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MTFDKVILGGRLFDGTGGPSALRNIGIRDGRVAAITADAVEGTETVDASGCWVMPGMIDIHTHYDAEVLA APGLTESLRHGVTSIVMGSCSLSTVHVNGSEAADLFGRVEAIPHEHVVRIVGEHKTWNNAEEYIEALEAR PLGPNVTAFIGHSDIRVAVMGLDRATRKDVRPTKAEQARMEQMLTDALDTGFIGLSSQQLLFDKLDGDVC RSRTLPSTYARAKELRRLKSILRRRDRTLQSGPDISHPHNIVSQAFQSVGIGRPRLKTSLLAAADMKSTP GGMWFTVALAAIANRLGGDFRFQHLPVPFEVYADGIDLVIFEEFGSGAAALHLKTEMERNKLLADEGYRR RFRKDYDNKFGPRAWHRDFFDAEIVACPDPSVIGKSFGDVGVERGRLHPVDAFLDLVLEHGSQLRWRTTI SNHRPKALRQLAVSSGIQVGFSDAGAHLRNMAFYNSGLRLLRHVRDAGFMSVEDAVYRLTGELADWYHLD AGHLRMGDWADVVVIDPQHLDAGLDEYHEAPVEAFGGMQRMVNRNDRTVKTVLVAGHTVFAEGTPTELVG RRRTGSFMRADGRPRNAPLRRESVAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1997 | - | - | 100% (586) | N-acyl-D-glutamate amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_6141 | - | e-168 | 51.95% (589) | N-acyl-D-glutamate amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_0883 | - | 1e-36 | 27.69% (585) | amidohydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2937c | - | 1e-174 | 54.59% (566) | D-amino acid aminohydrolase |
| M. gilvum PYR-GCK | Mflv_3313 | - | 1e-134 | 72.45% (323) | hypothetical protein Mflv_3313 |
| M. tuberculosis H37Rv | Rv2913c | - | 1e-174 | 54.59% (566) | D-amino acid aminohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2605c | - | 0.0 | 67.69% (585) | hypothetical protein MAB_2605c |
| M. marinum M | MMAR_1795 | - | 1e-171 | 52.71% (590) | D-amino acid aminohydrolase |
| M. avium 104 | MAV_2959 | - | 0.0 | 66.95% (581) | N-acyl-D-glutamate amidohydrolase |
| M. thermoresistible (build 8) | TH_2847 | - | 3e-32 | 25.79% (601) | PUTATIVE Amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_2043 | - | 1e-170 | 52.54% (590) | D-amino acid aminohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3035 | - | 0.0 | 70.42% (578) | hypothetical protein Mvan_3035 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2937c|M.bovis_AF2122/97 MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
Rv2913c|M.tuberculosis_H37Rv MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
MMAR_1795|M.marinum_M -------------MTYDVIIRDGLWFDGTGSAPQTRTLGIRDGVVATVSA
MUL_2043|M.ulcerans_Agy99 -------------MTYDVIIRDGLWFDGTGSAPQTRTLGIRDGMVATVSA
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 -----MRALFDEPVTFDTIIRNGRWFDGTGAPSAVRNLGIRDGHVVSISE
MAB_2605c|M.abscessus_ATCC_199 -------MVPCSDAQFDTVIRNGRWFDGTGAPSAIRNIGIKDGHVAAVSA
