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NGARSLLTTLVDQGVDVCFANPGTSEMHFVAALDTVPGMRGVLTLFEGVATGAADGYARMSGKPAAVLLH LGPGLGNGLANLHNARRAHVPMVVVVGDHATYHKKYDAPLESDIDALAHTVSGWVRRTLDVGDIAVDAVD AVAASRAGVVSTMIVPADVSWNDGEPTEPLPAGHPAPGIDDDAVREAADALNSGVPTVLLVGGDATLAPG LSAAVRIAERTGAKVLCETFPARLQRGAGVPAVERLAYFAEGAEAQLVGAEHLILAGAASPVSFFAYPGR PSDLVPQGCEVHVLAGHSGAAAALEQLADDVAPGTTASVAPLMRPDLPTGELTAFSAAAVIGALLPEGAV VVDESNTAGVGVAAATAGAPGHDVLTLTGGAIGYGMPAAIGAAMAAPDRPVLSLQADGSAMYTVSALWTQ ARENLDVTTVIFGNGAYDILRIELQRVGAENAATPGPSALRLLDLGSPTLDFVKIAEGMGVPARRVSTAE DLAAALTEAFAAPGPHLIEAVVPSLVNT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5213 | - | - | 100% (519) | hypothetical protein Mvan_5213 |
| M. vanbaalenii PYR-1 | Mvan_2122 | - | 3e-23 | 25.35% (564) | acetolactate synthase 1 catalytic subunit |
| M. vanbaalenii PYR-1 | Mvan_1352 | - | 1e-13 | 24.72% (538) | thiamine pyrophosphate binding domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3539c | ilvX | 0.0 | 73.03% (519) | hypothetical protein Mb3539c |
| M. gilvum PYR-GCK | Mflv_1545 | - | 0.0 | 80.94% (530) | hypothetical protein Mflv_1545 |
| M. tuberculosis H37Rv | Rv3509c | ilvX | 0.0 | 73.03% (519) | hypothetical protein Rv3509c |
| M. leprae Br4923 | MLBr_00354 | ilvX | 0.0 | 73.22% (519) | hypothetical protein MLBr_00354 |
| M. abscessus ATCC 19977 | MAB_3323c | - | 2e-23 | 26.44% (556) | acetolactate synthase 1 catalytic subunit |
| M. marinum M | MMAR_4997 | ilvX | 0.0 | 73.55% (518) | acetohydroxyacid synthase IlvX |
| M. avium 104 | MAV_0648 | - | 0.0 | 74.47% (517) | hypothetical protein MAV_0648 |
| M. smegmatis MC2 155 | MSMEG_4348 | - | 1e-155 | 57.80% (519) | hypothetical protein MSMEG_4348 |
| M. thermoresistible (build 8) | TH_2440 | - | 2e-20 | 24.41% (553) | PUTATIVE acetolactate synthase, large subunit |
| M. ulcerans Agy99 | MUL_4072 | ilvX | 0.0 | 73.75% (518) | hypothetical protein MUL_4072 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5213|M.vanbaalenii_PYR-1 ----------------------------------------------MNGA
Mflv_1545|M.gilvum_PYR-GCK ----------------------------------------------MNGA
Mb3539c|M.bovis_AF2122/97 ----------------------------------------------MNGA
Rv3509c|M.tuberculosis_H37Rv ----------------------------------------------MNGA
MMAR_4997|M.marinum_M ----------------------------------------------MNGA
MUL_4072|M.ulcerans_Agy99 ----------------------------------------------MNGA
MAV_0648|M.avium_104 ----------------------------------------------MNGA
