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MSDPAPRGPKRPSVISPMVLAPAGTTEAKALATDAADHERRLVLIELRLDGGMDPNEVRADFLRLFRRAL GGVPPAPTPIAGHYVRCSLTADEVKLLVNGGSKSGGTKSAQRALQLIYRVWPDLRVKPHLDKSVATIKAD AALRTYGSGGSGIVWGVLDSGIEASHPHFAKNGNLTGDAVSSLHKDFSLSQHPSTGPLVDMQGHGTHVAG IIAGECPDPTNVVIASTQPTAEGFPEWIPRTLAPGSRLSGVAPQAGLVSLKVLNDEGTTVESVLIDALHY VRERNSYGNELRIHGVNLSLGCDWIPRYYAAGQSPLCRELDLLTDSGVVTVVSAGNMGAGTDTGGLSGGI VGPQAGVYGQLSTITDPGNAASAITVGSTHRSRPHTSGVTYDSSKGPTLDGRTKPDLVAPGERITSAAAG QMAEAFEMLTRGATGNEARYVEDSGTSMAAAHVSGAIAAFLSARNEFIGEPERVKEIFRKAAIDLGRHEF FQGSGLVNLMQALSDV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3910 | - | - | 100% (506) | Serine peptidase |
| M. abscessus ATCC 19977 | MAB_2225c | - | 3e-08 | 23.14% (458) | peptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0299 | - | 3e-10 | 26.53% (377) | protease precursor |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0291 | mycP3 | 3e-10 | 26.53% (377) | membrane-anchored mycosin |
| M. leprae Br4923 | MLBr_02528 | - | 1e-08 | 24.10% (361) | putative protease |
| M. marinum M | MMAR_0550 | mycP3 | 5e-11 | 28.57% (329) | membrane-anchored mycosin MycP3 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_4203 | - | 2e-97 | 46.50% (514) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. thermoresistible (build 8) | TH_3265 | - | 1e-05 | 25.78% (322) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_1213 | mycP3 | 7e-11 | 28.53% (326) | membrane-anchored mycosin MycP3 |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0550|M.marinum_M --------------------------------------------------
MUL_1213|M.ulcerans_Agy99 --------------------------------------------------
Mb0299|M.bovis_AF2122/97 --------------------------------------------------
Rv0291|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02528|M.leprae_Br4923 --------------------------------------------------
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_3910|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4203|M.smegmatis_MC2_155 MDETDSTESSRWPSRVLCALATLEGLGQHPTDAATLKEAVAARYAAEFVE
MMAR_0550|M.marinum_M ------------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDS
MUL_1213|M.ulcerans_Agy99 ------------MKRAGSACLTAILAIFTTGALWAAPPVSAISPPAVDDS
Mb0299|M.bovis_AF2122/97 ------------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAA
Rv0291|M.tuberculosis_H37Rv ------------MIRAAFACLAATVVVAG----WWTPPAWAIGPPVVDAA