MAV_2959|M.avium_104 -------------MGYDTVITNGRWFDGTGGPSAMRDIGVRDGRVVTIAA
MSMEG_1997|M.smegmatis_MC2_155 -------------MTFDKVILGGRLFDGTGGPSALRNIGIRDGRVAAITA
TH_2847|M.thermoresistible__bu -------------MTFDLVIRNGTIVDGLGGEPFTGDVAVADGVIVAVGT
Mb2937c|M.bovis_AF2122/97 GALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
Rv2913c|M.tuberculosis_H37Rv GALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MMAR_1795|M.marinum_M GPLDETGCAQVIDAAGKWVMPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
MUL_2043|M.ulcerans_Agy99 GPLDETGCAQVIDAAGKWVMPGFIDVHTHYDAEVLLDPGLRESVRHGVTT
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 DELDATGCPQVIDAVGKWVLPGMLDIHTHYDIEVLGGPSLAESLRHGVTT
MAB_2605c|M.abscessus_ATCC_199 DDLDETHCPNIIDASGKWVLPGLVDIHTHYDIEVLAAPALSESVRHGVTT
MAV_2959|M.avium_104 GPLDTAG-ATVIDASGQWVIPGIIDIHTHYDVEILCEPELSESLRHGVTT
MSMEG_1997|M.smegmatis_MC2_155 ---DAVEGTETVDASGCWVMPGMIDIHTHYDAEVLAAPGLTESLRHGVTS
TH_2847|M.thermoresistible__bu ---ADGSGRREIDATGLLVTPGFIDLHTHYDGQSIWSDRLNPSSAHGVTT
Mb2937c|M.bovis_AF2122/97 VLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQ---TWSTPA
Rv2913c|M.tuberculosis_H37Rv VLLGNCSLSTVYANSEDAADLFSRVEAVPREFVLGALRDNQ---TWSTPA
MMAR_1795|M.marinum_M VLLGNCSLSTVYAGAEDAADLFSRVEAVPRQFVLGALSAAKSERAWSNAA
MUL_2043|M.ulcerans_Agy99 VLLGNCSLSTVYAGAEDAADLFSRVEAVPRQFVLGALSAAKSERAWSNAA
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 VLLGSCSLSTVYVDGVDAGDIFGRVEAIPREHVIAAVDRHK---TWTTGE
MAB_2605c|M.abscessus_ATCC_199 VLLGSCSLSVVHVDGVDAGDIFGRVEAIPRDHVIQVVDRYK---TWTNAG
MAV_2959|M.avium_104 VLVGSCSLSTVYLDNVDAGDIFGRVEAIPRRYVIEHLKAAR---SWTNPK
MSMEG_1997|M.smegmatis_MC2_155 IVMGSCSLSTVHVNGSEAADLFGRVEAIPHEHVVRIVGEHK---TWNNAE
TH_2847|M.thermoresistible__bu ALMGNCGVGFAPCRPEDHDVLVDVMAGVEDIPGVVMAEGLP--WTWETFP
Mb2937c|M.bovis_AF2122/97 EYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMA
Rv2913c|M.tuberculosis_H37Rv EYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEAELAKMA
MMAR_1795|M.marinum_M EYITAIDSLPLGPNVSSLLGHSDLRATVLGLERATDASVRPSEAELGRMA
MUL_2043|M.ulcerans_Agy99 EYITAIDSLPLGPNVSSLLGHSDLRATVLGLERATDASVRPSEAELGRMA
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 EYIAALESRPLGPNVAAFIGHSDMRTATMGLDRATRKDERPTGSEQAQME
MAB_2605c|M.abscessus_ATCC_199 QYVAALESLPLGPNVAAFLGHSDIRAAAMGLDRATRKDERPTAAEQAQMD
MAV_2959|M.avium_104 EYVAELERRNLGPNVAAFIGHSDMRAATMGLDRATRKDVRPSAAELARME
MSMEG_1997|M.smegmatis_MC2_155 EYIEALEARPLGPNVTAFIGHSDIRVAVMGLDRATRKDVRPTKAEQARME
