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MTHVAFVGVGTMAAPMVHRFLDGSGWRLHLVDTVADRTAPFRDHAQVSVHEQLTSLPQDIDFVLLCLPNA EALRTVASEIASRRCLGNTVVVNLSTVGRQALTEAADALTHAGYGCLDAPVSGGAEGARTGSLTIMASGD PTTIEQCSSVFDVIAGKVIVVGNQPGQAQAIKVANNVLSLGALVATAEATAITRKAGIPLDTALEALNAS SGRNTATAVKFPRHVLTGRFDFGFPTSGALKDVSLFLELAAELGVEAPLSSAVQAIWHTAAEQGFGQQDC TRIVSFYEARAGLSEGQPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4123 | - | - | 100% (299) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1496 | mmsB | 5e-22 | 27.01% (274) | 3-hydroxyisobutyrate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5857 | - | 7e-19 | 30.71% (267) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0773c | mmsB | 1e-23 | 27.95% (297) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. gilvum PYR-GCK | Mflv_1911 | - | 1e-36 | 34.33% (300) | 6-phosphogluconate dehydrogenase, NAD-binding |
| M. tuberculosis H37Rv | Rv0751c | mmsB | 1e-23 | 27.95% (297) | 3-hydroxyisobutyrate dehydrogenase MmsB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1043c | - | 4e-21 | 26.10% (295) | putative oxidoreductase |
| M. marinum M | MMAR_1077 | mmsB | 3e-20 | 27.04% (270) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. avium 104 | MAV_0931 | - | 4e-37 | 33.67% (300) | 3-hydroxyisobutyrate dehydrogenase |
| M. thermoresistible (build 8) | TH_0328 | mmsB | 2e-19 | 26.09% (276) | PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) |
| M. ulcerans Agy99 | MUL_0835 | mmsB | 1e-19 | 26.67% (270) | 3-hydroxyisobutyrate dehydrogenase, MmsB |
| M. vanbaalenii PYR-1 | Mvan_4822 | - | 3e-44 | 37.71% (297) | 3-hydroxyisobutyrate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1077|M.marinum_M MTKSCQIAFLGLGHMGAPMSANLIG-AGHTVRGFDPVPA-AASAAAAKGA
MUL_0835|M.ulcerans_Agy99 MTKSCQIAFLGLGHMGAPMSANLIG-AGHTVRGFDPVPA-AASATAAKGA
TH_0328|M.thermoresistible__bu --------------MGGPMAANLVA-AGHTVRGFDPVAE-SRAAAADKGV
Mb0773c|M.bovis_AF2122/97 ---MTTIAFLGLGNMGAPMSANLVG-AGHVVRGFDPAPT-AASGAAAHGV
Rv0751c|M.tuberculosis_H37Rv ---MTTIAFLGLGNMGAPMSANLVG-AGHVVRGFDPAPT-AASGAAAHGV
Mflv_1911|M.gilvum_PYR-GCK --MDTALGFLGLGNMGFPMMGRLLS-AGHPVVVFDTDPA-AVSRATALGA
Mvan_4822|M.vanbaalenii_PYR-1 --MNTELGFVGLGNMGFPIMTRLVE-AGHRVLVFDTRAD-VVAQAVRAGA
MAV_0931|M.avium_104 ----MTIGFIGLGNMGFPMASRLIR-EQHDVVAFDSRRE-ALERLVAAGA
MSMEG_4123|M.smegmatis_MC2_155 ---MTHVAFVGVGTMAAPMVHRFLDGSGWRLHLVDTVADRTAPFRDHAQV
MAB_1043c|M.abscessus_ATCC_199 ---MSTIAVIGLGAMGKAMADNLVQ-AGHQVSVWNRSPA-PVAELAAVGA
*. .: .:: : : .