MLBr_02528|M.leprae_Br4923 --------MMRSELRIGLAGIATTLVVFQATLLRGCPWALAISPPVVDPG
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_3910|M.abscessus_ATCC_1997 --------------MSDPAPRGPKRPSVISP--------MVLAPAG-TTE
MSMEG_4203|M.smegmatis_MC2_155 RDRQYENNLPFWHNRVDDAVRQLRRRRLLTAKNKGRPQEIAFTESGRQAA
MMAR_0550|M.marinum_M VQPPSGTPGPVQTME-----------------------------------
MUL_1213|M.ulcerans_Agy99 VQPPSGTPGPVQTME-----------------------------------
Mb0299|M.bovis_AF2122/97 AQPPSGDPGPVAPME-----------------------------------
Rv0291|M.tuberculosis_H37Rv AQPPSGDPGPVAPME-----------------------------------
MLBr_02528|M.leprae_Br4923 VPPPNGAPGPVQIMQ-----------------------------------
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_3910|M.abscessus_ATCC_1997 AKALATDAADHER-------------------------------------
MSMEG_4203|M.smegmatis_MC2_155 ERACAQDAGDAERAEKTVPAGRALTPRPARDERPRRDPVLAGVVTPPLRE
MMAR_0550|M.marinum_M -------QRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEG----
MUL_1213|M.ulcerans_Agy99 -------QRGACSVSGLIPGTDISVPGASQAMLNLPAAWQFSRGEG----
Mb0299|M.bovis_AF2122/97 -------QRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEG----
Rv0291|M.tuberculosis_H37Rv -------QRGACSVSGVIPGTDPGVPTPSQTMLNLPAAWQFSRGEG----
MLBr_02528|M.leprae_Br4923 -------QRGSCITSGVIPGTDLGIVTSSQSMLNLPAAWQFSRGEG----
TH_3265|M.thermoresistible__bu --------------------------------------------------
MAB_3910|M.abscessus_ATCC_1997 --------RLVLIELRLDGGMDPNEVRADFLRLFRRALGGVPPAPTPIAG
MSMEG_4203|M.smegmatis_MC2_155 RMAEVPDERPIPIMIELNLGFQPTAQAARDRVRSLWGLVGAAGEPGDLAD
MMAR_0550|M.marinum_M ----------QLVAILDTGVQPGPRLPNVDAGGDFVDSTDGLTDCDGRGT
MUL_1213|M.ulcerans_Agy99 ----------QLVAILDTGVQPGPRLPNVDAGGDFVDSTDGLTDCDGRGT
Mb0299|M.bovis_AF2122/97 ----------QLVAIIDTGVQPGPRLPNVDAGGDFVESTDGLTDCDGHGT
Rv0291|M.tuberculosis_H37Rv ----------QLVAIIDTGVQPGPRLPNVDAGGDFVESTDGLTDCDGHGT
MLBr_02528|M.leprae_Br4923 ----------QLVAIVDTGVRPGPRLPNVEAGGDYVESSDGLTDCDGHGT
TH_3265|M.thermoresistible__bu -----------------------------------VQNGDGLTDCDGHGT
MAB_3910|M.abscessus_ATCC_1997 HYVRCSLTADEVKLLVNGGSKSGGTKSAQRALQLIYRVWPDLRVKPHLDK
MSMEG_4203|M.smegmatis_MC2_155 QFMVGDLTAAQIKQLVSADAVP-----QIWPGRAIYRIWPDFDVQPLIDA
.: .
MMAR_0550|M.marinum_M LVAGIVAGQP---GNDGFSGVAPAARLLSIRVTSDKFSARSSGGDPSVER
MUL_1213|M.ulcerans_Agy99 LVAGIVAGQP---GNDGFSGVAPAARLLSIRVTSDKFSARSSGGDPSVER
Mb0299|M.bovis_AF2122/97 LVAGIVAGQP---GNDGFSGVAPAARLLSIRAMSTKFSPRTSGGDPQLAQ
Rv0291|M.tuberculosis_H37Rv LVAGIVAGQP---GNDGFSGVAPAARLLSIRAMSTKFSPRTSGGDPQLAQ
