For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_3168 (-)

annotation: phenolpthiocerol synthesis type-i polyketide synthase ppse
coordinates: 3242433 - 3242996
length: 187

MGARSWIADHDAAGPAGPADTSMMSTSLGGVLAAELDGARESLGCTTEEIVLAALGRAVARTMGEGLLAV
DLDSAGSDSVDGGAQSAARRVVVPCVSRRELSGAELLATARATVSTAEAHPRADVSLRINTDGVATVGEY
GLCVHVDHSGDSHLRIDWAYDTRNFDRYTVEELSEQFPLALIEVTSG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_3168--100% (187)phenolpthiocerol synthesis type-i polyketide synthase ppse

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2960ppsE1e-0926.07% (234) phenolpthiocerol synthesis type-I polyketide synthase PPSE
M. gilvum PYR-GCKMflv_3645-3e-1934.59% (185) hypothetical protein Mflv_3645
M. tuberculosis H37RvRv2935ppsE1e-0926.07% (234) phenolpthiocerol synthesis type-I polyketide synthase PPSE
M. leprae Br4923MLBr_02353-6e-1024.68% (231) polyketide synthase
M. abscessus ATCC 19977-----
M. marinum MMMAR_1772ppsE6e-1326.18% (233) phenolpthiocerol synthesis type-I polyketide synthase PpsE
M. avium 104-----
M. thermoresistible (build 8)TH_3886-1e-2132.24% (183) PUTATIVE -
M. ulcerans Agy99MUL_2015ppsE4e-1326.18% (233) phenolpthiocerol synthesis type-I polyketide synthase PpsE
M. vanbaalenii PYR-1Mvan_2768-5e-2340.91% (176) hypothetical protein Mvan_2768

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1772|M.marinum_M               MSTIPDNAIAVVGMAGKFPGAKDVSTFWSNLRRGKESIVTLSEEELREAG
MUL_2015|M.ulcerans_Agy99           MSTIPDNAIAVVGMAGKFPGAKDVSTFWSNLRRGKESIVTLSEEELREAG
Mb2960|M.bovis_AF2122/97            -MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAG
Rv2935|M.tuberculosis_H37Rv         -MSIPENAIAVVGMAGRFPGAKDVSAFWSNLRRGKESIVTLSEQELRDAG
MLBr_02353|M.leprae_Br4923          -MITPDNAIAVVGMAGKFPGANDVSAFWTNLRRGKESIVTLSEQELRDNG
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               VSDKTLADPSYVRRAPLVDGIDEFDADFFGFPPLAAQVLDPQHRLFLQCA
MUL_2015|M.ulcerans_Agy99           VSDKTLADPSYVRRAPLVDGIDEFDADFFGFPPLAAQVLDPQHRLFLQCA
Mb2960|M.bovis_AF2122/97            VSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCA
Rv2935|M.tuberculosis_H37Rv         VSDKTLADPAYVRRAPLLDGIDEFDAGFFGFPPLAAQVLDPQHRLFLQCA
MLBr_02353|M.leprae_Br4923          VSDKALADPAYVRRAPLLDGIDEFDADFFGLPPLAAQVLDPQHRLFLQCA
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               WHALEDANCDPAKFDGSIGVYGTSSPSGYLLHNLLSHRDPNTVLAEGLNF
MUL_2015|M.ulcerans_Agy99           WHALEDANCDPAKFDGSIGVYGTSSPSGYLLHNLLSHRDPNTVLAEGLNF
Mb2960|M.bovis_AF2122/97            WHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNF
Rv2935|M.tuberculosis_H37Rv         WHALEDAGADPARFDGSIGVYGTSSPSGYLLHNLLSHRDPNAVLAEGLNF
MLBr_02353|M.leprae_Br4923          WHALEDAGCDPAQFDGSIGVYGTSSPSGYLLHNLLSHRDPHTVLAEGLNF
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               DQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLL
MUL_2015|M.ulcerans_Agy99           DQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLL
Mb2960|M.bovis_AF2122/97            DQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLL
Rv2935|M.tuberculosis_H37Rv         DQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVAVHLACLSLL
MLBr_02353|M.leprae_Br4923          DQFSLFLQNDKDFLATRISHAFNLRGPSIAVQTACSSSLVALHLACLSLL
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               SGECDVALAGGSSLCVPHHVGYFTSPGSMVSAVGHCRPFDVRSDGTVFGS
MUL_2015|M.ulcerans_Agy99           SGECDVALAGGSSLCVPHHVGYFTSPGSMVSAVGHCRPFDVRSDGTVFGS
Mb2960|M.bovis_AF2122/97            SGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGS
Rv2935|M.tuberculosis_H37Rv         SGECDMALAGGSSLCIPHRVGYFTSPGSMVSAVGHCRPFDVRADGTVFGS
MLBr_02353|M.leprae_Br4923          SGECDMALAGGSSLCIPHRVGYWHSPGSMVSAVGHCRPFDVRADGTVFGS
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               GVAMVVLKPLQAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADV
MUL_2015|M.ulcerans_Agy99           GAAMVVLKPLQAAIDAGDRIHAVIRASAINNDGSAKMGYAAPNPAAQADV
Mb2960|M.bovis_AF2122/97            GVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADV
Rv2935|M.tuberculosis_H37Rv         GVGLVVLKPLAAAIDAGDRIHAVIRGSAINNDGSAKMGYAAPNPAAQADV
MLBr_02353|M.leprae_Br4923          GVALVALKPLQAAIDASDRIHAVILGSAINNDGSMKMGYAAPNPAAQADV
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               IAEAHAVSGIDASTVSYVECHGTGTPLGDPIEIQGLRTAFEASETTRTGP
MUL_2015|M.ulcerans_Agy99           IAEAHAVSGIDASTVSYVECHGTGTPLGDPIEIQGLRTAFEASETTRTGP
Mb2960|M.bovis_AF2122/97            IAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAP
Rv2935|M.tuberculosis_H37Rv         IAEAHAVSGIDSSTVSYVECHGTGTPLGDPIEIQGLRAAFEVSQTSRSAP
MLBr_02353|M.leprae_Br4923          IAEAHAVAGIDSSTVSYVETHGTGTPLGDPIEIQGLKTAFEVSQIPRPGP
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               CVLGSVKSNIGHLEVAAGIAGLIKTILCLKNRAIPATLHYTSPNPELRLE
MUL_2015|M.ulcerans_Agy99           CVLGSVKSNIGHLEVAAGIAGLIKTILCLKNRAIPATLHYTSPNPELRLE
Mb2960|M.bovis_AF2122/97            CVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLD
Rv2935|M.tuberculosis_H37Rv         CVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKALPATLHYTSPNPELRLD
MLBr_02353|M.leprae_Br4923          CVLGSVKSNIGHLEVAAGIAGLIKTILCLKNKAIPATLHYTSPNRELRLD
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               QSPFVVQNKYGPWEWDGVLRAGVSSFGVGGTNAHVVLEEAP----TVPAH
MUL_2015|M.ulcerans_Agy99           QSPFVVQNKYGPWEWDGVLRAGVSSFGVGGTNAHVVLEEAP----TVPAH
Mb2960|M.bovis_AF2122/97            QSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAH
Rv2935|M.tuberculosis_H37Rv         QSPFVVQSKYGPWECDGVRRAGVSSFGVGGTNAHVVLEEAPAEASEVSAH
MLBr_02353|M.leprae_Br4923          QTPFVVQSNYGPWKWDGVRRAGVSSFGVGGTNVHVVLEEASVEASTVAAS
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               DEPAGPQVLLLSAQTAAALTESRTALAEVLERSDSPDLSDVAYTLSRRRK
MUL_2015|M.ulcerans_Agy99           DEPAGPQVLLLSAQTAAALTESRTALAEVLGRSDSPDLSDVAYTLSRRRK
Mb2960|M.bovis_AF2122/97            AEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRK
Rv2935|M.tuberculosis_H37Rv         AEPAGPQVILLSAQTAAALGESRTALAAALETQDGPRLSDVAYTLARRRK
MLBr_02353|M.leprae_Br4923          ---TGPQVILLSAQTAAALGESREALATVLEKPGAPDLSDVAYTLAGRRK
