEG_4203|M.smegmatis_MC2_155 PEGGDAIMQPREVDP-DRLAGMAPRAKLVSLKVLGPGDHVSRVSRVMAAL
MAB_3910|M.abscessus_ATCC_1997 --EGFPEWIPRTLAPGSRLSGVAPQAGLVSLKVLN-DEGTTVESVLIDAL
. : :: . .
Mb0299|M.bovis_AF2122/97 NPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVLSVASLTSAGQPSKFSMPG
Rv0291|M.tuberculosis_H37Rv NPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVLSVASLTSAGQPSKFSMPG
MMAR_0550|M.marinum_M NPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVLSVASLTAGGQPSKFTMAG
MUL_1213|M.ulcerans_Agy99 NPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVLSVASLTAGGQPSKFTMAG
MLBr_02528|M.leprae_Br4923 NPLTDLGRPDDPRNWASVTSVSIPSWWQPYVLSVASLTPSGRPSKFTMAG
MAV_4862|M.avium_104 NPLTDLSRPSDPRNWAGVTSLSIPSWWQPYVLSVASLTPDGQPSKFTVAG
Mvan_0421|M.vanbaalenii_PYR-1 NPLSDPALPSDPRNWSGVTAVAIPAWWQQYVLSVGSLAPDGTPSSFTMAG
TH_3348|M.thermoresistible__bu NPPPDPAVPSDPRGWQQVQTIVSPAWYSPLVLTVGGIGPTGQPSNFSMSG
Mflv_4961|M.gilvum_PYR-GCK PNPRDVGAADQVR------TVASPAWYDDYVLTVGSVGTDGSPSEFSLAG
MSMEG_4203|M.smegmatis_MC2_155 AYVRELNAGSERVPRIHGVNLSLGYPFDAEWYACGQSPLCVEVDKTVRSG
MAB_3910|M.abscessus_ATCC_1997 HYVRERNSYGN-ELRIHGVNLSLGCDWIPRYYAAGQSPLCRELDLLTDSG
: .: : : : . . .*
Mb0299|M.bovis_AF2122/97 PWVGIAAPGENIASVSNSGDGALANGLPDAHQKLVALSGTSYAAGYVSGV
Rv0291|M.tuberculosis_H37Rv PWVGIAAPGENIASVSNSGDGALANGLPDAHQKLVALSGTSYAAGYVSGV
MMAR_0550|M.marinum_M PWVGIAAPGENIVSVSNADGGGLANGLPNQRQQLTPLSGTSYAAGYVSGV
MUL_1213|M.ulcerans_Agy99 PWVGIAAPGENIVSVSNADGGGLANGLPNQRQQLTPLSGTSYAAGYVSGV
MLBr_02528|M.leprae_Br4923 PWVGIAAPGENIVSVSNRDSGDLANALPNDRDQQIALNGTSYAAGYVSGV
MAV_4862|M.avium_104 PWVGVAAPGERIVSIGNGDGAGLTNGLPDEHQQLAALNGTGYAAGYVAGV
Mvan_0421|M.vanbaalenii_PYR-1 PWVGIAAPGEDITSVSNDEAGGLANGLPGDRDRIDPVRGTGYATAYVSGV
TH_3348|M.thermoresistible__bu PWVGAAAPAENITALG--YGGEPVNALQGQ-DGLVPVAGTSFAAAYVSGL
Mflv_4961|M.gilvum_PYR-GCK PWVDVAATGEGVVSLAATGDG-LADRSPSD----AALTGTSYAVPVVSAV
MSMEG_4203|M.smegmatis_MC2_155 VVVVVAAGNSGYVSLNVASS-----KDSMKFTADMTINDPGNTESAITVG
MAB_3910|M.abscessus_ATCC_1997 VVTVVSAGNMGAGTDTGGLSGGIVGPQAGVYGQLSTITDPGNAASAITVG
. :* : .: ... : ::
Mb0299|M.bovis_AF2122/97 AALVRSRYPGLNATEVVRRLTATAHRG-----ARESSNIVGAGNLDAVAA
Rv0291|M.tuberculosis_H37Rv AALVRSRYPGLNATEVVRRLTATAHRG-----ARESSNIVGAGNLDAVAA
