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VGAISLDGKTTRDEIFVDLKERVAALTAAGRTPGLGTVLVGDDPGSQAYVRGKHADCAKVGINSIRRDLP ADITTEQLNETIDELNANPDCTGYIVQLPLPKHLDENAALERIDPAKDADGLHPTNLGRLVLGKQAALPC TPRGIVHLLRRFDVPIAGAHVVVIGRGVTVGRPMGLLLTRRSENATVTLCHTGTRDLPALTRQADIIIAA VGVPHMVTADMVKPGAAVVDVGVSRVDGKLTGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVEAEES KLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1647 | - | - | 100% (283) | tetrahydrofolate dehydrogenase/cyclohydrolase FolD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3391c | folD | 1e-143 | 87.54% (281) | bifunctional methylenetetrahydrofolate |
| M. gilvum PYR-GCK | Mflv_4879 | - | 1e-138 | 85.16% (283) | methylenetetrahydrofolate dehydrogenase (NADP(+)) |
| M. tuberculosis H37Rv | Rv3356c | folD | 1e-143 | 87.54% (281) | bifunctional methylenetetrahydrofolate |
| M. leprae Br4923 | MLBr_00674 | folD | 1e-136 | 82.56% (281) | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ |
| M. abscessus ATCC 19977 | MAB_3692c | - | 1e-137 | 86.02% (279) | bifunctional 5,10-methylene-tetrahydrofolate |
| M. marinum M | MMAR_1176 | folD | 1e-146 | 88.97% (281) | bifunctional protein: methylenetetrahydrofolate |
| M. avium 104 | MAV_4323 | - | 1e-145 | 89.25% (279) | tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding |
| M. thermoresistible (build 8) | TH_1967 | folD | 1e-137 | 86.07% (280) | PROBABLE BIFUNCTIONAL PROTEIN FOLD: |
| M. ulcerans Agy99 | MUL_1428 | folD | 1e-145 | 88.61% (281) | bifunctional protein: methylenetetrahydrofolate |
| M. vanbaalenii PYR-1 | Mvan_1550 | - | 1e-139 | 87.19% (281) | methylenetetrahydrofolate dehydrogenase (NADP(+)) |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3391c|M.bovis_AF2122/97 ---MGAIMLDGKATRDEIFGDLKPRVAALDAAGRTPGLGTILVGDDPGSQ
Rv3356c|M.tuberculosis_H37Rv ---MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQ
MAV_4323|M.avium_104 ---MGAITLDGKATRDEIFVDLKQRVAALTAAGRTPGLGTILVGDDPGSQ
MLBr_00674|M.leprae_Br4923 ---MGAITLDGKATRDEILIDLKQRVAALTESGRTPGLGTILVGDDPGSH
MMAR_1176|M.marinum_M ---MGAITLDGKATRDEIFVDLKQRVSELNASGRTPGLATILVGEDPGSQ
MUL_1428|M.ulcerans_Agy99 ---MGAITLDGKATRDEIFVDLKQRVSELNASGRTPGLATILVGEDPGSQ
Mflv_4879|M.gilvum_PYR-GCK MMRVGAITLDGKATRDEIFVDLRERVARLAAAGRTPGLATVLVGDDPGSH
Mvan_1550|M.vanbaalenii_PYR-1 MMRVGAITLDGKATRDEIFVDLKERVTALTAAGRTPGLGTVLVGDDPGSQ
TH_1967|M.thermoresistible__bu ---VGAIRLDGKATRDEIFAELKERVAALTAAGRTPGLGTVLVGDDPGSH
MSMEG_1647|M.smegmatis_MC2_155 ---MGAISLDGKTTRDEIFVDLKERVAALTAAGRTPGLGTVLVGDDPGSQ
MAB_3692c|M.abscessus_ATCC_199 ---MTATRLDGKATRDEIFVELATRAAALKAAGKTPGLGTILVGDDPGSH
: * ****:*****: :* *.: * :*:****.*:***:****:
Mb3391c|M.bovis_AF2122/97 AYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQ
Rv3356c|M.tuberculosis_H37Rv AYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQ
MAV_4323|M.avium_104 AYVRGKHADCAKVGITSIRRDLPADISTAALNDTIDELNANPECTGYIVQ
MLBr_00674|M.leprae_Br4923 AYVRGKHADCAKVGITSIRRDLPVDITTAVLHDTIEELNANPDCTGYIVQ
MMAR_1176|M.marinum_M AYVRGKHSDCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQ
MUL_1428|M.ulcerans_Agy99 AYVRGKHSDCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQ
Mflv_4879|M.gilvum_PYR-GCK AYVRGKHADCAKVGINSIRRDLPADISQAVLDETIDELNANPECTGYIVQ
Mvan_1550|M.vanbaalenii_PYR-1 AYVRGKHADCAKVGIESIRRDLPADISQETLLETLDELNANPACTGYIVQ
TH_1967|M.thermoresistible__bu AYVRGKHSDCAKVGITSIRRDLPADISQAELADVLDELNADPACTGYIVQ
MSMEG_1647|M.smegmatis_MC2_155 AYVRGKHADCAKVGINSIRRDLPADITTEQLNETIDELNANPDCTGYIVQ
MAB_3692c|M.abscessus_ATCC_199 AYVRGKHADCAKVGLNSIRRDLPADIDQATLCATIDELNANPDCTGYIVQ
*******:******: *******.** * .::****:* *******
Mb3391c|M.bovis_AF2122/97 LPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVH
