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TDPHTSSQAAATAIADRTGVVEHDVAVVLGSGWAPAVAELGDPVGVVDMADLPGFTPPTAAGHGGQVLSV RIGEHRVLVLVGRIHAYEGHDLAHVVHPVRTAVATGVRTVVLTNAAGGLRPEYTVGQPVLISDHLNLTAR SPLVGPQFVDLVDAYSPRLRAVAREFDPSLAEGVYAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIA ARAAGAEVLAVSLVTNLAAGMTGEPLSHAEVLQAGRESATRMGALLASVIARL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1701 | - | - | 100% (264) | purine nucleoside phosphorylase |
| M. smegmatis MC2 155 | MSMEG_0990 | mtaP | 1e-08 | 29.52% (166) | 5'-methylthioadenosine phosphorylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3335 | deoD | 1e-114 | 79.31% (261) | purine nucleoside phosphorylase |
| M. gilvum PYR-GCK | Mflv_4828 | - | 1e-117 | 79.55% (264) | purine nucleoside phosphorylase |
| M. tuberculosis H37Rv | Rv3307 | deoD | 1e-114 | 79.31% (261) | purine nucleoside phosphorylase |
| M. leprae Br4923 | MLBr_00707 | deoD | 1e-104 | 72.03% (261) | purine nucleoside phosphorylase |
| M. abscessus ATCC 19977 | MAB_3660 | - | 1e-111 | 77.57% (263) | purine nucleoside phosphorylase |
| M. marinum M | MMAR_1219 | deoD | 1e-114 | 78.24% (262) | purine nucleoside phosphorylase DeoD |
| M. avium 104 | MAV_4284 | - | 1e-116 | 77.57% (263) | purine nucleoside phosphorylase |
| M. thermoresistible (build 8) | TH_2259 | deoD | 1e-125 | 84.09% (264) | PROBABLE PURINE NUCLEOSIDE PHOSPHORYLASE DEOD (INOSINE |
| M. ulcerans Agy99 | MUL_2673 | deoD | 1e-115 | 77.86% (262) | purine nucleoside phosphorylase |
| M. vanbaalenii PYR-1 | Mvan_1610 | - | 1e-120 | 79.92% (264) | purine nucleoside phosphorylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1219|M.marinum_M -------------------MTGPQPDPDELARRAAQVIGERTGIAEHDVA
MUL_2673|M.ulcerans_Agy99 -------------------MTGPQPDPDELARRAAQVIGERTGIAEHDVA
MLBr_00707|M.leprae_Br4923 -------------------MTYTLLDPDELARRAAQVIGERTGILKHDVA
Mb3335|M.bovis_AF2122/97 -------------------MADPRPDPDELARRAAQVIADRTGIGEHDVA
Rv3307|M.tuberculosis_H37Rv -------------------MADPRPDPDELARRAAQVIADRTGIGEHDVA
MAV_4284|M.avium_104 -------------------MAETPSNPGELARQAAAVIGERTGVAEHDVA
MSMEG_1701|M.smegmatis_MC2_155 --------------------MTD---PHTSSQAAATAIADRTGVVEHDVA
TH_2259|M.thermoresistible__bu --------------------VTD---PDTAATQAAAAIADRTGVPHHDVA
Mflv_4828|M.gilvum_PYR-GCK --------------------MDD---PGVLAQQAADELRRRTGVDTHDVA
Mvan_1610|M.vanbaalenii_PYR-1 --------------------MDD---PAALTRRAADALRERTGSDAHDVA
