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M. thermoresistible (build 8) TH_0497 ()

annotation: POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE) (LPAAT)
coordinates: 1066731 - 1067522
length: 264

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0497-100% (264)POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERINE PHOSPHOHYDROLASE) (PSP) (PSPASE) + 1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (1-AGP ACYLTRANSFERASE) (1-AGPAT) (LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE) (LPAAT)
M. thermoresistible (build 8)TH_1038-3e-7656.78% (236) POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONNAL
M. thermoresistible (build 8)TH_3424-1e-1929.73% (259) PUTATIVE HAD-superfamily subfamily IB hydrolase, TIGR01490

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2508cplsC8e-7554.86% (257) bifunctionnal putative L-3-phosphoserine
M. gilvum PYR-GCKMflv_3285-2e-9266.94% (248) HAD family hydrolase
M. tuberculosis H37RvRv2483cplsC1e-7354.47% (257) bifunctionnal putative L-3-phosphoserine
M. leprae Br4923MLBr_01245-6e-7354.96% (242) putative transferase
M. abscessus ATCC 19977MAB_2455c-2e-8563.20% (250) hypothetical protein MAB_2455c
M. marinum MMMAR_3834plsC1e-7355.56% (243) bifunctional transmembrane phospholipid biosynthesis enzyme
M. avium 104MAV_1687-4e-7253.91% (243) acyltransferase family protein
M. smegmatis MC2 155MSMEG_3517-2e-9273.15% (216) HAD-superfamily protein subfamily protein IB hydrolase
M. ulcerans Agy99MUL_3764plsC1e-7355.56% (243) bifunctional transmembrane phospholipid biosynthesis enzyme
M. vanbaalenii PYR-1Mvan_3004-6e-9165.61% (253) HAD family hydrolase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2508c|M.bovis_AF2122/97           MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVA
Rv2483c|M.tuberculosis_H37Rv        MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVA
MMAR_3834|M.marinum_M               MSAAEEPGDGREQDKAAGDLRLPGSVAEIMASPAGPKVGAFFDLDGTLVA
MUL_3764|M.ulcerans_Agy99           MSAAEEPGDGREQDKAAGDLRLPGSVAEIMASPAGPKVGAFFDLDGTLVA
MAV_1687|M.avium_104                -------------------MRLPGSVAEIMASPPGPRIGAFFDLDGTLVA
MLBr_01245|M.leprae_Br4923          MSAFDENG----TPKSGPEVRLPGSVAEILASPAGPQVGAFFDLDGTLVA
TH_0497|M.thermoresistible__bu      ------MANPMAASEASAPDPVAPVIAEVLAGPAGPTVGAFFDLDGTLVD
MSMEG_3517|M.smegmatis_MC2_155      -------------------------------------MGAFFDLDGTLVD
Mflv_3285|M.gilvum_PYR-GCK          ---------------MTPVDP----VARIEAGPEGPQIGVFFDLDGTLVD
Mvan_3004|M.vanbaalenii_PYR-1       ----------MTADAATPVDP----VADIDASPPGPQIGAFFDLDGTLVD
MAB_2455c|M.abscessus_ATCC_199      ------------MTANSTPHP----VADIALSPVGSEVGAFFDLDGTLVA
                                                                         :*.********* 

Mb2508c|M.bovis_AF2122/97           GFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAAL
Rv2483c|M.tuberculosis_H37Rv        GFTAVILTQERLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAAL
MMAR_3834|M.marinum_M               GFTAVILTQERLRRRDIGVGELLSMVQAGLNHTLGRIEFEQLINTASSAL
MUL_3764|M.ulcerans_Agy99           GFTAVILTQERLRRRDIGVGELLSMVQAGLNHTLGRIEFEQLINTASSAL
MAV_1687|M.avium_104                GFTAVILTQERLLRRDMGVGELLGMVQAGLSHTLGRIEFEDLIGKAAAAL
MLBr_01245|M.leprae_Br4923          GFTAVILTHERLRRCDMGVGELLSMIQAGLNHTLGRIEFEDLIGKVSSAL
TH_0497|M.thermoresistible__bu      GFTATAHAGHRIRNRQSSIGEVFGVIEASLRYRMGRMQFERLVVRAAGYL
MSMEG_3517|M.smegmatis_MC2_155      GFTATAHAGHRIRRRQAAFGEVLGIIEASVRYRIGRMPFERLLVRAAGYL
Mflv_3285|M.gilvum_PYR-GCK          GFTATAHAGDRIRRRQARIGEVTGVIEAAMRYRLGRVNFAKLLERAAGYL
Mvan_3004|M.vanbaalenii_PYR-1       GFTATAHAGDRIRRRQARIGEITGVIEAAMRYRMGRVNFAKLLERAAGYL
MAB_2455c|M.abscessus_ATCC_199      GFTPTAHARDRMRRRQASVGEVLGVLEATFRYKLGRMEFERLVVRAAGYL
                                    ***..  : .*: . :  .**: .:::* . : :**: *  *:  .:. *

