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MSDQKTVHDVTYDLLRKLGLTTVFGNPGSTEESFLRDFPEDFTYVLSLQEASALAMADGFAQATGKPALV NLHTAAGTGNAMGSLVAAYRANTPLIITAGQQTREMSVVDPYLNNPDATTMPKPWVKWSYEPARAEDVPA AFMQAYAVAMQPPMGPVFLSIPLDDWDKPALGPAAVRSVSTRVAPDAERLAQFAERINAAKHPMLVLGPE VDRAGAWDAGIEFAEKLGAPVHASALPDRMSFPEDHPLYAGPLPMTIAGVEQAVSAYDLVVVVGAEVFRY YPYVPGEYLPEGTDLLQITADPHRSAVAPVGDSLVGDVGIALSRLTELIDTPDDRVPPKPLVRQRHSDIP STAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPTTHPASFFATGSGGIGWGVPAAVGIALGDR ARGVDRTVVATIGDGSFQYSIQAIWTAAQHKLPIVFVVLRNGEYAILKSFADLEKTPNVPGLQLPGLDIS SIAAGFGCRTATVESTDMLEAELKTALQADGPTVLVVPTLPQLPQLG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1606 | - | - | 100% (537) | benzoylformate decarboxylase |
| M. smegmatis MC2 155 | MSMEG_4460 | - | 3e-37 | 28.31% (551) | acetolactate synthase |
| M. smegmatis MC2 155 | MSMEG_4348 | - | 1e-31 | 26.00% (550) | hypothetical protein MSMEG_4348 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3539c | ilvX | 2e-30 | 26.32% (532) | hypothetical protein Mb3539c |
| M. gilvum PYR-GCK | Mflv_1545 | - | 2e-33 | 26.81% (552) | hypothetical protein Mflv_1545 |
| M. tuberculosis H37Rv | Rv3509c | ilvX | 2e-30 | 26.32% (532) | hypothetical protein Rv3509c |
| M. leprae Br4923 | MLBr_00354 | ilvX | 2e-33 | 26.78% (534) | hypothetical protein MLBr_00354 |
| M. abscessus ATCC 19977 | MAB_3470c | - | 3e-33 | 24.91% (530) | acetolactate synthase |
| M. marinum M | MMAR_4997 | ilvX | 5e-37 | 28.60% (535) | acetohydroxyacid synthase IlvX |
| M. avium 104 | MAV_3788 | - | 4e-32 | 27.93% (469) | acetolactate synthase catalytic subunit |
| M. thermoresistible (build 8) | TH_4403 | - | 3e-29 | 27.19% (548) | PUTATIVE thiamine pyrophosphate enzyme, central domain family |
| M. ulcerans Agy99 | MUL_4072 | ilvX | 1e-36 | 28.22% (535) | hypothetical protein MUL_4072 |
| M. vanbaalenii PYR-1 | Mvan_5213 | - | 6e-38 | 27.08% (528) | hypothetical protein Mvan_5213 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4997|M.marinum_M ------MNGAQALINT----LVDGGVDVCFANPGTSEMHFVAALDTV---
MUL_4072|M.ulcerans_Agy99 ------MNGAQALINT----LVDGGVDVCFANPGTSEMHFVAALDTV---