MLBr_00354|M.leprae_Br4923 ----------------------------------------------MNGA
MSMEG_4348|M.smegmatis_MC2_155 ----------------------------------------MTDSQESTGA
MAB_3323c|M.abscessus_ATCC_199 MSAP----AKPKPASASGRAPGTAPEPN------------TVAPQRVTGA
TH_2440|M.thermoresistible__bu VSAPTTRTAERAAPHANGAAGTAAPEPTNPPAKPASAGQKRIAPHQLTGA
.**
Mvan_5213|M.vanbaalenii_PYR-1 RSLLTTLVDQGVDVCFANPGTSEMHFVAALDTVPGMRGVLTLFEGVATGA
Mflv_1545|M.gilvum_PYR-GCK YSLLTTLVDHGVEVCFANPGTSEMHFVAALDAVPRMRGVLTLFEGVATGA
Mb3539c|M.bovis_AF2122/97 QALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGA
Rv3509c|M.tuberculosis_H37Rv QALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGA
MMAR_4997|M.marinum_M QALINTLVDGGVDVCFANPGTSEMHFVAALDTVADMRGVLALFEGVATGA
MUL_4072|M.ulcerans_Agy99 QALINTLVDGGVDVCFANPGTSEMHFVAALDTVADMRGVLALFEGVATGA
MAV_0648|M.avium_104 QALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGA
MLBr_00354|M.leprae_Br4923 QAMISTLVDGGVDVCFANPGTSEMHFVAALDTVAGMRGVLTLFEGVATGA
MSMEG_4348|M.smegmatis_MC2_155 QVVMRRLLAEGVDVCFANPGTSEMHFVAALDTAPGMRPVLCLFEGVATGA
MAB_3323c|M.abscessus_ATCC_199 QSVVRSLEELGVEVIFGIPGGAVLPVYDPLYDSTKVRHVLVRHEQGAGHA
TH_2440|M.thermoresistible__bu QAVIRALEELDVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHA
:: * .*:* *. ** : : . .* :* :* .* * *
Mvan_5213|M.vanbaalenii_PYR-1 ADGYARMSGKPAAVLLHLGPGLGNGLANLHNARRAHVPMVVVVGDHATYH
Mflv_1545|M.gilvum_PYR-GCK ADGYARMTGTPAAVLLHLGPGLGNGLANLHNARRAHVPMVVVVGDHATYH
Mb3539c|M.bovis_AF2122/97 ADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
Rv3509c|M.tuberculosis_H37Rv ADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MMAR_4997|M.marinum_M ADGYARMADKPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MUL_4072|M.ulcerans_Agy99 ADGYARMADKPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MAV_0648|M.avium_104 ADGYARIADRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MLBr_00354|M.leprae_Br4923 ADGYARIAGRPAVVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MSMEG_4348|M.smegmatis_MC2_155 ADGYARIAGRPAATLLHLGPGMANGLANLHNARRAHSPVVNIVGDHATNH
MAB_3323c|M.abscessus_ATCC_199 ASGYAHANGKVGVMMATSGPGATNLVTPLADAQMDSIPVVAITGQVGRGL
TH_2440|M.thermoresistible__bu ASGYAHATGRVGVCMATSGPGATNLVTPLADAHMDSIPVVAITGQVGRGL
*.***: . .. : *** * :: * :*: *:* :.*: .
Mvan_5213|M.vanbaalenii_PYR-1 KKYDAPLESDIDALAHTVSGWVRRTLDVGDIAVDAVDAVAASRAG--VVS
Mflv_1545|M.gilvum_PYR-GCK KQYDAPLESDIDALARTVSGWTRRTLDCGDIAVDAVDAVTASRAG--IVS
Mb3539c|M.bovis_AF2122/97 KKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGS-QIA
