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VAAVKLHRHVGRRRAARFLAEGPNLVEAALRRGLVSEVFATEAALDRFGALLADAPVTPVTERAAKALSD TVTPVGLVAVCRLPEVSLDDVLAGPAGLIAVPVQLSEPGNAGTLIRVADAMGAAAVVLAGNSVDPYNSKC LRASAGSIFSIPVISDPDEARVVQRLRDAGLRVLATTVDGEADLDDPDLEAELTEPTAWLFGPEAHGLST DLAAMAHRRVQIPMPGHAESLNIASAASICLYQSARAQRRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3790 | - | - | 100% (252) | RNA methyltransferase, TrmH family protein |
| M. smegmatis MC2 155 | MSMEG_5687 | - | 1e-16 | 30.42% (240) | 23s ribosomal RNA methyltransferase |
| M. smegmatis MC2 155 | MSMEG_6073 | - | 8e-15 | 32.48% (157) | RNA methyltransferase, TrmH family protein, group 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1671 | tsnR | 2e-91 | 70.47% (254) | 23S rRNA methyltransferase TsnR |
| M. gilvum PYR-GCK | Mflv_3539 | - | 1e-100 | 76.10% (251) | tRNA/rRNA methyltransferase (SpoU) |
| M. tuberculosis H37Rv | Rv1644 | tsnR | 2e-90 | 70.08% (254) | 23S rRNA methyltransferase TsnR |
| M. leprae Br4923 | MLBr_01397 | tsnR | 2e-81 | 63.10% (252) | putative rRNA methyltransferase |
| M. abscessus ATCC 19977 | MAB_2324 | - | 6e-80 | 63.10% (252) | tRNA/rRNA methyltransferase |
| M. marinum M | MMAR_2451 | tsnR | 1e-89 | 69.20% (250) | 23S rRNA methyltransferase TsnR |
| M. avium 104 | MAV_3123 | - | 1e-91 | 70.80% (250) | TsnR protein |
| M. thermoresistible (build 8) | TH_1588 | tsnR | 2e-93 | 70.47% (254) | Possible 23S rRNA methyltransferase tsnR |
| M. ulcerans Agy99 | MUL_1630 | tsnR | 2e-89 | 68.80% (250) | 23S rRNA methyltransferase TsnR |
| M. vanbaalenii PYR-1 | Mvan_3325 | - | 1e-97 | 73.90% (249) | tRNA/rRNA methyltransferase (SpoU) |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3539|M.gilvum_PYR-GCK ----------------------MAAAVKLHRHTGRRRAARFLAEGPNLVE
Mvan_3325|M.vanbaalenii_PYR-1 ----------------------MAAAVKLHRHTGRRRAARFLAEGPNLVE
MSMEG_3790|M.smegmatis_MC2_155 ----------------------MVAAVKLHRHVGRRRAARFLAEGPNLVE
Mb1671|M.bovis_AF2122/97 --------------MLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVA
Rv1644|M.tuberculosis_H37Rv --------------MLTERSARVATAVKLHRHVGRRRAGRFLAEGPNLVA
MLBr_01397|M.leprae_Br4923 --------------MLTERSARVVAAVKLHRQVARRRVRRFLAEGPNLVE
MAV_3123|M.avium_104 --------------MLTERSGRVAAAAKLHRHVGRRRAARFLAEGPNLVE