MMAR_1077|M.marinum_M TMFDSAAEAVAGADVVITMLPNGAVVKRCYAEVLP--AARSGALFIDSST
MUL_0835|M.ulcerans_Agy99 TMFDSAAEAVARADVVITMLPNGAVVKRCYAEVLP--AARSGALFIDSST
TH_0328|M.thermoresistible__bu QTFDSGAEAVAGAEVVITSLPNGDIVKQCYAEVLP--AATSGALFIDTST
Mb0773c|M.bovis_AF2122/97 AVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLA--AARPATLFIDSST
Rv0751c|M.tuberculosis_H37Rv AVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLA--AARPATLFIDSST
Mflv_1911|M.gilvum_PYR-GCK DAAASVREVADRAGTVLASLPTPQVSNSVAEEVA---GGSRVRRFVDLST
Mvan_4822|M.vanbaalenii_PYR-1 EARTSARDVADRAETVLASLPTPQVSNSVASEVA---EGSRVRRFVDLST
MAV_0931|M.avium_104 RPASSPKEVADGAETVLASLPTPGASLEVATGTAGVIEGARVKRYVDLST
MSMEG_4123|M.smegmatis_MC2_155 SVHEQLTSLPQDIDFVLLCLPNAEALRTVASEIASR-RCLGNTVVVNLST
MAB_1043c|M.abscessus_ATCC_199 RPLDSVAQAFDSGVVFSVLADDHAVTETLLTPEVL--AAGHGALHVNLAT
. . . :: :*
MMAR_1077|M.marinum_M ISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQ
MUL_0835|M.ulcerans_Agy99 ISVNDAREVHALAESHGMAQLDAPVSGGVKGAVAGTLAFMVGGDQSALAQ
TH_0328|M.thermoresistible__bu ISVDDARTVHAQATGRGFAQVDAPVSGGVKGAVAGTLAFMVGGDAEAVER
Mb0773c|M.bovis_AF2122/97 ISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRR
Rv0751c|M.tuberculosis_H37Rv ISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRR
Mflv_1911|M.gilvum_PYR-GCK VGQHAAQRNSELLGPHGIAALDSPVSGGVHGAEAGTLAVMVSGPRHEFDA
Mvan_4822|M.vanbaalenii_PYR-1 VGQQAAQRNREVLSARGIAALDSPVSGGVHGARAGTLAVMVSGPRPEFEA
MAV_0931|M.avium_104 VGSRTAMRIHDLLARRNIVAIDSPVSGGVGGAEQGTLALMVSGPRGEFDV
MSMEG_4123|M.smegmatis_MC2_155 VGRQALTEAADALTHAGYGCLDAPVSGGAEGARTGSLTIMASGDPTTIEQ
MAB_1043c|M.abscessus_ATCC_199 VSARLADRATALHDEHGVGYVAAPVFGRVPVAQAGQLQVLAAGAAAQIDK
:. . : :** * . * . * .:..* .
MMAR_1077|M.marinum_M ARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENL
MUL_0835|M.ulcerans_Agy99 ARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIGEAFVLAENL
TH_0328|M.thermoresistible__bu ARPVLEPMAGKIIHCG-ASGTGQAAKLCNNMVLAVQQIAIGEAFVLAEKL
Mb0773c|M.bovis_AF2122/97 ARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKL
Rv0751c|M.tuberculosis_H37Rv ARPVLEPMAGKIIHCG-AAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKL
Mflv_1911|M.gilvum_PYR-GCK LEPVWSAIG-RATFVSEKAGAAQTMKLINNLIAATTLAVTAEAMVMGAKA
Mvan_4822|M.vanbaalenii_PYR-1 LASVFAVLG-RAIFVSEQPGAAQTMKLINNLMAATALAATAEVMVMGVKA
MAV_0931|M.avium_104 IRTTLEALG-RPFYVGDKPGAAQTMKLANNILAANVLAATAEVVVMGVKA
MSMEG_4123|M.smegmatis_MC2_155 CSSVFDVIAGKVIVVGNQPGQAQAIKVANNVLSLGALVATAEATAITRKA
MAB_1043c|M.abscessus_ATCC_199 AQSFFDVIGARTWRLGDAPRQANVVKIIGNFLIASAIQSLSEAVSMAERS
. :. : . . .:. *: .*.: .*. : .