Mb3539c|M.bovis_AF2122/97 ------MNGAQALINT----LVDGGVDVCFANPGTSEMHFVAALDAV---
Rv3509c|M.tuberculosis_H37Rv ------MNGAQALINT----LVDGGVDVCFANPGTSEMHFVAALDAV---
MLBr_00354|M.leprae_Br4923 ------MNGAQAMIST----LVDGGVDVCFANPGTSEMHFVAALDTV---
Mflv_1545|M.gilvum_PYR-GCK ------MNGAYSLLTT----LVDHGVEVCFANPGTSEMHFVAALDAV---
Mvan_5213|M.vanbaalenii_PYR-1 ------MNGARSLLTT----LVDQGVDVCFANPGTSEMHFVAALDTV---
MSMEG_1606|M.smegmatis_MC2_155 ------MSDQKTVHDVTYDLLRKLGLTTVFGNPGSTEESFLRDFP-----
MAV_3788|M.avium_104 MTLDNPLDGPEAAADLIA-LLADEGVADFFINPGTDSAPIQEALAAARAA
MAB_3470c|M.abscessus_ATCC_199 ---------------------------MVFGIPGEENIRFIQALAAS---
TH_4403|M.thermoresistible__bu --------MGVPVYKRILDLFEAEGINTLFGIPDPNFVHLFLEAETR---
* *. :
MMAR_4997|M.marinum_M --ADMRGVLALFEGVATGAADGYARMADKPAAVLLHLGPGLGNGLANLHN
MUL_4072|M.ulcerans_Agy99 --ADMRGVLALFEGVATGAADGYARMADKPAAVLLHLGPGLGNGLANLHN
Mb3539c|M.bovis_AF2122/97 --PRMRGMLTLFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHN
Rv3509c|M.tuberculosis_H37Rv --PRMRGMLTLFEGVATGAADGYARIAGRPAAVLLHLGPGLGNGLANLHN
MLBr_00354|M.leprae_Br4923 --AGMRGVLTLFEGVATGAADGYARIAGRPAVVLLHLGPGLGNGLANLHN
Mflv_1545|M.gilvum_PYR-GCK --PRMRGVLTLFEGVATGAADGYARMTGTPAAVLLHLGPGLGNGLANLHN
Mvan_5213|M.vanbaalenii_PYR-1 --PGMRGVLTLFEGVATGAADGYARMSGKPAAVLLHLGPGLGNGLANLHN
MSMEG_1606|M.smegmatis_MC2_155 --EDFTYVLSLQEASALAMADGFAQATGKPALVNLHTAAGTGNAMGSLVA
MAV_3788|M.avium_104 GTPSPRAVLCVHESVALAAAIGHHMASARPQAVMVHVDAGTLNLGCQLHN
MAB_3470c|M.abscessus_ATCC_199 ---DIRYILTRHEQGAAFMAEMYGRVTGRAGVVSATLGPGAINLQLGVAD
TH_4403|M.thermoresistible__bu ---GWSVVAPHHEESAGFMAEAASRMTGRPGLCIGTLGPGLANIAGAMMC
: * * * : . .* * :
MMAR_4997|M.marinum_M ARRARVPMVVVVG---------DHATYHKKYDAPLES-DIDALAGTVSGW
MUL_4072|M.ulcerans_Agy99 ARRARVPMVVVVG---------DHATYHKKYDAPLES-DIDALAGTVSGW
Mb3539c|M.bovis_AF2122/97 ARRARVPMVVVVG---------DHATYHKKYDAPLES-DIDAVAGTVSGW
Rv3509c|M.tuberculosis_H37Rv ARRARVPMVVVVG---------DHATYHKKYDAPLES-DIDAVAGTVSGW
MLBr_00354|M.leprae_Br4923 ARRARVPMVVVVG---------DHATYHKKYDAPLES-DIDALAGTVSGW
Mflv_1545|M.gilvum_PYR-GCK ARRAHVPMVVVVG---------DHATYHKQYDAPLES-DIDALARTVSGW
Mvan_5213|M.vanbaalenii_PYR-1 ARRAHVPMVVVVG---------DHATYHKKYDAPLES-DIDALAHTVSGW
