For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TLAYSLDADAEQFLGVVQDFCTSRVGPRAQDIDLTGEFFPDLLADAAAIGLQGLIFTDDGAIDATMFALA HETTELIASYSGAVALGISVARLHGYLLAAYAPSDIRDRWLPGLIDGSIRGSFALSEPHSGTDIRAGRTV AVEHGDGTVSITGEKAWITQSPAAHFCIVLAKLGSTDRDAPTAAFVVPLDTDGVTVGKDEPMSGFRGMPM ANVHFDNCRIPSSWRLQTDGFRGMMEGLNLARLDAGCYGVGFMRAALREATAYVRDRQAFGKTLADLQIV QEKLGRLHADYLAARGLLREGVASYAGGGGGDPHLISAAKMFATDAAMRNTVEAVQLLGGYGVHLHYPVQ RLMRDAKITQIIDGTSEIHALMLGRAAVRTAWS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4166 | - | - | 100% (384) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0108 | - | 5e-46 | 32.62% (374) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1821 | - | 3e-43 | 30.16% (378) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3302c | fadE25 | 2e-42 | 31.58% (380) | acyl-CoA dehydrogenase FADE25 |
| M. gilvum PYR-GCK | Mflv_4943 | - | 3e-47 | 34.87% (347) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3274c | fadE25 | 2e-42 | 31.58% (380) | acyl-CoA dehydrogenase FADE25 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 8e-43 | 30.87% (379) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3618c | - | 4e-46 | 31.20% (375) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_1262 | fadE25 | 3e-46 | 30.69% (378) | acyl-CoA dehydrogenase FadE25 |
| M. avium 104 | MAV_4243 | - | 2e-44 | 30.16% (378) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3846 | - | 1e-44 | 32.79% (366) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2626 | fadE25 | 7e-47 | 30.95% (378) | acyl-CoA dehydrogenase FadE25 |
| M. vanbaalenii PYR-1 | Mvan_1719 | - | 2e-45 | 29.89% (378) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3302c|M.bovis_AF2122/97 MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
Rv3274c|M.tuberculosis_H37Rv MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEE
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
TH_3846|M.thermoresistible__bu MAAWSGNPSFELFQLPEEHIALREAIRALAEKEIAPYAAEVDEKARFPEE
MMAR_1262|M.marinum_M MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
MUL_2626|M.ulcerans_Agy99 MAGWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
Mvan_1719|M.vanbaalenii_PYR-1 MASWAGNPSFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
MAV_4243|M.avium_104 MAGWAGNPDFDLFQLPEEHQELRAAIRALAEKEIAPHAADVDENSRFPQE
MAB_3618c|M.abscessus_ATCC_199 ---MAGNPSFDLFKLGEEHDELRAAIRGLAEKEIAPHAKDVDEKARFPQE
Mflv_4943|M.gilvum_PYR-GCK -------MPVDRLLPTDDARDLVELARQIADKVLDPIVDRHEKDETYPEG
MSMEG_4166|M.smegmatis_MC2_155 --------MTLAYSLDADAEQFLGVVQDFCTSRVGPRAQDIDLTGEFFPD
: : : :. . : * . : :
Mb3302c|M.bovis_AF2122/97 ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
Rv3274c|M.tuberculosis_H37Rv ALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVN
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
TH_3846|M.thermoresistible__bu ALAALNSSGFSAIHVPEEYGGQGADSVATCIVIEEVARVDCSASLIPAVN
MMAR_1262|M.marinum_M ALDALNASGFNAVHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
MUL_2626|M.ulcerans_Agy99 ALDALNASGFNALHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
