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MSENKHGTLYGVGLGPGDPELVTVKAARVIGEADVVAYHSARHGQSIARGIAEPYLRPGQLEEHLVYPVT TETTDHPGGYAGAMEDFYAEAAERIAAHLQAGRDVALLAEGDPLFYSSYMHMHTRLTERFDAVIVPGVTS VSAASAATGTPLVQGDEVLTILPGTLPADELKRRLADTDAAVVMKLGRSYTRVREALSSAGRLDEAFYVE RASTDRQKVAQAGEVESAKVPYFSLTMVPGGMARQEQRPERGSVVVVGLGPGDHDWMTPQSRRELAAATD LIGYGPYLDRVGLRPGQRHHPSDNTDEPERARLACTLAQQGHAVAVVSSGDPGVFAMATAVLEEAKQWPG VEVRVIPAMTAAQAVASRAGAPLGHDYAVISLSDRLKPWDVIVERLKAAAKADLVLAIYNPASKTRTWQV GAMRDLLLEHRDPSTPVIIGRAVSGARPGEGESVRVVRLAELDPAQVDMRCLLIIGSSQTQWYSAAVDDT AEDRVFTPRTYPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3873 | - | - | 100% (503) | cobalamin biosynthesis protein cobIJ |
| M. smegmatis MC2 155 | MSMEG_5548 | cobF | 2e-08 | 29.69% (192) | precorrin 6A synthase |
| M. smegmatis MC2 155 | MSMEG_2618 | cobA | 3e-08 | 32.39% (142) | uroporphyrin-III C-methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2092 | cobI | 0.0 | 79.23% (496) | bifunctional S-adenosyl-L-methionine-precorrin-2 methyl |
| M. gilvum PYR-GCK | Mflv_3104 | - | 0.0 | 79.72% (498) | precorrin-3B C17-methyltransferase |
| M. tuberculosis H37Rv | Rv2066 | cobI | 0.0 | 79.23% (496) | bifunctional S-adenosyl-L-methionine-precorrin-2 methyl |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2198c | - | 0.0 | 73.44% (497) | cobalamin biosynthesis protein CobI |
| M. marinum M | MMAR_3046 | cobI | 0.0 | 80.85% (496) | bifunctional protein: CobI-CobJ fusion protein |
| M. avium 104 | MAV_2430 | - | 0.0 | 80.12% (498) | cobalamin biosynthesis protein cobIJ |
| M. thermoresistible (build 8) | TH_0440 | cobI | 0.0 | 85.71% (497) | Probable bifunctional protein, CobI-CobJ fusion protein: |
| M. ulcerans Agy99 | MUL_2290 | cobI | 0.0 | 80.85% (496) | bifunctional protein, CobI-CobJ fusion protein |
| M. vanbaalenii PYR-1 | Mvan_3431 | - | 0.0 | 79.28% (502) | precorrin-3B C17-methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3873|M.smegmatis_MC2_155 MSENKHG------TLYGVGLGPGDPELVTVKAARVIGEADVVAYHSARHG
TH_0440|M.thermoresistible__bu MTVSQHGGAQHRGTLYGVGLGPGDPELVTVKAARVIGEADVVAYHSARHG
Mflv_3104|M.gilvum_PYR-GCK MSARQ-------GTLWGVGLGPGDPELVTVKAARVIGAADVIAYHSARHG
Mvan_3431|M.vanbaalenii_PYR-1 MTGSQEP----KGTLWGVGLGPGDPELVTVKAARVIGAADVVAYHSARHG
Mb2092|M.bovis_AF2122/97 MSA--------RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHG
Rv2066|M.tuberculosis_H37Rv MSA--------RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSAPHG
MMAR_3046|M.marinum_M MTD--------RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHG
MUL_2290|M.ulcerans_Agy99 MTD--------RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHG
MAV_2430|M.avium_104 MTAPANP----RGTLWGVGLGPGDPELVTVKAARVIGEADVVAYHSARHG
MAB_2198c|M.abscessus_ATCC_199 MTDANKP----RGVLWGVGLGPGDPELVTVKAARVIGDADVVAFHSARHG
*: .*:********************* ***:*:*** **
MSMEG_3873|M.smegmatis_MC2_155 QSIARGIAEPYLRPGQLEEHLVYPVTTETTDHPGGYAGAMEDFYAEAAER
TH_0440|M.thermoresistible__bu RSIARSIAEPYLRPGQLEEHLVYPVTTETTDHPGGYAGAMEDFYTEAADR
Mflv_3104|M.gilvum_PYR-GCK RSIARSIAEQYLRDGQIEEHLVYPVTTETSEHPGGYAGAMEDFYRESADR