MMAR_2451|M.marinum_M MHESERSRPTGPAQILTERSARVSAAAKLQRHVGRRRTSRFLAEGPNLVE
MUL_1630|M.ulcerans_Agy99 MHESERSRPTGPAQILTERSARVSAAAKLQRHVGRRRTSRFLAEGPNLVE
TH_1588|M.thermoresistible__bu --------------LLTERSARVVAAVKLHRQTARRRAARFLAEGPNLVE
MAB_2324|M.abscessus_ATCC_1997 ----------------------MIDAVKLHRPAARRRAGLFLAEGPNLVE
: *.**:* ..***. *********
Mflv_3539|M.gilvum_PYR-GCK AALRRGLVSEVFATESAADRFGPLLA----GAPVHLVTEKAAKALSDTVT
Mvan_3325|M.vanbaalenii_PYR-1 AALRRGLVHEVFATEGAAAKFAALLG----AASVHLVTDKAAKALSDTVT
MSMEG_3790|M.smegmatis_MC2_155 AALRRGLVSEVFATEAALDRFGALLA----DAPVTPVTERAAKALSDTVT
Mb1671|M.bovis_AF2122/97 AALARGLVREVFVTEVAARRHELLLA--AHEASVHLVTERAAKALSDTVT
Rv1644|M.tuberculosis_H37Rv AALARGLVREVFVTEVAARRHELLLA--AHEASVHLVTERAAKALSDTVT
MLBr_01397|M.leprae_Br4923 AAIVSGLVRDVFVTEVAAQRHATVLA--TLKCPVHPVSERAAKALSDTVT
MAV_3123|M.avium_104 AAAGRGLVRDVFVTEAAQQRYAPLLA--ALDCPVHLITERAAKALSDTVT
MMAR_2451|M.marinum_M AAAARGLIRELYVTEAAEQRHEPLLA--RQDAPVYVVTERAAKALSDTVT
MUL_1630|M.ulcerans_Agy99 AAAARGLIRELYVTEAAEQRHEPLLA--RQDAPVYVVTERAAKALSDTVT
TH_1588|M.thermoresistible__bu AALRRGLVSEVYATEAAAQRFAELLAGTPADVGVRLVTERAAKALSDTVT
MAB_2324|M.abscessus_ATCC_1997 AALRSGAVERIFATDAAIERFVDLLA----EAPVRRVTERAAKALSDTVT
** * : ::.*: * :. :*. * ::::**********
Mflv_3539|M.gilvum_PYR-GCK PVGLVAVCTLPEVDLTEVLAGEPTLVAVPVGISEPGNAGTVIRVADAMGA
Mvan_3325|M.vanbaalenii_PYR-1 PVGLVAVCSIPEADLDQVLAGNPKLVAVPVGISEPGNAGTLIRVADAMGA
MSMEG_3790|M.smegmatis_MC2_155 PVGLVAVCRLPEVSLDDVLAGPAGLIAVPVQLSEPGNAGTLIRVADAMGA
Mb1671|M.bovis_AF2122/97 PAGLVAVCDLPATRLEDVLAGSPQLIAVTVEIREPGNAGTVIRIADAMGA
Rv1644|M.tuberculosis_H37Rv PAGLVAVCDLPATRLEDVLAGSPQLIAVTVEIREPGNAGTVIRIADAMGA
MLBr_01397|M.leprae_Br4923 PTGLIAVCEMPTTRLATVLAGSPQLVVAAVEISEPGNAGTVIRIADAMGA
MAV_3123|M.avium_104 PAGLVAVCDLPATGLRDVLAGSPRLIAVAVQISEPGNAGTLIRLSDAMGA
MMAR_2451|M.marinum_M PSGLVAVCEMPTTGLAEVLSGAPRLVAVAVEIGEPGNAGTLIRIADAMGA
MUL_1630|M.ulcerans_Agy99 PSGLVAVCEMPTTGLAEVLSGAPRLVAVAVEIGEPGNAGTLIRIADAMGA
TH_1588|M.thermoresistible__bu PVGLVAVCRMPQTTLADVLAAAPRLVAVGVQIGEPGNAGTLIRTADAMGA
MAB_2324|M.abscessus_ATCC_1997 PVGLVAQCRTVVSTWSQVTARSPRFVIVAVDISEPGNAGTLIRVADAMGA
* **:* * * : . :: . * : *******:** :*****
Mflv_3539|M.gilvum_PYR-GCK DAVVLAGDSVDPYNGKCLRASAGSIFSIPVISHHDAADVVTQLKDAGLQV
Mvan_3325|M.vanbaalenii_PYR-1 DAVVLAGDSVDPYNGKCLRASAGSIFSIPVLSAPDAVAAVTKLKDAGLQV
