For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
IELGVLRGDGIGPEIVSATTQVVERALDAAAVGVRWVPLPFGRQAIDEFGTPVPDVTLERLDGLTGWIIG PHDNAGYPEQFRGTLSPGGVIRKRYNLFANIRPARALSKSVRAVCPDIDVVIVRENTEGFYADRNMYDGA GEFMPTADVALAVAVFTRAAIERIAHEAFRIAATRRRSVTIAHKTNVLTRTTGLFRDTCMAVADQYPDVE VRGEHVDALAALLVSRPTQFDVIVAENMFGDILSDLTGQLSGSLGMAPSLNASDSKAMAQASHGAAPDIA GRDVANPVAMMLSAAMLLRWLGERAGSGRALVGAADAVEHAVRRTLDAGLSTPDVGGSAGTREFTDGVLT ALRPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3285 | - | - | 100% (356) | 3-isopropylmalate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2379 | leuB | 2e-47 | 35.86% (343) | 3-isopropylmalate dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1986 | - | 1e-42 | 34.08% (355) | tartrate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3019c | leuB | 1e-48 | 36.44% (343) | 3-isopropylmalate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4233 | - | 2e-49 | 37.03% (343) | 3-isopropylmalate dehydrogenase |
| M. tuberculosis H37Rv | Rv2995c | leuB | 2e-48 | 36.44% (343) | 3-isopropylmalate dehydrogenase |
| M. leprae Br4923 | MLBr_01691 | leuB | 5e-47 | 36.71% (316) | 3-isopropylmalate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3303c | - | 6e-47 | 35.47% (344) | 3-isopropylmalate dehydrogenase |
| M. marinum M | MMAR_1716 | leuB | 9e-45 | 35.54% (332) | 3-isopropylmalate dehydrogenase LeuB |
| M. avium 104 | MAV_3845 | leuB | 6e-47 | 37.24% (333) | 3-isopropylmalate dehydrogenase |
| M. thermoresistible (build 8) | TH_2038 | leuB | 8e-50 | 37.32% (343) | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM |
| M. ulcerans Agy99 | MUL_1953 | leuB | 1e-44 | 35.58% (312) | 3-isopropylmalate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2129 | - | 1e-48 | 37.46% (347) | 3-isopropylmalate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01691|M.leprae_Br4923 --MKLAIIGGDGIGPEVVAQAVKILD----VVLPGVQKTTYDLGARRYHT
MAV_3845|M.avium_104 --MKLAVIGGDGIGPEVTAEALKVLD----AVLPGVDKTEYDLGARRYHA
Mb3019c|M.bovis_AF2122/97 --MKLAIIAGDGIGPEVTAEAVKVLD----AVVPGVQKTSYDLGARRFHA
Rv2995c|M.tuberculosis_H37Rv --MKLAIIAGDGIGPEVTAEAVKVLD----AVVPGVQKTSYDLGARRFHA
MMAR_1716|M.marinum_M --MKLAIVAGDGIGPEVVAQAVKVLD----VVQPGVEKTNYDLGARRFHA
MUL_1953|M.ulcerans_Agy99 --MKLAIVAGDGIGPEVVAQAVKILD----VVQPGVEKTNYDLGARRFHA