Mvan_1719|M.vanbaalenii_PYR-1 ALDALNASGFNAVHVPEEFGGQGADSVAACIVIEEVARVDASASLIPAVN
MAV_4243|M.avium_104 ALEALNAAGFNAVHVPEEYGGQGADSVAACIVIEEVARVDTSASLIPAVN
MAB_3618c|M.abscessus_ATCC_199 ALDALVASGFNAVHVPEEYDGQGADSVAACIVIEEVARVCASSSLIPAVN
Mflv_4943|M.gilvum_PYR-GCK VFATLGEAGLLSLPYPEEWGGGGQPYEVYLQVLEELAARWAAVAVAVSVH
MSMEG_4166|M.smegmatis_MC2_155 LLADAAAIGLQGLIFTDDGAIDATMFALAHETTELIASYSGAVALGISVA
: *: .: .:: . . * :* : :: :*
Mb3302c|M.bovis_AF2122/97 KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
Rv3274c|M.tuberculosis_H37Rv KLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRA
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
TH_3846|M.thermoresistible__bu KLGTMGLILRGSEELKKQVLPAVASGEAMASYALSEREAGSDAASMRTRA
MMAR_1262|M.marinum_M KLGTMGLILRGSDDLKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
MUL_2626|M.ulcerans_Agy99 KLGTMGLILRGSDELKKQVLPSLADGAAMASYALSEREAGSDAGAMRTRA
Mvan_1719|M.vanbaalenii_PYR-1 KLGTMGLILRGSDELKKKVLPSIASGEAMASYALSEREAGSDAAAMRTRA
MAV_4243|M.avium_104 KLGTMGLILRGSDELKKQVLPSIADGSAMASYALSEREAGSDAASMRTRA
MAB_3618c|M.abscessus_ATCC_199 KLGTMGLILNGSDELKKQVLPAIASGEAMASYALSEREAGSDAASMRTRA
Mflv_4943|M.gilvum_PYR-GCK SLSCHPLMSFGSDEQRQRWLPDMLGGSTIGAYSLSEPQAGSDAAALTCRA
MSMEG_4166|M.smegmatis_MC2_155 RLHGYLLAAYAPSDIRDRWLPGLIDGSIRGSFALSEPHSGTDIRAGRTVA
* * ...: :.: ** : .:::*** .:*:* : *
Mb3302c|M.bovis_AF2122/97 KADGD-HWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDD
Rv3274c|M.tuberculosis_H37Rv KADGD-HWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDD
MLBr_00737|M.leprae_Br4923 KADGD-DWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDD
TH_3846|M.thermoresistible__bu VADGD-DWILNGSKCWITNGGKSTWYTVMAVTDPDKGANGISAFMVHKDD
MMAR_1262|M.marinum_M KADGD-DWILNGTKCWITNGGKSSWYTVMAVTDPEKGANGISAFMVHKDD
MUL_2626|M.ulcerans_Agy99 KADGD-DWILNGTKCWITNGGKSSWYTVMAVTDPENGANGISAFVVHKDD
Mvan_1719|M.vanbaalenii_PYR-1 KADGD-DWILNGAKCWITNGGKSSWYTVMAVTDPDKGANGISAFMVHIDD
MAV_4243|M.avium_104 RADGD-DWILNGAKCWITNGGKSSWYTVMAVTDPDKGANGISSFMVHKDD
MAB_3618c|M.abscessus_ATCC_199 KADGD-DWIINGSKCWITNGGKSSWYTVMAVTDPEKKANGISAFMVHKDD
Mflv_4943|M.gilvum_PYR-GCK TAVDG-GYRITGSKAWITHGGIADFYNLFARTG--EGSQGISCFLVPRDT
MSMEG_4166|M.smegmatis_MC2_155 VEHGDGTVSITGEKAWITQSPAAHFCIVLAKLGSTDRDAPTAAFVVPLDT
.. :.* *.***:. : : ::* . :.*:* *
Mb3302c|M.bovis_AF2122/97 EGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLD
Rv3274c|M.tuberculosis_H37Rv EGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLD
MLBr_00737|M.leprae_Br4923 EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLD
TH_3846|M.thermoresistible__bu EGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLD
MMAR_1262|M.marinum_M EGFVVGPKERKLGIKGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLD
MUL_2626|M.ulcerans_Agy99 EGFVVGPKERKLGIKGSPTTELYFENCRVPGDRMIGEPGTGFKTALATLD
Mvan_1719|M.vanbaalenii_PYR-1 EGFTIGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLD
MAV_4243|M.avium_104 EGFTVGPKEKKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLD
MAB_3618c|M.abscessus_ATCC_199 EGFTVGPLEHKLGIKGSPTAELYFENCRIPGDRIIGEPGTGFKTALQTLD
