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ATDDGDTDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLL APEKADAIIAAAAEIADGRHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDDVNMSQSSND TFPTATHIAATEAAVRHLIPALQVLHDALASKAREWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGI ERVRATLPRLGELAIGGTAVGTGLNAPDGFGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGAL RTIAVSLTKIANDIRWMGSGPLTGLAEIALPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGNDAAVAVGG LSGAFELNVYIPMMARNILESFKLLTNVSRLFAERCISGLSANVEHLRELAESSPSIVTPLNSAIGYEEA AAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1221 | fumC | - | 100% (470) | fumarate hydratase |
| M. avium 104 | MAV_3111 | argH | 4e-15 | 25.19% (385) | argininosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1128c | fumC | 0.0 | 90.85% (470) | fumarate hydratase |
| M. gilvum PYR-GCK | Mflv_2065 | fumC | 0.0 | 89.06% (466) | fumarate hydratase |
| M. tuberculosis H37Rv | Rv1098c | fumC | 0.0 | 90.85% (470) | fumarate hydratase |
| M. leprae Br4923 | MLBr_01947 | fumC | 0.0 | 92.64% (462) | fumarate hydratase |
| M. abscessus ATCC 19977 | MAB_1250c | fumC | 0.0 | 87.47% (463) | fumarate hydratase |
| M. marinum M | MMAR_4368 | fumC | 0.0 | 91.20% (466) | fumarase Fum |
| M. smegmatis MC2 155 | MSMEG_5240 | fumC | 0.0 | 89.63% (463) | fumarate hydratase |
| M. thermoresistible (build 8) | TH_0559 | fum | 0.0 | 86.99% (469) | PROBABLE FUMARASE FUM (Fumarate hydratase) |
| M. ulcerans Agy99 | MUL_0181 | fumC | 0.0 | 90.56% (466) | fumarate hydratase |
| M. vanbaalenii PYR-1 | Mvan_4649 | fumC | 0.0 | 89.80% (461) | fumarate hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1128c|M.bovis_AF2122/97 MAVDA-DSAN----YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
Rv1098c|M.tuberculosis_H37Rv MAVDA-DSAN----YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MMAR_4368|M.marinum_M MAHSAHDDADNDTEYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MUL_0181|M.ulcerans_Agy99 MAHSAHDDADNDTEYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MAV_1221|M.avium_104 ---MATDDGD--TDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MLBr_01947|M.leprae_Br4923 MKRTQFMADS--AEYRIEHDTMGEVRVPAIALWRAQTQRAVENFPISGRG
Mflv_2065|M.gilvum_PYR-GCK ----MAD---KDVEYRIEHDTMGEVRVPKDALWRAQTQRAVENFPISFRP
Mvan_4649|M.vanbaalenii_PYR-1 ----MTDSAVDNTEYRIEHDTMGEVRVPKNALWRAQTQRAVENFPISFRP
MSMEG_5240|M.smegmatis_MC2_155 -------MADTDVEYRIEHDTMGEVRVPKDALWRAQTQRAVENFPISFRG
TH_0559|M.thermoresistible__bu -MSTDSAGQNGATEYRIEHDTMGEVRVPVNALWRAQTQRAVENFPISGRG
MAB_1250c|M.abscessus_ATCC_199 ---------MSEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRG
****:********* ***************** *
Mb1128c|M.bovis_AF2122/97 LERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQF
Rv1098c|M.tuberculosis_H37Rv LERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQF
MMAR_4368|M.marinum_M LERAQIRALGLLKGACAQVNMDLGLLAPEKAEAIIAAAAEIADGQHDDQF
MUL_0181|M.ulcerans_Agy99 LERAQMRALGLLKGACAQVNMDLGLLAPEKAQAIIAAAAEIADGQHDDQF
MAV_1221|M.avium_104 LERTQIRALGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDDQF
MLBr_01947|M.leprae_Br4923 LERTQIRALGLLKGACAQVNKDLGLLASEKANAIIAAAATIADGYHDDQF
Mflv_2065|M.gilvum_PYR-GCK LERTQIRAMGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDDQF
Mvan_4649|M.vanbaalenii_PYR-1 LERTQIRALGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDDQF
MSMEG_5240|M.smegmatis_MC2_155 LERTQIRALGLLKAACAQVNKDLGLLDPEKADAIIAAAGEIAEGKHDDQF
TH_0559|M.thermoresistible__bu LERAQIRALGLLKGACAQVNKDLGLLDPAKADAIIAAANEIAEGRHDDQF
MAB_1250c|M.abscessus_ATCC_199 LERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQEIADGKHDDQF
***:*:**:****.****** ***** . **:****** **:* *****
Mb1128c|M.bovis_AF2122/97 PIDVFQTGSGTSSNMNTNEVIASIAAKGG--VTLHPNDDVNMSQSSNDTF