MSMEG_1606|M.smegmatis_MC2_155 AYRANTPLIITAG---------QQTREMSVVDPYLNNPDATTMPKPWVKW
MAV_3788|M.avium_104 AQRNGTPVVVFAGRTPYSSAPDVRGHRDTHIHWQQEQLDQPAVMRNYAKW
MAB_3470c|M.abscessus_ATCC_199 ASTNSTPLVAIAA----------QVGQDRAYKESHQYVDLVAMFRPITRW
TH_4403|M.thermoresistible__bu AKVENSPVIFLGGQR-------ARITERRVRRGRIQFVQQEGMLAPMVKF
* *:: . : : : : :
MMAR_4997|M.marinum_M VHRTETAADVGADTAKAIAASRQGPQVCTLILPADASWSDGAEPAVVPPA
MUL_4072|M.ulcerans_Agy99 VHRTETAADVGADTAKAIAASREGSQVSTLILPADASWSDGAEPAMVPPA
Mb3539c|M.bovis_AF2122/97 VRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCWSDGAHAAAGVPA
Rv3509c|M.tuberculosis_H37Rv VRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCWSDGAHAAAGVPA
MLBr_00354|M.leprae_Br4923 LHRTMDTADVGVDAAEAISASLVGSQISTLILPADVSWSDGAIPAASVSD
Mflv_1545|M.gilvum_PYR-GCK TRRTLDCGDIAVDAVDAVTASRAG-IVSTLILPADVSWSDGEPAERSLRS
Mvan_5213|M.vanbaalenii_PYR-1 VRRTLDVGDIAVDAVDAVAASRAG-VVSTMIVPADVSWNDGEPTEPLPAG
MSMEG_1606|M.smegmatis_MC2_155 SYEPARAEDVPAAFMQAYAVAMQPPMGPVFLSIPLDDWDKPALGPAAVRS
MAV_3788|M.avium_104 HMEVPRGRELAPIVRRAFQVAQSSPPGPAYVMLPREALMEPGGRALQRRL
MAB_3470c|M.abscessus_ATCC_199 ADGVPTARAIPEMFRKAFKLAETERPAAVFLAVPENIDADGANYELNPLP
TH_4403|M.thermoresistible__bu SSSIEYAEQTDEIIREAIRRAMSGTPGPAYVEYPQHVILEELDVPDPLPP
* : . : . .
MMAR_4997|M.marinum_M QPAPVT------------GDVVSIAKMLRSAEPALLLIGGDATRGPGLAA
MUL_4072|M.ulcerans_Agy99 QPAPVT------------GDVVSIAKMLRSAEPALLLIGGDATRGPGLAA
Mb3539c|M.bovis_AF2122/97 QAAAAP------------VDVGPVAGVLRSGEPAMMLIGGDATRGPGLTA
Rv3509c|M.tuberculosis_H37Rv QAAAAP------------VDVGPVAGVLRSGEPAMMLIGGDATRGPGLTA
MLBr_00354|M.leprae_Br4923 QPASAG------------VDVGAVRTALESGEPTVILIGADATGWSGLAA
Mflv_1545|M.gilvum_PYR-GCK DHVPDPFLPEVEPVAADEDAVRDAADVLNSGAPAVLLIGGDATRMPGLSA
Mvan_5213|M.vanbaalenii_PYR-1 HPAPG----------IDDDAVREAADALNSGVPTVLLVGGDATLAPGLSA
MSMEG_1606|M.smegmatis_MC2_155 VSTRVAP---------DAERLAQFAERINAAKHPMLVLGPEVDRAGAWDA
MAV_3788|M.avium_104 PPAVPPG--------PDPAALGRLAGILVAGQRVVIVTARTAADPAAATV
MAB_3470c|M.abscessus_ATCC_199 RNVVHPEAP-------MAGQVQRAVDILRRAHRPVLLAGHGAARGGATAA
TH_4403|M.thermoresistible__bu HRYRLVDQR------AGAAEIAEAVRLIRAAEHPILLVGHAVHTSRTQQP
: : . ::: . .