MLBr_02528|M.leprae_Br4923 LVAGIVAGQPAPSGEDGFSGVAPAARLLSIRVTSAKFSLRSLGGDPQLKQ
TH_3265|M.thermoresistible__bu AVAGLIAGQP---GPDGFSGVAPAARLLAIRQTSNHFAPTDAGADPVVTR
MAB_3910|M.abscessus_ATCC_1997 SVATIKADAALRTYGSGGSGIVWGVLDSGIEASHPHFAKNGNLTGDAVSS
MSMEG_4203|M.smegmatis_MC2_155 SSRTVKAVAAQRSFDSFGDGIVWAVVDSGIEKRHPHFAAHQNLDHPSVAD
: * . . .*:. .. .*. :*: :
MMAR_0550|M.marinum_M ATIDVAA----LGRAIVHAADRGARVINISSITCLPADRQVDQAA-----
MUL_1213|M.ulcerans_Agy99 ATIDVAA----LGRAIVHAADRGARVINISSITCLPADRQVDQAA-----
Mb0299|M.bovis_AF2122/97 ATLDVAV----LAGAIVHAADLGAKVINVSTITCLPADRMVDQAA-----
Rv0291|M.tuberculosis_H37Rv ATLDVAV----LAGAIVHAADLGAKVINVSTITCLPADRMVDQAA-----
MLBr_02528|M.leprae_Br4923 ASLEVTR----LSRAIVHAADLGARVINISAITCLPADRSIDQSG-----
TH_3265|M.thermoresistible__bu AGLDVLN----MARAVVRAADLGARVITISTATCLPADNTVAQSQ-----
MAB_3910|M.abscessus_ATCC_1997 LHKDFSLSQHPSTGPLVDMQGHGTHVAGIIAGECPDPT-NVVIASTQPTA
MSMEG_4203|M.smegmatis_MC2_155 LHRDFTG----GAAPLTDTDGHGTHVAGIIAGGLVGWTGKVVVAEKRLNA
:. .:. . *::* : : : :
MMAR_0550|M.marinum_M ------------LGAAIRYAAVDKDVVIVAAAGNS-GAGGSGSG-GTCES
MUL_1213|M.ulcerans_Agy99 ------------LGAAIRYAAVDKDVVIVAAAGNS-GAGGSGSG-GTCES
Mb0299|M.bovis_AF2122/97 ------------LGAAIRYAAVDKDAVIVAAAGNT-GASGSVS--ASCDS
Rv0291|M.tuberculosis_H37Rv ------------LGAAIRYAAVDKDAVIVAAAGNT-GASGSVS--ASCDS
MLBr_02528|M.leprae_Br4923 ------------LGAAIRYAAVDKDALLVAPAGNA-GSTGTVGGNMNCES
TH_3265|M.thermoresistible__bu ------------LGAALRYAAVERDAVIVAAAGDV-RSGGPTG--TACRS
MAB_3910|M.abscessus_ATCC_1997 --EGFPEWIPRTLAPGSRLSGVAPQAGLVSLKVLN-DEGTTVESVLIDAL
MSMEG_4203|M.smegmatis_MC2_155 PEGGDAIMQPREVDP-DRLAGMAPRAKLVSLKVLGPGDHVSRVSRVMAAL
: . * :.: . :*: .
MMAR_0550|M.marinum_M NPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVLSVASLTAGGQPSKFTMAG
MUL_1213|M.ulcerans_Agy99 NPLTDLSHPDDPRNWAGVTSVSIPSLWQPYVLSVASLTAGGQPSKFTMAG
Mb0299|M.bovis_AF2122/97 NPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVLSVASLTSAGQPSKFSMPG
Rv0291|M.tuberculosis_H37Rv NPLTDLSRPDDPRNWAGVTSVSIPSWWQPYVLSVASLTSAGQPSKFSMPG
MLBr_02528|M.leprae_Br4923 NPLTDLGRPDDPRNWASVTSVSIPSWWQPYVLSVASLTPSGRPSKFTMAG
TH_3265|M.thermoresistible__bu NPLGDLSRPDDPRDWAGVGSVSIPSWWQPYVLSVGSLNTAGQPSDFTMSG
MAB_3910|M.abscessus_ATCC_1997 HYVRERNSYGN-ELRIHGVNLSLGCDWIPRYYAAGQSPLCRELDLLTDSG
MSMEG_4203|M.smegmatis_MC2_155 AYVRELNAGSERVPRIHGVNLSLGYPFDAEWYACGQSPLCVEVDKTVRSG
: : . .: .:*: : . : .. . . .*
MMAR_0550|M.marinum_M PWVGIAAPGENIVSVSNADG-----------GGLANGLP-NQRQQLTPLS
