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SGGEQRDGVDLTHLDEPLAPDIVATKRDLVDYLDAVADHILPVLADRPLTVLRTLRGQKPFVQKNIPKYA PDWVRTVPMWAESSKREIRYIVCDDRRTLLWLANQRAVEYHPALGLADNIYRPTHLVLDLDPPGSGDFSA VVAVAHLVRTALSNCGLSGVVKTSGSRGVHIFVPIDDHAPVDDVAAATRALAARAEALDPSIATTAFIVE DREGKVFVDATRSGGATVAAAYSPRLRPGLPVSFPVDWSELDRVTPSDFTVHTAIDALSGRTSWTDAMPA PQRLPADLIEQGHTIPVARVAAMHEGKRRAKARRERDASS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2105 | - | - | 100% (321) | ATP dependent DNA ligase |
| M. smegmatis MC2 155 | MSMEG_0597 | - | 7e-31 | 33.96% (265) | hypothetical protein MSMEG_0597 |
| M. smegmatis MC2 155 | MSMEG_6301 | ligD | 5e-29 | 33.46% (266) | DNA polymerase LigD polymerase subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0275c | - | 4e-29 | 35.08% (248) | hypothetical protein Mb0275c |
| M. gilvum PYR-GCK | Mflv_4421 | - | 1e-149 | 79.87% (318) | DNA primase, small subunit |
| M. tuberculosis H37Rv | Rv0269c | - | 4e-29 | 35.08% (248) | hypothetical protein Rv0269c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4341 | - | 3e-35 | 35.52% (259) | hypothetical protein MAB_4341 |
| M. marinum M | MMAR_0527 | - | 2e-31 | 33.11% (302) | hypothetical protein MMAR_0527 |
| M. avium 104 | MAV_4893 | - | 1e-29 | 35.95% (242) | hypothetical protein MAV_4893 |
| M. thermoresistible (build 8) | TH_3847 | - | 2e-32 | 36.29% (248) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1190 | - | 6e-31 | 32.78% (302) | hypothetical protein MUL_1190 |
| M. vanbaalenii PYR-1 | Mvan_1933 | - | 1e-148 | 80.32% (315) | hypothetical protein Mvan_1933 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0275c|M.bovis_AF2122/97 -------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG-----Y
Rv0269c|M.tuberculosis_H37Rv -------MSRMAAPVSLDVHGRQVIVTHPGRVVFP--AHNDRKG-----Y
MMAR_0527|M.marinum_M ----------MTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS-----R
MUL_1190|M.ulcerans_Agy99 -------MIPMTGPVSLELAGRQVKITHPDRVVFP--GQGDRPS-----R
MAV_4893|M.avium_104 -------MNHMTRPVSLEVAGRRVTITHPDKVVFPRAGGGETTGSAAGPY
TH_3847|M.thermoresistible__bu ----------MAESRTVEVDGRRVVVSNPNKVVFP------QLG-----L
MAB_4341|M.abscessus_ATCC_1997 MADGLRASGSSKADLVLQVAGRDVTITHPDKVIFP------DSG-----I
Mflv_4421|M.gilvum_PYR-GCK --------------MGTSENRDGVDLTNLDQPLSD------DAD-----A
Mvan_1933|M.vanbaalenii_PYR-1 --------------MGTSEKRDGVELTNLDQPLTD------DAG-----A
MSMEG_2105|M.smegmatis_MC2_155 --------------MSGGEQRDGVDLTHLDEPLAP------DIV-----A
* ::: .. :
Mb0275c|M.bovis_AF2122/97 TKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPANRPD
Rv0269c|M.tuberculosis_H37Rv TKFDLVRYYLAVAEGAMRGVAGRPMILKRFVKGISAEAVFQKRAPANRPD
MMAR_0527|M.marinum_M TKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPTNRPD
MUL_1190|M.ulcerans_Agy99 TKLDLVRYYLSVADGALRGVAGRPMMLKRFVKGIDVEAVFQKRAPTNRPD
MAV_4893|M.avium_104 TKLDLVRYYLSVADGALRGVAGRPMILKRFVKGITQEAVFQKRAPANRPD
TH_3847|M.thermoresistible__bu TKSDLVDYYLSVAEPALRGVRNRPMILKRFVKGITEEAVFQKRAPAKRPD
MAB_4341|M.abscessus_ATCC_1997 TKGNLVHYYLDVAEGALRGVRDRPMILKRFVKGIAQEAVFQKRVPEKRPD
