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PKAQDWEETLADLQRRRQHAFDMGGPERLDKHRNKGKLDARARIEYLLDPGTFRELGTLVGGEIAADGLV VGSGEINGTPVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLLEGAGFRPTGGHYGRTPTDL LAQAQCSGRVPTVAAVLGPSAGHGALVAPVCDFRIMSRQGAIFTAGPPVVKESTGEDISKEDLGGPDVAL PSGVIHNVAENDEAVLDDVRRYLSYFPPSAWSYPPSLPAGDAAMPRPTPELLDIVSRDNRRVYDMRAVLD VVFDSPDWFEVQPQFGKAIICALAHLGGHPVAVVANQPQVLAGSIDADAADKAAHFIMVADSFHLPIVFL ADNPGMLPGSRSERSGVLRAGARMFAAQTAATTLKLHVTLRKAYGFGSMVMSLLGFDHQVATFAYPGATM GAMSAAALSRASHAGEDLSTKLRNAELQASYRSAEHMGFDELIDPRETRDALLASLRRGLSSRQAAAEPV SRTVIMP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1608 | - | - | 100% (498) | carboxyl transferase domain-containing protein |
| M. avium 104 | MAV_0220 | - | 2e-68 | 35.54% (498) | propionyl-CoA carboxylase beta chain |
| M. avium 104 | MAV_4250 | - | 2e-64 | 33.13% (504) | propionyl-CoA carboxylase beta chain |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3829c | accD4 | 2e-66 | 35.28% (496) | propionyl-CoA carboxylase beta chain |
| M. gilvum PYR-GCK | Mflv_4327 | - | 0.0 | 77.91% (498) | propionyl-CoA carboxylase |
| M. tuberculosis H37Rv | Rv3799c | accD4 | 2e-66 | 35.28% (496) | propionyl-CoA carboxylase beta chain |
| M. leprae Br4923 | MLBr_00102 | accD4 | 4e-64 | 35.27% (499) | putative acyl CoA carboxylase beta subunit |
| M. abscessus ATCC 19977 | MAB_0181 | - | 1e-68 | 35.81% (497) | propionyl-CoA carboxylase, beta subunit (PccB) |
| M. marinum M | MMAR_4000 | accD4_2 | 0.0 | 86.14% (498) | propionyl-CoA carboxylase beta chain 4 AccD4_2 |
| M. smegmatis MC2 155 | MSMEG_2255 | - | 0.0 | 80.56% (499) | carboxyl transferase domain-containing protein |
| M. thermoresistible (build 8) | TH_3934 | - | 0.0 | 81.33% (498) | PUTATIVE Propionyl-CoA carboxylase |
| M. ulcerans Agy99 | MUL_3864 | accD4_2 | 0.0 | 85.34% (498) | propionyl-CoA carboxylase beta chain 4 AccD4_2 |
| M. vanbaalenii PYR-1 | Mvan_2019 | - | 0.0 | 79.12% (498) | propionyl-CoA carboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4000|M.marinum_M ------------------MAKAQDWDETLDDLDRRRGRARSMGGPERLDR
MUL_3864|M.ulcerans_Agy99 ------------------MTKAQDWDETLDDLDRRRGRARSMGGPERLDR
MAV_1608|M.avium_104 ------------------MPKAQDWEETLADLQRRRQHAFDMGGPERLDK
MSMEG_2255|M.smegmatis_MC2_155 MVNGDRLHGDRRFERETDMTHAPEWKESLEDLDRRRQNSYGMGGPERLAK
TH_3934|M.thermoresistible__bu ------------------MTDAQDWKETLEDLACRRERAYGMGGPERLAK
Mflv_4327|M.gilvum_PYR-GCK ------------------MAKAEDWAETLDELSRRRDHSRAMGGDERLAR