Mb2508c|M.bovis_AF2122/97           AGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
Rv2483c|M.tuberculosis_H37Rv        AGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MMAR_3834|M.marinum_M               RGRQLVDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MUL_3764|M.ulcerans_Agy99           RGRQLVDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALT
MAV_1687|M.avium_104                AGRLIDDLEEIGERMFVQRIESRIYPEMRELVRAHMARGHTVVLSSSALT
MLBr_01245|M.leprae_Br4923          RGRLLTDLEEIGERLFAQRIESRIYPEMRKLVQAHVARGHTVVLSSSALT
TH_0497|M.thermoresistible__bu      RGESLAELDELGEQLFIEQVASWIYPQMRELVRAHQQREHTVALCSSALT
MSMEG_3517|M.smegmatis_MC2_155      RGEALADLDVLGEELFENRISPRVYPHMRDVVRKHQDRGHTVVLSSSALT
Mflv_3285|M.gilvum_PYR-GCK          RGESLADLDAVGERLFQERVQSRMYPVMHEIVLAHQRRGHTVVMSSSALT
Mvan_3004|M.vanbaalenii_PYR-1       RDESLTDLEEIGERLFRERVRSRLFPVMHDIVLAHQRRGHTVVMSSSALT
MAB_2455c|M.abscessus_ATCC_199      RGDSLAELEAVGERIFHQHNAAMIYPQMRERVSAHQNQGHTVVLSSSALT
                                     .  : :*: :**.:* ::  . ::* *:. *  *  : ***.:.*****

Mb2508c|M.bovis_AF2122/97           IQVGPVARFLGINNMLTNKFETNEDGILTGGVLKPILWGPGKATAVQRFA
Rv2483c|M.tuberculosis_H37Rv        IQVGPVARFLGINNMLTNKFETNEDGILTGGVLKPILWCPGKATAVQRFA
MMAR_3834|M.marinum_M               IQVNPVARFLGIVNMLTNKFETNEDGLLTGGVVKPILWGPGKAAAVQRFA
MUL_3764|M.ulcerans_Agy99           IQVNPVARFLGIVNMLTNKFETNEDGLLTGGVVKPILWGPGKAAAVQRFA
MAV_1687|M.avium_104                IQVNPVARFLGIPNTLTNKFETTEDGILTGGLQKPILWGPGKAAAVQRFA
MLBr_01245|M.leprae_Br4923          IQVGPVARFLGIAHMLTNKFEINEDGMLTGGVVKPILWGPGKAAAVQRFA
TH_0497|M.thermoresistible__bu      IHAEPVARFLGVDHVLCNHFTVDEHGRLTGDVVEPIIWGPQKAAAVQRFC
MSMEG_3517|M.smegmatis_MC2_155      IHAEPVARHLGIDHVLCNHFETDEHGRLTGDIVKPVIWGARKAEVVQNFC
Mflv_3285|M.gilvum_PYR-GCK          IHAEPVAKFLEIDHVLCNQFEVDAEGRLTGRIARPVIWGKRKAAAVQEFC
Mvan_3004|M.vanbaalenii_PYR-1       IHAEPVARYLEIDHVLCNHFEVGDDRRLTGRIARPVIWGRRKAAAVQEFC
MAB_2455c|M.abscessus_ATCC_199      IHAEPVARHLGITHVLCNHFDVDNRGLLTGDIRKPIVWGRNKASVVRSFC
                                    *:. ***:.* : : * *:*       *** : .*::*   ** .*: *.