Mflv_4421|M.gilvum_PYR-GCK TKRDLVDYLDAVADRILPVLAGRPLTVLRALR--GRAPFMQKNVPKYTPD
Mvan_1933|M.vanbaalenii_PYR-1 TKRDLVDYLDAVADRILPVLAGRPLTVLRALR--GRAPFMQKNVPKYTPE
MSMEG_2105|M.smegmatis_MC2_155 TKRDLVDYLDAVADHILPVLADRPLTVLRTLR--GQKPFVQKNIPKYAPD
** :** * **: : : .**: : * :: ...**. * *:
Mb0275c|M.bovis_AF2122/97 WVDVAELHYASG-RSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDH
Rv0269c|M.tuberculosis_H37Rv WVDVAELHYASG-RSAAEAVIHDAAGLAWVINLGCVDLNPHPVLAGDLDH
MMAR_0527|M.marinum_M WVDVAELRYASG-TSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARDLDH
MUL_1190|M.ulcerans_Agy99 WVDVAELRYASG-TSAQEAVIHDAAGLAWAINLGCVDLNPHPVLARDLDH
MAV_4893|M.avium_104 WVDVAELRYARG-TSAAEAVIHDAAGLAWVINLGCVDLNPHPVLADDLDH
TH_3847|M.thermoresistible__bu FVDTAELRYASG-TSAAEAVIHDAAGLVWAVNLGCVDLNPHPVRADDLAH
MAB_4341|M.abscessus_ATCC_1997 WIASAELHYARG-TSAREAVVTDAASLAWVVNLGCVDLNPHPVRADDLDH
Mflv_4421|M.gilvum_PYR-GCK WVRTVPIWAEASRREIRYAVCDDRRTLLWLANQRAVEYHPALGPADDVYR
Mvan_1933|M.vanbaalenii_PYR-1 WVRTVAIWAEASHREIRYAVCDDRRTLLWLANQRAIEYHPALGPADDIYR
MSMEG_2105|M.smegmatis_MC2_155 WVRTVPMWAESSKREIRYIVCDDRRTLLWLANQRAVEYHPALGLADNIYR
:: . : . . * * * * * .:: :* * :: :
Mb0275c|M.bovis_AF2122/97 PDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGFHVY
Rv0269c|M.tuberculosis_H37Rv PDELRVDLDPMPGVAWQRVVEVALVVREVLEDYGLTAWPKTSGSRGFHVY
MMAR_0527|M.marinum_M PDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGFHVY
MUL_1190|M.ulcerans_Agy99 PDELRIDLDPMPGVEWRRILDVAQVVREVLEDYGLTPWPKTSGSRGFHVY
MAV_4893|M.avium_104 PDELRVDLDPMPGVSWRRIVDVALVAREVLEDYGLTPWPKTSGSRGFHIY
TH_3847|M.thermoresistible__bu PDELRVDLDPMPGVGWRQIIDVAWVAREVLEDHGLTAWPKTSGSRGFHIY
MAB_4341|M.abscessus_ATCC_1997 PDELRIDLDPVPGVPWSQILDVAFVVRGVLEDHGLTAWPKTSGSRGFHIY
Mflv_4421|M.gilvum_PYR-GCK PTHLILDLDPPDDGDFASVVAVAHLVRRALADCGLDGAVKTSGSRGLHVF
Mvan_1933|M.vanbaalenii_PYR-1 PTHLVLDLDPPGGADFAAVVAVAHLVRQALTDSGLTGAVKTSGSRGIHIF
MSMEG_2105|M.smegmatis_MC2_155 PTHLVLDLDPPGSGDFSAVVAVAHLVRTALSNCGLSGVVKTSGSRGVHIF
* .* :**** . : :: ** :.* .* : ** *******.*::
Mb0275c|M.bovis_AF2122/97 ARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREG-VFVDFNQ
Rv0269c|M.tuberculosis_H37Rv ARIAPCWSFPQVRLAAQTVAREVERRLPDAATSRWWKEEREG-VFVDFNQ
MMAR_0527|M.marinum_M ARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREG-VFVDFNQ
MUL_1190|M.ulcerans_Agy99 ARIAPQWSFSQVRLAAQTVAREVERRMPGVATSRWWKEEREG-VFVDFNQ
MAV_4893|M.avium_104 AHIARRWEFRQVRLAAQTVAREVERRAPEAATSRWWKEEREG-VFVDFNQ
TH_3847|M.thermoresistible__bu ARIERRWPFKQVRLAAQAVAREVERRAPESATARWWKEERHG-VFVDFNQ
MAB_4341|M.abscessus_ATCC_1997 APVARRWTYRELRLAAETVAREVERRAPELATSRWWKEERHG-VFVDFNQ
Mflv_4421|M.gilvum_PYR-GCK VPIDDSAPVDDVAAATRALAARTEALDPTVATTAFIVADRAGKVFVDATR
Mvan_1933|M.vanbaalenii_PYR-1 VPIDDSAPVDDVAAATRALAARAEALDPAVATTAFIVADRAGKVFIDATR
MSMEG_2105|M.smegmatis_MC2_155 VPIDDHAPVDDVAAATRALAARAEALDPSIATTAFIVEDREGKVFVDATR
. : :: *:.::* ..* * **: : :* * **:* .:
Mb0275c|M.bovis_AF2122/97 NAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLADI
Rv0269c|M.tuberculosis_H37Rv NAKDRTVASAYSVRATPDARVSTPLHWEEVPGCDPAVFTMATVPSRLADI
