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VKVTYMSDIRAVVYGVGAMNSIVAGMLLDKGVQIVGAIARSPQKVGQDLGDLLGLGRQLGVAVSDDAAEV LEQTHPDIAVIAVNSYLTDAVEQLRICAEHGVNAVTLSEEMLYPWETSPELSAELDALAKSTGATLTGTG YQDTFWVNMIALLMGTAHRIDTVRGKASWNVDDFGPELATAQQVGRTVAEFDEWVRGAQRPPTFGRNVLD ALVADTGLTVKSITTATRPDIASAAMRSEALGIDLAPGDVIGFTDIDRIETEEGPVFEFEMSGRVYGPGE GDINEWTIEGEPNLFLSNGTVPTQTTTCTQMVNRIPDVIAAPPGIVTVDRLPRLRYRPQF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3317 | dapB | - | 100% (340) | dihydrodipicolinate reductase N-terminus domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5586 | - | 1e-15 | 27.81% (356) | hypothetical protein MSMEG_5586 |
| M. smegmatis MC2 155 | MSMEG_0560 | dapB | 1e-11 | 26.24% (343) | dihydrodipicolinate reductase N-terminus domain-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1088 | - | 5e-06 | 22.99% (361) | hypothetical protein Mb1088 |
| M. gilvum PYR-GCK | Mflv_1277 | - | 2e-12 | 29.36% (344) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv1059 | - | 5e-06 | 22.99% (361) | hypothetical protein Rv1059 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 4e-14 | 24.86% (358) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_0386 | - | 4e-11 | 25.14% (358) | hypothetical protein MMAR_0386 |
| M. avium 104 | MAV_5137 | - | 3e-13 | 25.61% (371) | homoserine dehydrogenase |
| M. thermoresistible (build 8) | TH_3380 | - | 1e-14 | 26.80% (362) | PUTATIVE dihydrodipicolinate reductase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3001 | - | 3e-12 | 25.50% (349) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0386|M.marinum_M ------MAIRVAHVGTGNVGRLALSELVTNPAFELTAVCVSTPEKVGRDA
MAV_5137|M.avium_104 ------MAIRVAHVGTGNVGGLALAELITNPRYELTGVCVSTPEKVGKDA
Mvan_3001|M.vanbaalenii_PYR-1 ------MAIRVALIGTGNCGSLALRQLIEDPRFALTGVWVSSQEKVGRDA
MAB_4633|M.abscessus_ATCC_1997 -----MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDA
TH_3380|M.thermoresistible__bu ----LSKPIRTVVWSTGGVGSIAIDAISRRPDLELVGVWVHSEEKVGKDA
Mb1088|M.bovis_AF2122/97 ----MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDV
Rv1059|M.tuberculosis_H37Rv ----MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDV
Mflv_1277|M.gilvum_PYR-GCK --MPNNAPHRVVQWTTGNVGKSSVAAITANPTLELVGCYAWSDDKVGRDV
MSMEG_3317|M.smegmatis_MC2_155 MKVTYMSDIRAVVYGVGAMN-SIVAGMLLDKGVQIVGAIARSPQKVGQDL
