For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4509 | aceA | - | 100% (429) | isocitrate lyase |
| M. thermoresistible (build 8) | TH_0417 | aceAb | 8e-42 | 37.55% (245) | PROBABLE ISOCITRATE LYASE aceAb |
| M. thermoresistible (build 8) | TH_1918 | - | 5e-05 | 34.34% (99) | transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0476 | icl | 0.0 | 90.19% (428) | isocitrate lyase |
| M. gilvum PYR-GCK | Mflv_0107 | - | 0.0 | 89.25% (428) | isocitrate lyase |
| M. tuberculosis H37Rv | Rv0467 | icl | 0.0 | 90.19% (428) | isocitrate lyase |
| M. leprae Br4923 | MLBr_01985 | aceA | 2e-41 | 37.55% (245) | isocitrate lyase |
| M. abscessus ATCC 19977 | MAB_4095c | - | 0.0 | 85.12% (430) | isocitrate lyase (AceA) |
| M. marinum M | MMAR_0792 | icl | 0.0 | 89.95% (428) | isocitrate lyase Icl |
| M. avium 104 | MAV_4682 | aceA | 0.0 | 90.89% (428) | isocitrate lyase |
| M. smegmatis MC2 155 | MSMEG_0911 | aceA | 0.0 | 92.06% (428) | isocitrate lyase |
| M. ulcerans Agy99 | MUL_4536 | icl | 0.0 | 89.49% (428) | isocitrate lyase Icl |
| M. vanbaalenii PYR-1 | Mvan_0801 | - | 0.0 | 90.89% (428) | isocitrate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0476|M.bovis_AF2122/97 ----------------------MSVVGTPKSAEQ----------------
Rv0467|M.tuberculosis_H37Rv ----------------------MSVVGTPKSAEQ----------------
MAV_4682|M.avium_104 ----------------------MSVVGTPKSAEE----------------
Mflv_0107|M.gilvum_PYR-GCK ----------------------MSTVGMPKSPEQ----------------
Mvan_0801|M.vanbaalenii_PYR-1 ----------------------MSTVGTPKSPEQ----------------
MSMEG_0911|M.smegmatis_MC2_155 ----------------------MSTVGTPKSPEQ----------------
MMAR_0792|M.marinum_M ----------------------MSVVGTPKSAEQ----------------
MUL_4536|M.ulcerans_Agy99 ----------------------MSVVGTPKCAEQ----------------
TH_4509|M.thermoresistible__bu ----------------------MSNVGTPRSAEQ----------------
MAB_4095c|M.abscessus_ATCC_199 ----------------------MSNVGKPRTAAE----------------
MLBr_01985|M.leprae_Br4923 MAGIPATVVQRCNSTNLDDRLHYSPLGDRAKEERNPMAIMDTNTEVHTLF
* :* .
Mb0476|M.bovis_AF2122/97 -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW
Rv0467|M.tuberculosis_H37Rv -----IQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLW
MAV_4682|M.avium_104 -----IQKDWDTNPRWKDVTRTYTAEDVVALQGTVVEENTLARRGAEVLW
Mflv_0107|M.gilvum_PYR-GCK -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW
Mvan_0801|M.vanbaalenii_PYR-1 -----IQHDWDHNPRWKGITRTYTPADVVALQGHVVEEHTLARRGAEVLW
MSMEG_0911|M.smegmatis_MC2_155 -----IQHDWDHNPRWKGIKRDYTPEDVVALQGTVVEEHTLARRGAEVLW
MMAR_0792|M.marinum_M -----IQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLW
MUL_4536|M.ulcerans_Agy99 -----IQHDWDHNPRWKGITRTYTPQDVVALQGHVVEEHTLARRGSEVLW
TH_4509|M.thermoresistible__bu -----IKKDWETNPRWKNVKRDYTAEDVVALQGTVVEEHTLARRGAEILW
MAB_4095c|M.abscessus_ATCC_199 -----IQQDWDTNPRWKGITRDYTAAQVEELQGSVVEENTLARRGAEILW
MLBr_01985|M.leprae_Br4923 TQEVAATQQYFDDPRFAGIIRLYTARQVVEQRGTIPTDYTVARDAATAFY
::: :**: .: * *:. :* :* : : *:** .: ::
Mb0476|M.bovis_AF2122/97 EQLH----DLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Rv0467|M.tuberculosis_H37Rv EQLH----DLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MAV_4682|M.avium_104 EQLH----DLEYINALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Mflv_0107|M.gilvum_PYR-GCK EQLH----DMDFVNSLGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
Mvan_0801|M.vanbaalenii_PYR-1 DQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MSMEG_0911|M.smegmatis_MC2_155 EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MMAR_0792|M.marinum_M EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MUL_4536|M.ulcerans_Agy99 EQLH----DMDFVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