Rv3356c|M.tuberculosis_H37Rv LPLPKHLDENAALERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVH
MAV_4323|M.avium_104 LPLPKQLDENAALERVDPDKDADGLHPTNLGRLVLNNPAPLPCTPRGIVH
MLBr_00674|M.leprae_Br4923 LPLPKYLDENTALERVDPAKDADGLHPTNLGRLVLSTPAPLPCTARGILH
MMAR_1176|M.marinum_M LPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNTPAPLPCTPRGIVH
MUL_1428|M.ulcerans_Agy99 LPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNTPAPLPCTPRGIVH
Mflv_4879|M.gilvum_PYR-GCK LPLPKHLNENAALERIDPSKDADGLHPTNLGRLVLNEPAPLPCTPRGIVH
Mvan_1550|M.vanbaalenii_PYR-1 LPLPKHLNENAALERIDPGKDADGLHPMNLGRLVLNEPAALPCTPRGIVH
TH_1967|M.thermoresistible__bu LPLPGHLDENAALERIDPAKDADGLHPMNLGRLVLNEPAPLPCTPRGIVH
MSMEG_1647|M.smegmatis_MC2_155 LPLPKHLDENAALERIDPAKDADGLHPTNLGRLVLGKQAALPCTPRGIVH
MAB_3692c|M.abscessus_ATCC_199 LPLPKHLDENEALERIDPDKDADGLHPTNLGRLVLGKEAPLPCTPRGIVY
**** *:** ****:** ******** *******. *.****.***::
Mb3391c|M.bovis_AF2122/97 LLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
Rv3356c|M.tuberculosis_H37Rv LLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
MAV_4323|M.avium_104 LLRRYDVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
MLBr_00674|M.leprae_Br4923 LLRRYGVEIAGTHVVIIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNL
MMAR_1176|M.marinum_M LLRRYDVPIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
MUL_1428|M.ulcerans_Agy99 LLRRYDVPIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
Mflv_4879|M.gilvum_PYR-GCK LLRRFEVEIAGAHVAVLGRGVTVGRPLGLLLTRRSENATVTLCHTATRHL
Mvan_1550|M.vanbaalenii_PYR-1 LLRRYQVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHL
TH_1967|M.thermoresistible__bu LLRRFDVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRNL
MSMEG_1647|M.smegmatis_MC2_155 LLRRFDVPIAGAHVVVIGRGVTVGRPMGLLLTRRSENATVTLCHTGTRDL
MAB_3692c|M.abscessus_ATCC_199 LLRRYDVKLDGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDL
****: : : *:**.::*********:******************.**.*
Mb3391c|M.bovis_AF2122/97 PALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDD-GLVGDVHP
Rv3356c|M.tuberculosis_H37Rv PALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDD-GLVGDVHP
MAV_4323|M.avium_104 PALTRQADIVVAAVGVPHLLTADMVRPGAAVLDVGVSRVDG-KLAGDVHP
MLBr_00674|M.leprae_Br4923 AALTKQADIIVAAVGVPHLLTADMVRPGAVVVDVGVSRVET-RLVGDVHP
MMAR_1176|M.marinum_M PTLTRQADIIVAAVGVPHMLTADMVRPGAAVVDVGVSRVDG-KLTGDVHP
MUL_1428|M.ulcerans_Agy99 ATLTRQADIIVAAVGVPHMLTADMVRPGAAVVDVGVSRVDG-KLTGDVHP
Mflv_4879|M.gilvum_PYR-GCK PEITREADIIVAAAGVPHMVTADMVRPGAAVVDVGVSRDDAGKLVGDVHP
Mvan_1550|M.vanbaalenii_PYR-1 PQITREADIIIAAAGVPHMVTAEMVRPGAAVVDVGVSRDEAGKLVGDVHP
TH_1967|M.thermoresistible__bu PEIARQADIIIAAAGVPHMVTADMVRPGAAVVDVGVSRDEQGKLVGDVHP
MSMEG_1647|M.smegmatis_MC2_155 PALTRQADIIIAAVGVPHMVTADMVKPGAAVVDVGVSRVDG-KLTGDVAP
MAB_3692c|M.abscessus_ATCC_199 AALTRQADIIVAAAGVPHMVTADMVKPGAAVVDVGVSRVDD-KLTGDVAE
. ::::***::**.**.*::**:**:***.*:****** : *.***
Mb3391c|M.bovis_AF2122/97 DVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR---
Rv3356c|M.tuberculosis_H37Rv DVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR---
MAV_4323|M.avium_104 DVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAERE---
MLBr_00674|M.leprae_Br4923 DVWEVAGHVSPNPGGVGPLTRVFLLTNVVELAEGRQ--
MMAR_1176|M.marinum_M DVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAEQR---
MUL_1428|M.ulcerans_Agy99 DVWEVAGHVSPNPGGVGPLTRAFLLTNVVELAEQR---
Mflv_4879|M.gilvum_PYR-GCK GVWDVAGHVSPNPGGVGPLTRAFLLTNVVERAEANL--
Mvan_1550|M.vanbaalenii_PYR-1 DVWEVAGHVSPNPGGVGPLTRAFLLTNVVERAEALAGS
TH_1967|M.thermoresistible__bu DVWDVAGHVSPNPGGVGPLTRAFLLTNVVELAEKA---
MSMEG_1647|M.smegmatis_MC2_155 DVWEVAGHVSPNPGGVGPLTRAFLLTNVVEAEESKLA-
MAB_3692c|M.abscessus_ATCC_199 DVWDVAGYVSPNPGGVGPLTRAFLLTNVIERAERS---
.**::**:*************.******:* *