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               HNVTMAAVVSDREEAATALRAADNDSIFVGESVAG-----VADATAAAAE
MUL_2015|M.ulcerans_Agy99           HNVTMAAVVSDREEAATALRAADNDSIFVGESVAG-----VADATAAAAE
Mb2960|M.bovis_AF2122/97            HNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPT-SD
Rv2935|M.tuberculosis_H37Rv         HNVTMAAVVHDREHAATVLRAAEHDNVFVGEAAHDGEHGDRADAAPT-SD
MLBr_02353|M.leprae_Br4923          HNITMAAVVRDREHAVTVLRAAEHDNVFVGESGADTGRSAAASITTLGSD
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               RVVFLFPGQGAQHVGMAKGLYETEPVFAEHFDACAAGFRAEMG-VDLNAE
MUL_2015|M.ulcerans_Agy99           RVVFLFPGQGAQHVGMAKGLYETEPVFAEHFDACAAGFRAEMG-VDLNAE
Mb2960|M.bovis_AF2122/97            RVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETG-IDLHAE
Rv2935|M.tuberculosis_H37Rv         RVVFLFPGQGAQHVGMAKGLYDTEPVFAQHFDTCAAGFRDETG-IDLHAE
MLBr_02353|M.leprae_Br4923          RVVFLFPGQGAQHVGMAKGLYDTESVFAEHFDTCSAGFREAMDDLDLHSA
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               IFNGTATDLERIDRSQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYIA
MUL_2015|M.ulcerans_Agy99           IFNGTGTDLERIDRSQPALFTVEYALAKLVDTYGVRAGAYIGYSTGEYIA
Mb2960|M.bovis_AF2122/97            VFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIA
Rv2935|M.tuberculosis_H37Rv         VFDGTATDLERIDRSQPALFTVEYALAKLVDTFGVRAGAYIGYSTGEYIA
MLBr_02353|M.leprae_Br4923          IFNGTAIDLERIDRSQPALFTVEYALAKLVESFGVGAGAYIGYSTGEYIA
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               ATLAGVFDLETAIKTVSLRARLMHESPPGAMVAVAVGPDEIAQYLGD---
MUL_2015|M.ulcerans_Agy99           ATLAGVFDLETAIKTVSLRARLMHESPPGAMVAVAVGPDDFAQYLGD---
Mb2960|M.bovis_AF2122/97            ATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPP---
Rv2935|M.tuberculosis_H37Rv         ATLAGVFDLQTAIKTVSLRARLMHESPPGAMVAVALGPDDVTQYLPP---
MLBr_02353|M.leprae_Br4923          ATLAGVFDLETAIKTVSLRARLMHESPPGAMVAVALGPEDITEYLAEYSA
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               -GVELSAVNDPGNCVVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHSSS
MUL_2015|M.ulcerans_Agy99           -GVELSAVNDPGNCVVAGPKDEIRAFSQRLNEAGIPVRRVRATHAFHSSS
Mb2960|M.bovis_AF2122/97            -EVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSA
Rv2935|M.tuberculosis_H37Rv         -EVELSAVNDPGNCVVAGPKDQIRALRQRLTEAGIPVRRVRATHAFHTSA
MLBr_02353|M.leprae_Br4923          KGVELSAVNDPGNCVVAGPKDQIRAFSQRLDEVGIPVRRVRATHAFHTSS
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               MEPMLGEFQEFLSRQQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQISS
MUL_2015|M.ulcerans_Agy99           MEPMLGEFQEFLSRQQLRAPQTPLLSNLTGTWLSEQQVTDPATWARQISS
Mb2960|M.bovis_AF2122/97            MDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISS
Rv2935|M.tuberculosis_H37Rv         MDPMLGQFQEFLSRQQLRPPRTPLLSNLTGSWMSDQQVVDPASWTRQISS
MLBr_02353|M.leprae_Br4923          MEPMLREFSEFLSRQQLRVPNTPLLSNLTGTWMSEQQVTDPENWTRQISS
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               TVRFADELDVVLSQPNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRLMRH
MUL_2015|M.ulcerans_Agy99           TVRFADELDVVLSQPNRILVEIGPGGSLTGSAIRHPKWSDGHRSVRLMRH
Mb2960|M.bovis_AF2122/97            PIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRH
Rv2935|M.tuberculosis_H37Rv         PIRFADELDVVLAAPSRILVEVGPGGSLTGSAMRHPKWSTTHRTVRLMRH
MLBr_02353|M.leprae_Br4923          TIRFADELDVVLSQSGRVLVEVGPGGSLTGSAMRHPRWSSGHRAVRLMRH
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               PIQNLDDRETFLRALGELWSAGVDVDWTPRRAASPRIVSLPGYPFARQRH
MUL_2015|M.ulcerans_Agy99           PIQNLDDRETFLRALGELWSAGVDVDWTPRRAASPRIVSLPGYPFARQRH
Mb2960|M.bovis_AF2122/97            PLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRH
Rv2935|M.tuberculosis_H37Rv         PLQDVDDRDTFLRALGELWSAGVEVDWTPRRPAVPHLVSLPGYPFARQRH
MLBr_02353|M.leprae_Br4923          PLQNVDDHDTFLRALGELWSAGIEVDWAPQRSVMPHLVSLPGYPFARQRH
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               WVEPKHMAWAQIPTASNGSSVGAKLGSGADSGIRGGAQTGESQTEDVLQR
MUL_2015|M.ulcerans_Agy99           WVEPKHMAWAQIPTASNGSSVGAKLGSGADSGIRGGAQTGESQTEDVLQR
Mb2960|M.bovis_AF2122/97            WVEPNHTVWAQAPGANNGSPAGTADGSTA--ATVDAARNGESQTEVTLQR
Rv2935|M.tuberculosis_H37Rv         WVEPNHTVWAQAPGANNGSPAGTADGSTA--ATVDAARNGESQTEVTLQR
MLBr_02353|M.leprae_Br4923          WVEPRYTIWAQIPGASSGSPVDSSVDS----ATVEGVRGGESQTEATLQR
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               IWSQCLGVGSVDRNANFFDMGGDSLMAISIAMSAANEGLTITPQDLYEHP
MUL_2015|M.ulcerans_Agy99           IWSQCLGVGSVDRNANFFDMGGDSLMAISIAMSAANEGLTITPQDLYEHP
Mb2960|M.bovis_AF2122/97            IWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYP
Rv2935|M.tuberculosis_H37Rv         IWSQCLGVSSVDRNANFFDLGGDSLMAISIAMAAANEGLTITPQDLYEYP
MLBr_02353|M.leprae_Br4923          IWSQCLGVSSVDRNANFFDLGGDSLMAISISMAAANEGMTITPQDMYEHP
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               TLASLTAAIDASFASSGLAKPPEADANPAVPPNIAYFLDRGLRDTGRWRV
MUL_2015|M.ulcerans_Agy99           TLASLTAAIDASFASSGLAKPPEADANPAVPPNIAYFLDRGLRDTGRWRV
Mb2960|M.bovis_AF2122/97            TLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRV
Rv2935|M.tuberculosis_H37Rv         TLASLTAAVDASFASSGLAKPPEAQANPAVPPNVTYFLDRGLRDTGRCRV
MLBr_02353|M.leprae_Br4923          TLASLTAAVDASFASSGLAKPPEAAAHPAVPPNIAYFLERGLCDTGRWRV
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               PLILRLDPQVGPEDIRAVLSAVTNHHDALRLRLVENGGVWEQHIAAPADF
MUL_2015|M.ulcerans_Agy99           PLILRLDPQVGPEDIRAVLSAVTNHHDALRLRLVENGGVWEQHIAAPADF
Mb2960|M.bovis_AF2122/97            PLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEF
Rv2935|M.tuberculosis_H37Rv         PLILRLDPKIGLPDIRAVLTAVVNHHDALRLHLVGNDGIWEQHIAAPAEF
MLBr_02353|M.leprae_Br4923          PLILRLDPKIGSDDIRAVLTAVVNHHDVLRLSLVDNDGMWEQHIAATGEF
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               TELATRQLPGDLAAGEADEHGAVSNIVAELIAEQGDSNAPLIAVHVTAPN
MUL_2015|M.ulcerans_Agy99           TELATRQLPDDLAADEADEHSAVSNIVAELIAEQGDSNAPLIAVHVTAPN
Mb2960|M.bovis_AF2122/97            TGLSNRSVPDGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAH
Rv2935|M.tuberculosis_H37Rv         TGLSNRSVPNGVAAGSPEERAAVLGILAELLEDQTDPNAPLAAVHIAAAH