Rv3509c|M.tuberculosis_H37Rv KKYDAPLESDIDAVAGTVSGWVRRTEAAADVGADAEAAIAASRSGS-QIA
MMAR_4997|M.marinum_M KKYDAPLESDIDALAGTVSGWVHRTETAADVGADTAKAIAASRQGP-QVC
MUL_4072|M.ulcerans_Agy99 KKYDAPLESDIDALAGTVSGWVHRTETAADVGADTAKAIAASREGS-QVS
MAV_0648|M.avium_104 KKYDAPLESDIDALAGSVSGWVRRTSDASQVSADAVEGIAASRWGS-QIS
MLBr_00354|M.leprae_Br4923 KKYDAPLESDIDALAGTVSGWLHRTMDTADVGVDAAEAISASLVGS-QIS
MSMEG_4348|M.smegmatis_MC2_155 KALDAPLESDIDALGTWLHGAVHRPESAADLDAAVRDAVRDAVGPLGKVA
MAB_3323c|M.abscessus_ATCC_199 IGTDAFQEADISGITMPITKHNFLVSNAEDIPKVIAEAFYIAQSGRPGAV
TH_2440|M.thermoresistible__bu IGTDAFQEADISGITMPITKHNFLVRDGDDIPRILAEAFHIASSGRPGPV
** *:**..: : :: .. :
Mvan_5213|M.vanbaalenii_PYR-1 TMIVPADVSWNDGEPTEPLPAGHPAPG----------IDDDAVREAADAL
Mflv_1545|M.gilvum_PYR-GCK TLILPADVSWSDGEPAERSLRSDHVPDPFLPEVEPVAADEDAVRDAADVL
Mb3539c|M.bovis_AF2122/97 TLILPADVCWSDGAHAAAGVPAQAAAAP-----------VDVGP-VAGVL
Rv3509c|M.tuberculosis_H37Rv TLILPADVCWSDGAHAAAGVPAQAAAAP-----------VDVGP-VAGVL
MMAR_4997|M.marinum_M TLILPADASWSDGAEPAVVPPAQPAPVT-----------GDVVS-IAKML
MUL_4072|M.ulcerans_Agy99 TLILPADASWSDGAEPAMVPPAQPAPVT-----------GDVVS-IAKML
MAV_0648|M.avium_104 TLILPADVSWSDGAQLFSTMDARPAGAD-----------PLLAPEVVEVL
MLBr_00354|M.leprae_Br4923 TLILPADVSWSDGAIPAASVSDQPASAG-----------VDVGA-VRTAL
MSMEG_4348|M.smegmatis_MC2_155 TVILPADFSWGPAEVPAAEVEPSEQSDS--------SETIDVTAAAELLR
MAB_3323c|M.abscessus_ATCC_199 LVDIPKDILQAQTTFSWPPQIYLPGYKP------VTKPHGKQVREAVRLI
TH_2440|M.thermoresistible__bu LVDIPKDILQGQCTFSWPPRFELPGYKP------NTKPHSRQIREAAKLI
: :* *
Mvan_5213|M.vanbaalenii_PYR-1 NSGVPTVLLVGGDATLAPGLSAAVRIAERTGAKVLCETFPARLQRGAGVP
Mflv_1545|M.gilvum_PYR-GCK NSGAPAVLLIGGDATRMPGLSAAARIAEATGARVLCETFPARLQRGAGVP
Mb3539c|M.bovis_AF2122/97 RSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGIP
Rv3509c|M.tuberculosis_H37Rv RSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGIP
MMAR_4997|M.marinum_M RSAEPALLLIGGDATRGPGLAAAARIAEATGARWLCETFPTRLERGAGVP
MUL_4072|M.ulcerans_Agy99 RSAEPALLLIGGDATRGPGLAAAARIAEATGARWLCETFPTRLERGAGVP
MAV_0648|M.avium_104 RSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAGIP
MLBr_00354|M.leprae_Br4923 ESGEPTVILIGADATGWSGLAAVARIGAATGARWFCETFPARLERGAGVP
MSMEG_4348|M.smegmatis_MC2_155 AHGDKVVILLGGTATGASGVSAAARIHAATGARTLVETFPARLARGRGIP
MAB_3323c|M.abscessus_ATCC_199 AAAKRPVLYVGGGVIRADASPELKELAELTGIPVVTTLMARGAFPDSHEL
TH_2440|M.thermoresistible__bu AAARKPVLYVGGGVIRGAAGEELRELAELTGIPVVTTLMARGAFPDSHPQ
. :: :*. . . .: ** . :. .
