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VNGDRLHGDRRFERETDMTHAPEWKESLEDLDRRRQNSYGMGGPERLAKHHAKGKLDARARIGHLLDPGT FQEFGTLVGGDIPSDGIVTGTGLVNGTPVMVGAEDFTTYAGSIGPGGNAKRYRLAELALRSKIPLVMLLE GAGFRAAAGEHYGRTPTDLLAQARCSGKVPTVSAIMGASAGHGALVAPVCDFTIMSPHGAIFTAGPPVVK ESIGEEISKEDLGGPDVALASGVIHNLADSDEAVLDDIRRYLSYFPASAWSYPPAAEIDESVEPRATPEL LDIVSRDNRRIYDMRKVLDVVFDRTDWFEVQPKFGRAIICALAHLGGHPVAVVANQPQVLAGSIDADAAD KAAHFITVADSFHLPIVFLADNPGMLPGSRSERAGVLRSGARMFAAQTAATTLKMHVTLRKAFGFGSMVM SLLGFDDQVATFAYPGATMGAMGAAALSRAAHAGEDVAEVLKTMELEASYRSAGHLGFDELIAPEETRNA LLVALHQGLYSRQAPAEPVSRTMIMP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2255 | - | - | 100% (517) | carboxyl transferase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6391 | - | 1e-68 | 35.47% (499) | propionyl-CoA carboxylase beta chain |
| M. smegmatis MC2 155 | MSMEG_1813 | - | 2e-65 | 34.19% (503) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3829c | accD4 | 3e-66 | 35.20% (500) | propionyl-CoA carboxylase beta chain |
| M. gilvum PYR-GCK | Mflv_4327 | - | 0.0 | 76.35% (499) | propionyl-CoA carboxylase |
| M. tuberculosis H37Rv | Rv3799c | accD4 | 3e-66 | 35.20% (500) | propionyl-CoA carboxylase beta chain |
| M. leprae Br4923 | MLBr_00731 | accD5 | 7e-64 | 33.27% (526) | acetyl/propionyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 4e-66 | 34.27% (499) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_4000 | accD4_2 | 0.0 | 77.96% (499) | propionyl-CoA carboxylase beta chain 4 AccD4_2 |
| M. avium 104 | MAV_1608 | - | 0.0 | 80.56% (499) | carboxyl transferase domain-containing protein |
| M. thermoresistible (build 8) | TH_3934 | - | 0.0 | 82.77% (499) | PUTATIVE Propionyl-CoA carboxylase |
| M. ulcerans Agy99 | MUL_3864 | accD4_2 | 0.0 | 77.35% (499) | propionyl-CoA carboxylase beta chain 4 AccD4_2 |
| M. vanbaalenii PYR-1 | Mvan_2019 | - | 0.0 | 78.56% (499) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2255|M.smegmatis_MC2_155 MVNGDRLHGDRRFERETDMTHAPEWKESLEDLDRRRQNSYGMGGPERLAK
TH_3934|M.thermoresistible__bu ------------------MTDAQDWKETLEDLACRRERAYGMGGPERLAK
MMAR_4000|M.marinum_M ------------------MAKAQDWDETLDDLDRRRGRARSMGGPERLDR
MUL_3864|M.ulcerans_Agy99 ------------------MTKAQDWDETLDDLDRRRGRARSMGGPERLDR
MAV_1608|M.avium_104 ------------------MPKAQDWEETLADLQRRRQHAFDMGGPERLDK
Mflv_4327|M.gilvum_PYR-GCK ------------------MAKAEDWAETLDELSRRRDHSRAMGGDERLAR
Mvan_2019|M.vanbaalenii_PYR-1 ------------------MASAEDWQDTLDELERRRAVSRSMGGDERLAR
Mb3829c|M.bovis_AF2122/97 --------------MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAK
Rv3799c|M.tuberculosis_H37Rv --------------MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAK
MAB_0181|M.abscessus_ATCC_1997 --------------MPP-----HTTAEKLADLRERIALTREPGDAKAIAR
MLBr_00731|M.leprae_Br4923 MTSVTDHSAHSMERAAEHTINIHTTAGKLAELHKRTEEALHPVGAAAFEK