MMAR_4997|M.marinum_M AARIAEATGARWLCETFPTRLERGAGVPSVERLGYFAEAAAAQLDGAKHL
MUL_4072|M.ulcerans_Agy99 AARIAEATGARWLCETFPTRLERGAGVPAVERLGYFAEAAAAQLDGAKHL
Mb3539c|M.bovis_AF2122/97 AARIVQATGARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHL
Rv3509c|M.tuberculosis_H37Rv AARIVQATGARWLCETFPTCLERGAGIPAVERLAYFAEGAAAQLDGVKHL
MLBr_00354|M.leprae_Br4923 VARIGAATGARWFCETFPARLERGAGVPAVERLAYFAEVAAAQLDGAKHL
Mflv_1545|M.gilvum_PYR-GCK AARIAEATGARVLCETFPARLQRGAGVPAVERLAYFAEAAEEQLRGAEHL
Mvan_5213|M.vanbaalenii_PYR-1 AVRIAERTGAKVLCETFPARLQRGAGVPAVERLAYFAEGAEAQLVGAEHL
MSMEG_1606|M.smegmatis_MC2_155 GIEFAEKLGAPVHASALPDRMSFPEDHPLYAGPLPMTIAGVEQAVSAYDL
MAV_3788|M.avium_104 LARIAEILGAPVIDQGDRANLPPGHPLHVTGDAAPLQDADTVLLLDSEVP
MAB_3470c|M.abscessus_ATCC_199 LIRFSEELGVPVAN-TFHGKGAMPDDHPNSMGTVGFMRRDYANFGFEHAD
TH_4403|M.thermoresistible__bu VRELAELMGCPVIQTSGGTSFIPGIEDRTFPYGFSPAAIEAVRTSDLCVA
.: *
MMAR_4997|M.marinum_M VLAGAKSPVSFFAYPGMASDLV-PAGCTVHELAGH--------------R
MUL_4072|M.ulcerans_Agy99 VLAGAKSPVSFFAYPGMASDLV-PAGCTVHELAGH--------------R
Mb3539c|M.bovis_AF2122/97 VLAGARSPVSFFAYPGMPSDLV-PAGCEVHVLAEP--------------G
Rv3509c|M.tuberculosis_H37Rv VLAGARSPVSFFAYPGMPSDLV-PAGCEVHVLAEP--------------G
MLBr_00354|M.leprae_Br4923 VLAGAQSPVSFFAYPGMPSDLV-PAGCEVHVLAEH--------------G
Mflv_1545|M.gilvum_PYR-GCK ILAGAAAPVSFFAYPGRASSLV-PPGCEVRTLAQH--------------L
Mvan_5213|M.vanbaalenii_PYR-1 ILAGAASPVSFFAYPGRPSDLV-PQGCEVHVLAGH--------------S
MSMEG_1606|M.smegmatis_MC2_155 VVVVGAEVFRYYPY--VPGEYL-PEGTDLLQITADPHRSAVAPVGDSLVG
MAV_3788|M.avium_104 WVPAQLAPPATARVVQIDADPV-KPSMPLWSYPVEIALT----------A
MAB_3470c|M.abscessus_ATCC_199 VIVAVGYELQEFDPVRINPHGD-KQIIHLHRFPAEVDAHYSVSVG--IIG
TH_4403|M.thermoresistible__bu LGTELGEPVHFGRHRHWVDNEANRKWVYVEQDPAAIGVNRPIDVP--LIG
: .
MMAR_4997|M.marinum_M GAADALIALADEVAPG--------------TSAPLAALSRPQLP------
MUL_4072|M.ulcerans_Agy99 GAADALIALADEVAPG--------------TSAPLAALSRPQLP------
Mb3539c|M.bovis_AF2122/97 GAADALAALADEVAPG--------------TVAPVAGASRPQLP------
Rv3509c|M.tuberculosis_H37Rv GAADALAALADEVAPG--------------TVAPVAGASRPQLP------
MLBr_00354|M.leprae_Br4923 GAAYALNALADEVASG--------------TAAPVVAASRPQLP------
Mflv_1545|M.gilvum_PYR-GCK GATAALEALADELTSD--------------TRVRVASSARPDMP------
Mvan_5213|M.vanbaalenii_PYR-1 GAAAALEQLADDVAPG--------------TTASVAPLMRPDLP------
MSMEG_1606|M.smegmatis_MC2_155 DVGIALSRLTELIDTPD----------DRVPPKPLVRQRHSDIPS-----
MAV_3788|M.avium_104 DTRVALLLLEQTLLRLANDELREKWSTRRGAVESQVAQRRREAARRAESD
MAB_3470c|M.abscessus_ATCC_199 DISASVNALTDALAGHR----------FDCAAAPGSALLAEEFTRGQQDS
TH_4403|M.thermoresistible__bu DLRGVVPQLVEALREQPRQPSPDLDRWIRQDAERLAELAETAPTG-----
. : * : : .