Mvan_2019|M.vanbaalenii_PYR-1 ------------------MASAEDWQDTLDELERRRAVSRSMGGDERLAR
Mb3829c|M.bovis_AF2122/97 --------------MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAK
Rv3799c|M.tuberculosis_H37Rv --------------MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAK
MLBr_00102|M.leprae_Br4923 -------------------MIMKSTAEKLAELRVRLELANEPGGEKAAAK
MAB_0181|M.abscessus_ATCC_1997 -------------------MPPHTTAEKLADLRERIALTREPGDAKAIAR
:.* :* * : *. : :
MMAR_4000|M.marinum_M HHGQGKLDARARVQELLDPGTFRELGTLVGG-----EIAADAIITGAGQI
MUL_3864|M.ulcerans_Agy99 HHGQGKLDARARVQRLLDPGTFRELGTLVGG-----EIAADAIITGAGQI
MAV_1608|M.avium_104 HRNKGKLDARARIEYLLDPGTFRELGTLVGG-----EIAADGLVVGSGEI
MSMEG_2255|M.smegmatis_MC2_155 HHAKGKLDARARIGHLLDPGTFQEFGTLVGG-----DIPSDGIVTGTGLV
TH_3934|M.thermoresistible__bu HHATGKLDARARIDRLLDPGSFHELGTLVGG-----DIAADGLVAGAGRI
Mflv_4327|M.gilvum_PYR-GCK HHGKGKLDARGRIQHLVDKGSFREFGTLVGG-----DIAADGIITGAALI
Mvan_2019|M.vanbaalenii_PYR-1 HHGKGKLDARGRIDHLLDKGSFREFGTLVGG-----DIAADGIVAGSGLV
Mb3829c|M.bovis_AF2122/97 RDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLI
Rv3799c|M.tuberculosis_H37Rv RDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLI
MLBr_00102|M.leprae_Br4923 RDKKNIPSARARIYALVDPGTFLEIGALTRTPGDPNALYGDGVVTGHGLI
MAB_0181|M.abscessus_ATCC_1997 RDKKGIPSARARIDALLDKGSFLELDAFARTPGDANAPYTDGVVTGLGRI
: . .**.*: *:* *:* *:.:: *.::.* . :
MMAR_4000|M.marinum_M NGVPVLVGAEDFTTLAGTIAPGSNSKRYRIAELAVRDKIPLVMLLEGAGF
MUL_3864|M.ulcerans_Agy99 NGVPVLVGAEDFTTLAGTIAPGSNSKRYRIAELAVRDKIPLVMLLEGAGF
MAV_1608|M.avium_104 NGTPVMLGAEDFTTLAGSIGPGGNSKRYRIAELALRDKIPLVMLLEGAGF
MSMEG_2255|M.smegmatis_MC2_155 NGTPVMVGAEDFTTYAGSIGPGGNAKRYRLAELALRSKIPLVMLLEGAGF
TH_3934|M.thermoresistible__bu DGAPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRNKVPLIMLLEGAGF
Mflv_4327|M.gilvum_PYR-GCK DGRPVMVGAEDFTTLAGSIGPGGNAKRYRLAELALRDRVPMVMLLEGAGF
Mvan_2019|M.vanbaalenii_PYR-1 DGRPVLVGAEDFTTLAGSIGPGGNAKRYRLAELALRDRVPLVMLLEGAGF
Mb3829c|M.bovis_AF2122/97 NGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGA
Rv3799c|M.tuberculosis_H37Rv NGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGA
MLBr_00102|M.leprae_Br4923 NGRQVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMAGCPIVGINDSGGA
MAB_0181|M.abscessus_ATCC_1997 DGRPVAVFSHDQTVYQGSVGEMFGRKVAKLMEWAATNGCPVIGINDSAGA
:* * : :.* *. *::. . * :: * . *:: : :..*
MMAR_4000|M.marinum_M RPT-GVHYGRTPTDL-LAQARCSGRVPTITAVLGPSAGHGALVAPVCDFT
MUL_3864|M.ulcerans_Agy99 RPT-GVHYGRTPTDL-LAQARCSGRVPTITAVLGPSAGHGAPVAPMCDFT
MAV_1608|M.avium_104 RPT-GGHYGRTPTDL-LAQAQCSGRVPTVAAVLGPSAGHGALVAPVCDFR