.* :* * : . :
MSMEG_2255|M.smegmatis_MC2_155 HHAKGKLDARARIGHLLDPGTFQEFGTLVGGDIP----------SDGIVT
TH_3934|M.thermoresistible__bu HHATGKLDARARIDRLLDPGSFHELGTLVGGDIA----------ADGLVA
MMAR_4000|M.marinum_M HHGQGKLDARARVQELLDPGTFRELGTLVGGEIA----------ADAIIT
MUL_3864|M.ulcerans_Agy99 HHGQGKLDARARVQRLLDPGTFRELGTLVGGEIA----------ADAIIT
MAV_1608|M.avium_104 HRNKGKLDARARIEYLLDPGTFRELGTLVGGEIA----------ADGLVV
Mflv_4327|M.gilvum_PYR-GCK HHGKGKLDARGRIQHLVDKGSFREFGTLVGGDIA----------ADGIIT
Mvan_2019|M.vanbaalenii_PYR-1 HHGKGKLDARGRIDHLLDKGSFREFGTLVGGDIA----------ADGIVA
Mb3829c|M.bovis_AF2122/97 RDKKGIPSARARIYELVDPGSFMEIGALCRTPGD-----PNALYGDGVVT
Rv3799c|M.tuberculosis_H37Rv RDKKGIPSARARIYELVDPGSFMEIGALCRTPGD-----PNALYGDGVVT
MAB_0181|M.abscessus_ATCC_1997 RDKKGIPSARARIDALLDKGSFLELDAFARTPGD-----ANAPYTDGVVT
MLBr_00731|M.leprae_Br4923 VHAKGKFTARERIYALLDDDSFVELDALARHRSTNFGLGENRPVGDGVVT
* ** *: *:* .:* *:.:: *.::.
MSMEG_2255|M.smegmatis_MC2_155 GTGLVNGTPVMVGAEDFTTYAGSIGPGGNAKRYRLAELALRSKIPLVMLL
TH_3934|M.thermoresistible__bu GAGRIDGAPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKVPLIMLL
MMAR_4000|M.marinum_M GAGQINGVPVLVGAEDFTTLAGTIAPGSNSKRYRIAELAVRDKIPLVMLL
MUL_3864|M.ulcerans_Agy99 GAGQINGVPVLVGAEDFTTLAGTIAPGSNSKRYRIAELAVRDKIPLVMLL
MAV_1608|M.avium_104 GSGEINGTPVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLL
Mflv_4327|M.gilvum_PYR-GCK GAALIDGRPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRDRVPMVMLL
Mvan_2019|M.vanbaalenii_PYR-1 GSGLVDGRPVLVGAEDFTTLAGSIGPGGNAKRYRLAELALRDRVPLVMLL
Mb3829c|M.bovis_AF2122/97 GHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGIN
Rv3799c|M.tuberculosis_H37Rv GHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGIN
MAB_0181|M.abscessus_ATCC_1997 GLGRIDGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGIN
MLBr_00731|M.leprae_Br4923 GYGTIDGRDVCIFSQDVTVFGGSLGEVYGEKIVKVQELAIKTGRPLIGIN
* . ::* * : :.* *. *::. . * :: * . *:: :
MSMEG_2255|M.smegmatis_MC2_155 EGAGFRAAA-GEHYGRTPTDLLAQARCSGKVPTVSAIMGASAGHGALVAP
TH_3934|M.thermoresistible__bu EGAGFRPS--GEHYGRTPTDLIAQARCSGKVPTVSAVLGPSAGHGALVAP
MMAR_4000|M.marinum_M EGAGFRPT--GVHYGRTPTDLLAQARCSGRVPTITAVLGPSAGHGALVAP
MUL_3864|M.ulcerans_Agy99 EGAGFRPT--GVHYGRTPTDLLAQARCSGRVPTITAVLGPSAGHGAPVAP
MAV_1608|M.avium_104 EGAGFRPT--GGHYGRTPTDLLAQAQCSGRVPTVAAVLGPSAGHGALVAP
Mflv_4327|M.gilvum_PYR-GCK EGAGFRPS--GEHYGRTPTDLLAQAQCSGKVPTVGGLFGPSAGHGALVAP
Mvan_2019|M.vanbaalenii_PYR-1 EGAGFRPS--GEHYGRTPTDLLAQAQCSGKVPTVSGLFGPSAGHGALVAP
Mb3829c|M.bovis_AF2122/97 DSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPI
Rv3799c|M.tuberculosis_H37Rv DSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPI
MAB_0181|M.abscessus_ATCC_1997 DSAGARIQDTATSLAWYAELGRRHELLRGTVPEISIILGKCAGGAVYSPI
MLBr_00731|M.leprae_Br4923 DGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPA
:..* * . . : * :* : ::* .** . .