*. .* . : : :.. . * *:*
MMAR_0386|M.marinum_M GDLAGVGIET----GIAAINDLDAVLATAPECVVYCAMGDTRLPDAMADV
MAV_5137|M.avium_104 GELCGVGLDAGVVTGVAAVGDLDAVIAAKPECVVYCAMADTRLPEAMADV
Mvan_3001|M.vanbaalenii_PYR-1 GELARLDVTT----GVAAVDDMAAIIDAKPDCAVYCAMGDVRPKEALADV
MAB_4633|M.abscessus_ATCC_1997 GALAGLDILT----GITATTDAAQILALRPDCVVYTAMTDNRLMEALKDL
TH_3380|M.thermoresistible__bu GELAGVGPLG-----VSATDDAGALIALQPDCVVYAASGPERDAGAVPDY
Mb1088|M.bovis_AF2122/97 GEIIGSPPLG-----VIATNSIDDVLALDADAVIYAPLLPS-----VDEV
Rv1059|M.tuberculosis_H37Rv GEIIGSPPLG-----VIATNSIDDVLALDADAVIYAPLLPS-----VDEV
Mflv_1277|M.gilvum_PYR-GCK GELVGIEPLG-----VAATNDVDALLALKPDAVVYNPMWID-----VDEL
MSMEG_3317|M.smegmatis_MC2_155 GDLLGLGRQLG----VAVSDDAAEVLEQTHPDIAVIAVNSY-LTDAVEQL
* : : . . :: . : :
MMAR_0386|M.marinum_M MRILAAGSNVVGSSPGLLQYPWGVIPDKYIARVQRAAEQGNSSIFITGVD
MAV_5137|M.avium_104 MRILAAGINVVGSSPGLLQYPWGVMPEKYIARVEDAARQGNSSIFISGVD
Mvan_3001|M.vanbaalenii_PYR-1 RGLLEAGINVVGSSPGFLAYPWGVIPDRAIERVESAARQGNTSLFITGVD
MAB_4633|M.abscessus_ATCC_1997 TDLLSAGINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGID
TH_3380|M.thermoresistible__bu VRLLEAGINVVSTTSTMLVYPPSYHSEEWRDQLEAAAKSGSASFYASGIF
Mb1088|M.bovis_AF2122/97 AALLRSGKNVVTPLGWFYPS------EKEAAPLEVAAQAGNATLHGAGIG
Rv1059|M.tuberculosis_H37Rv AALLRSGKNVVTPLGWFYPS------EKEAAPLEVAAQAGNATLHGAGIG
Mflv_1277|M.gilvum_PYR-GCK VRILEAGVNVVASASFITGHNL----GDGRAKLADACERGGSTLFGSGVS
MSMEG_3317|M.smegmatis_MC2_155 RICAEHGVNAVTLSEEMLYP--WETSPELSAELDALAKSTGATLTGTGYQ
* *.. : : .. .::: *
MMAR_0386|M.marinum_M PGFINDLLPFALAGTCQRIEQVRCMEIHDYASYDGAEVMH-YMGFGRSLD
MAV_5137|M.avium_104 PGFANDLIPLALAGTCQRVEQVRCMEIHDYASYNGAEVMG-YMGFGRPLD
Mvan_3001|M.vanbaalenii_PYR-1 PGFVTDLLPLALASTCQSVSQVRTMEIADYATYDGATVMFDVMGFGNEIG
MAB_4633|M.abscessus_ATCC_1997 PGFANDLLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFGKPME
TH_3380|M.thermoresistible__bu PGFGSDELALLLTTQSKNIRRITATEIALNDHYPVADVMMDGMGFGRPLD
Mb1088|M.bovis_AF2122/97 PGAVTELFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPD
Rv1059|M.tuberculosis_H37Rv PGAVTELFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPD
Mflv_1277|M.gilvum_PYR-GCK PG-FAELLAIVAGTACDRIDKVVISESADTTLYDSPDTER-PVGFDMAID
MSMEG_3317|M.smegmatis_MC2_155 DTFWVNMIALLMG-TAHRIDTVRGKASWNVDDFG--PELATAQQVGRTVA
: :.: . : : : ..