MLBr_02353|M.leprae_Br4923          TRLLTQTLPDGVAAGSAEERAVVSSILAELIASQSDLNEPLTAVQITTAH
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               GGAQYLGLALHEMVADDASRQLLGADIITAFAQRLGDQEIKLDPVTTGWR
MUL_2015|M.ulcerans_Agy99           GGAQYLGLALHETVADDASRQLLGADIITAFAQRLDDQEIKLDPVTTGWR
Mb2960|M.bovis_AF2122/97            GGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWR
Rv2935|M.tuberculosis_H37Rv         GGPHYLCLAIHAMVTDDSSRQILATDIVTAFGQRLAGEEITLEPVSTGWR
MLBr_02353|M.leprae_Br4923          GGPHYLGLAVHQMVIDDASRQILGTDIITAFGQRLAGEEITLEPVTTGWR
TH_3886|M.thermoresistible__bu      --------------------------------------------------
Mflv_3645|M.gilvum_PYR-GCK          -------------------------------------------------M
Mvan_2768|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_3168|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

MMAR_1772|M.marinum_M               DWSVRCAALATHPAALDTRSYWIEQSTKANLWLTDG----DAAQPPSATD
MUL_2015|M.ulcerans_Agy99           DWSVRCAALATHPAALDTRSYWIEQSTKANLWLTDG----DAAQPPSATD
Mb2960|M.bovis_AF2122/97            EWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADE
Rv2935|M.tuberculosis_H37Rv         EWSLRCAALATHPAALDTRSYWIENSTKATLWLADALPNAHTAHPPRADE
MLBr_02353|M.leprae_Br4923          EWSLRCAALATHPAALDTRSFWIENANKVNLWLADVSLNTDVIQPPGADD
TH_3886|M.thermoresistible__bu      -------MVAPSFARLDTEYLRLTDH--------------DVADPPRPED
Mflv_3645|M.gilvum_PYR-GCK          GHSLYGKAMVAPYITGEVKQRPLRSAPAALDVFDHS------SIDALPHQ
Mvan_2768|M.vanbaalenii_PYR-1       --------MVAPYISDEVKPRPVPSVPEILDVFDRP------AADALPAR
MSMEG_3168|M.smegmatis_MC2_155      -------MGARSWIADHDAAGPAG-----------------------PAD
                                             .      .                              .  

MMAR_1772|M.marinum_M               LTKLPSVLNAEQTSELDDARRRFRRSIQTILLAALGRTIAQTVGDGVVAV
MUL_2015|M.ulcerans_Agy99           LTKLPSVLNAEQTSELDDARRRFRRSIQTILLAALGRTIAQTVGDGVVAV
Mb2960|M.bovis_AF2122/97            LTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTVGEGVVAV
Rv2935|M.tuberculosis_H37Rv         LTKLSSTLSVEQTSELDDGRRRFRRSIQTILLAALGRTIAQTVGEGVVAV
MLBr_02353|M.leprae_Br4923          LIRMPCTLSVEQTSELDDARRRFRRSIQAIVLAALGRTIAQTVGDGVVAV
TH_3886|M.thermoresistible__bu      LVRHPAPLSPVLSGELDGAAQALDSSAEELLLAALARTIGRTIGTGTVVV
Mflv_3645|M.gilvum_PYR-GCK          LEKFSTTPSSELTEEVEASAEWLGVPIEEILLAALGRTLGRTRGEGNITI
Mvan_2768|M.vanbaalenii_PYR-1       SQKFGTSSSSELTEELDGAAEWLGVRVEEILLAALGRTFGRTRGEGAVDV
MSMEG_3168|M.smegmatis_MC2_155      TSMMSTSLGGVLAAELDGARESLGCTTEEIVLAALGRAVARTMGEGLLAV
                                            .   : *:: . . :    : ::****.*:..:* * * : :

MMAR_1772|M.marinum_M               ELDGEGRSVLRPDVDVRRTVGRFTTYYPVALTCATGQGAAALKGLDAVHD
MUL_2015|M.ulcerans_Agy99           ELDGEGRSVLRPDVDVRRTVGRFTTYYPVALTCATGQGAAALKGLDAVHD
Mb2960|M.bovis_AF2122/97            ELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLG--ALAQLDAVHN
Rv2935|M.tuberculosis_H37Rv         ELEGEGRSVLRPDVDLRRTVGWFTTYYPVPLACATGLG--ALAQLDAVHN
MLBr_02353|M.leprae_Br4923          ELEGEGRSVLRPDVDVRRTIGWFTNYYPIPLVCVKGQG--ALAQLDAVHN