MSMEG_2255|M.smegmatis_MC2_155 VCDFTIMSP-HGAIFTAGPPVVKESIGEEISKEDLGGPD-VALASGVIHN
TH_3934|M.thermoresistible__bu VCDFTIMST-QGAIFTAGPPVVKESTGEEVSKEDLGGPE-VALASGVIHN
MMAR_4000|M.marinum_M VCDFTVMSR-QGAIFTAGPPVVKESTGEDISKEDLGGPD-IALASGVIHN
MUL_3864|M.ulcerans_Agy99 MCDFTVMTR-QGAIFTAGPPVVKESTGEDISKEDLGGPD-IALASGVIHN
MAV_1608|M.avium_104 VCDFRIMSR-QGAIFTAGPPVVKESTGEDISKEDLGGPD-VALPSGVIHN
Mflv_4327|M.gilvum_PYR-GCK VCDWTIMTG-QGAIFTAGPPVVKESTGEDISKEDLGGPS-VALASGVIHN
Mvan_2019|M.vanbaalenii_PYR-1 VCDWTIMTT-QGAIFTAGPPVVKESTGEEISKEDLGGPA-VALASGVIHN
Mb3829c|M.bovis_AF2122/97 QTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGAD-HQASYGNIHQ
Rv3799c|M.tuberculosis_H37Rv QTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGAD-HQASYGNIHQ
MAB_0181|M.abscessus_ATCC_1997 QTDLLVAVRDQGYMFITGPDVIKDVTGEDVSFDELGGAD-VQAQRGNIHK
MLBr_00731|M.leprae_Br4923 LTDFVVMVDQTSQMFITGPDVIKTVTGEDVTMEELGGAHTHMAKSGTAHY
* : . :* :** *:* **::: ::***. * *
MSMEG_2255|M.smegmatis_MC2_155 LADSDEAVLDDIRRYLSYFPASAWSYPP------AAEIDESVEPRATPEL
TH_3934|M.thermoresistible__bu HAEDDEAVIDDIRRYLSYFPSSAWSYPP------TRLADDTAEPRPTPEL
MMAR_4000|M.marinum_M VADDDAAALDTIRRYLSYFPPSAWSYPP------SLPASGTTARRSTPEL
MUL_3864|M.ulcerans_Agy99 VADDDAAALDMIRRSLSYFPPSAWSYPP------SLPASGTTARRSTPEL
MAV_1608|M.avium_104 VAENDEAVLDDVRRYLSYFPPSAWSYPP------SLPAGDAAMPRPTPEL
Mflv_4327|M.gilvum_PYR-GCK LGADDAAVLDDIRRYLSFFPSSAWSYPS------STPPGEGTGHRATPEL
Mvan_2019|M.vanbaalenii_PYR-1 LGQDDAAVLDEIRRYLSYFPSSAWSYPP------SSPAGDSTGRRATPEL
Mb3829c|M.bovis_AF2122/97 VVESEAAAYQYVRDFLSFLPSNCFDKPP-----VVNPGLEPEITGHDLEL
Rv3799c|M.tuberculosis_H37Rv VVESEAAAYQYVRDFLSFLPSNCFDKPP-----VVNPGLEPEITGHDLEL
MAB_0181|M.abscessus_ATCC_1997 VVEDEAAAFQYVRDYLSFLPSNTFDYPP-----IVNPGLEPEITEDDLYL
MLBr_00731|M.leprae_Br4923 VASGEQDAFDWVRDVLSYLPSNNFTDAPRYSKPVPHGSIEDNLTAKDLEL
.: . : :* **::*.. : .. *
MSMEG_2255|M.smegmatis_MC2_155 LDIVSRDNRRIYDMRKVLDVVFDRTDWFEVQPKFGRAIICALAHLGGHPV
TH_3934|M.thermoresistible__bu LDIVSRDNRHAYDMRAVLDVVFDRPDWFEVQPRFGPAIICALAHLGGYPV
MMAR_4000|M.marinum_M LDIVSRDNRRVYDMRAVLDVVFDSTEWFEVQPQFGKAIICALAHLGGHPV
MUL_3864|M.ulcerans_Agy99 LDIVSRDNRRVYDMRAVLDVVFDSTEWFEVQPQFGKAIICALAHLGGHPV
MAV_1608|M.avium_104 LDIVSRDNRRVYDMRAVLDVVFDSPDWFEVQPQFGKAIICALAHLGGHPV
Mflv_4327|M.gilvum_PYR-GCK LDIVPRGNRQVYDMSDVLDVVFDDSGWFEVQPRFGRAMITALARLGGHPV