MSMEG_2255|M.smegmatis_MC2_155 RAAAGEHYGRTPTDL-LAQARCSGKVPTVSAIMGASAGHGALVAPVCDFT
TH_3934|M.thermoresistible__bu RPS-GEHYGRTPTDL-IAQARCSGKVPTVSAVLGPSAGHGALVAPVCDFT
Mflv_4327|M.gilvum_PYR-GCK RPS-GEHYGRTPTDL-LAQAQCSGKVPTVGGLFGPSAGHGALVAPVCDWT
Mvan_2019|M.vanbaalenii_PYR-1 RPS-GEHYGRTPTDL-LAQAQCSGKVPTVSGLFGPSAGHGALVAPVCDWT
Mb3829c|M.bovis_AF2122/97 RIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLV
Rv3799c|M.tuberculosis_H37Rv RIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLV
MLBr_00102|M.leprae_Br4923 RIQDAVTSLAWYAELGRRHELLSGIVPQISIVLGKCAGGAVYSPIQTDLV
MAB_0181|M.abscessus_ATCC_1997 RIQDTATSLAWYAELGRRHELLRGTVPEISIILGKCAGGAVYSPIQTDLL
* ::* : * ** : ::* .** .. . *
MMAR_4000|M.marinum_M VMSR-QGAIFTAGPPVVKESTGEDISKEDLGGPDIALASGVIHNVADDDA
MUL_3864|M.ulcerans_Agy99 VMTR-QGAIFTAGPPVVKESTGEDISKEDLGGPDIALASGVIHNVADDDA
MAV_1608|M.avium_104 IMSR-QGAIFTAGPPVVKESTGEDISKEDLGGPDVALPSGVIHNVAENDE
MSMEG_2255|M.smegmatis_MC2_155 IMSP-HGAIFTAGPPVVKESIGEEISKEDLGGPDVALASGVIHNLADSDE
TH_3934|M.thermoresistible__bu IMST-QGAIFTAGPPVVKESTGEEVSKEDLGGPEVALASGVIHNHAEDDE
Mflv_4327|M.gilvum_PYR-GCK IMTG-QGAIFTAGPPVVKESTGEDISKEDLGGPSVALASGVIHNLGADDA
Mvan_2019|M.vanbaalenii_PYR-1 IMTT-QGAIFTAGPPVVKESTGEEISKEDLGGPAVALASGVIHNLGQDDA
Mb3829c|M.bovis_AF2122/97 VAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEA
Rv3799c|M.tuberculosis_H37Rv VAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEA
MLBr_00102|M.leprae_Br4923 VAVRGQGYMFVTGPDVIKDVTGEEVSLDELGGVDSQAKYGNIHQVVESEA
MAB_0181|M.abscessus_ATCC_1997 VAVRDQGYMFITGPDVIKDVTGEDVSFDELGGADVQAQRGNIHKVVEDEA
: :* :* :** *:*: **::* ::*** * **: .:
MMAR_4000|M.marinum_M AALDTIRRYLSYFPPSAWSYPPSL-PASGTTARRSTPELLDIVSRDNRRV
MUL_3864|M.ulcerans_Agy99 AALDMIRRSLSYFPPSAWSYPPSL-PASGTTARRSTPELLDIVSRDNRRV
MAV_1608|M.avium_104 AVLDDVRRYLSYFPPSAWSYPPSL-PAGDAAMPRPTPELLDIVSRDNRRV
MSMEG_2255|M.smegmatis_MC2_155 AVLDDIRRYLSYFPASAWSYPPAA-EIDESVEPRATPELLDIVSRDNRRI
TH_3934|M.thermoresistible__bu AVIDDIRRYLSYFPSSAWSYPPTR-LADDTAEPRPTPELLDIVSRDNRHA
Mflv_4327|M.gilvum_PYR-GCK AVLDDIRRYLSFFPSSAWSYPSST-PPGEGTGHRATPELLDIVPRGNRQV
Mvan_2019|M.vanbaalenii_PYR-1 AVLDEIRRYLSYFPSSAWSYPPSS-PAGDSTGRRATPELLDIVPRGNRQV
Mb3829c|M.bovis_AF2122/97 AAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMA
Rv3799c|M.tuberculosis_H37Rv AAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMA
MLBr_00102|M.leprae_Br4923 AAFGYVRDFLSFLPPNCFDKAPIVNPGLEPEIMAHDLELDSIVPDSDNTA
MAB_0181|M.abscessus_ATCC_1997 AAFQYVRDYLSFLPSNTFDYPPIVNPGLEPEITEDDLYLDTFIPDSDNQG
*. :* **::*.. :. .. * ::. .:.