MMAR_0386|M.marinum_M EVPMLLQPGVLGIAWG-TAIRQLAAGLGIEVD-EITESYQREPAPEDFEI
MAV_5137|M.avium_104 EIPMLLQPGVLSIAWG-TAIRQLAAGLGIQVD-EITESYQREPAPEDFDI
Mvan_3001|M.vanbaalenii_PYR-1 DLPFLYQPGMLSAAWG-VGVRQLAAGLGVEVD-EIRDSVEQEPAPEDFDV
MAB_4633|M.abscessus_ATCC_1997 ETPMLLQPGVLSLAWG-SVVRQLAAGLGVELD-EVTEVYEKLSAPEDFDI
TH_3380|M.thermoresistible__bu FEPWLKTPGFIEMAWR-APIHLIADGLGVEVE-ELRGTFDRSVTHRDIDV
Mb1088|M.bovis_AF2122/97 SALTGPMQKILDGGFL-QSVRLCVDRLGFAADPQIRTSQEVAVATAPIDS
Rv1059|M.tuberculosis_H37Rv SALTGPMQKILDGGFL-QSVRLCVDRLGFAADPQIRTSQEVAVATAPIDS
Mflv_1277|M.gilvum_PYR-GCK DPALQPMAAQGTAVFA-EAVQLVADALGIELD-EITCVSEYAQTTEDLPM
MSMEG_3317|M.smegmatis_MC2_155 EFDEWVRGAQRPPTFGRNVLDALVADTGLTVK-SITTATRPDIASAAMRS
: : . *. . .: : :
MMAR_0386|M.marinum_M AVGPVAKGTQAVLQFEIRGMVDGQAAIVIEHITRLRPDLRPDWPQPASGG
MAV_5137|M.avium_104 AVGRVAKGTLAVLQFEIRGMVNGHPAIVIEHVTRLRPDLRPDLPQPAAGD
Mvan_3001|M.vanbaalenii_PYR-1 AVGTIKKGTVAAVRFLIEGLVDGAPAIVVEHITRLRGDLRPDWAQPAQEG
MAB_4633|M.abscessus_ATCC_1997 SSGHIPAGTMAALHFEVRGIKDGRAVTVLEHFTRLREDLAPNWPQPAHEG
TH_3380|M.thermoresistible__bu AFGRVEAGTCGAVRTRVAGIVGGREAIVIEHIIRMARDVAPEWLTSEFD-
Mb1088|M.bovis_AF2122/97 PIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAG
Rv1059|M.tuberculosis_H37Rv PIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAG
Mflv_1277|M.gilvum_PYR-GCK ASWTIKAGHVAGVFASWQGIYQGRTVIDINVRWKKG-QTLEPDWQLD--G
MSMEG_3317|M.smegmatis_MC2_155 EALGIDLAPGDVIGFTDIDRIETEEGPVFEFEMSGRVYGPG-------EG
: . .
MMAR_0386|M.marinum_M GSYRIEITGEP--SYAVDIVPSSRNGDHNHAAI-------VGAAGRIVNA
MAV_5137|M.avium_104 GSYRVEITGEP--SYAVDIVPSSRKGDHNHAAI-------AGAAGRIVNA
Mvan_3001|M.vanbaalenii_PYR-1 GSYRVEITGEP--SYVMDICPTSNNGDHNYAAI-------LAAAGRIVNA
MAB_4633|M.abscessus_ATCC_1997 GTYRVEITGEP--SYLLDLGSFSARGDHNYANL-------IATAMRVVNA
TH_3380|M.thermoresistible__bu ATYRVDIEGDPDIHCAMNLGAAEGHG-AGRAAM-------AATAMRVVNA
Mb1088|M.bovis_AF2122/97 ERYEIEVRGSPDTCVTIKGWQPQTVAAGLKSNP-----GIVATAAHCVNA
Rv1059|M.tuberculosis_H37Rv ERYEIEVRGSPDTCVTIKGWQPQTVAAGLKSNP-----GIVATAAHCVNA
Mflv_1277|M.gilvum_PYR-GCK DGWKITIEGRPTVNMSVGFLPPQDMIENAKTLEDFFVLGHIMTALPPIHA
MSMEG_3317|M.smegmatis_MC2_155 DINEWTIEGEPNLFLSNGTVPT-----------------QTTTCTQMVNR
. : * * :. ::
MMAR_0386|M.marinum_M IPAVLTATPGIRTTLDLPLITGKGLYTP--MVSN
MAV_5137|M.avium_104 IPAVIAAPPGIRTTLDLPLVTGKGLYAPSTLVTT
Mvan_3001|M.vanbaalenii_PYR-1 IPDVVAAEPGIRSTLDLPFGTGRGTYRAP-----
MAB_4633|M.abscessus_ATCC_1997 VPAVVAAEAGIRTTLDLPLITGKGRAV-------
TH_3380|M.thermoresistible__bu IPYVVAAPAGLLSSLDLPTTLPRHAFD-------
Mb1088|M.bovis_AF2122/97 IPATCAAPAGIQSFFDLPLITGRAAPGLAR----
Rv1059|M.tuberculosis_H37Rv IPATCAAPAGIQSFFDLPLITGRAAPGLAR----
Mflv_1277|M.gilvum_PYR-GCK IPAVVAAAPGIATYNDLPLPLPRGVVPTR-----
MSMEG_3317|M.smegmatis_MC2_155 IPDVIAAPPGIVTVDRLPRLRYRPQF--------
:* . :* .*: : ** :