MMAR_4997|M.marinum_M TGALTSMSAADVIGALMPERAIVVDESNTSGVLLPQATAGAPAHDWLTLT
MUL_4072|M.ulcerans_Agy99 TGALTSMSAADVIGALMPERAIVVDESNTSGVLLPQATAGAPAHDWLTLT
Mb3539c|M.bovis_AF2122/97 TGDLTSVSAADVVGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLT
Rv3509c|M.tuberculosis_H37Rv TGDLTSVSAADVVGALLPERAIVVDESNTCGVLLPQATAGAPAHDWLTLT
MLBr_00354|M.leprae_Br4923 SGPLTSGAAANVIGALLPERAIVVDESNTSGVLLAAATAGAPAHDWLTLT
Mflv_1545|M.gilvum_PYR-GCK TGHLTAFSAAGVIGALLPEGAVLVDESNTAGIGVASATAGAPAHDVLTLT
Mvan_5213|M.vanbaalenii_PYR-1 TGELTAFSAAAVIGALLPEGAVVVDESNTAGVGVAAATAGAPGHDVLTLT
MSMEG_1606|M.smegmatis_MC2_155 TAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPTTHPASFFATG
MAV_3788|M.avium_104 SDADAPDAMLAALGGALPDDAVVVQEAVTNRPAVARQVR-RPPGQLFDTG
MAB_3470c|M.abscessus_ATCC_199 RFPMAPQRIVADIRAALGRSDVVLVDTGATKMWMARLYPTYEPNTCLVSN
TH_4403|M.thermoresistible__bu RKPVHPARFVVEATKALPDDAILVRDGGATVIFQWTYSQAKPRDVIWNQN
. :: : :
MMAR_4997|M.marinum_M GG-AIGYGIPAAVGAAVAAPER----PVLCLQSDGSAMYTIS--GLWTQA
MUL_4072|M.ulcerans_Agy99 GG-AIGYGIPAGVGAAVAAPER----PVLCLQSDGSAMYTIS--GLWTQA
Mb3539c|M.bovis_AF2122/97 GG-AIGYGIPAAVGAAVAAPDR----PVLCLESDGSAMYTIS--GLWSQA
Rv3509c|M.tuberculosis_H37Rv GG-AIGYGIPAAVGAAVAAPDR----PVLCLESDGSAMYTIS--GLWSQA
MLBr_00354|M.leprae_Br4923 GG-AIGHGIPASVGAAVAAPDR----PVLCLESDGSAMYTIS--GLWTQA
Mflv_1545|M.gilvum_PYR-GCK GG-AIGYGMPAAIGAAIAAPGR----PVVSLQADGSAMYTVS--ALWTQA
Mvan_5213|M.vanbaalenii_PYR-1 GG-AIGYGMPAAIGAAMAAPDR----PVLSLQADGSAMYTVS--ALWTQA
MSMEG_1606|M.smegmatis_MC2_155 SG-GIGWGVPAAVGIALGDRARGVDRTVVATIGDGSFQYSIQ--AIWTAA
MAV_3788|M.avium_104 AP-ALGWALGGAFGIKLARPHA----PVVAICGDGSFNFGVPTAALWSAH
MAB_3470c|M.abscessus_ATCC_199 GLSTMGFALPGALGVKLARPDT----KVLAVAGDGAFLMNSQ--EIETAV
TH_4403|M.thermoresistible__bu FG-HLGTGLPYAVGASVAEGGK---RPVMLLTSDSAFLFHIA--ELETAA
:* .: ..* :. *: .*.: : :
MMAR_4997|M.marinum_M RENLDVTTVIYNNGAYDILRVELQRVGAG--SAPGPKALDLLDISRPTMD
MUL_4072|M.ulcerans_Agy99 RENLDVTTVIYNNGAYDILRVELQRVGAG--SAPGPKALDLLDISRPTMD
Mb3539c|M.bovis_AF2122/97 RENLDVTTVIYNNGAYDILRIELQRVGAG--SDPGPKALDLLDISRPTMD