TH_2847|M.thermoresistible__bu QYLDAVASRPRDIDVAAYLPHSPLRVYVMGRRGVDREPATP--DDLERMR
Mb2937c|M.bovis_AF2122/97 KLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLIS-
Rv2913c|M.tuberculosis_H37Rv KLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRERRKLIS-
MMAR_1795|M.marinum_M TLLDEALDAGMLGMSGMDSAIDKLDGERFRSRALPSTFATWRERRRLIK-
MUL_2043|M.ulcerans_Agy99 TLLDEALDAGMLGMSGMDSAIDKLDGERFRSRALPSTFATWRERRRLIK-
Mflv_3313|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3035|M.vanbaalenii_PYR-1 RMLTEALRAGFVGMSSQQLLFDKLDGEVCRSRTLPSTYAKPRELRRLKS-
MAB_2605c|M.abscessus_ATCC_199 RWLTEALDAGFVGMSSQQLLFDKLDGDVCRSRTLPSTYAKPRELRRLKA-
MAV_2959|M.avium_104 TMLNEALDEGFVGMSSQQLLFDKLDGEVCRSRTLPSTYAAPRELRRLNA-
MSMEG_1997|M.smegmatis_MC2_155 QMLTDALDTGFIGLSSQQLLFDKLDGDVCRSRTLPSTYARAKELRRLKS-
TH_2847|M.thermoresistible__bu ALAAEAVAAGALGFASSRFALHKTES----GSPIPTYDAAQEEIAAIARG
Mb2937c|M.bovis_AF2122/97 VLRHRGRILQSAPDVDNP-VSALLFFLASSRIFNRRKGVRMSMLVSADAK
Rv2913c|M.tuberculosis_H37Rv VLRHRGRILQSAPDVDNP-VSALLFFLASSRIFNRRKGVRMSMLVSADAK
MMAR_1795|M.marinum_M VLRKRGRILQSAPNVDKP-ASALLFFLASSRILNRRKGVRMSLLVSADSK
MUL_2043|M.ulcerans_Agy99 VLRKRGRILQSAPNVDKP-ASALLFFLASSRILNRRKGVRMSLLVSADSK
Mflv_3313|M.gilvum_PYR-GCK -------------------------MFQSLGIV--RNPLKTSLLSAADVK
Mvan_3035|M.vanbaalenii_PYR-1 LLRRSGRVLQSGPDITNP-LNVASQVFQSLGLV--RNPLKTSLLSAADVK
MAB_2605c|M.abscessus_ATCC_199 QLRQRNRVLQSGPDIQNP-LNVLSQAVQSLGIL--RRPLSTSLLSAADIK
MAV_2959|M.avium_104 ILRRRDKILQSGPDITNP-LSVLSQLMTSLGIG--RPRLKTSLLSAADIK
MSMEG_1997|M.smegmatis_MC2_155 ILRRRDRTLQSGPDISHP-HNIVSQAFQSVGIG--RPRLKTSLLAAADMK
TH_2847|M.thermoresistible__bu VADAGGGLLQFVPDIPAGGYESVLRQVFEVGAETGLPVTFSLLTGNAGEP
. . : *.
Mb2937c|M.bovis_AF2122/97 SMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYS----DGIDLPVFE
Rv2913c|M.tuberculosis_H37Rv SMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYS----DGIDLPVFE
MMAR_1795|M.marinum_M SMPMAVHTFGLGARLLNKLLAASVRFQHLPVPFELYS----DGIDLPVFE
MUL_2043|M.ulcerans_Agy99 SMPMAVRTFGLGARLLNKLLAASVRFQHLPVPFELYS----DGIDLPVFE
Mflv_3313|M.gilvum_PYR-GCK SNPVAVKLLGPLARLANRLGG-NFRWQHLPVPFEVYA----DGIDLVIFE
Mvan_3035|M.vanbaalenii_PYR-1 SNPVAVKLLGPLARLANRLGG-NFRWQHLPVPFEVYA----DGIDLVIFE
MAB_2605c|M.abscessus_ATCC_199 ANPYAIRAMGPVASLVNKLGG-NFRWQHLPVPFEVYA----DGIDLVIFE
MAV_2959|M.avium_104 AIPFVIHVMDRLARVVNALGG-DFRWQHLPVPFEVYA----DGISLVVFE
MSMEG_1997|M.smegmatis_MC2_155 STPGGMWFTVALAAIANRLGG-DFRFQHLPVPFEVYA----DGIDLVIFE