MMAR_4000|M.marinum_M YDMRAVLDVVFDSTEWFEVQPQFGKAIICALAHLGGHPVAVVANQPRVLA
MUL_3864|M.ulcerans_Agy99 YDMRAVLDVVFDSTEWFEVQPQFGKAIICALAHLGGHPVAVVANQPRVLA
MAV_1608|M.avium_104 YDMRAVLDVVFDSPDWFEVQPQFGKAIICALAHLGGHPVAVVANQPQVLA
MSMEG_2255|M.smegmatis_MC2_155 YDMRKVLDVVFDRTDWFEVQPKFGRAIICALAHLGGHPVAVVANQPQVLA
TH_3934|M.thermoresistible__bu YDMRAVLDVVFDRPDWFEVQPRFGPAIICALAHLGGYPVAVVANQPQVMA
Mflv_4327|M.gilvum_PYR-GCK YDMSDVLDVVFDDSGWFEVQPRFGRAMITALARLGGHPVAVVANQPKVLA
Mvan_2019|M.vanbaalenii_PYR-1 YDMRAVLDVVFDDTDWFEVQPKFGPAMITALARLGGHPVAVVANQPKVMA
Mb3829c|M.bovis_AF2122/97 YDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMS
Rv3799c|M.tuberculosis_H37Rv YDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMS
MLBr_00102|M.leprae_Br4923 YDMREVLLRIFDDGHFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHLS
MAB_0181|M.abscessus_ATCC_1997 YDMMEILLRIFDDGDIFEISEQRGPAMITAFARVDGHPVGVIANQPLQMA
*** :* :** ::: : * *:* . *::.* .*.*:**** ::
MMAR_4000|M.marinum_M GSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSRSERAGVLRSGA
MUL_3864|M.ulcerans_Agy99 GSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSRSERAGVLRSGA
MAV_1608|M.avium_104 GSIDADAADKAAHFIMVADSFHLPIVFLADNPGMLPGSRSERSGVLRAGA
MSMEG_2255|M.smegmatis_MC2_155 GSIDADAADKAAHFITVADSFHLPIVFLADNPGMLPGSRSERAGVLRSGA
TH_3934|M.thermoresistible__bu GSIDADAADKAAHFISVADSFHLPIVFLADNPGMLPGSASERAGVLRSGA
Mflv_4327|M.gilvum_PYR-GCK GSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSRSEKTGVLRSGA
Mvan_2019|M.vanbaalenii_PYR-1 GSIDADAADKAAHFIMVADAFHLPIVFLADNPGMLPGSRSEKTGVLRSGA
Mb3829c|M.bovis_AF2122/97 GAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGG
Rv3799c|M.tuberculosis_H37Rv GAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGG
MLBr_00102|M.leprae_Br4923 GAIDNEASDKAARFIRFCDAFNIPLVFVVDTPGFLPGVEQEKNGIIKRGG
MAB_0181|M.abscessus_ATCC_1997 GAVDTDASDKAASFIRFCDAYNLPLVFVVDTPGALPGVSEEKNGIIKKGG
*::* :*:**** ** ..*::.:*:**:.*.** *** .*: *::: *.
