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GAFFDLDGTLVDGFTATAHAGHRIRRRQAAFGEVLGIIEASVRYRIGRMPFERLLVRAAGYLRGEALADL DVLGEELFENRISPRVYPHMRDVVRKHQDRGHTVVLSSSALTIHAEPVARHLGIDHVLCNHFETDEHGRL TGDIVKPVIWGARKAEVVQNFCVQNSVELRHSFFYADGAEDCALMHLVGHPRPVNPRPGLATAAAEHGWP VLSLARMPARRW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3517 | - | - | 100% (223) | HAD-superfamily protein subfamily protein IB hydrolase |
| M. smegmatis MC2 155 | MSMEG_4704 | - | 7e-68 | 57.28% (213) | acyltransferase family protein |
| M. smegmatis MC2 155 | MSMEG_0949 | - | 3e-22 | 28.89% (225) | HAD-superfamily protein subfamily protein IB hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2508c | plsC | 1e-65 | 54.93% (213) | bifunctionnal putative L-3-phosphoserine |
| M. gilvum PYR-GCK | Mflv_3285 | - | 3e-84 | 69.48% (213) | HAD family hydrolase |
| M. tuberculosis H37Rv | Rv2483c | plsC | 1e-64 | 54.46% (213) | bifunctionnal putative L-3-phosphoserine |
| M. leprae Br4923 | MLBr_01245 | - | 7e-64 | 53.99% (213) | putative transferase |
| M. abscessus ATCC 19977 | MAB_2455c | - | 2e-83 | 67.44% (215) | hypothetical protein MAB_2455c |
| M. marinum M | MMAR_3834 | plsC | 3e-65 | 54.93% (213) | bifunctional transmembrane phospholipid biosynthesis enzyme |
| M. avium 104 | MAV_1687 | - | 3e-63 | 53.05% (213) | acyltransferase family protein |
| M. thermoresistible (build 8) | TH_0497 | - | 9e-93 | 73.15% (216) | POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL |
| M. ulcerans Agy99 | MUL_3764 | plsC | 2e-65 | 54.93% (213) | bifunctional transmembrane phospholipid biosynthesis enzyme |
| M. vanbaalenii PYR-1 | Mvan_3004 | - | 1e-83 | 68.52% (216) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2508c|M.bovis_AF2122/97 MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVA
Rv2483c|M.tuberculosis_H37Rv MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVA
MMAR_3834|M.marinum_M MSAAEEPGDGREQDKAAGDLRLPGSVAEIMASPAGPKVGAFFDLDGTLVA
MUL_3764|M.ulcerans_Agy99 MSAAEEPGDGREQDKAAGDLRLPGSVAEIMASPAGPKVGAFFDLDGTLVA
MAV_1687|M.avium_104 -------------------MRLPGSVAEIMASPPGPRIGAFFDLDGTLVA
MLBr_01245|M.leprae_Br4923 MSAFDENG----TPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVA
MSMEG_3517|M.smegmatis_MC2_155 -------------------------------------MGAFFDLDGTLVD
TH_0497|M.thermoresistible__bu ------MANPMAASEASAPDPVAPVIAEVLAGPAGPTVGAFFDLDGTLVD
Mflv_3285|M.gilvum_PYR-GCK ---------------MTPVDP----VARIEAGPEGPQIGVFFDLDGTLVD
Mvan_3004|M.vanbaalenii_PYR-1 ----------MTADAATPVDP----VADIDASPPGPQIGAFFDLDGTLVD
MAB_2455c|M.abscessus_ATCC_199 ------------MTANSTPHP----VADIALSPVGSEVGAFFDLDGTLVA
:*.*********
Mb2508c|M.bovis_AF2122/97 GFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAAL
Rv2483c|M.tuberculosis_H37Rv GFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAAL
MMAR_3834|M.marinum_M GFTAVILTQERLRRRDIGVGELLSMVQAGLNHTLGRIEFEQLINTASSAL
MUL_3764|M.ulcerans_Agy99 GFTAVILTQERLRRRDIGVGELLSMVQAGLNHTLGRIEFEQLINTASSAL
MAV_1687|M.avium_104 GFTAVILTQERLLRRDMGVGELLGMVQAGLSHTLGRIEFEDLIGKAAAAL
MLBr_01245|M.leprae_Br4923 GFTAVILTHERLRRCDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSAL
MSMEG_3517|M.smegmatis_MC2_155 GFTATAHAGHRIRRRQAAFGEVLGIIEASVRYRIGRMPFERLLVRAAGYL
TH_0497|M.thermoresistible__bu GFTATAHAGHRIRNRQSSIGEVFGVIEASLRYRMGRMQFERLVVRAAGYL
Mflv_3285|M.gilvum_PYR-GCK GFTATAHAGDRIRRRQARIGEVTGVIEAAMRYRLGRVNFAKLLERAAGYL
Mvan_3004|M.vanbaalenii_PYR-1 GFTATAHAGDRIRRRQARIGEITGVIEAAMRYRMGRVNFAKLLERAAGYL
MAB_2455c|M.abscessus_ATCC_199 GFTPTAHARDRMRRRQASVGEVLGVLEATFRYKLGRMEFERLVVRAAGYL
***.. : .*: . : .**: .:::* . : :**: * *: .:. *
Mb2508c|M.bovis_AF2122/97 AGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
Rv2483c|M.tuberculosis_H37Rv AGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MMAR_3834|M.marinum_M RGRQLVDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MUL_3764|M.ulcerans_Agy99 RGRQLVDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MAV_1687|M.avium_104 AGRLIDDLEEIGERMFVQRIESRIYPEMRELVRAHMARGHTVVLSSSALT
MLBr_01245|M.leprae_Br4923 RGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALT
MSMEG_3517|M.smegmatis_MC2_155 RGEALADLDVLGEELFENRISPRVYPHMRDVVRKHQDRGHTVVLSSSALT
TH_0497|M.thermoresistible__bu RGESLAELDELGEQLFIEQVASWIYPQMRELVRAHQQREHTVALCSSALT
Mflv_3285|M.gilvum_PYR-GCK RGESLADLDAVGERLFQERVQSRMYPVMHEIVLAHQRRGHTVVMSSSALT
Mvan_3004|M.vanbaalenii_PYR-1 RDESLTDLEEIGERLFRERVRSRLFPVMHDIVLAHQRRGHTVVMSSSALT
MAB_2455c|M.abscessus_ATCC_199 RGDSLAELEAVGERIFHQHNAAMIYPQMRERVSAHQNQGHTVVLSSSALT
. : :*: :**.:* :: . ::* *:. * * : ***.:.*****
Mb2508c|M.bovis_AF2122/97 IQVGPVARFLGINNMLTNKFETNEDGILTGGVLKPILWGPGKATAVQRFA
Rv2483c|M.tuberculosis_H37Rv IQVGPVARFLGINNMLTNKFETNEDGILTGGVLKPILWCPGKATAVQRFA
MMAR_3834|M.marinum_M IQVNPVARFLGIVNMLTNKFETNEDGLLTGGVVKPILWGPGKAAAVQRFA
MUL_3764|M.ulcerans_Agy99 IQVNPVARFLGIVNMLTNKFETNEDGLLTGGVVKPILWGPGKAAAVQRFA
MAV_1687|M.avium_104 IQVNPVARFLGIPNTLTNKFETTEDGILTGGLQKPILWGPGKAAAVQRFA
MLBr_01245|M.leprae_Br4923 IQVGPVARFLGIAHMLTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFA
MSMEG_3517|M.smegmatis_MC2_155 IHAEPVARHLGIDHVLCNHFETDEHGRLTGDIVKPVIWGARKAEVVQNFC
TH_0497|M.thermoresistible__bu IHAEPVARFLGVDHVLCNHFTVDEHGRLTGDVVEPIIWGPQKAAAVQRFC
Mflv_3285|M.gilvum_PYR-GCK IHAEPVAKFLEIDHVLCNQFEVDAEGRLTGRIARPVIWGKRKAAAVQEFC
Mvan_3004|M.vanbaalenii_PYR-1 IHAEPVARYLEIDHVLCNHFEVGDDRRLTGRIARPVIWGRRKAAAVQEFC
MAB_2455c|M.abscessus_ATCC_199 IHAEPVARHLGITHVLCNHFDVDNRGLLTGDIRKPIVWGRNKASVVRSFC
*:. ***:.* : : * *:* *** : .*::* ** .*: *.