Mvan_5213|M.vanbaalenii_PYR-1 AVERLAYFAEGAEAQLVGAEHLILAG-------AASPVSFFAYPG--RPS
Mflv_1545|M.gilvum_PYR-GCK AVERLAYFAEAAEEQLRGAEHLILAG-------AAAPVSFFAYPG--RAS
Mb3539c|M.bovis_AF2122/97 AVERLAYFAEGAAAQLDGVKHLVLAG-------ARSPVSFFAYPG--MPS
Rv3509c|M.tuberculosis_H37Rv AVERLAYFAEGAAAQLDGVKHLVLAG-------ARSPVSFFAYPG--MPS
MMAR_4997|M.marinum_M SVERLGYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAYPG--MAS
MUL_4072|M.ulcerans_Agy99 AVERLGYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAYPG--MAS
MAV_0648|M.avium_104 AVERLAYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAYPG--MPS
MLBr_00354|M.leprae_Br4923 AVERLAYFAEVAAAQLDGAKHLVLAG-------AQSPVSFFAYPG--MPS
MSMEG_4348|M.smegmatis_MC2_155 PLDRLQYLGEVATQQLAGATHLILAG-------TRKPVWFFAYPG--KPS
MAB_3323c|M.abscessus_ATCC_199 HMGMPGMHGTVGAVAALQRSDLLITLGARFDDRVTGQLDSFAPEAKVIHA
TH_2440|M.thermoresistible__bu NLGMPGMHGTVAAVAAMQKSDLLIALGTRFDDRVTGQLDSFAPEAKVIHA
: . . .*::: . : ** . :
Mvan_5213|M.vanbaalenii_PYR-1 DLVPQGCEVHVLAGHSGAAAALEQLADDVAPGTTASVA------------
Mflv_1545|M.gilvum_PYR-GCK SLVPPGCEVRTLAQHLGATAALEALADELTSDTRVRVA------------
Mb3539c|M.bovis_AF2122/97 DLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVA------------
Rv3509c|M.tuberculosis_H37Rv DLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVA------------
MMAR_4997|M.marinum_M DLVPAGCTVHELAGHRGAADALIALADEVAPGTSAPLA------------
MUL_4072|M.ulcerans_Agy99 DLVPAGCTVHELAGHRGAADALIALADEVAPGTSAPLA------------
MAV_0648|M.avium_104 DLVPAGCEVHVLAGHTGAADALSALADQLAPGTAAPVA------------
MLBr_00354|M.leprae_Br4923 DLVPAGCEVHVLAEHGGAAYALNALADEVASGTAAPVV------------
MSMEG_4348|M.smegmatis_MC2_155 ELAPEDAQVHTLAP-----ADLEKLADALGAVAPEPAE------------
MAB_3323c|M.abscessus_ATCC_199 DIDPAEIGKNRHADVPIVGDVKNVIIELIEAIRADRAAGTVADPLSEWWE
TH_2440|M.thermoresistible__bu DIDPAEIGKNRHADVPIVGDVKAVIADLLAVLRRDGVADSIK--IDGWWE
.: * . * : : :
Mvan_5213|M.vanbaalenii_PYR-1 ---------PLMRPDLPTGELTAFSAAAVIGALLPEGAVVVDESNTAGVG
Mflv_1545|M.gilvum_PYR-GCK ---------SSARPDMPTGHLTAFSAAGVIGALLPEGAVLVDESNTAGIG
Mb3539c|M.bovis_AF2122/97 ---------GASRPQLPTGDLTSVSAADVVGALLPERAIVVDESNTCGVL
Rv3509c|M.tuberculosis_H37Rv ---------GASRPQLPTGDLTSVSAADVVGALLPERAIVVDESNTCGVL
MMAR_4997|M.marinum_M ---------ALSRPQLPTGALTSMSAADVIGALMPERAIVVDESNTSGVL
MUL_4072|M.ulcerans_Agy99 ---------ALSRPQLPTGALTSMSAADVIGALMPERAIVVDESNTSGVL
MAV_0648|M.avium_104 ---------AASRPALPTGPLTSVSAADVIGALLPERAIVVDESNTSGVL
MLBr_00354|M.leprae_Br4923 ---------AASRPQLPSGPLTSGAAANVIGALLPERAIVVDESNTSGVL
