For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSVCCRVRLQITGVVQGVGFRPAVARLARDHGVGGFVYNDAGAVYCELEGPQDAVDVVVGALQADPPPLA RIDSISVHPVAPLGERTFDIVESSTGDAGERTLIPPDSAICADCLREVRDPADRRFGHAFITCTNCGPRY TVITDLPYDRPATTMARFPMCERCAAEYHDPVDRRYHAQTIACPDCGPRLSWNGDEHDDPIGAAAAALLA GRIVAIKGIGGFHLACVATDTTTVAELRRRKNRPAKPFAVMVADLGAARRIADISAAAAAELSSPAAPIV LVPGRDDTVRDAVAPGLRDVGVMLAYSPVHHLLFDRLGPVVLVMTSANAGGSPIVYRDEDLHWIDGLADA VLSHDRPIHVPCEDSVLTVTDDGHTVPIRRSRGFAPLPMTVRVPGRRDGGAPVILATGGDLKTTFCLLGG DGRAHLSSHLGDMADPRTQLCFTSAYAHVSQMTRRRPDLIACDAHPRYATTNWALRQDLPVWTVQHHHAH AASLLAEHDRLGSLALVVAYDGTGYGTDGTIWGGELLALGDPATFTRVGHLGVFSLPGGDGAVRQPARIA LDLLHRAGIEWDPALPCVAELDANAMKILAQQIPRQFRCIPTSSMGRLFDAVSSLLGVCQTVTYEGQAAV ELEHVARSGRAVPMDFGVHGGILDPLPLLGDLVAGLRARTEIADLAAGFHAAVIRATVTAVTDCAESAGV GTVGLTGGVFVNRILLDGLREELTSRGLEVLTHACLPCNDGGLALGQAAVVAAGGGIRKGEA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2273 | hypF | - | 100% (762) | [NiFe] hydrogenase maturation protein HypF [Mycobacterium smegmatis str. MC2 155] |
| M. smegmatis MC2 155 | MSMEG_2711 | hypF | 0.0 | 48.25% (771) | [NiFe] hydrogenase maturation protein HypF [Mycobacterium |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_3979 | - | 1e-177 | 48.11% (767) | (NiFe) hydrogenase maturation protein HypF |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_1862 | hypF | 0.0 | 51.94% (774) | hydrogenase maturation factor, HypF |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1524 | hypF | 5e-46 | 53.67% (177) | - |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2359 | - | 0.0 | 66.09% (755) | (NiFe) hydrogenase maturation protein HypF |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2273|M.smegmatis_MC2_155 ------------MSVCCRVRLQITGVVQGVGFRPAVARLARDHGVGGFVY
Mvan_2359|M.vanbaalenii_PYR-1 ----------------MRVRLTITGVVQGVGFRPAVARIAAQNRLAGFVL
Mflv_3979|M.gilvum_PYR-GCK ------------MTARRRVHAGVRGVVQGVGFRPFVYTQATLLGLSGWVR
MMAR_1862|M.marinum_M MAGLPLLRPAMVRCAETRQRFTVTGVVQGVGFRPFVHQLASELGLSGFVG
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 NDAGAVYCELEGPQDAVDVVVGALQADPPPLARIDSISV-HPVAPLGERT
Mvan_2359|M.vanbaalenii_PYR-1 NDARAVRCELEGPGPRVDAAVRTLRDGPPPLACVDSFVT-EMRPALGETV
Mflv_3979|M.gilvum_PYR-GCK NDSSGAIIEVEGGNDALERFLDVLRHHPPPLAVIDSIDVRYIAVTGG-TG
MMAR_1862|M.marinum_M NDSAAVFIEVQGGRAGLDEFARRLRADAPPLAGISSVSATELALQAGAAG
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 FDIVESS-TGDAGERTLIPPDSAICADCLREVRDPADRRFGHAFITCTNC
Mvan_2359|M.vanbaalenii_PYR-1 FRILDSTPSGDNGDRTLVSPDIATCADCLRELFDPADRRHRHPFITCTNC
Mflv_3979|M.gilvum_PYR-GCK FTIVDTS--RTDGGRTLASPDVAMCAECAAEQRDPRNRRYRHAFVNCTNC
MMAR_1862|M.marinum_M FRIVASQ--GATGATTPIPPDIAVCDDCVRELFDPRDRRFRHPFVTCTNC
TH_1524|M.thermoresistible__bu ----------------------------VAELFDPADRRYRHPFITCTDC
* ** :**. *.*:.**:*
MSMEG_2273|M.smegmatis_MC2_155 GPRYTVITDLPYDRPATTMARFPMCERCAAEYHDPVDRRYHAQTIACPDC
Mvan_2359|M.vanbaalenii_PYR-1 GPRYTVITDVPYDRPTTTMAGFAMCPSCAAEYGDPADRRYHAQTIACPEC
Mflv_3979|M.gilvum_PYR-GCK GPRFTLIASLPYDRASTTMAEFEMCADCAREYHDPADRRFHAQPICCPGC
MMAR_1862|M.marinum_M GPRLTVIRTLPYDRPGTTMSAFPMCERCAAEYHDPGDRRFHAQPIACPNC
TH_1524|M.thermoresistible__bu GPRFTIIKALPYDRPATTMADFPMCDRCAEEYHDPTDRRFHAQPISCPDC
*** *:* :****. ***: * ** ** ** ** ***:***.*.** *
MSMEG_2273|M.smegmatis_MC2_155 GPRLSWNG-DEHDDP-------IGAAAAALLAGRIVAIKGIGGFHLACVA
Mvan_2359|M.vanbaalenii_PYR-1 GPTLSWHGPGPHGGA-------VESAAAALRAGLIVAVKGVGGYHLACRA
Mflv_3979|M.gilvum_PYR-GCK GPTLRYRDRAGRELAG---ESGLRAARRMLRAGKIVAVKGIGGYHLACDA
MMAR_1862|M.marinum_M GPSLWFRSATEHVAGA---DAALAATQHALTAAKVVAIKGIGGYHLACAV
TH_1524|M.thermoresistible__bu GPRLGFRRGDQPVPDTHHTDAAISAAQGALAEGAVVAVKGIGGYHLACRA