Mb2508c|M.bovis_AF2122/97 AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
Rv2483c|M.tuberculosis_H37Rv AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MMAR_3834|M.marinum_M AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MUL_3764|M.ulcerans_Agy99 AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MAV_1687|M.avium_104 AEHDIDLKESYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MLBr_01245|M.leprae_Br4923 AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MSMEG_3517|M.smegmatis_MC2_155 VQNSVELRHSFFYADGAEDCALMHLVGHPRPVNPRPGLATAAAEHGWPVL
TH_0497|M.thermoresistible__bu AETGVALDRSHFYADGDEDTALMELVGHPRPVNPRPGLAAAAARNGWPVL
Mflv_3285|M.gilvum_PYR-GCK GRHGIALQTSYFYADGNEDIALMSLVGHPRPVNPRRELAAMAAARGWPVL
Mvan_3004|M.vanbaalenii_PYR-1 AGNDVDLGRSYFYADGNEDIALMTLVGRPRPVNPRRELAAAAAEQGWPVL
MAB_2455c|M.abscessus_ATCC_199 ETNGVDLQRSYFYADGEEDIDLMALVGEPRPVNPRGRLAVMAAEQGWPVL
.: * *.***** ** ** ***.***.**. :*. * .***:*
Mb2508c|M.bovis_AF2122/97 KFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
Rv2483c|M.tuberculosis_H37Rv KFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
MMAR_3834|M.marinum_M KFNSRGGVGLRRQIRTLAGFSTMFPVAAGAVGIGLLTGNRRRGVNFFTSN
MUL_3764|M.ulcerans_Agy99 KFNSRGGVGLRRQIRTLAGFSTMFPVAAGAVGIGLLTGNRRRGVNFFTSN
MAV_1687|M.avium_104 RFSSRGPVGLRRQLRTLAGFGSMFPVAAGAVGVGVLTRNRRRGVNFFTST
MLBr_01245|M.leprae_Br4923 KFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSV
MSMEG_3517|M.smegmatis_MC2_155 SLA-RMP-ARRW--------------------------------------
TH_0497|M.thermoresistible__bu RVA-GSGRARRGLLRRRLRV------------------------------
Mflv_3285|M.gilvum_PYR-GCK RVE-NPGKGNHGGLRGVLK-------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 RVS-GSGRGGSSGLRGVLK-------------------------------
MAB_2455c|M.abscessus_ATCC_199 RLEDPRPRGMRPSLRRLAGLARP---------------------------
. .