Mvan_3431|M.vanbaalenii_PYR-1 RSIARSIAEPYLREGQIEEHLVYPVTTETSDHPGGYAGAMEDFYRESADR
Mb2092|M.bovis_AF2122/97 HSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATER
Rv2066|M.tuberculosis_H37Rv HSIARGIAEPYLRPGQLEEHLVYPVTTEATNHPGGYAGALEDFYADATER
MMAR_3046|M.marinum_M RSIARGIAERYLRPGQIEEHLIYPVTTETTDHPGGYAGALEDFYEQATER
MUL_2290|M.ulcerans_Agy99 RSIARGIAERYLRPGQIEEHLIYPVTTETTDHPGGYAGALEDFYEQATER
MAV_2430|M.avium_104 RSIARGIAEPYLRPGQIEEHLVYPVTTEVTDHPGGYAGAIEDFYVEATAR
MAB_2198c|M.abscessus_ATCC_199 RSIARSIAEPYLRPGQIEEHLVYPVTTETTDHPGGYRGAIDDFYEESANR
:****.*** *** **:****:******.::***** **::*** ::: *
MSMEG_3873|M.smegmatis_MC2_155 IAAHLQAGRDVALLAEGDPLFYSSYMHMHTRLTERFDAVIVPGVTSVSAA
TH_0440|M.thermoresistible__bu IAAHLEAGRDVALLAEGDPLFYSSYMHMHTRLTERFDAVIVPGVTSVSAA
Mflv_3104|M.gilvum_PYR-GCK IAAHLDAGRDVALLAEGDPLFYSSYMHMHTRLTERFDAIIVPGVTSVSAA
Mvan_3431|M.vanbaalenii_PYR-1 IAAHLDAGRDVALLAEGDPLFYSSYMHMHTRLTERFDALIVPGVTSVSAA
Mb2092|M.bovis_AF2122/97 IATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAA
Rv2066|M.tuberculosis_H37Rv IATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTRRFNAVIVPGVTSVSAA
MMAR_3046|M.marinum_M IATHLDAGRNVALLAEGDPLFYSSYMHLHTRLTQRFDAVIVPGVTSVSAA
MUL_2290|M.ulcerans_Agy99 IAAHLDAGRNVALLAEGDPLFYSSYVHLHTRLTQRFDAVIVPGVTSVSAA
MAV_2430|M.avium_104 IAAHLDAGRDVALLAEGDPLFYSSYMHLHTRLTQRFDAVIVPGVTSVSAA
MAB_2198c|M.abscessus_ATCC_199 IAAHLDSGRNVALLAEGDPLFYSSYMHMHRRLTDRFDAVIIPGVTSFSAA
**:**::**:***************:*:* *** **:*:*:*****.***
MSMEG_3873|M.smegmatis_MC2_155 SAATGTPLVQGDEVLTILPGTLPADELKRRLADTDAAVVMKLGRSYTRVR
TH_0440|M.thermoresistible__bu SAATGTPLVQGDEVLSILPGTLPADELTRRLADTDAAVVLKLGRSYPTVR
Mflv_3104|M.gilvum_PYR-GCK SAAVSTPLVQGDQVLTILPGTLPQAELRRRLADTDAAVILKLGRSYPAVR
Mvan_3431|M.vanbaalenii_PYR-1 SAAVSTPLVQGDQVLTILPGTLPADELRRRLADTDAAVILKLGRSYPAVR
Mb2092|M.bovis_AF2122/97 SAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVR
Rv2066|M.tuberculosis_H37Rv SAAVATPLVAGDQVLSVLPGTLPVGELTRRLADADAAVVVKLGRSYHNVR
MMAR_3046|M.marinum_M SAAIATPLVAGDEVLSVLPGTLPVAELTRRLADVDAAVVLKLGRSYHNVR
MUL_2290|M.ulcerans_Agy99 SAAIATPLVAGDEVLSVLPGTLPVAELTRRLADVDAAVVLKLGRSYHNVR
MAV_2430|M.avium_104 SAAIATPLVAGDEVLSVLPGTLPVTELTRRLADADAAVVLKLGRSYHAVR
MAB_2198c|M.abscessus_ATCC_199 SAATGTPLVEGDEILTVIPGTLPADEITRRLGDSHAAVIMKLGRSYGAVR
*** .**** **::*:::***** *: ***.* .***::****** **
MSMEG_3873|M.smegmatis_MC2_155 EALSSAGRLDEAFYVERASTDRQKVAQAGEVESAKVPYFSLTMVPGGM--
TH_0440|M.thermoresistible__bu QALSDAGRLDEAFYVERASTPAQRVAPAGEVDAERVPYFSLAMVPSAV--
Mflv_3104|M.gilvum_PYR-GCK QALSEAGRLDDAFYVERASTERQRVLPAADVDADSVPYFALAMLTGDG--
Mvan_3431|M.vanbaalenii_PYR-1 QALSAAGRIDDAFYVERASTERQRVLPASEVDDQSVPYFALTMLPGGR--
Mb2092|M.bovis_AF2122/97 EALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR--
Rv2066|M.tuberculosis_H37Rv EALSASGLLGDAFYVERASTAGQRVLPAADVDETSVPYFSLAMLPGGR--
MMAR_3046|M.marinum_M EALSASGQLDDTFYVERASTPGQRVLPAADVDEASVPYFSLAMLPGGR--
MUL_2290|M.ulcerans_Agy99 EALSTSGQLDDTFYVERASTPGQRVLPAADVDEASVPYFSLAMLPGGR--
MAV_2430|M.avium_104 EALSQSGQLDDAVYVERASTSAQRIVPAADVDADGVPYFSLAILPGGQRA
MAB_2198c|M.abscessus_ATCC_199 QALDASGLLDRAYYVERASTPGQRVLPAAEVDPASVPYFSLVLVPGAQS-
:**. :* :. : ******* *:: *.:*: ****:*.::..