TH_4509|M.thermoresistible__bu NQLH----DMEFVNALGALTGNQAVQQVRAGLKAIYLSGWQVAGDANLSG
MAB_4095c|M.abscessus_ATCC_199 DAVSKD--DDSYINALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSG
MLBr_01985|M.leprae_Br4923 ARLRELFAAGKSVTTFGPYSPGQAVSLKRMGIEAIYLGGWATSAKGSITE
: . :.::*. : . **. * *::****.** .:....::
Mb0476|M.bovis_AF2122/97 HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE
Rv0467|M.tuberculosis_H37Rv HTYPDQSLYPANSVPQVVRRINNALQRADQIAKIE---------GDTSVE
MAV_4682|M.avium_104 HTYPDQSLYPANSVPTVVRRINNALLRADQIAKVE---------GDTSVK
Mflv_0107|M.gilvum_PYR-GCK HTYPDQSLYPANSVPQVIRRINNALLRADEIAKVE---------GDTSVE
Mvan_0801|M.vanbaalenii_PYR-1 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------GDTSVE
MSMEG_0911|M.smegmatis_MC2_155 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------GDTSVE
MMAR_0792|M.marinum_M HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------NDRSVD
MUL_4536|M.ulcerans_Agy99 HTYPDQSLYPANSVPQVVRRINNALLRADEIAKVE---------NDRSVD
TH_4509|M.thermoresistible__bu HTYPDQSLYPANSVPQVVRRINNALMRADQIAKVE---------GDTSVE
MAB_4095c|M.abscessus_ATCC_199 HTYPDQSLYPANSVPAVVRRINNALLRADEIARVE---------GDTSVD
MLBr_01985|M.leprae_Br4923 DPGPDLASYPLSQVPDDAAVLVRALLAADRNQQYLRLHMTEQQRAATPAY
.. ** : ** ..** : .** **. : ..
Mb0476|M.bovis_AF2122/97 NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL
Rv0467|M.tuberculosis_H37Rv NWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHL
MAV_4682|M.avium_104 NWLAPIVADGEAGFGGALNVFELQKAMIAAGVAGSHWEDQLASEKKCGHL
Mflv_0107|M.gilvum_PYR-GCK NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
Mvan_0801|M.vanbaalenii_PYR-1 NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
MSMEG_0911|M.smegmatis_MC2_155 NWLAPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
MMAR_0792|M.marinum_M NWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
MUL_4536|M.ulcerans_Agy99 NWLVPIVADGEAGFGGALNVYELQKAMIAAGVAGSHWEDQLASEKKCGHL
TH_4509|M.thermoresistible__bu NWLVPIVADGEAGFGGALNVYELQKAMITAGVAGSHWEDQLASEKKCGHL
MAB_4095c|M.abscessus_ATCC_199 NWLVPIVADGEAGFGGALNVYELQKAMIAAGAAGTHWEDQLASEKKCGHL
MLBr_01985|M.leprae_Br4923 DYRPFIIADADTGHGGDSHVRNLIRRFVEIGVPGYHIEDQRPGTKKCGHQ
:: *:**.::*.** :* :* : :: *..* * *** .. *****
Mb0476|M.bovis_AF2122/97 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
Rv0467|M.tuberculosis_H37Rv GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
MAV_4682|M.avium_104 GGKVLIPTQQHIRTLTSARLAADVCDVPTVVIARTDAEAATLITSDVDER
Mflv_0107|M.gilvum_PYR-GCK GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER
Mvan_0801|M.vanbaalenii_PYR-1 GGKVLIPTQQHIRTLTSARLAADVAGVPTVVIARTDAEAATLITSDVDER
MSMEG_0911|M.smegmatis_MC2_155 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
MMAR_0792|M.marinum_M GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
MUL_4536|M.ulcerans_Agy99 GGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDER
TH_4509|M.thermoresistible__bu GGKVLIPTQQHIRTLTAARLAADVADVPTVIIARTDAEAATLITSDVDER
MAB_4095c|M.abscessus_ATCC_199 GGKVLIPTQQHIRTLTSARLAADVANTPTVVIARTDAEAATLITSDVDER
MLBr_01985|M.leprae_Br4923 GGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAEAANLIDSRADER
*****:*::::*: *.:**: *: .* :::********.** * .***
Mb0476|M.bovis_AF2122/97 DQPFITGER-----------------------------------------
Rv0467|M.tuberculosis_H37Rv DQPFITGER-----------------------------------------
MAV_4682|M.avium_104 DQPFITGER-----------------------------------------
Mflv_0107|M.gilvum_PYR-GCK DQPFITGDR-----------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 DRPFITGER-----------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 DQPFITGER-----------------------------------------