** * :. : :: * . :**:**:**:**** .
MSMEG_2273|M.smegmatis_MC2_155 TDTTTVAELRRRKNRPAKPFAVMVADLGAARRIADISAAAAAELSSPAAP
Mvan_2359|M.vanbaalenii_PYR-1 DDDDAVARLRRRKNRPAKPFAVMAADIEAARRICHVDDAAARSLTSAAAP
Mflv_3979|M.gilvum_PYR-GCK TGPRAVTTLRARKRRGDKPFAVMVPDLDAARRVAEVDPASAALLTGPARP
MMAR_1862|M.marinum_M DDDAVVGVLRSCKSRGAKPFAILVRDLDVARRYAFIDDAEAAVLSGPARP
TH_1524|M.thermoresistible__bu DDEDVVRALRSRKHRXGXXXQRPVGRIGLGR------GRLGGRLGFPARL
. .* ** * * . : .* . * .*
MSMEG_2273|M.smegmatis_MC2_155 IVLVPGR-DDTVRDAVAPGLRDVGVMLAYSPVHHLLFD------RLGPVV
Mvan_2359|M.vanbaalenii_PYR-1 IVLLPAR-AGAVSVHVAPNLTDLGVMLAYSPVHHLLFA------EPDMPA
Mflv_3979|M.gilvum_PYR-GCK IVLMPRRAGAAVADAVAPHNPDLGVVLAYAPLHTLLFG--FGGDEPAPQT
MMAR_1862|M.marinum_M IVLLRRRPDAPVADAVASGSPLLGLMLPYSPIHHLLLAPVPGADAAAPEA
TH_1524|M.thermoresistible__bu RRRVPGR-------------------------------------------
: *
MSMEG_2273|M.smegmatis_MC2_155 LVMTSANAGGSPIVYRDED-LHWIDGLADAVLSHDRPIHVPCEDSVLTVT
Mvan_2359|M.vanbaalenii_PYR-1 LVMTSANQGGSPIVFRDGD-LDWIDGLADAVLTHDRPIHVPCEDSVVSID
Mflv_3979|M.gilvum_PYR-GCK LVMTSGNVAGEPICFTDDDAWQRLRPLADGWLYHDRAILVPCDDSVMR--
MMAR_1862|M.marinum_M LVLTSANRSDEPICFTESDAAERLSMLCDAVLDHDRPIHVPCDDSVVRVV
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 DDG---HTVPIRRSRGFAPLPMTVRV---PGRRDGGAP-VILATGGDLKT
Mvan_2359|M.vanbaalenii_PYR-1 DDG---NEVPLRRSRGYAPLPVSVGAGAGDGDGDGDDPAVILATGGDIKT
Mflv_3979|M.gilvum_PYR-GCK ------ADTAIRRSRGYAPLPVAL--------PVALAP--TLAVGADIKN
MMAR_1862|M.marinum_M EDAGLARELPIRRSRGYAPLPVDLGH-----IAVESPP--VLAVGGELKN
TH_1524|M.thermoresistible__bu -----------RRASGQGDQ-----------------------QGGDEQR
**: * . *.: :
MSMEG_2273|M.smegmatis_MC2_155 TFCLLGGDGRAHLSSHLGDMADPRTQLCFTSAYAHVSQMTRRRPDLIACD
Mvan_2359|M.vanbaalenii_PYR-1 TFALTGRYGRAHLSSHLGDMADPRTQACFAAAVDHLGFLTGSAPTVLAHD
Mflv_3979|M.gilvum_PYR-GCK TMAVADG-RYAWVSQHIGDMDDAATLSAFDSTRRHLEQLTRVDPELLVAD
MMAR_1862|M.marinum_M TFCLTDG-TRAYLSGHIGDMATWETLRAFERAVGQLSEIR-GHPVRLAAD
TH_1524|M.thermoresistible__bu -----------------------------ETAGKTLR-------------
: :
MSMEG_2273|M.smegmatis_MC2_155 AHPRYATTNWALR--QDLPVWTVQHHHAHAASLLAEHDR-LGSLALVVAY
Mvan_2359|M.vanbaalenii_PYR-1 LHPQYATTRWAQR--RGERLLAVQHHHAHAVSLLAEHRR-LGEPIIAVTY
Mflv_3979|M.gilvum_PYR-GCK AHPAYRSTAWAHRNAAGRPVRTVAHHHAHIAAVMAEHGLDGDEPVLGFAF