Mvan_2019|M.vanbaalenii_PYR-1 LDIVPRGNRQVYDMRAVLDVVFDDTDWFEVQPKFGPAMITALARLGGHPV
Mb3829c|M.bovis_AF2122/97 DSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTV
Rv3799c|M.tuberculosis_H37Rv DSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTV
MAB_0181|M.abscessus_ATCC_1997 DTFIPDSDNQGYDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPV
MLBr_00731|M.leprae_Br4923 DTLIPDSPNQPYDMHEVVTRLLDEEEFLEVQAGYATNIVVGLGRIDDRPV
::. . . *** :: ::* ::: . :: . .::.. .*
MSMEG_2255|M.smegmatis_MC2_155 AVVANQPQVLAGSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPGSR
TH_3934|M.thermoresistible__bu AVVANQPQVMAGSIDADAADKAAHFISVADSFHLPIVFLADNPGMLPGSA
MMAR_4000|M.marinum_M AVVANQPRVLAGSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSR
MUL_3864|M.ulcerans_Agy99 AVVANQPRVLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSR
MAV_1608|M.avium_104 AVVANQPQVLAGSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSR
Mflv_4327|M.gilvum_PYR-GCK AVVANQPKVLAGSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSR
Mvan_2019|M.vanbaalenii_PYR-1 AVVANQPKVMAGSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSR
Mb3829c|M.bovis_AF2122/97 GVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVE
Rv3799c|M.tuberculosis_H37Rv GVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVE
MAB_0181|M.abscessus_ATCC_1997 GVIANQPLQMAGAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVS
MLBr_00731|M.leprae_Br4923 GIVANQPIQFAGCLDINASEKAARFVRVCDCFNIPIVMLVDVPGFLPGTE
.::**** ::*.:* :*::*** *: ..*.:.:*:*::.* ** ***
MSMEG_2255|M.smegmatis_MC2_155 SERAGVLRSGARMFAAQTAATTLKMHVTLRKAFG--FGSMVMSLLGFDDQ
TH_3934|M.thermoresistible__bu SERAGVLRSGARMFAAQTAATTLKLHLTLRKAFG--FGSMAMSLLGFDNQ
MMAR_4000|M.marinum_M SERAGVLRSGARMFAAQTAATTLKLHVTLRKAYG--FGSMVMGLISFDGQ
MUL_3864|M.ulcerans_Agy99 SERAGVLRSGARMFAAQTAATTLKLHVTLRKAYG--FGSMVMGLISFDGQ
MAV_1608|M.avium_104 SERSGVLRAGARMFAAQTAATTLKLHVTLRKAYG--FGSMVMSLLGFDHQ
Mflv_4327|M.gilvum_PYR-GCK SEKTGVLRSGARMFAAQTAASTIKLHVTLRKAYG--FGSMVMSLLGFDNQ
Mvan_2019|M.vanbaalenii_PYR-1 SEKTGVLRSGARMFAAQTAATTLKLHVTLRKAYG--FGSMVMSLLGFDNQ
Mb3829c|M.bovis_AF2122/97 QEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLN
Rv3799c|M.tuberculosis_H37Rv QEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLN
MAB_0181|M.abscessus_ATCC_1997 EEKNGIIKKGGRFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSADLN
MLBr_00731|M.leprae_Br4923 QEYDGIIRRGAKLLFAYGEATVPKITVITRKAYGGAYCVMGSKNMGCDVN
.* *::: *.::: * * . *: : **::* : * : * :
MSMEG_2255|M.smegmatis_MC2_155 VATFAYPGATMGAMGAAALSRAAHAGEDVA------------EVLKTMEL
TH_3934|M.thermoresistible__bu VATFAYPGATMGAMSAAALSRATKAGEDYT------------EVLKQMEL
MMAR_4000|M.marinum_M VATFAYPGATMGAMGAAALSRASHADEDLS------------AKLRNAEL
MUL_3864|M.ulcerans_Agy99 VATFAYPGATMGPMGAAALSRASHADEDLS------------AKLRNAEL
MAV_1608|M.avium_104 VATFAYPGATMGAMSAAALSRASHAGEDLS------------TKLRNAEL
Mflv_4327|M.gilvum_PYR-GCK SATFAYPGATMGAMSAAALSRASNATEDLE------------AKLRQAEV
Mvan_2019|M.vanbaalenii_PYR-1 SATFAYPGATMGAMSAAALSRASHATEDIE------------AKLRQAEV
Mb3829c|M.bovis_AF2122/97 FAWPTARIAVIGADGAAQLLMKRFPDPNAP---EAQAIRKSFVENYNLNM
Rv3799c|M.tuberculosis_H37Rv FAWPTARIAVIGADGAAQLLMKRFPDPNAP---EAQAIRKSFVENYNLNM
MAB_0181|M.abscessus_ATCC_1997 YVWPTARIAVIGAEGAAQLLVKRFPDPTAP---EVQKIRADFIEGYNKNL
MLBr_00731|M.leprae_Br4923 LAWPTAQIAVMGASGAVGFVYRKELAQAAKNGANVDELRLQLQQEYEDTL
. : *.:*. .*. : :
MSMEG_2255|M.smegmatis_MC2_155 EASYRSAGHLGFDELIAPEETRNALLVALHQGLYSRQAPAEPVSRTMIMP
TH_3934|M.thermoresistible__bu EASYRSAGHLGFDELISPVETRNRLLAALQHGIFSRQEMAEPVARTVITP
MMAR_4000|M.marinum_M QASYRSAEQMGFDELIDPRETRDALLAALQRGIYHRQAAAEPVSRTLIMP
MUL_3864|M.ulcerans_Agy99 QASYRSAEQMGFDELIDPRETRDALLAALQRGIYHRQAAAEPVSRTLIMP
MAV_1608|M.avium_104 QASYRSAEHMGFDELIDPRETRDALLASLRRGLSSRQAAAEPVSRTVIMP
Mflv_4327|M.gilvum_PYR-GCK DASFRSAGHLGFDDLIHPQETRDVLLDALERGLYSRQAAAQPVTRTVITP
Mvan_2019|M.vanbaalenii_PYR-1 DASFRSAGHLGFDDLIHPEETRDVLLDALERGLYSRQAAAQPVTRTVITP
Mb3829c|M.bovis_AF2122/97 AIPWIAAERGFIDAVIDPHETRLLLRKSMHL-LRDKQLWWRVGRKHGLIP
Rv3799c|M.tuberculosis_H37Rv AIPWIAAERGFIDAVIDPHETRLLLRKSMHL-LRDKQLWWRVGRKHGLIP
MAB_0181|M.abscessus_ATCC_1997 ATPWIAAERGYIDGVIEPHQTRLLLRKSLKL-LRDKQKHDRMQRKHGLTP
MLBr_00731|M.leprae_Br4923 VNPYIAAERGYVDAVIPPSHTRGYIATALHL-LERKIAHLPP-KKHGNIP
.: :* : .* :* * .** : ::. : : : *
MSMEG_2255|M.smegmatis_MC2_155 -
TH_3934|M.thermoresistible__bu -
MMAR_4000|M.marinum_M -
MUL_3864|M.ulcerans_Agy99 -
MAV_1608|M.avium_104 -
Mflv_4327|M.gilvum_PYR-GCK -
Mvan_2019|M.vanbaalenii_PYR-1 -
Mb3829c|M.bovis_AF2122/97 V
Rv3799c|M.tuberculosis_H37Rv V
MAB_0181|M.abscessus_ATCC_1997 I
MLBr_00731|M.leprae_Br4923 L