TH_2847|M.thermoresistible__bu TWPQALNLVEKFNAAAGGAAP-AVTAQVFPRPIGMVMSLELSANPFVMYP
: * : . . * :* *: : .. : ::
Mb2937c|M.bovis_AF2122/97 EFGAGT-AALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFH
Rv2913c|M.tuberculosis_H37Rv EFGAGT-AALHLRDQLQRNELLADRSYRRSFRREFDRIKLGPSLWHRDFH
MMAR_1795|M.marinum_M EFGAGT-AALHLREQVQRNQLLADESYRREFRREFDRTKLGPSLWHKDFH
MUL_2043|M.ulcerans_Agy99 EFGAGT-AALHLREQVQRNQLLADESYRSEFRREFDRTKLGPSLWHKDFH
Mflv_3313|M.gilvum_PYR-GCK EFGSGA-AALHLKDEVERNALLRDENYRREFRKDYD-AKFGMRVWHRDFF
Mvan_3035|M.vanbaalenii_PYR-1 EFGSGA-AALHLADEVDRNALLRDESYRRRFRKDYD-ARFGMRVWHRDFF
MAB_2605c|M.abscessus_ATCC_199 EFGAGA-AALHLRDEVERNELLRDEKYRRRFRKEYE-SKFGVRVWHRDFF
MAV_2959|M.avium_104 EFGSGA-AALHLQTEIERNRLMRDEGYRRRFRKDYD-SRFGPRVWHRDFF
MSMEG_1997|M.smegmatis_MC2_155 EFGSGA-AALHLKTEMERNKLLADEGYRRRFRKDYD-NKFGPRAWHRDFF
TH_2847|M.thermoresistible__bu SYREIAGLPLPQQVAEMRKPEVRERILNDKPAGDGHPLFFMTQAWDWIYP
.: : .* *: : :. . : . : *. :
Mb2937c|M.bovis_AF2122/97 DAVIVECPDKSLIGKSFGAIADERG-LHPLDAFLDVLVDNGERNVRWTTI
Rv2913c|M.tuberculosis_H37Rv DAVIVECPDKSLIGKSFGAIADERG-LHPLDAFLDVLVDNGERNVRWTTI
MMAR_1795|M.marinum_M DAVIVECPDESLIGKSFGAIADERG-LHPLDAFLDVLVENGERNVRWTTV
MUL_2043|M.ulcerans_Agy99 DAVIVECPDESLIGKSFGAIADERG-LHPLDAFLDVLVENGERNVRWTTV
Mflv_3313|M.gilvum_PYR-GCK DAEIVACPDPAVIGKSFGEVGRDRGGLHPVDAFLDLVLEHG-NELRWRTT
Mvan_3035|M.vanbaalenii_PYR-1 DAQIVACPDVSVIGKSFGEVGRERGGLHPVDAFLDLVLEHG-KGLRWRTT
MAB_2605c|M.abscessus_ATCC_199 DAEIVSCPDKSVLGKSFGQVGMDRGGLHPVDAFLDLVLEHG-TAMRWRTT
MAV_2959|M.avium_104 DAEIVACPEQAVVGKSFGQVGLERGGLHPVDAFLDLVVEHG-ERLRWRTT
MSMEG_1997|M.smegmatis_MC2_155 DAEIVACPDPSVIGKSFGDVGVERGRLHPVDAFLDLVLEHG-SQLRWRTT
TH_2847|M.thermoresistible__bu LGEQPDYEPDAST--SIAARARARG-VSPLEEAYDRLLDDDGHAMLLIAM
. : *:. . ** : *:: * :::.. : :
Mb2937c|M.bovis_AF2122/97 --VANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDA
Rv2913c|M.tuberculosis_H37Rv --VANHRPNQLNKLAAEPSVHMGFSDAGAHLRNMAFYNFGLRLLKRARDA
MMAR_1795|M.marinum_M --VANHRPKQLNKLAAEPGVHMGFSDAGAHLRNMAFYNFPLRLLKRTWDA
MUL_2043|M.ulcerans_Agy99 --VANHRPKQLNKLAAEPGVHMGFSDAGAHLRNMAFYNFPLRLLKRTWDA
Mflv_3313|M.gilvum_PYR-GCK --ISNHRPEVLRKLAADSGIQMGFSDAGAHLRNMAFYNMGLRLLRHVQDA
Mvan_3035|M.vanbaalenii_PYR-1 --ISNHRPEVLRKLAADPGIQMGFSDAGAHLRNMAFYNMGLRLLRHVQDA
MAB_2605c|M.abscessus_ATCC_199 --ISNHRPEVLKQLAQDPGVQIGFSDAGAHLRNMAFYNFGLRLLRHVREA
MAV_2959|M.avium_104 --ISNHRPEVLRKMAQSPTVQMGFSDAGAHLRNMAFYNSGLRLLRHAHDA
MSMEG_1997|M.smegmatis_MC2_155 --ISNHRPKALRQLAVSSGIQVGFSDAGAHLRNMAFYNSGLRLLRHVRDA