MSMEG_3873|M.smegmatis_MC2_155 ARQEQRPERGSVVVVGLGPGDHDWMTPQSRRELAAATDLIGYGPYLDRVG
TH_0440|M.thermoresistible__bu NRP-ARTGTGSVAVVGLGPGDPDWMTPQSRRELAAATDLIGYGPYLDRIP
Mflv_3104|M.gilvum_PYR-GCK RRR---VGTGSVAVVGLGPGDTAWMTPQSRSELAAATDLIGYGPYLNRVG
Mvan_3431|M.vanbaalenii_PYR-1 RAA---SVTGSVAVVGLGPGDAGWTTPQSRQVLAAATDLIGYGPYLDRVP
Mb2092|M.bovis_AF2122/97 RRALL---TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVE
Rv2066|M.tuberculosis_H37Rv RRALL---TGTVAVVGLGPGDSDWMTPQSRRELAAATDLIGYRGYLDRVE
MMAR_3046|M.marinum_M RSTVV---AGTVAVVGLGPGDTDWMTPQSRRELARATDLIGYGPYLDRIS
MUL_2290|M.ulcerans_Agy99 RSTVV---AGTVAVVGLGPGDTDWMTPQSRRELARATDLIGYGPYLDRIS
MAV_2430|M.avium_104 RRAPG---AGTVAVVGLGPGDAQWMTPQSRRELAAATDLVGYGRYLDRVP
MAB_2198c|M.abscessus_ATCC_199 ATDIDTDPDGMVTVLGLGPGHHDWTTTEVRQELARATDLIGYGPYLDRIP
* *.*:*****. * *.: * ** ****:** **:*:
MSMEG_3873|M.smegmatis_MC2_155 LRPGQRHHPSDNTDEPERARLACTLAQQGHAVAVVSSGDPGVFAMATAVL
TH_0440|M.thermoresistible__bu VRAGQRRHPSDNTDEPARARLACSLAEQGCAVAVVSSGDPGVFAMATAVL
Mflv_3104|M.gilvum_PYR-GCK VREGQRRHPSDNTDEPARARLACELAEQGRAVAVVSSGDPGVFAMATAVL
Mvan_3431|M.vanbaalenii_PYR-1 VRDGQRRHPSDNTDEPARARLACELAEQGRTVAVVSSGDPGVFAMATAVL
Mb2092|M.bovis_AF2122/97 VRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVL
Rv2066|M.tuberculosis_H37Rv VRDGQRRHPSDNTDEPARARLACSLADQGRAVAVVSSGDPGVFAMATAVL
MMAR_3046|M.marinum_M VRDGQRRHPSDNTDEPARARLACSLAEQGRAVAVVSSGDPGVFAMATAVL
MUL_2290|M.ulcerans_Agy99 VRDGQRRHPSDNTDEPARARLACSLAEQGRAVAVVSSGDPGVFAMATAVL
MAV_2430|M.avium_104 VRDGQRRHPSDNRDEPERARLACALAEQGRAVAVVSSGDPGVFAMATAVL
MAB_2198c|M.abscessus_ATCC_199 ARDGQVRHASDNRDEPARAELAFKLAAGGRRVAVVSSGDPGVFAMAAAVL
* ** :*.*** *** **.** ** * ***************:***
MSMEG_3873|M.smegmatis_MC2_155 EEAKQWPGVEVRVIPAMTAAQAVASRAGAPLGHDYAVISLSDRLKPWDVI
TH_0440|M.thermoresistible__bu EEARAWPGVQVRVVPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVI
Mflv_3104|M.gilvum_PYR-GCK EEAEQWPGVDVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVI
Mvan_3431|M.vanbaalenii_PYR-1 EEAEQWPDVDVRVVPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDII
Mb2092|M.bovis_AF2122/97 EEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVI
Rv2066|M.tuberculosis_H37Rv EEAEQWPGVRVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWDVI
MMAR_3046|M.marinum_M EEAKQWPGVPVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVI
MUL_2290|M.ulcerans_Agy99 EEAKQWPGVPVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVI
MAV_2430|M.avium_104 EEAKQWPGVQVRVIPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWEVI
MAB_2198c|M.abscessus_ATCC_199 EEARAWPDVTVRVLPAMTAAQAVASRVGAPLGHDYAVISLSDRLKPWKVI
***. **.* ***:************.********************.:*
MSMEG_3873|M.smegmatis_MC2_155 VERLKAAAKADLVLAIYNPASKTRTWQVGAMRDLLLEHRDPSTPVIIGRA
TH_0440|M.thermoresistible__bu AARLKAAASADLVLAIYNPASKTRTWQVGAMRDLLLEHRDPATPVVIGRD
Mflv_3104|M.gilvum_PYR-GCK ARRLAAAAEADMVLAIYNPASKTRTWQVGAMRDLLLEHRDPATPVVIGRD
Mvan_3431|M.vanbaalenii_PYR-1 ARRLTAAAAADMVLAVYNPASKTRNWQVAAMRDLLLEHRDADTPVVIGRD
Mb2092|M.bovis_AF2122/97 AARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRN
Rv2066|M.tuberculosis_H37Rv AARLTAAAAADLVLAIYNPASVTRTWQVGAMRELLLAHRDPGIPVVIGRN
MMAR_3046|M.marinum_M AARLGAAAAADLVLAIYNPASKTRTWQVGAMRELLLQHRDPGTPVVIGHN
MUL_2290|M.ulcerans_Agy99 AARLGAAAAADLVLAIYNPASKTRAWQVGAMRELLLQHRDPGTPVVIGRN
MAV_2430|M.avium_104 AARLEAAAAADLVLAIYNPASKARTWQVGAMRDILLARREPGTPVVIGRD
MAB_2198c|M.abscessus_ATCC_199 ESRLRAAAAADLVLAVYNPASKSRTWQVASMRDVLLEHRDPATPVVLGRD
** *** **:***:***** :* ***.:**::** :*:. **::*:
MSMEG_3873|M.smegmatis_MC2_155 VSGARPGEGESVRVVRLAELDPAQVDMRCLLIIGSSQTQWYSAAVDDTAE
TH_0440|M.thermoresistible__bu VSGPQ----ESVRVVRLAELDPADVDMRCLLIIGSSQTRWYTD-----GG
Mflv_3104|M.gilvum_PYR-GCK VAGPR----ESVTVVALGDLDPATVDMRCLLIIGSTQTRWQRTT---DGA
Mvan_3431|M.vanbaalenii_PYR-1 VAGPR----ESVRVVPLGELDPADVDMRCLLIVGSSRTRWHTTT---DGA
Mb2092|M.bovis_AF2122/97 VSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVD----SQ
Rv2066|M.tuberculosis_H37Rv VSGPVSGPNEDVRVVKLADLNPAEIDMRCLLIVGSSQTRWYSVD----SQ
MMAR_3046|M.marinum_M VS----GPDEAVRVVRLADLNPADVDMRCLLIIGSSQTQWYAVD----ST
MUL_2290|M.ulcerans_Agy99 VS----GPDEDVRVVRLADLNPADVDMRCLLIIGSSQTQWYAVD----ST
MAV_2430|M.avium_104 VS----GPDEDVRVVRLADLDPAEIDMRCLLIVGSSQTQWYSDD----SA
MAB_2198c|M.abscessus_ATCC_199 VGGAG----ESVRVTTLGELDPTVVDMRTLLIIGSSQTQWHDTD----SG
*. * * *. *.:*:*: :*** ***:**::*:* .
MSMEG_3873|M.smegmatis_MC2_155 DRVFTPRTYPG--------------
TH_0440|M.thermoresistible__bu DRVFTPRRYPG--------------
Mflv_3104|M.gilvum_PYR-GCK DRVFTLRRYPT--------------
Mvan_3431|M.vanbaalenii_PYR-1 DRVFTPRTYPG--------------
Mb2092|M.bovis_AF2122/97 DRVFTPRRYPEAGRATATKSSRHSD
Rv2066|M.tuberculosis_H37Rv DRVFTPRRYPEAGRATATKSSRHSD
MMAR_3046|M.marinum_M DRVFTPRRYP---------------
MUL_2290|M.ulcerans_Agy99 DRVFTPRHYP---------------
MAV_2430|M.avium_104 DRVFTPRRYEM--------------
MAB_2198c|M.abscessus_ATCC_199 PQVFTPRRYPAR-------------
:*** * *