Mb2508c|M.bovis_AF2122/97           AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
Rv2483c|M.tuberculosis_H37Rv        AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MMAR_3834|M.marinum_M               AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MUL_3764|M.ulcerans_Agy99           AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MAV_1687|M.avium_104                AEHDIDLKESYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
MLBr_01245|M.leprae_Br4923          AEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAVAKRRGWPIL
TH_0497|M.thermoresistible__bu      AETGVALDRSHFYADGDEDTALMELVGHPRPVNPRPGLAAAAARNGWPVL
MSMEG_3517|M.smegmatis_MC2_155      VQNSVELRHSFFYADGAEDCALMHLVGHPRPVNPRPGLATAAAEHGWPVL
Mflv_3285|M.gilvum_PYR-GCK          GRHGIALQTSYFYADGNEDIALMSLVGHPRPVNPRRELAAMAAARGWPVL
Mvan_3004|M.vanbaalenii_PYR-1       AGNDVDLGRSYFYADGNEDIALMTLVGRPRPVNPRRELAAAAAEQGWPVL
MAB_2455c|M.abscessus_ATCC_199      ETNGVDLQRSYFYADGEEDIDLMALVGEPRPVNPRGRLAVMAAEQGWPVL
                                       .: *  *.***** **  ** ***.***.**.  :*. *  .***:*

Mb2508c|M.bovis_AF2122/97           KFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
Rv2483c|M.tuberculosis_H37Rv        KFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
MMAR_3834|M.marinum_M               KFNSRGGVGLRRQIRTLAGFSTMFPVAAGAVGIGLLTGNRRRGVNFFTSN
MUL_3764|M.ulcerans_Agy99           KFNSRGGVGLRRQIRTLAGFSTMFPVAAGAVGIGLLTGNRRRGVNFFTSN
MAV_1687|M.avium_104                RFSSRGPVGLRRQLRTLAGFGSMFPVAAGAVGVGVLTRNRRRGVNFFTST
MLBr_01245|M.leprae_Br4923          KFNSRGGVGIGAQLRTLVGLSSVLPLVAGAVGIGVLTGSRRRGANFFTSV
TH_0497|M.thermoresistible__bu      RVA-GSGRARRGLLRRRLRV------------------------------
MSMEG_3517|M.smegmatis_MC2_155      SLA-RMP-ARRW--------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          RVE-NPGKGNHGGLRGVLK-------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       RVS-GSGRGGSSGLRGVLK-------------------------------
MAB_2455c|M.abscessus_ATCC_199      RLEDPRPRGMRPSLRRLAGLARP---------------------------
                                     .      .                                         