MMAR_1862|M.marinum_M LHPGYHTRNWAERHADDRPLDLIQHHHAHVVSLLAEHGR-INEPVVGVSF
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 DGTGYGTDGTIWGGELLALGDPAT-FTRVGHLGVFSLPGGDGAVRQPARI
Mvan_2359|M.vanbaalenii_PYR-1 DGTGFGTDGTIWGGELLAVRDPAR-FTRVGHLAPFALPGGEGAVRQPARI
Mflv_3979|M.gilvum_PYR-GCK DGTGYGPDGAVWGGEVLLADYKG--YQRLARLRYVPLAGGDVSVKRPYRM
MMAR_1862|M.marinum_M DGTGYGCDETIWGGEILVLGPQSHRFTRAGHLLAVPLPGGDAAVRNPWRM
TH_1524|M.thermoresistible__bu ----FG-DCRAWRGRVDVLAGQG-------------IPPDD---------
:* * * *.: . :. .:
MSMEG_2273|M.smegmatis_MC2_155 ALDLLHRAGIEWDPALPCVAELDANAMKILAQQIPRQFRCIPTSSMGRLF
Mvan_2359|M.vanbaalenii_PYR-1 ALDLLDRAGIEASDDLPPVAALGAAGLHILTQQLRRGVGCVPTTSMGRLF
Mflv_3979|M.gilvum_PYR-GCK ALAHLWAAGLPWDRDLAPVRSCPAEELSVLRHQLETGLGCVPTSSMGRLF
MMAR_1862|M.marinum_M ALSQLWTAHIEWSPDLAPVAAAGVDELRVTRSQLASGAGCVPCSSMGRLF
TH_1524|M.thermoresistible__bu ---------------------------------------RVNRSRPGRLH
: : ***.
MSMEG_2273|M.smegmatis_MC2_155 DAVSSLLGVCQTVTYEGQAAVELEHVAR-------SGR-AVPMDFGVHGG
Mvan_2359|M.vanbaalenii_PYR-1 DAVSSLLGVCQQVGYEGQAAIELEHRAR-------AGRPWRAVDFEVTAG
Mflv_3979|M.gilvum_PYR-GCK DAVSALAGVRQVVGYEAQAAIELEGLSR--HENCGDTRYRFGIGTGSSPV
MMAR_1862|M.marinum_M DAVASLLGVRHRIDYEGQAAIELEALAESALAECNGPRPSLPLTVRPDGV
TH_1524|M.thermoresistible__bu PHVQ----------------------------------------------
*
MSMEG_2273|M.smegmatis_MC2_155 ILDPLPLLGDLVAGLRARTEIADLAAGFHAAVIRATVTAVTDCAESAGVG
Mvan_2359|M.vanbaalenii_PYR-1 VLDPAPVITALVDGVRRGVPSADLAMAFHDAVVRATVRAAGDAAVAAGVS
Mflv_3979|M.gilvum_PYR-GCK DLDPAPVLAAVVADAGRGIAPGVIGARFHRAVAALIADLASMSPGYR---
MMAR_1862|M.marinum_M -IDPTTMVQTLVSALRAGTPPPVLAASFHQAVARAVAEVVAQVAGQVRL-
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 TVGLTGGVFVNRILLDGLREELTSRGLEVLTHACLPCNDGGLALGQAAVV
Mvan_2359|M.vanbaalenii_PYR-1 TIGLTGGVFANRRLLAGIAHGLRVRGLEVLTHRVVPCNDGGLALGQAAVA
Mflv_3979|M.gilvum_PYR-GCK -VALSGGVFQNRLLLQLAQDMLRANGFDVLTHRHVPPNDGGIALGQLMIG
MMAR_1862|M.marinum_M -VGLTGGVFQNVLLLRACRERLQRKGFEVLTHHTVPPNDGGLALGQAVVS
TH_1524|M.thermoresistible__bu --------------------------------------------------
MSMEG_2273|M.smegmatis_MC2_155 AAGGGIRKGEA------------
Mvan_2359|M.vanbaalenii_PYR-1 AATLSQRMFRERSGPCASESPAR
Mflv_3979|M.gilvum_PYR-GCK NAV--------------------
MMAR_1862|M.marinum_M LLIGLDEDWKRTDR---------
TH_1524|M.thermoresistible__bu -----------------------