TH_3886|M.thermoresistible__bu      GLADHG---------------------PLALACATEKTISATDLLTGVRS
Mflv_3645|M.gilvum_PYR-GCK          DVT----------------GGNRWLSQPAAIFCSADPALSPTDILQSAHT
Mvan_2768|M.vanbaalenii_PYR-1       DVT----------------GGHRWASRPVSMICAAGQPMGPTEMLQGAHS
MSMEG_3168|M.smegmatis_MC2_155      DLDSAGSDSV--------DGGAQSAARRVVVPCVSRRELSGAELLATARA
                                     :                            : *           *  .: 

MMAR_1772|M.marinum_M               TLKSVPHYGIGYGLLRYLYAPTGRVLGAQRTPDIHFRYAGTIPELPPVDA
MUL_2015|M.ulcerans_Agy99           TLKSVPHYGIGYGLLRYLYAPTGRVLGAQRTPDIHFRYAGTIPELPPVDA
Mb2960|M.bovis_AF2122/97            TLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDA
Rv2935|M.tuberculosis_H37Rv         TLKSVPHYGIGYGLLRYVYAPTGRVLGAQRTPDIHFRYAGVIPELPSGDA
MLBr_02353|M.leprae_Br4923          TLKSIPHYGIGYGLLRYMYAPTGRVFSAQRTPDIHFRYVGVVPEPPSVDA
TH_3886|M.thermoresistible__bu      SLG-------------------ARTPAAGGAREIAVTFSGPVSELPD---
Mflv_3645|M.gilvum_PYR-GCK          ALVS------------------SPRRSAEPADVLLNVSVGSLLDAPAG--
Mvan_2768|M.vanbaalenii_PYR-1       VLAG------------------APFRAGAQSEVLLNVANG-VVDRPCT--
MSMEG_3168|M.smegmatis_MC2_155      TVST------------------AEAHP--RADVSLRINTDGVATVGEY--
                                     :                    .       :        . :        

MMAR_1772|M.marinum_M               PVQFDSDLAMPVREPLPGLGHAVEIRAYRSGSSLHVDWWYDTRRITAETA
MUL_2015|M.ulcerans_Agy99           PVQFDSDLAMPVREPLPGLGHAVEIRAYRSGSSLHVDWWYDTRRITAETA
Mb2960|M.bovis_AF2122/97            PVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATA
Rv2935|M.tuberculosis_H37Rv         PVQFDSDMTLPVREPIPGMGHAIELRVYRFGGSLHLDWWYDTRRIPAATA
MLBr_02353|M.leprae_Br4923          TVQFDSDMTIPVQEPVPGMGHAIELRTYRFGGSLHLDWWYDIRRIPQVTA
TH_3886|M.thermoresistible__bu      -----------------SPCHAIELRIHRSHDRVHLDWWYDPARFYPYTV
Mflv_3645|M.gilvum_PYR-GCK          --------------------RALELRVQRLDGGLQIDWWYDAQRFDPYSI
Mvan_2768|M.vanbaalenii_PYR-1       --------------------RPLELRVQRVDGLLQIDWWYDESRLDAYSV
MSMEG_3168|M.smegmatis_MC2_155      --------------------GLCVHVDHSGDSHLRIDWAYDTRNFDRYTV
                                                                   . :::** **  .:   : 

MMAR_1772|M.marinum_M               TALARSFPTALSELIQESIAAEQEERDEDEKVGVIEAGALVDLSSLDAG
MUL_2015|M.ulcerans_Agy99           TALARSFPTALSELIQESIAAEQEERDEDEKVGVIEAGALVDLPSLDAG
Mb2960|M.bovis_AF2122/97            EALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG
Rv2935|M.tuberculosis_H37Rv         EALERTFPLALSALIQEAIAAEHTEHDDSEIVGEPEAGALVDLSSMDAG
MLBr_02353|M.leprae_Br4923          EALAQSFPVTLSKLIQEGIATQKDAHDESEMAGAPQAGVLVDLSTLDAG
TH_3886|M.thermoresistible__bu      VELAEQFPLALIEVCSEATVPSVPRPARSLICTAP--------------
Mflv_3645|M.gilvum_PYR-GCK          EEMAEQFPQAVIDITSDASAPL---------------------------
Mvan_2768|M.vanbaalenii_PYR-1       EEMAEQFPLAAIEITSDAAAPL---------------------------
MSMEG_3168|M.smegmatis_MC2_155      EELSEQFPLALIEVTSG--------------------------------
                                      : . ** :   : .