MMAR_0792|M.marinum_M DRPFITGER-----------------------------------------
MUL_4536|M.ulcerans_Agy99 DRPFITGEP-----------------------------------------
TH_4509|M.thermoresistible__bu DRPFITGER-----------------------------------------
MAB_4095c|M.abscessus_ATCC_199 DKPFVTGER-----------------------------------------
MLBr_01985|M.leprae_Br4923 DQPFLLGATNLKIPSYKACFLALVRCFYELGVKELHGHLLYALGDGEYAA
*:**: *
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4682|M.avium_104 --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0792|M.marinum_M --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MAB_4095c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 ASAWLDRQGILAQVSGTVNAWQENGKQSIDDLFEQVEYRLLAAWEKDAGL
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4682|M.avium_104 --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0792|M.marinum_M --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MAB_4095c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 MTYGEAVEEMLQFGESEGELIGMSPEEWRRFVGRASLYAAREKAKELGVD
Mb0476|M.bovis_AF2122/97 ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA
Rv0467|M.tuberculosis_H37Rv ---------TREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAA
MAV_4682|M.avium_104 ---------TKEGFYRVRNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
Mflv_0107|M.gilvum_PYR-GCK ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
Mvan_0801|M.vanbaalenii_PYR-1 ---------TAEGFYRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
MSMEG_0911|M.smegmatis_MC2_155 ---------TKEGFFRVKNGLEPCIARAKAYAPYSDLIWMETGTPDLELA
MMAR_0792|M.marinum_M ---------TKEGFYRIKNGLEPCIARAKAYAPFSDLIWMETGTPDLKLA
MUL_4536|M.ulcerans_Agy99 ---------TKEGFYRIKNGLEPCIARAKAYAPFSDLIWMETGTPDLKLA
TH_4509|M.thermoresistible__bu ---------TKEGFYRVQNGIEPCIARAKAYAPYADLIWMETGTPDLELA
MAB_4095c|M.abscessus_ATCC_199 ---------TSEGFYNVQKGIEPCIARAKAYAPYADLIWMETGVPDLEVA
MLBr_01985|M.leprae_Br4923 PGWDCELAKTPEGYYQIRGGIQYAIAKSLAAAPFADILWMETKTADLADA
* **::. : *:: .**:: * **::*::**** ..** *
Mb0476|M.bovis_AF2122/97 RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF
Rv0467|M.tuberculosis_H37Rv RQFSEAVKAEYPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF
MAV_4682|M.avium_104 AKFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELAAMGFKF
Mflv_0107|M.gilvum_PYR-GCK KKFAEGVKSEFPDQMLAYNCSPSFNWKQH-LDDATIAKFQKELGAMGFKF
Mvan_0801|M.vanbaalenii_PYR-1 KKFAEGVKSEFPDQMLAYNCSPSFNWRKH-LDDATIAKFQKELGAMGFKF
MSMEG_0911|M.smegmatis_MC2_155 KKFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDATIAKFQKELGAMGFKF
MMAR_0792|M.marinum_M KQFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDETIAKFQKELGAMGFKF
MUL_4536|M.ulcerans_Agy99 KQFAEGVKAEFPDQMLAYNCSPSFNWKKH-LDDETIAKFQKELGAMGFKF
TH_4509|M.thermoresistible__bu KRFAEAVKAEFPDQMLAYNCSPSFNWRKH-LDDATIARFQKELGAMGYKF
MAB_4095c|M.abscessus_ATCC_199 RKFAEAVKADFPDQLLSYNCSPSFNWKQH-LDDSTIAKFQKELGAMGFKF
MLBr_01985|M.leprae_Br4923 RQFAEAIHAEFPEQMLAYNLSPSFNWDTTGMSDEEMKRFPEELGKMGFVF
:*:*.:::::*:*:*:** ****** :.* : :* :**. **: *
Mb0476|M.bovis_AF2122/97 QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ----------------
Rv0467|M.tuberculosis_H37Rv QFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQ----------------
MAV_4682|M.avium_104 QFITLAGFHALNYSMFDLAYGYARNQMTAYVELQ----------------
Mflv_0107|M.gilvum_PYR-GCK QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
Mvan_0801|M.vanbaalenii_PYR-1 QFITLAGFHALNYSMFDLAHGYARNQMTAYVELQ----------------
MSMEG_0911|M.smegmatis_MC2_155 QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
MMAR_0792|M.marinum_M QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