MMAR_0527|M.marinum_M NAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDTVPDRFAEM
MUL_1190|M.ulcerans_Agy99 NAKDRTVASAYSVRANPDARVSTPLHWHEVADCDPQDFTLDAVPDRFAEL
MAV_4893|M.avium_104 NAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPEAFTIDTVPARLAEI
TH_3847|M.thermoresistible__bu NAYDRTVASAYSVRATPDARVSTPLRWDEVSRCDPAEFTIATVPGRVADI
MAB_4341|M.abscessus_ATCC_1997 NAKDRTVASAYSVRATPDARVSTPLRWDEVAGCRPESFTLHTVRERFADI
Mflv_4421|M.gilvum_PYR-GCK -AGGATVAAAYSPRLRPGTPVSFPVAWDALDRIHPSDFTVRTAVSALAGR
Mvan_1933|M.vanbaalenii_PYR-1 -AGGATVAAAYSPRLRPGTPVSFPVAWSDLDRVRPADFTVHTAVDALAGS
MSMEG_2105|M.smegmatis_MC2_155 -SGGATVAAAYSPRLRPGLPVSFPVDWSELDRVTPSDFTVHTAIDALSGR
: . ***:*** * *. ** *: * : * **: :. .:
Mb0275c|M.bovis_AF2122/97 GDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPLIE
Rv0269c|M.tuberculosis_H37Rv GDPWAGMDDAVGRLDRLLMLAEELGPPQKA------------QSAKPLIE
MMAR_0527|M.marinum_M GDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRSDGRRQPSMPLIE
MUL_1190|M.ulcerans_Agy99 GDPWSGMDGAVGALDRLLMLAEELGPPQRAPAGAGKRRDGRRQPSMPLIE
MAV_4893|M.avium_104 GDPWAGMDDAVGDLDRLLVLAEELGPPERAPKGAGTRSGGRRRSSMPLIE
TH_3847|M.thermoresistible__bu GDPWEPMDDHAGSLDALLTLAEDLGPPERAPRGVS-RGTGRRQSSKPLIE
MAB_4341|M.abscessus_ATCC_1997 DDPWRGMDDATGTLDQLLELAAELGPAEKAPKGAS--RDGRRRPTMPLIE
Mflv_4421|M.gilvum_PYR-GCK -DPWADAMPAPTRLPTDLIEQGRAIP------------------------
Mvan_1933|M.vanbaalenii_PYR-1 -DPWADAMPAPQRLPGALIEHGRTIP------------------------
MSMEG_2105|M.smegmatis_MC2_155 -TSWTDAMPAPQRLPADLIEQGHTIP------------------------
.* * * *
Mb0275c|M.bovis_AF2122/97 IARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRIRI
Rv0269c|M.tuberculosis_H37Rv IARAKTRAEAMAALDIWRDRYPGAAALLRPADVLVDGMRGPSSIWYRIRI
MMAR_0527|M.marinum_M VARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRIRI
MUL_1190|M.ulcerans_Agy99 VARTKTKDEAMAALDTWRARHPAVADRLQPADVLVDGMRGPSSIWYRIRI
MAV_4893|M.avium_104 VARTKTRDEAMAALDVWRDRHPGAAARLQPADVLVDGMRGPSSIWYRIRI
TH_3847|M.thermoresistible__bu IARTRTRDEAMAALDTWRDRYPAVAEKLQPADILVDGMRGPSSIWYRIRI
MAB_4341|M.abscessus_ATCC_1997 IARTKTKPEAQAALDVWRDTYPRVAGLLEPQDILIDGMRGPSSVWYRVRI
Mflv_4421|M.gilvum_PYR-GCK VARVAAMHEGKRRARARRKDDEAGADQTG---------------------
Mvan_1933|M.vanbaalenii_PYR-1 VARVAAVHEGKRRARARRASG-----------------------------
MSMEG_2105|M.smegmatis_MC2_155 VARVAAMHEGKRRAKARRERDASS--------------------------
:**. : *. *
Mb0275c|M.bovis_AF2122/97 NLQHVPADQRPPQEELIADYSPWPR--------------
Rv0269c|M.tuberculosis_H37Rv NLQHVPADQRPPQEELIADYSPWPR--------------
MMAR_0527|M.marinum_M NLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
MUL_1190|M.ulcerans_Agy99 NLQHIPPEARPPQEELIAEYNPWHGYRPPDGRGRPGADG
MAV_4893|M.avium_104 NLQHVPEDQRPPQEELIADYSPWQGYG---GRQKPSWG-
TH_3847|M.thermoresistible__bu NLEHVPEAERPPQEPLLADYDPWQNYSGHQQRRS-----
MAB_4341|M.abscessus_ATCC_1997 NLVHVPEGQRPAQEELIADYSPWS---------------
Mflv_4421|M.gilvum_PYR-GCK ---------------------------------------
Mvan_1933|M.vanbaalenii_PYR-1 ---------------------------------------
MSMEG_2105|M.smegmatis_MC2_155 ---------------------------------------