TH_2847|M.thermoresistible__bu GNYENNSLDTVGQWMRRDDVVLGLGDGGAHYGMICDASYPTFLLAHWARD
*: . : : : :*:.*.*** :. . ** :
Mb2937c|M.bovis_AF2122/97 DRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTHLD
Rv2913c|M.tuberculosis_H37Rv DRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQGDRADFAVIDPTHLD
MMAR_1795|M.marinum_M ERAGKPFLSLQQAVYRLTGELAEWFGVD-AGTLREGDRADFVVIDPAHLD
MUL_2043|M.ulcerans_Agy99 ERAGKPFLSLQQAVYRLTGELAEWFGVD-AGTLREGDRADFVVIDPAHLD
Mflv_3313|M.gilvum_PYR-GCK VRAGRPFMTIEAAVHRLTGELADWYRID-AGHLRLGDRADIVILDPERLD
Mvan_3035|M.vanbaalenii_PYR-1 ARSGRPFMTVEQAVHRLTGELADWYRID-AGHLRLGDRADLVIVDPERLD
MAB_2605c|M.abscessus_ATCC_199 QQAGRPFMTVEQAVHRLTGELADWYQID-AGHLRIGDRADLFVIDPEKLD
MAV_2959|M.avium_104 QKAGKPFISMEHAVHRLTGELGRWYGID-AGTLRVGDRADIVVIDPARLD
MSMEG_1997|M.smegmatis_MC2_155 G-----FMSVEDAVYRLTGELADWYHLD-AGHLRMGDWADVVVIDPQHLD
TH_2847|M.thermoresistible__bu RASGR--LTVAEAVRALTSVPARVAGFGDRGRIAVGYKADLNVID----H
::: ** **. . .. * : * **. ::* .
Mb2937c|M.bovis_AF2122/97 ESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRD
Rv2913c|M.tuberculosis_H37Rv ESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGGTVVFRGGQFGGQFRD
MMAR_1795|M.marinum_M ESVDGYHEAQVPFYGGLSRMVNRNDATVIATGVAGAVVFGS----GQFRD
MUL_2043|M.ulcerans_Agy99 ESVDGYHEAQVPFYGGLSRMVNRNDATVIATGVAGAVVFGT----GQFRD
Mflv_3313|M.gilvum_PYR-GCK ASLDAYAEETVDQYGGLSRMVNRNDDTVSAVFVGGRAVFNG----GVPTP
Mvan_3035|M.vanbaalenii_PYR-1 DTLDRYAEEPVEQYGGLSRMVNRNDDTVAAVFVGGRAVFLD----GRPTP
MAB_2605c|M.abscessus_ATCC_199 ATLTAYAEESVDAYGGLSRMVNRNDATVSTVLIGGQPVVVD----GQLRD
MAV_2959|M.avium_104 ESLDRYAEHPVASYGGLSRMVNRNDDTVTAVLVAGKLAFGS----GRAAP
MSMEG_1997|M.smegmatis_MC2_155 AGLDEYHEAPVEAFGGMQRMVNRNDRTVKTVLVAGHTVFAE----GTPTE
TH_2847|M.thermoresistible__bu AALRLHRPVILHDLPSGGRRLDQRADGYVATVVSGHIIAEN---------
: : : . * :::. :. :.*
Mb2937c|M.bovis_AF2122/97 GYGQNVKSGRYLRAGELGAALSRSA-------
Rv2913c|M.tuberculosis_H37Rv GYGQNVKSGRYLRAGELGAALSRSA-------
MMAR_1795|M.marinum_M GYGQTVRSGRYLRAGQRYTAASVSA-------
MUL_2043|M.ulcerans_Agy99 GYGQTVRSGRYLRAGQRYTAASVSA-------
Mflv_3313|M.gilvum_PYR-GCK LVGE-HRTGRFLRAAHRVPALPATEGVLTHAG
Mvan_3035|M.vanbaalenii_PYR-1 LVGA-ERTGRFLRAAHKAPALLAQNGALAHAG
MAB_2605c|M.abscessus_ATCC_199 LLGK-RRTGRFLPAGAKARAVPVDTAPAPH--
MAV_2959|M.avium_104 QLGK-QRYGQFLRAGRPSRTLVSTG-------
MSMEG_1997|M.smegmatis_MC2_155 LVGR-RRTGSFMRADGRPRNAPLRRESVAV--
TH_2847|M.thermoresistible__bu GVPTDARPGTLVRGRQPAPKVAG---------
: * : .