Rv1098c|M.tuberculosis_H37Rv PIDVFQTGSGTSSNMNTNEVIASIAAKGG--VTLHPNDDVNMSQSSNDTF
MMAR_4368|M.marinum_M PIDVFQTGSGTSSNMNTNEVIASIAGANG--VAVHPNDDVNMSQSSNDTF
MUL_0181|M.ulcerans_Agy99 PIDVFQTGSGTSSNMNTNEVIASIAGANG--VAVHPNDDVNMSQSSNDTF
MAV_1221|M.avium_104 PIDVFQTGSGTSSNMNTNEVIASIAAANG--VTVHPNDDVNMSQSSNDTF
MLBr_01947|M.leprae_Br4923 PIDVFQTGSGTSSNMNTNEVIGSIAAANG--VPVHPNDDVNMSQSSNDTF
Mflv_2065|M.gilvum_PYR-GCK PIDVFQTGSGTSSNMNTNEVIASIAAANG--VTIHPNDDVNMSQSSNDTF
Mvan_4649|M.vanbaalenii_PYR-1 PIDVFQTGSGTSSNMNTNEVIASIAAANG--VTVHPNDDVNMSQSSNDTF
MSMEG_5240|M.smegmatis_MC2_155 PIDVFQTGSGTSSNMNTNEVIASIAAANG--VTVHPNDHVNMSQSSNDTF
TH_0559|M.thermoresistible__bu PIDVFQTGSGTSSNMNTNEVIASIAARNG--VTVHPNDDVNMSQSSNDTF
MAB_1250c|M.abscessus_ATCC_199 PIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTF
****************:****.***. * :****.***********
Mb1128c|M.bovis_AF2122/97 PTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVP
Rv1098c|M.tuberculosis_H37Rv PTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVP
MMAR_4368|M.marinum_M PTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRTHLMDAVP
MUL_0181|M.ulcerans_Agy99 PTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRTHLMDAVP
MAV_1221|M.avium_104 PTATHIAATEAAVRHLIPALQVLHDALASKAREWHTVVKSGRTHLMDAVP
MLBr_01947|M.leprae_Br4923 PTATHIAATEAAVRHLIPALQELHAALATKSSEWHTVVKSGRTHLMDAVP
Mflv_2065|M.gilvum_PYR-GCK PTATHIAATEAAVRHLIPALEVLHESLDAKARQWRTTVKSGRTHLMDAVP
Mvan_4649|M.vanbaalenii_PYR-1 PTATHIAATEAAVRHLIPALEVLHESLDAKARQWRTTVKSGRTHLMDAVP
MSMEG_5240|M.smegmatis_MC2_155 PTATHIAATEAAVRHLIPALEVLHASLAAKAKQWRTVVKSGRTHLMDAVP
TH_0559|M.thermoresistible__bu PTATHVAATEAAVRDLIPALEVLHASLAAKARQWRTVVKSGRTHLMDAVP
MAB_1250c|M.abscessus_ATCC_199 PTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVP
*****:******* .*****: *: :* :*: *::.*************
Mb1128c|M.bovis_AF2122/97 VTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGV
Rv1098c|M.tuberculosis_H37Rv VTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGV
MMAR_4368|M.marinum_M VTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPEGFGV
MUL_0181|M.ulcerans_Agy99 VTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPEGFGV
MAV_1221|M.avium_104 VTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDGFGA
MLBr_01947|M.leprae_Br4923 VTLGQEFGGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPDGFGA
Mflv_2065|M.gilvum_PYR-GCK VTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLNAPDGFGA
Mvan_4649|M.vanbaalenii_PYR-1 VTLGQEFGGYARQIQAGIERVKASLPRLGELAIGGTAVGTGLNAPDGFGA
MSMEG_5240|M.smegmatis_MC2_155 VTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLNAPEGFGA
TH_0559|M.thermoresistible__bu VTLGQEFGGYARQIEAGIERVRATLPRLGELPIGGTAVGTGLNAPEGFGP
MAB_1250c|M.abscessus_ATCC_199 VTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFGA
*******.******:******:* *******.*************:.**
Mb1128c|M.bovis_AF2122/97 RVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIAN
Rv1098c|M.tuberculosis_H37Rv RVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIAN
MMAR_4368|M.marinum_M KVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRTIAVSLTKIAN
MUL_0181|M.ulcerans_Agy99 KVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRIIAVSLTKIAN
MAV_1221|M.avium_104 KVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAVSLTKIAN
MLBr_01947|M.leprae_Br4923 KVVEALIATTGLTELRPAANSFEAQAARDGLVEASGALRTIAVSLTKIAN
Mflv_2065|M.gilvum_PYR-GCK KVVEVLVDQTGIAELRTAKDSFEAQAARDGLVEASGALKTIAASLTKIAN
Mvan_4649|M.vanbaalenii_PYR-1 KVVDVLVDQTGIAELRTAVDSFEAQAARDGLVEASGALKTIAVSLTKIAN
MSMEG_5240|M.smegmatis_MC2_155 KVVEVLVNETGLAELRTAVDSFEAQAARDGLVEASGALRTIAVSLTKIAN
TH_0559|M.thermoresistible__bu KVVEVLVAQTGLAELRPAVDSFEAQAARDGLVEASGALRTIAVSLTKIAN
MAB_1250c|M.abscessus_ATCC_199 KVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIAN
:** .* **:.:*:.* :*************.****: **.*******
Mb1128c|M.bovis_AF2122/97 DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
Rv1098c|M.tuberculosis_H37Rv DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
MMAR_4368|M.marinum_M DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
MUL_0181|M.ulcerans_Agy99 DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
MAV_1221|M.avium_104 DIRWMGSGPLTGLAEIALPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGN
MLBr_01947|M.leprae_Br4923 DIRLMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
Mflv_2065|M.gilvum_PYR-GCK DIRWMGSGPLTGLGELQLPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGN
Mvan_4649|M.vanbaalenii_PYR-1 DIRWMGSGPLTGLGELQLPDLQPGSSIMPGKVNPVIPEAVTQVAAQVIGN
MSMEG_5240|M.smegmatis_MC2_155 DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVACQVVGN
TH_0559|M.thermoresistible__bu DIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVIPEAVTQVACQVVGN
MAB_1250c|M.abscessus_ATCC_199 DIRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGN
*** *********.*: ******************:********.**:**
Mb1128c|M.bovis_AF2122/97 DAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTA
Rv1098c|M.tuberculosis_H37Rv DAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTA
MMAR_4368|M.marinum_M DAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQRCIAGLTA
MUL_0181|M.ulcerans_Agy99 DAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQRCIAGLTA
MAV_1221|M.avium_104 DAAVAVGGLSGAFELNVYIPMMARNILESFKLLTNVSRLFAERCISGLSA
MLBr_01947|M.leprae_Br4923 DAAVAWGGANGAFELNVYIPMMARNILESYQLLTNVSRLFAERCIKGLSA
Mflv_2065|M.gilvum_PYR-GCK DAAVTVGGLSGAFELNVYIPMMARNVLESFTLLANVSKLFAAKCIDGLIA
Mvan_4649|M.vanbaalenii_PYR-1 DAAVTVGGLSGAFELNVYIPMMARNLLESFTLLANVSKLFAAKCIDGLVA
MSMEG_5240|M.smegmatis_MC2_155 DAAIAFGGASGAFELNVYIPMMARNLLESFTLLSNVSRLFAERCIDGLVA
TH_0559|M.thermoresistible__bu DAAIAFGGASGAFELNVYIPMMARNLLESFRLLANSSRLFAEKCIDGLVA
MAB_1250c|M.abscessus_ATCC_199 DAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVA
***:: ** .**********:****:***: **:* *:**. :*: ** *
Mb1128c|M.bovis_AF2122/97 NVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRG
Rv1098c|M.tuberculosis_H37Rv NVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRG
MMAR_4368|M.marinum_M NAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRG
MUL_0181|M.ulcerans_Agy99 NAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRG
MAV_1221|M.avium_104 NVEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRG
MLBr_01947|M.leprae_Br4923 NIEHLRELAESSQSIVTPLNSAIGYEEAAAVVKQALKERKTLRQTVIDRG
Mflv_2065|M.gilvum_PYR-GCK NDQHIREQAESSPSIVTPLNSAIGYEEAAKVAKQALKEKKTIRQTVIDRG
Mvan_4649|M.vanbaalenii_PYR-1 NDDHLRELAESSPSIVTPLNSAIGYEEAAKVAKQALKEKKTIRQTVIDRG
MSMEG_5240|M.smegmatis_MC2_155 NEERLRELAESSPSIVTPLNSAIGYEEAAKVAKQALAEKKTIRQTVIDRG
TH_0559|M.thermoresistible__bu NEERLRKLAESSPSIVTPLNRAIGYEEAAKVAKQALAEGKTIRQTVIDRG
MAB_1250c|M.abscessus_ATCC_199 NEDHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRG
* :::* **** ******* ******** *.*:** * **:********
Mb1128c|M.bovis_AF2122/97 LIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
Rv1098c|M.tuberculosis_H37Rv LIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
MMAR_4368|M.marinum_M LIGDKLSLEELDRRLDVLAMAKVEATDD---
MUL_0181|M.ulcerans_Agy99 LIGNKLSLEELDRRLDVLAMAKVEATDD---
MAV_1221|M.avium_104 LIGDKLSLEELDRRLDVLAMAKVKPQD----
MLBr_01947|M.leprae_Br4923 LIGDKLSLEELDRRLDVLAMAKVKPADS---
Mflv_2065|M.gilvum_PYR-GCK LIGDKLSEEELDKRLDVLAMAKVKPGDQ---
Mvan_4649|M.vanbaalenii_PYR-1 LIGDKLSEEELDRRLDVLAMAKVRDGS----
MSMEG_5240|M.smegmatis_MC2_155 LIGDKLSLEELDRRLDVLAMARVKDGE----
TH_0559|M.thermoresistible__bu LVGEKLTLEELDELLDVLAMARVKDND----
MAB_1250c|M.abscessus_ATCC_199 LIGDKLSIEELDKRLDVLAMAKVKD------
*:*::*: *:**. *******:..