MAB_3660|M.abscessus_ATCC_1997 MTDEAPARGRYPQPARRVDDADDRLAPDDAAALAAAEIATRTGVPAHRVA
* : ** : *** * **
MMAR_1219|M.marinum_M VVLGSGWSAAIAALGSPTAVLAQTEVPGFTPPSAAGHTGELLSVPVG--D
MUL_2673|M.ulcerans_Agy99 VVLGSGWSAAIAALGSPTAVLAQTEVPGFTPPSAAGHAGELLSVPVG--D
MLBr_00707|M.leprae_Br4923 VVLGSGWSSAVAALGSSRAVFPQAELPGFITPNAAGHTGELLSVRIG--A
Mb3335|M.bovis_AF2122/97 VVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIG--A
Rv3307|M.tuberculosis_H37Rv VVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIG--A
MAV_4284|M.avium_104 IVLGSGWSPAVAALGTPTAVLPQAELPGFRPPTAVGHTGELVSMRIG--E
MSMEG_1701|M.smegmatis_MC2_155 VVLGSGWAPAVAELGDPVGVVDMADLPGFTPPTAAGHGGQVLSVRIG--E
TH_2259|M.thermoresistible__bu VVLGSGWAPAVTELGEPVATVPMAELPGFTPPTAAGHRGQLMSTRIG--E
Mflv_4828|M.gilvum_PYR-GCK VVLGSGWAPAATSLGEPDAAIPMADLPGFTPPSAQGHGGQVLSVRAG--P
Mvan_1610|M.vanbaalenii_PYR-1 VVLGSGWAPAAAQIGDPTAAIPMAELPGFTPPSAQGHGGQVLSLRVG--A
MAB_3660|M.abscessus_ATCC_1997 VVLGSGWAPAAGELGTPATTIPMAELPAFSPPSAAGHGGSVLSVPIGGSD
:****** .* :* . .. :::*.* .*.* ** *.::* *
MMAR_1219|M.marinum_M HRVLVLAGRIHAYEGHDLRHVVHPVRTACAAGARTVVLTNAAGGLRPDMQ
MUL_2673|M.ulcerans_Agy99 HRVLVLAGRIHAYEGHDLRHVVHPVRTACAAGARTVVLTNAAGGLRPDMQ
MLBr_00707|M.leprae_Br4923 HRVLVLAGRIHPYEGHDLRHVVHPVRTACAAGARIIVLTNAAGGLRADMA
Mb3335|M.bovis_AF2122/97 HRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQ
Rv3307|M.tuberculosis_H37Rv HRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQ
MAV_4284|M.avium_104 HRVLVLVGRIHAYEGHDLCHVVHPVRAACAAGVRAVVLTNAAGGLRPDLA
MSMEG_1701|M.smegmatis_MC2_155 HRVLVLVGRIHAYEGHDLAHVVHPVRTAVATGVRTVVLTNAAGGLRPEYT
TH_2259|M.thermoresistible__bu HRALVLIGRIHAYEGHDLSHVVHPVRAACASGVHTVVLTNAAGGLREDFT
Mflv_4828|M.gilvum_PYR-GCK HRVLVLLGRIHAYEGHNLRHVVHPVRTACAAGARTVVLTNAAGGVREDMT
Mvan_1610|M.vanbaalenii_PYR-1 HRVLVLLGRIHAYEGHDLRHVVHPVRTACAAGVHTVVLTNAAGGLRADFS
MAB_3660|M.abscessus_ATCC_1997 ERMLILLGRIHAYEGHDLRHVVHPVRTACAAGARTIILTNAAGGLREDYA
.* *:* ****.****:* :******:* *:*.: ::*******:* :
MMAR_1219|M.marinum_M VGQPVLISDHLNLTARSPLVGAQFVDLTDAYSARLRAVARQADPELAEGV
MUL_2673|M.ulcerans_Agy99 VGQPVLISDHLNLTARSPLVGAQFVDLTDAYSARLRAVARQADPELAEGV
MLBr_00707|M.leprae_Br4923 VGQLVLISDHLNLTTRSPLVGTHFVDLTNAYTTRLRKLASDTDPTLTEGV
Mb3335|M.bovis_AF2122/97 VGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGV
Rv3307|M.tuberculosis_H37Rv VGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGV
MAV_4284|M.avium_104 VGEPVLISDHLNLTGRSPLVGPQFVDLTDAYSPRLRELARQADPTLAEGV
MSMEG_1701|M.smegmatis_MC2_155 VGQPVLISDHLNLTARSPLVGPQFVDLVDAYSPRLRAVAREFDPSLAEGV
TH_2259|M.thermoresistible__bu VGQPVLISDHLNLTARSPLVGPQFVDLVDAYSPRLRRIALGIDPSLAEGV
Mflv_4828|M.gilvum_PYR-GCK VGQPVLISDHLNLTARSPLVGAQFVDMVDAYSPALRALARDIDPSLTEGV
Mvan_1610|M.vanbaalenii_PYR-1 VGQPVLISDHLNLTARSPLVGAQFVDLVDAYSPRLRALAREIEPGLAEGV
MAB_3660|M.abscessus_ATCC_1997 VGQPVLISDHLNLTARSPLVGAQFVDLVDAYSPRLRALAREIDDNLTEGV
**: ********** ****** .***:.:**:. ** :* : *:***
MMAR_1219|M.marinum_M YAGLPGPHYETPAEIRMLRVLGADLVGMSTVHETIAARAAGAEVLGVSLV
MUL_2673|M.ulcerans_Agy99 YAGLPGPHYETPAEIRMLRVLGADLVGMSTMHETIAARAAGAEVLGVSLV
MLBr_00707|M.leprae_Br4923 YAAQPGPHYETPAEIRMLRMLGADLVGMSTVHETIAARAAGAEVLGVSLV
Mb3335|M.bovis_AF2122/97 YAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLV
Rv3307|M.tuberculosis_H37Rv YAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLV
MAV_4284|M.avium_104 YAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIATRAAGAEVLGVSLV
MSMEG_1701|M.smegmatis_MC2_155 YAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAEVLAVSLV
TH_2259|M.thermoresistible__bu YAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARAAGAQVLGLSLV
Mflv_4828|M.gilvum_PYR-GCK YAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARACGAAVLGVSLV
Mvan_1610|M.vanbaalenii_PYR-1 YAGLPGPHYETPAEIRMLRTLGADLVGMSTVHETIAARGAGASVLGLSLV
MAB_3660|M.abscessus_ATCC_1997 YAGLPGPHYETPAEIRMLRTLGADLVGMSTVQETIAARAAGAEVLGVSLV
**. **************: **********::****:*..** **.:***
MMAR_1219|M.marinum_M TNLAAGITGEPLSHAEVLAAGAASAARIGSLLATVIAGLRNSDA
MUL_2673|M.ulcerans_Agy99 TNLAAGITGEPLSHAEVLAAGAASAARIGSLLATVIAGLRNSDA
MLBr_00707|M.leprae_Br4923 TNLAAGITGKPLNHAEVLAAGTASANRIGSLLADIIARF-----
Mb3335|M.bovis_AF2122/97 TNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF-----
Rv3307|M.tuberculosis_H37Rv TNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF-----
MAV_4284|M.avium_104 TNLAAGISGEPLSHTEVLAAGAASATRMGALLALILRQLPRF--
MSMEG_1701|M.smegmatis_MC2_155 TNLAAGMTGEPLSHAEVLQAGRESATRMGALLASVIARL-----
TH_2259|M.thermoresistible__bu TNLAAGMTGEPLSHADVLAAGRESAARMGALLATVIAAM-----
Mflv_4828|M.gilvum_PYR-GCK TNLAAGMTGQPLSHEEVLAAGRQSATRMGSLLSAVIAGL-----
Mvan_1610|M.vanbaalenii_PYR-1 TNMAAGMTGRPLSHAEVLEAGRQSATRMGSLLSAVIARL-----
MAB_3660|M.abscessus_ATCC_1997 TNLAAGMTGESLNHEEVLAAGRASATRMGQLLRAVIGRL-----
**:***::*..*.* :** ** ** *:* ** :: :