MMAR_0550|M.marinum_M AALVRSKYPELTAAQVMHRLTATAHNG-----ARDPSNVVGAGILDPAAA
MUL_1213|M.ulcerans_Agy99 ATLVRSNYPELTAAQVMHRLTATAHNG-----ARDPSNVVGAGILDPAAA
MLBr_02528|M.leprae_Br4923 AALVRSKYPELTAKQVMRRITATAHTG-----ARTLSNVVGSGTLDSVAA
MAV_4862|M.avium_104 AALVRSKYPDLSATAVVHRITATAHNG-----ARDPSNVVGAGSVDPVAA
Mvan_0421|M.vanbaalenii_PYR-1 AALVRSRFPDLTARQVIERLTGTAQSA-----ARSPSNLVGAGRIDPVAA
TH_3348|M.thermoresistible__bu AALIRQRYPDLTPAQVINRITATARHP-----GGGVDNYVGAGVIDPVAA
Mflv_4961|M.gilvum_PYR-GCK AALVRARFPEMTARQVMQRIEDTARPS-----SAEWDPVVGHGVVDALAA
MSMEG_4203|M.smegmatis_MC2_155 STHRSSPHTFGVSYFSSRGPTGDGRAKPDLVAPGERITSAAAGTRRSTVT
MAB_3910|M.abscessus_ATCC_1997 STHRSRPHTSGVTYDSSKGPTLDGRTKPDLVAPGERITSAAAGQMAEAFE
:: .. . . .: .. *
Mb0299|M.bovis_AF2122/97 LTWQLPAEPGGG--AAPAKPVADPPVP-APKDTTPRNVAFAGAAALSVLV
Rv0291|M.tuberculosis_H37Rv LTWQLPAEPGGG--AAPAKPVADPPVP-APKDTTPRNVAFAGAAALSVLV
MMAR_0550|M.marinum_M LTWELPAADGGAPQVAPAKPVSVPPAP-QPRNTTPRNVAFAGAAALTVLV
MUL_1213|M.ulcerans_Agy99 LTWELPAADGGAPQVAPAKPVSVPPAP-QPRNTTPRNVAFAGAAALTVLV
MLBr_02528|M.leprae_Br4923 LTWDLPATNDSP--PVPVKLVTVPPPP-APKDNTPRNVAFAGTATLVMVV
MAV_4862|M.avium_104 LTWQLPAGDQPG---PAAKPIAVPPAP-APPDTTPRTVAVAGTAALAVLV
Mvan_0421|M.vanbaalenii_PYR-1 LTWNVPATEEIG--TTAARPVAAPAPP-PPKDPVPRAVAFAGAGVLALVV
TH_3348|M.thermoresistible__bu LTWDVPEGPETA--PYRAKEIPEPEFI-PPPDRGPITWVVVSSAAVALAL
Mflv_4961|M.gilvum_PYR-GCK VSGPGSHPAALP----AAPPVDAPTPA-PARVQRQGATAVRGALICVALT
MSMEG_4203|M.smegmatis_MC2_155 NQIDVPDG-VPVYIEESGTSMAAPHVSGAVAAFLSVQREFVSRPEAVKRI
MAB_3910|M.abscessus_ATCC_1997 MLTRGATGNEARYVEDSGTSMAAAHVSGAIAAFLSARNEFIGEPERVKEI
. : . . .
Mb0299|M.bovis_AF2122/97 GLTAATVAIARRRREPTE-----------
Rv0291|M.tuberculosis_H37Rv GLTAATVAIARRRREPTE-----------
MMAR_0550|M.marinum_M AGVAATVAIARRRKDAEGRTAREL-----
MUL_1213|M.ulcerans_Agy99 AGVAATVAIARRRKDAEGRTAREL-----
MLBr_02528|M.leprae_Br4923 AAVVGTATIAARRREGTTP----------
MAV_4862|M.avium_104 AVAGAVTALAARRRKDPTA----------
Mvan_0421|M.vanbaalenii_PYR-1 LTVS---LMSTRRKETSS-----------
TH_3348|M.thermoresistible__bu GIGALTRRALRRR----------------
Mflv_4961|M.gilvum_PYR-GCK VCVALVSAVIARSRRHG------------
MSMEG_4203|M.smegmatis_MC2_155 FTESATSLGRDRSFQGSGLVDLLRALQSV
MAB_3910|M.abscessus_ATCC_1997 FRKAAIDLGRHEFFQGSGLVNLMQALSDV
.