Mflv_4943|M.gilvum_PYR-GCK EGLTFGKPEEKMGLHAVPTTAAHYDDANLDSDRRIGTEGQGLQIAFSALD
MSMEG_4166|M.smegmatis_MC2_155 DGVTVGKDEPMSGFRGMPMANVHFDNCRIPSSWRLQTDG--FRGMMEGLN
:*. .* * *::. * : :::...: .. : * :: : *:
Mb3302c|M.bovis_AF2122/97 HTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAM
Rv3274c|M.tuberculosis_H37Rv HTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAM
MLBr_00737|M.leprae_Br4923 HTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAM
TH_3846|M.thermoresistible__bu HTRPTIGAQAVGIAQGALDAAIAYTKERKQFGRPVSDNQGVQFMLADMAM
MMAR_1262|M.marinum_M HTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAM
MUL_2626|M.ulcerans_Agy99 HTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGKSISDFQAVQFMLADMAM
Mvan_1719|M.vanbaalenii_PYR-1 HTRPTIGAQAVGIAQGALDASLEYVKDRKQFGKSISEFQAVQFMLADMAM
MAV_4243|M.avium_104 HTRPTIGAQAVGIAQGALDAAIAYTKERKQFGRPVSDNQGVQFMLADMAM
MAB_3618c|M.abscessus_ATCC_199 HTRPTIGAQALGIAQGALDQAIAYTKDRKQFGKSISDFQGVQFMLADMAM
Mflv_4943|M.gilvum_PYR-GCK SGRLGIAAVAVGLAQAALDEAVAYSQERTTFGRKIIDHQGLAFLLADMAA
MSMEG_4166|M.smegmatis_MC2_155 LARLDAGCYGVGFMRAALREATAYVRDRQAFGKTLADLQIVQEKLGRLHA
* .. .:*: :.** : * ::* **. : * : *. :
Mb3302c|M.bovis_AF2122/97 KVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFG
Rv3274c|M.tuberculosis_H37Rv KVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFG
MLBr_00737|M.leprae_Br4923 KVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFG
TH_3846|M.thermoresistible__bu KIEAARLMVYSAAARAERGEGDLGFISAASKCFASDVAMEVTTDAVQLFG
MMAR_1262|M.marinum_M KVESARLMVYSAAARAERGESNLGFISAASKCLASDVAMEVTTDAVQLFG
MUL_2626|M.ulcerans_Agy99 KVESARLMVYSAAARAERGESNLGFISAASKCLASDVAMEVTTDAVQLFG
Mvan_1719|M.vanbaalenii_PYR-1 KVEAARLMVYSAAARAERGEGNLGFISAASKCLASDVAMEVTTDAVQLFG
MAV_4243|M.avium_104 KVESARLMVYHAAARAERGESHLGFISAASKCLASDVAMEVTTDAVQLFG
MAB_3618c|M.abscessus_ATCC_199 KVEAARLMVYTAAARAERGEKNLGFISSASKCFASDVAMEVTTDAVQLFG
Mflv_4943|M.gilvum_PYR-GCK AVDSARATYLDAARRRDAGLPYSRHASVA-KLVATDAAMKVTTDAVQVLG
MSMEG_4166|M.smegmatis_MC2_155 DYLAARGLLREGVASYAGGGGGDPHLISAAKMFATDAAMRNTVEAVQLLG
:** .. * . * * .*:* **. *.:***::*
Mb3302c|M.bovis_AF2122/97 GAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
Rv3274c|M.tuberculosis_H37Rv GAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
MLBr_00737|M.leprae_Br4923 GAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
TH_3846|M.thermoresistible__bu GYGYTQDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR----
MMAR_1262|M.marinum_M GAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR----
MUL_2626|M.ulcerans_Agy99 GAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR----
Mvan_1719|M.vanbaalenii_PYR-1 GAGYTVDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLK----
MAV_4243|M.avium_104 GYGYTQDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLR----
MAB_3618c|M.abscessus_ATCC_199 GAGYTTDFPVERMMRDAKITQIYEGTNQIQRVVMSRALLTS---
Mflv_4943|M.gilvum_PYR-GCK GAGYTRDYRVERYMREAKITQIFEGTNQIQRLVISRHLTRG---
MSMEG_4166|M.smegmatis_MC2_155 GYGVHLHYPVQRLMRDAKITQIIDGTSEIHALMLGRAAVRTAWS
* * .: *:* **:****** :**.:*: :::.*