TH_2038|M.thermoresistible__bu VTMKLAIIPGDGIGPEVIGEAVKVLD----AVLPDVDKTHFDLGARRFHA
Mflv_4233|M.gilvum_PYR-GCK --MKLAVIAGDGIGPEVIGEALRVLD----AVVPGVEKTEYDLGARLYHR
Mvan_2129|M.vanbaalenii_PYR-1 --MRLAVIAGDGIGPEVITEALKVLD----AVLPGVEKTEYDLGARQYHK
MAB_3303c|M.abscessus_ATCC_199 -MTKLAIIAGDGIGPEVIGEAVKVLD----AVLPGVDKTEYDLGARRYLA
MSMEG_3285|M.smegmatis_MC2_155 -MIELGVLRGDGIGPEIVSATTQVVERALDAAAVGVRWVPLPFGRQAIDE
.*.:: *******: : :::: .. .* . :* :
MLBr_01691|M.leprae_Br4923 TGELLPESVLAELREHDAILLG---AVGDPSVPSGVLERGLLLRLRFELD
MAV_3845|M.avium_104 TGELLPDSVIDELRAHDAILLG---AIGDPSVPSGVLERGLLLRLRFELD
Mb3019c|M.bovis_AF2122/97 TGEVLPDSVVAELRNHDAILLG---AIGDPSVPSGVLERGLLLRLRFELD
Rv2995c|M.tuberculosis_H37Rv TGEVLPDSVVAELRNHDAILLG---AIGDPSVPSGVLERGLLLRLRFELD
MMAR_1716|M.marinum_M TGEILPDSVIAELREHDAILLG---AIGDPSVPSGVLERGLLLRLRFELD
MUL_1953|M.ulcerans_Agy99 TGEILPDSVIAELREHDAILLG---AIGDPSVPSGVLERGLLLRLRFELD
TH_2038|M.thermoresistible__bu TGEVLPDSVIDELRAHDAILLG---AIGDPSVPSGVLERGLLLRIRFELD
Mflv_4233|M.gilvum_PYR-GCK TGEVLPDSVLDELKGHDAILLG---AIGDPSMPSGVLERGLLLRIRFELD
Mvan_2129|M.vanbaalenii_PYR-1 TGEVLPDSVLEELKGHDAILLG---AIGDPSVPSGLLERGLLLRIRFELD
MAB_3303c|M.abscessus_ATCC_199 TGELMPDSVLDELRGHDAILLG---AIGDPAVPSGVLERGLLLNTRFALD
MSMEG_3285|M.smegmatis_MC2_155 FGTPVPDVTLERLDGLTGWIIGPHDNAGYPEQFRGTLSPGGVIRKRYNL-
* :*: .: .* . ::* * * * *. * ::. *: *
MLBr_01691|M.leprae_Br4923 HHINLRPARLYPG---VNSLLA---GKPDIDFVVVREGTEGPYTGT---G
MAV_3845|M.avium_104 HHINLRPGRLYPG---VSSPLA---GNPDIDFVVVREGTEGPYTGT---G
Mb3019c|M.bovis_AF2122/97 HHINLRPARLYPG---VASPLS---GNPGIDFVVVREGTEGPYTGN---G
Rv2995c|M.tuberculosis_H37Rv HHINLRPARLYPG---VASPLS---GNPGIDFVVVREGTEGPYTGN---G
MMAR_1716|M.marinum_M HHINLRPGRLYPG---VKSPLALEPGNPEIDFVVVREGTEGPYTGN---G
MUL_1953|M.ulcerans_Agy99 YHINLRPGRLYPG---VKSPLALEPGNPEIDFVVVREGTEGPYTGN---G
TH_2038|M.thermoresistible__bu HHINLRPARLYEG---VSSPLA---GNPDIDFVVVREGTEGPYTGT---G
Mflv_4233|M.gilvum_PYR-GCK HHINLRPGRLYPG---VQSPLA---GNPEIDFVVVREGTEGPYTGN---G
Mvan_2129|M.vanbaalenii_PYR-1 HHINLRPARLYPG---VQSPLA---GNPEIDFVVVREGTEGPYTGN---G
MAB_3303c|M.abscessus_ATCC_199 HHINLRPAKLYPG---VTGPLA---GNPAIDLVVVREGTEGPYTGN---G
MSMEG_3285|M.smegmatis_MC2_155 -FANIRPARALSKSVRAVC--------PDIDVVIVRENTEGFYADRNMYD
. *:**.: . * **.*:***.*** *:. .
