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MTYRLTQYAHGGGCACKIPPGELEDVVRGLTHADPKDPLGELLVGLDDGDDAAAVRINGDTALIATTDFF TPVVDDAYDWGRIAATNALSDVYAMGGRPVVAVNLLGWPRDVLPFELAAETLRGGLDVCAAAGCHLAGGH SVDDPEPKYGLAVTGIADPKRLLRNDSGKPGVPLSLTKPLGIGVLNSRHKATGEVFPQAIEAMTTLNAAA SAAALAAGVECATDVTGFGLLGHLHKLARASGVTAVIDSKAVPYLEGAREAIAAGFVSGGSRRNLEWVSP HIDVSEVKEDEALLLADAQTSGGLLIAGEIPGAPVIGELVARGDHTIVVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1852 | selD | - | 100% (330) | selenide, water dikinase |
| M. smegmatis MC2 155 | MSMEG_2398 | thiL | 5e-08 | 28.26% (230) | thiamine monophosphate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3001c | thiL | 2e-08 | 26.97% (241) | thiamine monophosphate kinase |
| M. gilvum PYR-GCK | Mflv_4216 | - | 2e-12 | 29.72% (249) | thiamine monophosphate kinase |
| M. tuberculosis H37Rv | Rv2977c | thiL | 2e-08 | 26.97% (241) | thiamine monophosphate kinase |
| M. leprae Br4923 | MLBr_01676 | thiL | 1e-10 | 27.43% (288) | thiamine monophosphate kinase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_5189 | - | 1e-166 | 87.88% (330) | thiamine-monophosphate kinase |
| M. avium 104 | MAV_0420 | selD | 1e-169 | 87.88% (330) | selenide, water dikinase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1978 | thiL | 7e-08 | 26.80% (250) | thiamine monophosphate kinase |
| M. vanbaalenii PYR-1 | Mvan_2151 | - | 5e-08 | 26.80% (250) | thiamine monophosphate kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3001c|M.bovis_AF2122/97 ---------MTTKDHSLATESPTLQQLGEFAVIDR--LVRGRRQPA---T
Rv2977c|M.tuberculosis_H37Rv ---------MTTKDHSLATESPTLQQLGEFAVIDR--LVRGRRQPA---T
MLBr_01676|M.leprae_Br4923 ---------MCNHECGALGESVTLEQLGEFAVIDR--LVRGRRQPA---V
MUL_1978|M.ulcerans_Agy99 ------------MGQDTSGQTPTLRELGEFAVIDR--LVQGRNQPA---V
Mflv_4216|M.gilvum_PYR-GCK --------------MAAEDADAKLSELGEFAVIDR--LVADRRQPP---A
Mvan_2151|M.vanbaalenii_PYR-1 --------------MAGEDADDTLSARGEFAVIDR--LTAGRRQPP---F
MSMEG_1852|M.smegmatis_MC2_155 -------MTYRLTQYAHGGGCACKIPPGELEDVVRGLTHADPKDPLGELL
MAV_0420|M.avium_104 -------MTYRLTQYAHGGGCACKIPPGELEDVVRGLGAASPRDPLGELL
MMAR_5189|M.marinum_M MGMVTDQGTYRLTQYAHGGGCACKIPPGELEDVVRGLGAAAPRDPVGELL
**: : * .:*
Mb3001c|M.bovis_AF2122/97 VLLGPGDDAALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQN
Rv2977c|M.tuberculosis_H37Rv VLLGPGDDAALVSAGDGRTVVSTDMLVQDSHFRLDWSTPQDVGRKAIAQN
MLBr_01676|M.leprae_Br4923 VALGPGDDAAVVTASDGRIVVSTDVLVQDRHFRLDWSTPHDVGRKAIAQN
MUL_1978|M.ulcerans_Agy99 VELGPGDDAAVVAAPDGRTVISTDMLVQDRHFRLDWSSPHDVGRKAIAQN
Mflv_4216|M.gilvum_PYR-GCK VSLGPGDDAAVVFAADGRTVVCTDMLVEGRHFRLDWSTPHDIGRKAIAQN
Mvan_2151|M.vanbaalenii_PYR-1 VTLGPGDDAAVVLAPDGRVVVCTDMLVENRHFRLDWSSPHDVGRKAIAQN
MSMEG_1852|M.smegmatis_MC2_155 VGLDDGDDAAAVRINGD-----TALIATTDFFTPVVDDAYDWGRIAATNA
MAV_0420|M.avium_104 VGLDSGDDAAVVRIQQG-----TALIATTDFFTPVVDDAYDWGRIAATNA
MMAR_5189|M.marinum_M VGLESGDDAAAVLIAEG-----TALIATTDFFTPVVDDPYDWGRIAATNA
* * ***** * . * ::. .* . . * ** * ::
Mb3001c|M.bovis_AF2122/97 AADIEAMGARATAFVVGFGAP-AETPAAQASALVDGMWEEAGRIGAGIVG
Rv2977c|M.tuberculosis_H37Rv AADIEAMGARATAFVVGFGAP-AETPAAQASALVDGMWEEAGRIGAGIVG
MLBr_01676|M.leprae_Br4923 AADIEAMGARATTFVVGLGAP-GDTPVAQVDALVDGLWDEAGRIGAGIVG
MUL_1978|M.ulcerans_Agy99 AADIAAMGARPTAFVVSLGAP-AHTPVAEVTALLDGMWEEAGRIGTGIVG
Mflv_4216|M.gilvum_PYR-GCK AADIEAMGARATAFVVAFGAP-GDTPTAAAVQVADGMWHEAALLGAGIVG
Mvan_2151|M.vanbaalenii_PYR-1 AADIEAMGGRSTAFVVAFGAP-GDTDTASAVELADGMWHEAGLMGAGIVG
MSMEG_1852|M.smegmatis_MC2_155 LSDVYAMGGRPVVAVNLLGWPRDVLPFELAAETLRGGLDVCAAAGCHLAG
MAV_0420|M.avium_104 LSDVYAMGGRPVVAVNLLGWPREVLPFELAAETLRGGLDVCGLAGCHLAG
MMAR_5189|M.marinum_M LSDVYAMGGRPVVAVNLLGWPRDVLPFELATETLRGGRDVCASAGCHLAG
:*: ***.*... * :* * . * . .. * :.*
Mb3001c|M.bovis_AF2122/97 GDLVSCRQWVVSVTAIGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYA
Rv2977c|M.tuberculosis_H37Rv GDLVSCRQWVVSVTAIGDLDGRAPVLRSGAKAGSVLAVVGELGRSAAGYA
MLBr_01676|M.leprae_Br4923 GDLVSCPQWVLSVTVLGDLDGRAPVLRSGAKNGSMVAVAGALGRSAAGYA
MUL_1978|M.ulcerans_Agy99 GDMVRCPQWVVSVTVLGDLEGRPPVTRGGAKPGSSVAVAGELGRSAAGYA
Mflv_4216|M.gilvum_PYR-GCK GDTVAAPQWVISVAALGDLGGREPVRRDGARPGDTVAVTGVLGRSAAGYE
Mvan_2151|M.vanbaalenii_PYR-1 GDVVAAPQWVVSVAALGDLGGRDPVRRDGAKPGDMVAVVGELGRSQAGFT
MSMEG_1852|M.smegmatis_MC2_155 GHSVDDPEPKYGLAVTGIADPKRLLRNDSGKPGVPLSLTKPLG---IGVL
MAV_0420|M.avium_104 GHSVDDPEPKYGLAVTGIADPNRLLRNDSGKPGLPLSLTKPLG---IGVL
MMAR_5189|M.marinum_M GHSVDDPEPKYGLAVTGIADPNRLLRNDSGRPGTPLSLTKPLG---IGVL
*. * : .::. * . : ....: * :::. ** *
Mb3001c|M.bovis_AF2122/97 LWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVS-DGLLADLR
Rv2977c|M.tuberculosis_H37Rv LWCNGIEDFAELRRRHLVPQPPYGHGAAAAAVGAQAMIDVS-DGLLADLR