MMAR_4000|M.marinum_M RMFAAQTAATTLKLHVTLRKAYG--FGSMVMGLISFDGQVATFAYPGATM
MUL_3864|M.ulcerans_Agy99 RMFAAQTAATTLKLHVTLRKAYG--FGSMVMGLISFDGQVATFAYPGATM
MAV_1608|M.avium_104 RMFAAQTAATTLKLHVTLRKAYG--FGSMVMSLLGFDHQVATFAYPGATM
MSMEG_2255|M.smegmatis_MC2_155 RMFAAQTAATTLKMHVTLRKAFG--FGSMVMSLLGFDDQVATFAYPGATM
TH_3934|M.thermoresistible__bu RMFAAQTAATTLKLHLTLRKAFG--FGSMAMSLLGFDNQVATFAYPGATM
Mflv_4327|M.gilvum_PYR-GCK RMFAAQTAASTIKLHVTLRKAYG--FGSMVMSLLGFDNQSATFAYPGATM
Mvan_2019|M.vanbaalenii_PYR-1 RMFAAQTAATTLKLHVTLRKAYG--FGSMVMSLLGFDNQSATFAYPGATM
Mb3829c|M.bovis_AF2122/97 RFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVI
Rv3799c|M.tuberculosis_H37Rv RFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVI
MLBr_00102|M.leprae_Br4923 RFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLAADLNFAWPTARIAVI
MAB_0181|M.abscessus_ATCC_1997 RFFNAVVEADVPKVTIITRKAYGGGYAVMGSKQLSADLNYVWPTARIAVI
*:: * . * . *: : **::* :. * : * : . : *.:
MMAR_4000|M.marinum_M GAMGAAALSRASHADEDLSAKLRN---------AELQASYRSAEQMGFDE
MUL_3864|M.ulcerans_Agy99 GPMGAAALSRASHADEDLSAKLRN---------AELQASYRSAEQMGFDE
MAV_1608|M.avium_104 GAMSAAALSRASHAGEDLSTKLRN---------AELQASYRSAEHMGFDE
MSMEG_2255|M.smegmatis_MC2_155 GAMGAAALSRAAHAGEDVAEVLKT---------MELEASYRSAGHLGFDE
TH_3934|M.thermoresistible__bu GAMSAAALSRATKAGEDYTEVLKQ---------MELEASYRSAGHLGFDE
Mflv_4327|M.gilvum_PYR-GCK GAMSAAALSRASNATEDLEAKLRQ---------AEVDASFRSAGHLGFDD
Mvan_2019|M.vanbaalenii_PYR-1 GAMSAAALSRASHATEDIEAKLRQ---------AEVDASFRSAGHLGFDD
Mb3829c|M.bovis_AF2122/97 GADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDA
Rv3799c|M.tuberculosis_H37Rv GADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDA
MLBr_00102|M.leprae_Br4923 GADGAAQLLMKRFPDPSSPDVQAIRKTFVDNYNLNMAIPWIAAERGFIDA
MAB_0181|M.abscessus_ATCC_1997 GAEGAAQLLVKRFPDPTAPEVQKIRADFIEGYNKNLATPWIAAERGYIDG
*. .** * . :: .: :* : :*
MMAR_4000|M.marinum_M LIDPRETRDALLAALQRGIYHRQAAAEPVSRTLIMP-
MUL_3864|M.ulcerans_Agy99 LIDPRETRDALLAALQRGIYHRQAAAEPVSRTLIMP-
MAV_1608|M.avium_104 LIDPRETRDALLASLRRGLSSRQAAAEPVSRTVIMP-
MSMEG_2255|M.smegmatis_MC2_155 LIAPEETRNALLVALHQGLYSRQAPAEPVSRTMIMP-
TH_3934|M.thermoresistible__bu LISPVETRNRLLAALQHGIFSRQEMAEPVARTVITP-
Mflv_4327|M.gilvum_PYR-GCK LIHPQETRDVLLDALERGLYSRQAAAQPVTRTVITP-
Mvan_2019|M.vanbaalenii_PYR-1 LIHPEETRDVLLDALERGLYSRQAAAQPVTRTVITP-
Mb3829c|M.bovis_AF2122/97 VIDPHETR-LLLRKSMHLLRDKQLWWRVGRKHGLIPV
Rv3799c|M.tuberculosis_H37Rv VIDPHETR-LLLRKSMHLLRDKQLWWRVGRKHGLIPV
MLBr_00102|M.leprae_Br4923 VVEPHQTR-LLLRKSLHLLRDKQQWWRVGRKHGLIPL
MAB_0181|M.abscessus_ATCC_1997 VIEPHQTR-LLLRKSLKLLRDKQKHDRMQRKHGLTPI
:: * :** ** : : :* . : : *