MUL_4536|M.ulcerans_Agy99 QFITLAGFHALNYSMFDLAYGYARNQMSAYVELQ----------------
TH_4509|M.thermoresistible__bu QFITLAGFHALNYSMFDLAYGYARNQMTAYVDLQ----------------
MAB_4095c|M.abscessus_ATCC_199 QFITLAGFHALNYSMFDLAYGYAREGMTAYVDLQ----------------
MLBr_01985|M.leprae_Br4923 NFITYGGHQIDGVAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTL
:*** .*.: . : ::* . :: * * . **
Mb0476|M.bovis_AF2122/97 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS
Rv0467|M.tuberculosis_H37Rv ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGS
MAV_4682|M.avium_104 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALTGS
Mflv_0107|M.gilvum_PYR-GCK ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
Mvan_0801|M.vanbaalenii_PYR-1 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
MSMEG_0911|M.smegmatis_MC2_155 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALAGS
MMAR_0792|M.marinum_M ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
MUL_4536|M.ulcerans_Agy99 ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPTSSTTALAGS
TH_4509|M.thermoresistible__bu ------EREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALKGS
MAB_4095c|M.abscessus_ATCC_199 ------EREFASEARGYTATKHQREVGAGYFDKIATTVDPNTSTAALKGS
MLBr_01985|M.leprae_Br4923 VGGPRSDAALAASSGRTATTKAMGKGSTQHQHLVQTEVPKKLLEEWLALW
: :*:. ::** : .: : . : * * . *
Mb0476|M.bovis_AF2122/97 TEEGQFH-------------------------------------------
Rv0467|M.tuberculosis_H37Rv TEEGQFH-------------------------------------------
MAV_4682|M.avium_104 TEEGQFH-------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK TEEGQFH-------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 TEEGQFH-------------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 TEEGQFH-------------------------------------------
MMAR_0792|M.marinum_M TEEGQFH-------------------------------------------
MUL_4536|M.ulcerans_Agy99 TEEGQFH-------------------------------------------
TH_4509|M.thermoresistible__bu TEEDQFH-------------------------------------------
MAB_4095c|M.abscessus_ATCC_199 TEEGQFH-------------------------------------------
MLBr_01985|M.leprae_Br4923 SEHYQLGEKLRVQLRPRRAGSDVLELGIYGNGDEQLANVIVDPIKDRRGR
:*. *:
Mb0476|M.bovis_AF2122/97 --------------------------------------------------
Rv0467|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4682|M.avium_104 --------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0792|M.marinum_M --------------------------------------------------
MUL_4536|M.ulcerans_Agy99 --------------------------------------------------
TH_4509|M.thermoresistible__bu --------------------------------------------------
MAB_4095c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01985|M.leprae_Br4923 SILQVRDQNTFAEKLRQKRLMTLIHFWLVHRFKADTVIYVTPTEDNLYQT
Mb0476|M.bovis_AF2122/97 ------------------------------------------------
Rv0467|M.tuberculosis_H37Rv ------------------------------------------------
MAV_4682|M.avium_104 ------------------------------------------------
Mflv_0107|M.gilvum_PYR-GCK ------------------------------------------------
Mvan_0801|M.vanbaalenii_PYR-1 ------------------------------------------------
MSMEG_0911|M.smegmatis_MC2_155 ------------------------------------------------
MMAR_0792|M.marinum_M ------------------------------------------------
MUL_4536|M.ulcerans_Agy99 ------------------------------------------------
TH_4509|M.thermoresistible__bu ------------------------------------------------
MAB_4095c|M.abscessus_ATCC_199 ------------------------------------------------
MLBr_01985|M.leprae_Br4923 SKMKSHGIFSEVYQEVGEIIVAEVNHPRLVELLTPDRVALRRLITKEG