MLBr_01676|M.leprae_Br4923 LWHKGIDGFDDLRRRHLVPEPPYGKGVAAAACGAQAMIDVS-DGLIADLR
MUL_1978|M.ulcerans_Agy99 LWHNEIAGFDELRRRHLVPDPPYGQGVAAAVAGAQAMIDVS-DGLVADLR
Mflv_4216|M.gilvum_PYR-GCK LLRNGIDGFDELRRQHRVPSPPYGQGAIAAQAGATAMTDVS-DGLLADLA
Mvan_2151|M.vanbaalenii_PYR-1 LWDSGISGHDALRRRHLVPEPPYGQGEIAARGGATAMTDVS-DGLLADLG
MSMEG_1852|M.smegmatis_MC2_155 NSRHKATGEVFPQAIEAMTTLNAAASAAALAAGVECATDVTGFGLLGHLH
MAV_0420|M.avium_104 NNRHKATGERFEEAIAVMTTLNAEAAGAALAAGVECATDVTGFGLLGHLH
MMAR_5189|M.marinum_M NSRHKATGERFAQAIDAMTTLNADAAAAAVAAGVECATDITGFGLLGHLH
. . :. . * *. . *:: **:..*
Mb3001c|M.bovis_AF2122/97 HIAEASGVRIDLS---AAALAADRDALTAAATALGTDPWPWVLSGGEDHA
Rv2977c|M.tuberculosis_H37Rv HIAEASGVRIDLS---AAALAADRDALTAAATALGTDPWPWVLSGGEDHA
MLBr_01676|M.leprae_Br4923 HVARASGVSIDLS---TAALAADHAALIAAATAVGGDPWPWVLGGGEDHA
MUL_1978|M.ulcerans_Agy99 HIADAAAVGIDVA---TAALAQDHRALIAAADAVGADPCGWVLGGGEDHA
Mflv_4216|M.gilvum_PYR-GCK HIASASGVSIDIT---LDTLTSDEAAVADAAGATGVDARQWVLGGGEDHA
Mvan_2151|M.vanbaalenii_PYR-1 HIASASEVSIDLA---IGHLQPDIDALAEAAAAVGADARQWVLGGGEDHA
MSMEG_1852|M.smegmatis_MC2_155 KLARASGVTAVIDSKAVPYLEGAREAIAAGFVSGGSRRNLEWVSPHIDVS
MAV_0420|M.avium_104 KLARASGVTAVLDAAAVPYLDGAREALAAGYLSGGTRRNLDWVAPHVDLS
MMAR_5189|M.marinum_M KLARASGVTAVIDSTAVPYLDGARQALAAGYVSGGTRRNLEWVGPHVDLS
::* *: * : * *: . : * :. * :
Mb3001c|M.bovis_AF2122/97 LVACFVGPVPAGWRTIGRVL----DGPARVLVDGEEWTGYAGWQSFGEPD
Rv2977c|M.tuberculosis_H37Rv LVACFVGPVPAGWRTIGRVL----DGPARVLVDGEEWTGYAGWQSFGEPD
MLBr_01676|M.leprae_Br4923 LVACFAGTALSGWRIIGRVF----DGPARVLVDGQEWRGHAGWQSFGG--
MUL_1978|M.ulcerans_Agy99 LVACFSGAVPDGWRVIGRVL----DGPARVLVDGQQWSGYAGWQSFD---
Mflv_4216|M.gilvum_PYR-GCK LVATFPGAVPPNWRVLGTVAATAADGAPAVTVDGSPWIGNAGWQSF----
Mvan_2151|M.vanbaalenii_PYR-1 LVATFASQPPPGWRVIGTVG--ASDGTTAVTVDGARWRGSAGWQSF----
MSMEG_1852|M.smegmatis_MC2_155 EVKEDEALLLADAQTSGGLL--IAGEIPGAPVIGELVAR-GDHTIVVR--
MAV_0420|M.avium_104 GVGEDEALLLADAQTSGGLL--IAGEIPGAPVIGELVPR-GEHTIVVR--
MMAR_5189|M.marinum_M AVDESEALLLADAQTSGGLL--IAGEIPGAPVIGELVARRAGHTIVVR--
* . . : * : . . . * * . .
Mb3001c|M.bovis_AF2122/97 NQGSLG
Rv2977c|M.tuberculosis_H37Rv NQGSLG
MLBr_01676|M.leprae_Br4923 ------
MUL_1978|M.ulcerans_Agy99 ------
Mflv_4216|M.gilvum_PYR-GCK ------
Mvan_2151|M.vanbaalenii_PYR-1 ------
MSMEG_1852|M.smegmatis_MC2_155 ------
MAV_0420|M.avium_104 ------
MMAR_5189|M.marinum_M ------