Mb2508c|M.bovis_AF2122/97 FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
Rv2483c|M.tuberculosis_H37Rv FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MMAR_3834|M.marinum_M FSQLLLATSGVHLNVVGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MUL_3764|M.ulcerans_Agy99 FSQLLLATSGVHLNVVGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MAV_1687|M.avium_104 FSQLSLAIAGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MLBr_01245|M.leprae_Br4923 FPPLVLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGALVRGNW
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 VGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
Rv2483c|M.tuberculosis_H37Rv VGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
MMAR_3834|M.marinum_M VGVGKKELQNDPIMGTLGKVLDGVFIDRDDPASAVETLHTVEERAKNGLS
MUL_3764|M.ulcerans_Agy99 VGVGKKELQNDPIMGTLGKVLDGVFIDRDDPASAVETLHTVEERAKNGLS
MAV_1687|M.avium_104 VAVGKKELEKDPVMGTLGKLLDGVFIDRDDPAAAVETLHTVEDRARNGLS
MLBr_01245|M.leprae_Br4923 IAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLS
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNST
Rv2483c|M.tuberculosis_H37Rv IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNST
MMAR_3834|M.marinum_M IVIAPEGTRLDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAEIVASRNST
MUL_3764|M.ulcerans_Agy99 IVIAPEGTRLDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAEIVASRNST
MAV_1687|M.avium_104 ILIAPEGTRVDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAELVAARNST
MLBr_01245|M.leprae_Br4923 ILMAPEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSN
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 TINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPA
Rv2483c|M.tuberculosis_H37Rv TINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPA
MMAR_3834|M.marinum_M TINPGTVDIAVFPPIPVDDWTLDTLPDRIAEVRQLYLDTLKDWPVDELPE
MUL_3764|M.ulcerans_Agy99 TINPGTVDIAVFPPIPVDDWTLDTLPDRIAEVRQLYLDTLKDWPVDELPE
MAV_1687|M.avium_104 VINPGTVDVAVFPPISVQDWTLDTLPERIAEVRQLYLDTLANWPVGELPE
MLBr_01245|M.leprae_Br4923 TINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQLYLDILADWPVDELPK
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 VDLYAEQKAARKARAQVAKATAKRV-------PAKKAPAKSAAN------
Rv2483c|M.tuberculosis_H37Rv VDLYAEQKAARKARAQVAKATAKRV-------PAKKAPAKSAAN------
MMAR_3834|M.marinum_M VNLYAEEKAAKKAKAQLAKASAKETPAK--KAPAKKAPAKKAAAKKETSA
MUL_3764|M.ulcerans_Agy99 VNLYAEEKAAKKAKAQLAKASAKET-------PAKKAPAKKAAAKKET--
MAV_1687|M.avium_104 VDLYAEKKAAQKARSRAAKSPATSPAKTPAKSPAKRPAKKSAAKKT----
MLBr_01245|M.leprae_Br4923 AALYTRATKATVKKAEPKKGGRTSAAKT----TAKKTATKATAAKT----
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 ----------KGAAATKAATKKASPKAKPSESKIAGKD------------
Rv2483c|M.tuberculosis_H37Rv ----------KGAAATKAATKKASPKAKPSESKIAGKD------------
MMAR_3834|M.marinum_M KKAPAKKAPAKKAAAKKAPAKKATAKKAPAKKAPAKKVPESAAAKAATPA
MUL_3764|M.ulcerans_Agy99 ---PAKKAPAKKAPAKKAPAKKATAKKAPANKAPAKKVPESAAAKAATRA
MAV_1687|M.avium_104 ----------AATAAAKTRAKKTAAKPNPAAPNPEAAASHN---------
MLBr_01245|M.leprae_Br4923 ----------ANTAVTKSMLTPPTRISDKENPKVPKVVS-----------
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 -----------GEAS---------------------------ASPSSSAK
Rv2483c|M.tuberculosis_H37Rv -----------GEAS---------------------------ASPSSSAK
MMAR_3834|M.marinum_M TDTELPAPKPVGEASNPTEIAPEPIAHDGDAQQLGAGRSDAAESSSSRPK
MUL_3764|M.ulcerans_Agy99 TDTELSAPKPVGEASNPTEIAPEPIAHDGDAQQLGAGRSDAAESSSSRPK
MAV_1687|M.avium_104 -----------GEVSPSRATDPIG-----------------ADPPEAPPR
MLBr_01245|M.leprae_Br4923 -----------------------------------------QDLVVKQPR
MSMEG_3517|M.smegmatis_MC2_155 --------------------------------------------------
TH_0497|M.thermoresistible__bu --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2508c|M.bovis_AF2122/97 GRS
Rv2483c|M.tuberculosis_H37Rv GRS
MMAR_3834|M.marinum_M GRP
MUL_3764|M.ulcerans_Agy99 GRP
MAV_1687|M.avium_104 GRP
MLBr_01245|M.leprae_Br4923 ERS
MSMEG_3517|M.smegmatis_MC2_155 ---
TH_0497|M.thermoresistible__bu ---
Mflv_3285|M.gilvum_PYR-GCK ---
Mvan_3004|M.vanbaalenii_PYR-1 ---
MAB_2455c|M.abscessus_ATCC_199 ---