MSMEG_3790|M.smegmatis_MC2_155 AAVVLAGNSVDPYNSKCLRASAGSIFSIPVISDPDEARVVQRLRDAGLRV
Mb1671|M.bovis_AF2122/97 AAVILAGRSVDPYNGKCLRASTGSIFAIPVVVAPDVGAAIADLRAAGLQV
Rv1644|M.tuberculosis_H37Rv AAVILAGRSVDPYNGKCLRASTGSIFAIPVVVAPDVGAAIADLRAAGLQV
MLBr_01397|M.leprae_Br4923 AAVIFGGYTVDPYNGKCLRSSAGSIFSITVVVASDAYAAVTELRAAGLQV
MAV_3123|M.avium_104 AGVLLAGHSVDPYNGKCLRASAGSIFSVPVVAAPDLREAVAAVREAGLQL
MMAR_2451|M.marinum_M NAVVLAGNSVDPYNGKCLRASAGSIFAIPVIVAPDTSAALGALRGAGLQV
MUL_1630|M.ulcerans_Agy99 NAVVLAGNSVDPYNGKCLRASAGSIFAIPVIVAPDTSAALGALRGAGLQA
TH_1588|M.thermoresistible__bu DAVVLAGAGVDPYNSKCLRASAGAIFTIPVVAGPDPVETVGRLQASGLQV
MAB_2324|M.abscessus_ATCC_1997 DAVVLAGNSVDPFNGKSLRASAGSIFNIPVVPEGDVGAIAADLAQTGVAL
.*::.* ***:*.*.**:*:*:** :.*: * : :*:
Mflv_3539|M.gilvum_PYR-GCK LATVLGGSVSLDE----VDLSGPTAWLFGPEAHGLPAEVAALATAGVEIP
Mvan_3325|M.vanbaalenii_PYR-1 LATVLDGPVSLED----ADLSVPTAWLFGPEAHGLPADVAGLATAGVRIP
MSMEG_3790|M.smegmatis_MC2_155 LATTVDGEADLDDPDLEAELTEPTAWLFGPEAHGLSTDLAAMAHRRVQIP
Mb1671|M.bovis_AF2122/97 LATAVDGEMALDDAD--RLLAEPTAWLFGPEAHGLSAEIAALADHRVHIP
Rv1644|M.tuberculosis_H37Rv LATAVDGEMALDDAD--RLLAEPTAWLFGPEAHGLSAEIAALADHRVHIL
MLBr_01397|M.leprae_Br4923 LATMVDGETSLDEAK--PLLGKPTAWLFGSEPHGLSTEIAEAADYRVRIP
MAV_3123|M.avium_104 LATTVDGEVRLDRAG--ELLAKPTAWLFGPESHGLPSEVAAAADHRVRIP
MMAR_2451|M.marinum_M LASVLDGEKSLDDID--QLLEAPTAWLFGPEAHGLSAEVAAAAHHRVRIP
MUL_1630|M.ulcerans_Agy99 LASVLDGEKSLDDID--QLLEAPTAWLFGPEAHGLSAEVAAAAHHRVRIP
TH_1588|M.thermoresistible__bu LATTLDGEISLDSAESHVNLDRPTAWLFGGEAHGLPPEVAAAADHRVHIP
MAB_2324|M.abscessus_ATCC_1997 LATTLDGDLSLDEAD--AVLAGPCAWFFGNEAHGLDGATAALATHRINIP
**: :.* *: * * **:** *.*** * * :.*
Mflv_3539|M.gilvum_PYR-GCK MTGGAESLNVASAAAICLYQSAAAHRRAASST
Mvan_3325|M.vanbaalenii_PYR-1 MPGNAESLNVASAAAICLYQSARSQAPV----
MSMEG_3790|M.smegmatis_MC2_155 MPGHAESLNIASAASICLYQSARAQRRR----
Mb1671|M.bovis_AF2122/97 MSGGAESLNVAAAAAICLYESARALGRR----
Rv1644|M.tuberculosis_H37Rv MSGGAESLNVAAAAAICLYESARALGRR----
MLBr_01397|M.leprae_Br4923 MVGGVESLNVAATAAICLYQSSRALRL-----
MAV_3123|M.avium_104 MAGGAESLNVASAAAICLYQSARALELFMRP-
MMAR_2451|M.marinum_M MSGGAESLNVAAAAAICLYQSARALSSDR---
MUL_1630|M.ulcerans_Agy99 MSGGAESLNVAAAAAICLYQSARALSSDR---
TH_1588|M.thermoresistible__bu MAGRTESLNVAAAAAICLYQSARAARSADHPA
MAB_2324|M.abscessus_ATCC_1997 MRGGAESLNLASAASICLYATARMHRRQ----
* * .****:*::*:**** ::