MMAR_1077|M.marinum_M GLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATALM
MUL_0835|M.ulcerans_Agy99 GLDAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATALM
TH_0328|M.thermoresistible__bu GLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FATALM
Mb0773c|M.bovis_AF2122/97 GLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FSTALM
Rv0751c|M.tuberculosis_H37Rv GLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPG-FSTALM
Mflv_1911|M.gilvum_PYR-GCK GLDSQVMLDVLNAGSGGTHASRD------KFPRAVLPRTFDYG-FATGLM
Mvan_4822|M.vanbaalenii_PYR-1 GLDPQVVIDVLNAGSGGTHASRD------KFPRAVLPRTFDYG-FATGLM
MAV_0931|M.avium_104 GLDPAVMIEVLNAGSGATSASRD------KFPRAILPRSFDYG-FATGLM
MSMEG_4123|M.smegmatis_MC2_155 GIPLDTALEALNASSGRNTATAV------KFPRHVLTGRFDFG-FPTSGA
MAB_1043c|M.abscessus_ATCC_199 GVDSALLVELLTSTLFQGPAYSS-------YGKLIATSAYEPAGFTTTLG
*: .: :.. * :. . *.*
MMAR_1077|M.marinum_M NKDLGLAMDAVTSTGSAAPLGSHAAEIYAKF---AADHADQDFSAVIEML
MUL_0835|M.ulcerans_Agy99 NKDLGLAMDAVTSTASAAPLGSHAAEIYAKF---ATDHADQDFSAVIEML
TH_0328|M.thermoresistible__bu NKDLGLAMDAVKSSGASAPLGSHAAEIYAEFIRAADGNADKDFSAVIELL
Mb0773c|M.bovis_AF2122/97 NKDLGLAMDAVAATGATAPLGSHAADIYAKF---AADHADLDFSAVIHTL
Rv0751c|M.tuberculosis_H37Rv NKDLGLAMDAVAATGATAPLGSHAADIYAKF---AADHADLDFSAVIHTL
Mflv_1911|M.gilvum_PYR-GCK TKDVLLYLSETQAMGSPSALAEVVARVWRDTQ--DEEGPASDFTSVVKPM
Mvan_4822|M.vanbaalenii_PYR-1 TKDVLLYLDEARALGTPVALAESVMRLWEQTQ--DEEGPSSDFTSVVKPL
MAV_0931|M.avium_104 VKDVRLYLDEAKALGVPAEVAETIARLWETAA--REEGPEADFTTVIKPL
MSMEG_4123|M.smegmatis_MC2_155 LKDVSLFLELAAELGVEAPLSSAVQAIWHTAA--EQGFGQQDCTRIVSFY
MAB_1043c|M.abscessus_ATCC_199 RKDVGLALEVAADTGLRLPFGEILRTVFDEAL--AGGHANLDWSSIADLQ
**: * :. . . ... :: * : :
MMAR_1077|M.marinum_M RGS----------
MUL_0835|M.ulcerans_Agy99 RGS----------
TH_0328|M.thermoresistible__bu RNS----------
Mb0773c|M.bovis_AF2122/97 RARADA-------
Rv0751c|M.tuberculosis_H37Rv RARADA-------
Mflv_1911|M.gilvum_PYR-GCK ERRAGVTLGPQ--
Mvan_4822|M.vanbaalenii_PYR-1 ERIAGVTIGPT--
MAV_0931|M.avium_104 ERAAGVTVGRSAR
MSMEG_4123|M.smegmatis_MC2_155 EARAGLSEGQPV-
MAB_1043c|M.abscessus_ATCC_199 RARDAE-------
.