Rv3509c|M.tuberculosis_H37Rv RENLDVTTVIYNNGAYDILRIELQRVGAG--SDPGPKALDLLDISRPTMD
MLBr_00354|M.leprae_Br4923 RENLDVTTIIYNNGAYNILRIELQRMGAG--STPGPKALSLLDLSSPTMD
Mflv_1545|M.gilvum_PYR-GCK RENLDVTTVIFANGAYDILRLELHRVGAANAEAPGPRALQLLDLGSPTID
Mvan_5213|M.vanbaalenii_PYR-1 RENLDVTTVIFGNGAYDILRIELQRVGAENAATPGPSALRLLDLGSPTLD
MSMEG_1606|M.smegmatis_MC2_155 QHKLPIVFVVLRNGEYAILKSFADLEKTP--NVPG--------LQLPGLD
MAV_3788|M.avium_104 RYGAPFVTVVLNNHSYLASKTPVTELYPQG--ISVRDNDFPETRLTPETD
MAB_3470c|M.abscessus_ATCC_199 RERIPLVVLIWEDGGYGLIEWKMDLELGEH-----------HHVSFTNPD
TH_4403|M.thermoresistible__bu RQNLPLVCVVGVDHAWGLEVGVYKRTFEQPSPQPG-------VHWSKNVR
: .. :: : :
MMAR_4997|M.marinum_M FVKIAEGMGVPARRVGSCEEFADALRGAFNEPGP---HLIDAVVPSLLG-
MUL_4072|M.ulcerans_Agy99 FVKIAAGMGVPARRVSSCEEFADALRGAFNEPGP---HLIDAVVPSLLG-
Mb3539c|M.bovis_AF2122/97 FVKIAEGMGVPARRVTTCEEFADALRAAFAEPGP---HLIDVVVPSLVG-
Rv3509c|M.tuberculosis_H37Rv FVKIAEGMGVPARRVTTCEEFADALRAAFAEPGP---HLIDVVVPSLVG-
MLBr_00354|M.leprae_Br4923 FVKIAEGMGVSARRVNTTEGLADALRLAFTEPGP---HLIDTVVPSIVG-
Mflv_1545|M.gilvum_PYR-GCK FVNIAEGMGVPGRRVTTAEELADALSAAFAEPGP---HLIEAVVPSLASS
Mvan_5213|M.vanbaalenii_PYR-1 FVKIAEGMGVPARRVSTAEDLAAALTEAFAAPGP---HLIEAVVPSLVNT
MSMEG_1606|M.smegmatis_MC2_155 ISSIAAGFGCRTATVESTDMLEAELKTALQADGPT--VLVVPTLPQLPQL
MAV_3788|M.avium_104 YAVLARACGGSGRDVHTPAQMREAIGWALDEAGQGRCAVLDVRLPQT---
MAB_3470c|M.abscessus_ATCC_199 IVSYAESFGAKGYRITAADQLLPTLQAALDDGGVS---LIACPVDYSENL
TH_4403|M.thermoresistible__bu FDKIAEGLDCHGEFVDSEEEIGPAIKRAYASGRTAVVHVAIDPKANSEEM
* . . : : : : * :
MMAR_4997|M.marinum_M ---------------
MUL_4072|M.ulcerans_Agy99 ---------------
Mb3539c|M.bovis_AF2122/97 ---------------
Rv3509c|M.tuberculosis_H37Rv ---------------
MLBr_00354|M.leprae_Br4923 ---------------
Mflv_1545|M.gilvum_PYR-GCK AV-------------
Mvan_5213|M.vanbaalenii_PYR-1 ---------------
MSMEG_1606|M.smegmatis_MC2_155 G--------------
MAV_3788|M.avium_104 ---------------
MAB_3470c|M.abscessus_ATCC_199 RLTDRLGQLDATL--
TH_4403|M.thermoresistible__bu PSYDEFRTWYAEGQQ