MUL_1213|M.ulcerans_Agy99 PWVGIAAPGENIVSVSNADG-----------GGLANGLP-NQRQQLTPLS
Mb0299|M.bovis_AF2122/97 PWVGIAAPGENIASVSNSGD-----------GALANGLP-DAHQKLVALS
Rv0291|M.tuberculosis_H37Rv PWVGIAAPGENIASVSNSGD-----------GALANGLP-DAHQKLVALS
MLBr_02528|M.leprae_Br4923 PWVGIAAPGENIVSVSNRDS-----------GDLANALP-NDRDQQIALN
TH_3265|M.thermoresistible__bu PWVGVAAPGEDIASVSNAPG-----------GGLANALPRGQDQQLAPLA
MAB_3910|M.abscessus_ATCC_1997 VVTVVSAGNMGAGTDTGGLSGGIVGPQAGVYGQLSTITDPGNAASAITVG
MSMEG_4203|M.smegmatis_MC2_155 VVVVVAAGNSGYVSLNVASS-----KDSMKFTADMTINDPGNTESAITVG
. ::* . . : . . . . . .:
MMAR_0550|M.marinum_M GTSYAAGYVSGVAALVR-----SKYPELTAAQVMHRLTATAHNGARDPSN
MUL_1213|M.ulcerans_Agy99 GTSYAAGYVSGVATLVR-----SNYPELTAAQVMHRLTATAHNGARDPSN
Mb0299|M.bovis_AF2122/97 GTSYAAGYVSGVAALVR-----SRYPGLNATEVVRRLTATAHRGARESSN
Rv0291|M.tuberculosis_H37Rv GTSYAAGYVSGVAALVR-----SRYPGLNATEVVRRLTATAHRGARESSN
MLBr_02528|M.leprae_Br4923 GTSYAAGYVSGVAALVR-----SKYPELTAKQVMRRITATAHTGARTLSN
TH_3265|M.thermoresistible__bu GTGYAAGYVAGVAALVR-----SRYPELTAAQVVHRITATAQGAARSPSN
MAB_3910|M.abscessus_ATCC_1997 STHRSRPHTSGVTYDSSKGPTLDGRTKPDLVAPGERITSAAAGQMAEAFE
MSMEG_4203|M.smegmatis_MC2_155 STHRSSPHTFGVSYFSSRGPTGDGRAKPDLVAPGERITSAAAGTRRSTVT
.* : :. **: . . .*:*::*
MMAR_0550|M.marinum_M VVGAGILDPAAALTWELPAADGGAPQVAPAKPVSVPPAPQPRNTTPRNVA
MUL_1213|M.ulcerans_Agy99 VVGAGILDPAAALTWELPAADGGAPQVAPAKPVSVPPAPQPRNTTPRNVA
Mb0299|M.bovis_AF2122/97 IVGAGNLDAVAALTWQLPAEPGGG--AAPAKPVADPPVPAPKDTTPRNVA
Rv0291|M.tuberculosis_H37Rv IVGAGNLDAVAALTWQLPAEPGGG--AAPAKPVADPPVPAPKDTTPRNVA
MLBr_02528|M.leprae_Br4923 VVGSGTLDSVAALTWDLPATNDSP--PVPVKLVTVPPPPAPKDNTPRNVA
TH_3265|M.thermoresistible__bu LIGAGRVDPVAALTWDVPTEPETT--GPAAKPVAAPPEPEAADNTPKIVA
MAB_3910|M.abscessus_ATCC_1997 MLTRGATGNEARYVEDSGTSMAAAHVSGAIAAFLSARNEFIGEPERVKEI
MSMEG_4203|M.smegmatis_MC2_155 NQIDVPDG-VPVYIEESGTSMAAPHVSGAVAAFLSVQREFVSRPEAVKRI
. . : : . .
MMAR_0550|M.marinum_M FAGAAALTVLVAGVAATVAIARRRKDAEGRTAREL
MUL_1213|M.ulcerans_Agy99 FAGAAALTVLVAGVAATVAIARRRKDAEGRTAREL
Mb0299|M.bovis_AF2122/97 FAGAAALSVLVGLTAATVAIARRRREPTE------
Rv0291|M.tuberculosis_H37Rv FAGAAALSVLVGLTAATVAIARRRREPTE------
MLBr_02528|M.leprae_Br4923 FAGTATLVMVVAAVVGTATIAARRREGTTP-----
TH_3265|M.thermoresistible__bu FAGVGVIALLL--VVAAAVAAHRRKDSQT------
MAB_3910|M.abscessus_ATCC_1997 FRKAAIDLGRHEFFQGSGLVNLMQALSDV------
MSMEG_4203|M.smegmatis_MC2_155 FTESATSLGRDRSFQGSGLVDLLRALQSV------
* . .: :