MLBr_01691|M.leprae_Br4923 GAIRVGTPNEVATEVSVNTAFGVRRVVQDAFERARQRRKHLTLVHKNNVL
MAV_3845|M.avium_104 GAIRVGTPNEVATEVSQNTAFGVRRVVVDAFERARRRRKHLTLVHKTNVL
Mb3019c|M.bovis_AF2122/97 GAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVL
Rv2995c|M.tuberculosis_H37Rv GAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVL
MMAR_1716|M.marinum_M GAIRVGTANEVATEVSVNTAFGVRRVVRDAFERAMRRRKHLTLVHKNNVL
MUL_1953|M.ulcerans_Agy99 GAIRVGTANEVATEVSVNTAFGVRRVVRDAFERAMRRRKHLTLVHKNNVL
TH_2038|M.thermoresistible__bu GAIRVGTPNEVATEVSLNTAFGVRRVVENAFQRAAQRRKHLTLVHKTNVL
Mflv_4233|M.gilvum_PYR-GCK GAIRVGTPHEIATEVSVNTAYGVRRVVQDAFKRAQQRRKHLTLVHKNNVL
Mvan_2129|M.vanbaalenii_PYR-1 GAIRVGTPHEIATEVSVNTAFGVRRAVQDAFGRAQQRRKHLTLVHKNNVL
MAB_3303c|M.abscessus_ATCC_199 GAIRVDTPHEVATEVSLNTRFGVERVVRNAFERAEARSKNLTLVHKNNVL
MSMEG_3285|M.smegmatis_MC2_155 GAGEFMPTADVALAVAVFTRAAIERIAHEAFRIAATRRRSVTIAHKTNVL
** .. .. ::* *: * .:.* . :** * * : :*:.**.***
MLBr_01691|M.leprae_Br4923 TYAGTLWCRIVQEVGEKYPDVEVVYQHIDAATIYLVTEPSRFDVIVTDNL
MAV_3845|M.avium_104 TFAGKLWSRIVAEVGRDYPDVEVAYQHIDAATIFMVTDPGRFDVIVTDNL
Mb3019c|M.bovis_AF2122/97 TLAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNL
Rv2995c|M.tuberculosis_H37Rv TFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNL
MMAR_1716|M.marinum_M TFAGSLWWRTVQEIGEEYPDVELAYQHVDAATIHMVTDPGRFDVIVTDNL
MUL_1953|M.ulcerans_Agy99 TFAGSLWWRTVQEIGEEYPDVELAYQHVDAATIHMVTDPGRFDVIVTDNL
TH_2038|M.thermoresistible__bu TYAGALWSRTVQEVGEQYPDVEVAYQHVDAATIHLVTDPGRFDVIVTDNL
Mflv_4233|M.gilvum_PYR-GCK TNAGSLWWRTVQAVAAEYPEVEVAYQHVDAATIHMVTDPGRFDVIVTDNL
Mvan_2129|M.vanbaalenii_PYR-1 TNAGSLWWRTVQTVAAEYPDVEVAYQHVDAATIHMVTDPGRFDVIVTDNL
MAB_3303c|M.abscessus_ATCC_199 KYAGTLWTRTVNEVAAEYPDVQVSYQHIDAATIHMVTDPGRFDVIVTDNL
MSMEG_3285|M.smegmatis_MC2_155 TRTTGLFRDTCMAVADQYPDVEVRGEHVDALAALLVSRPTQFDVIVAENM
. : *: :. **:*:: :*:** : ::: * :*****::*:
MLBr_01691|M.leprae_Br4923 FGDIITDLAAAVCGGIALAASGNIDATRTNPSMFEPVHGSAPDIAGQGIA
MAV_3845|M.avium_104 FGDIITDLSAAVCGGIGLAASGNIDGTRTNPSMFEPVHGSAPDIAGQGVA
Mb3019c|M.bovis_AF2122/97 FGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIA
Rv2995c|M.tuberculosis_H37Rv FGDIITDLAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIA
MMAR_1716|M.marinum_M FGDIITDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIA
MUL_1953|M.ulcerans_Agy99 FGDIITDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIA
TH_2038|M.thermoresistible__bu FGDIVTDLAAAVCGGIGLAASGNIDATGTNPSMFEPVHGSAPDIAGTGAA
Mflv_4233|M.gilvum_PYR-GCK FGDIITDLAAAVCGGIGLAASGNIDATLTNPSMFEPVHGSAPDIAGQGIA
Mvan_2129|M.vanbaalenii_PYR-1 FGDIITDLAAAVCGGIGLAASGNIDATLTHPSMFEPVHGSAPDIAGQGIA
MAB_3303c|M.abscessus_ATCC_199 FGDIITDLTAAVTGGIGLAASGNIDGSGKNPSMFEPVHGSAPDIAGQGIA
MSMEG_3285|M.smegmatis_MC2_155 FGDILSDLTGQLSGSLGMAPSLNASDSK---AMAQASHGAAPDIAGRDVA
****::**:. : *.:.:*.* * . : :* :. **:****** . *
MLBr_01691|M.leprae_Br4923 DPTAAIMSLALLLAHLGEDEPAARLDQ----AVASYLATRGNGRFSTGEV
MAV_3845|M.avium_104 DPTAAIMSVALLLAHLGEDAAATRVDR----AVERYLATRGNERPATTEV
Mb3019c|M.bovis_AF2122/97 DPTAAIMSVALLLSHLGEHDAAARVDR----AVEAHLATRGSERLATSDV
Rv2995c|M.tuberculosis_H37Rv DPTAAIMSVALLLSHLGEHDAAARVDR----AVEAHLATRGSERLATSDV
MMAR_1716|M.marinum_M DPTAAIMSVSLLLAHLGLDDAASRVDR----AVEGYLATRGNERLATAAV
MUL_1953|M.ulcerans_Agy99 DPTAAIMSVSLLLAHLGLDDTASRVDR----AVEGYLATRGNERLATAAV
TH_2038|M.thermoresistible__bu DPTAAIMSVALLLAHVGESDAAARVDR----AVAEHLATRGDARMSTTEI
Mflv_4233|M.gilvum_PYR-GCK DPTAAIMSVSLLLAHMAEIDAAARVDK----AVAEHLATRGDEKLSTTQV
Mvan_2129|M.vanbaalenii_PYR-1 DPTAAVMSVSLLLAHMAEVDAAARVDK----AVAEHLATRGDEKLSTAAV
MAB_3303c|M.abscessus_ATCC_199 DPTAAIVSVSLLLDHLGETEAAARVER----AVEQHLATRGEEKLSTSAT
MSMEG_3285|M.smegmatis_MC2_155 NPVAMMLSAAMLLRWLGERAGSGRALVGAADAVEHAVRRTLDAGLSTPDV
:*.* ::* ::** :. : * ** : . :*
MLBr_01691|M.leprae_Br4923 G---------ERIAAAL---
MAV_3845|M.avium_104 G---------ERIAAAL---
Mb3019c|M.bovis_AF2122/97 G---------ERIAAAL---
Rv2995c|M.tuberculosis_H37Rv G---------ERIAAAL---
MMAR_1716|M.marinum_M G---------ERIAAAL---
MUL_1953|M.ulcerans_Agy99 G---------ERIAAAL---
TH_2038|M.thermoresistible__bu G---------DRIAAKL---
Mflv_4233|M.gilvum_PYR-GCK G---------DRILGKL---
Mvan_2129|M.vanbaalenii_PYR-1 G---------ERILGKL---
MAB_3303c|M.abscessus_ATCC_199 G---------DRIASFL---
MSMEG_3285|M.smegmatis_MC2_155 GGSAGTREFTDGVLTALRPT
* : : *