Mb2508c|M.bovis_AF2122/97           FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
Rv2483c|M.tuberculosis_H37Rv        FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MMAR_3834|M.marinum_M               FSQLLLATSGVHLNVVGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MUL_3764|M.ulcerans_Agy99           FSQLLLATSGVHLNVVGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MAV_1687|M.avium_104                FSQLSLAIAGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNW
MLBr_01245|M.leprae_Br4923          FPPLVLAAAGVHLNVIGNENLTMQRPAVFIYNHRNQIDPLIAGALVRGNW
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           VGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
Rv2483c|M.tuberculosis_H37Rv        VGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
MMAR_3834|M.marinum_M               VGVGKKELQNDPIMGTLGKVLDGVFIDRDDPASAVETLHTVEERAKNGLS
MUL_3764|M.ulcerans_Agy99           VGVGKKELQNDPIMGTLGKVLDGVFIDRDDPASAVETLHTVEERAKNGLS
MAV_1687|M.avium_104                VAVGKKELEKDPVMGTLGKLLDGVFIDRDDPAAAVETLHTVEDRARNGLS
MLBr_01245|M.leprae_Br4923          IAVAKKELAKNPIIRALGKLTDGVFIDRDDPVGAVETLHAVEDRARKGLS
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNST
Rv2483c|M.tuberculosis_H37Rv        IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNST
MMAR_3834|M.marinum_M               IVIAPEGTRLDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAEIVASRNST
MUL_3764|M.ulcerans_Agy99           IVIAPEGTRLDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAEIVASRNST
MAV_1687|M.avium_104                ILIAPEGTRVDTTEVGPFKKGPFRIAMAAGIPIVPIVIRNAELVAARNST
MLBr_01245|M.leprae_Br4923          ILMAPEGTRLDTTEVGPFKKGPFRIAMAVGIPIVPIVFRNAEIVAARNSN
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           TINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPA
Rv2483c|M.tuberculosis_H37Rv        TINPGTVDVAVFPPIPVDDWTLDALPDRIAEVRQLYLDTLADWPVDGLPA
MMAR_3834|M.marinum_M               TINPGTVDIAVFPPIPVDDWTLDTLPDRIAEVRQLYLDTLKDWPVDELPE
MUL_3764|M.ulcerans_Agy99           TINPGTVDIAVFPPIPVDDWTLDTLPDRIAEVRQLYLDTLKDWPVDELPE
MAV_1687|M.avium_104                VINPGTVDVAVFPPISVQDWTLDTLPERIAEVRQLYLDTLANWPVGELPE
MLBr_01245|M.leprae_Br4923          TINPGMVDVAVLPAIPVDDWTLDALSERIAEVRQLYLDILADWPVDELPK
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           VDLYAEQKAARKARAQVAKATAKRV-------PAKKAPAKSAAN------
Rv2483c|M.tuberculosis_H37Rv        VDLYAEQKAARKARAQVAKATAKRV-------PAKKAPAKSAAN------
MMAR_3834|M.marinum_M               VNLYAEEKAAKKAKAQLAKASAKETPAK--KAPAKKAPAKKAAAKKETSA
MUL_3764|M.ulcerans_Agy99           VNLYAEEKAAKKAKAQLAKASAKET-------PAKKAPAKKAAAKKET--
MAV_1687|M.avium_104                VDLYAEKKAAQKARSRAAKSPATSPAKTPAKSPAKRPAKKSAAKKT----
MLBr_01245|M.leprae_Br4923          AALYTRATKATVKKAEPKKGGRTSAAKT----TAKKTATKATAAKT----
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           ----------KGAAATKAATKKASPKAKPSESKIAGKD------------
Rv2483c|M.tuberculosis_H37Rv        ----------KGAAATKAATKKASPKAKPSESKIAGKD------------
MMAR_3834|M.marinum_M               KKAPAKKAPAKKAAAKKAPAKKATAKKAPAKKAPAKKVPESAAAKAATPA
MUL_3764|M.ulcerans_Agy99           ---PAKKAPAKKAPAKKAPAKKATAKKAPANKAPAKKVPESAAAKAATRA
MAV_1687|M.avium_104                ----------AATAAAKTRAKKTAAKPNPAAPNPEAAASHN---------
MLBr_01245|M.leprae_Br4923          ----------ANTAVTKSMLTPPTRISDKENPKVPKVVS-----------
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           -----------GEAS---------------------------ASPSSSAK
Rv2483c|M.tuberculosis_H37Rv        -----------GEAS---------------------------ASPSSSAK
MMAR_3834|M.marinum_M               TDTELPAPKPVGEASNPTEIAPEPIAHDGDAQQLGAGRSDAAESSSSRPK
MUL_3764|M.ulcerans_Agy99           TDTELSAPKPVGEASNPTEIAPEPIAHDGDAQQLGAGRSDAAESSSSRPK
MAV_1687|M.avium_104                -----------GEVSPSRATDPIG-----------------ADPPEAPPR
MLBr_01245|M.leprae_Br4923          -----------------------------------------QDLVVKQPR
TH_0497|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3517|M.smegmatis_MC2_155      --------------------------------------------------
Mflv_3285|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_3004|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2455c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mb2508c|M.bovis_AF2122/97           GRS
Rv2483c|M.tuberculosis_H37Rv        GRS
MMAR_3834|M.marinum_M               GRP
MUL_3764|M.ulcerans_Agy99           GRP
MAV_1687|M.avium_104                GRP
MLBr_01245|M.leprae_Br4923          ERS
TH_0497|M.thermoresistible__bu      ---
MSMEG_3517|M.smegmatis_MC2_155      ---
Mflv_3285|M.gilvum_PYR-GCK          ---
Mvan_3004|M.vanbaalenii_PYR-1       ---
MAB_2455c|M.abscessus_ATCC_199      ---