MSMEG_4348|M.smegmatis_MC2_155 ---------PDPLP-APTGPLTVQNWPLVIGALLPENAIISDEANTSGVL
MAB_3323c|M.abscessus_ATCC_199 YLSDVRKTYPLGYDAQHDGSLGPEFVIETLGKIAGPDAVYVAGVGQHQMW
TH_2440|M.thermoresistible__bu YLRGVQQTYPLSYGPQSDGSLSPEYVIETLGKMAGPDAIYVAGVGQHQMW
* * .:* : *: . :
Mvan_5213|M.vanbaalenii_PYR-1 VAAATAGAPGHDVLTLTG-GAIGYGMPAAIGAAMAAPDRPVLSLQADGSA
Mflv_1545|M.gilvum_PYR-GCK VASATAGAPAHDVLTLTG-GAIGYGMPAAIGAAIAAPGRPVVSLQADGSA
Mb3539c|M.bovis_AF2122/97 LPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLESDGSA
Rv3509c|M.tuberculosis_H37Rv LPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLESDGSA
MMAR_4997|M.marinum_M LPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPERPVLCLQSDGSA
MUL_4072|M.ulcerans_Agy99 LPQATAGAPAHDWLTLTG-GAIGYGIPAGVGAAVAAPERPVLCLQSDGSA
MAV_0648|M.avium_104 LAQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLESDGSA
MLBr_00354|M.leprae_Br4923 LAAATAGAPAHDWLTLTG-GAIGHGIPASVGAAVAAPDRPVLCLESDGSA
MSMEG_4348|M.smegmatis_MC2_155 LPAATASSPPHDVLTLTG-GAIGQGLPVAVGAAVAAPDRPVIALQADGSA
MAB_3323c|M.abscessus_ATCC_199 AAQFIKYENPRTWLNSGGLGTMGFAVPAAMGAKMARPEAEVWAIDGDGCF
TH_2440|M.thermoresistible__bu AAQFISYEKPQTWINSGGLGTMGFAVPAAMGAKMGRPDAEVWAIDGDGCF
. : :. * *::* .:*..:** :. * * .::.**.
Mvan_5213|M.vanbaalenii_PYR-1 MYTVSALWTQARENLDVTTVIFGNGAYDILRIELQRVGAENAATPGPSAL
Mflv_1545|M.gilvum_PYR-GCK MYTVSALWTQARENLDVTTVIFANGAYDILRLELHRVGAANAEAPGPRAL
Mb3539c|M.bovis_AF2122/97 MYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG--SDPGPKAL
Rv3509c|M.tuberculosis_H37Rv MYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG--SDPGPKAL
MMAR_4997|M.marinum_M MYTISGLWTQARENLDVTTVIYNNGAYDILRVELQRVGAG--SAPGPKAL
MUL_4072|M.ulcerans_Agy99 MYTISGLWTQARENLDVTTVIYNNGAYDILRVELQRVGAG--SAPGPKAL
MAV_0648|M.avium_104 MYTISGLWTQARENLNVTTVLYDNSAYDILRIELQRVGAG--SAPGPEAL
MLBr_00354|M.leprae_Br4923 MYTISGLWTQARENLDVTTIIYNNGAYNILRIELQRMGAG--STPGPKAL
MSMEG_4348|M.smegmatis_MC2_155 AYTISALWTMAREQLDVTVVILNNRSYAILQMELQRVGTA---ATGERSR
MAB_3323c|M.abscessus_ATCC_199 QMTNQELATCAIEGVPIKVALINNGNLGMVRQWQTLFYEER-----YSQT
TH_2440|M.thermoresistible__bu QMTNQELATCAVEGVPIKVALINNGNLGMVRQWQTLFYEER-----YSQT
* . * : * * : :.. : * ::: .
Mvan_5213|M.vanbaalenii_PYR-1 RLLDLGSPTLDFVKIAEGMGVPARRVSTAEDLAAALTEAFAAPG-PHLIE
Mflv_1545|M.gilvum_PYR-GCK QLLDLGSPTIDFVNIAEGMGVPGRRVTTAEELADALSAAFAEPG-PHLIE
Mb3539c|M.bovis_AF2122/97 DLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPG-PHLID
Rv3509c|M.tuberculosis_H37Rv DLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPG-PHLID
MMAR_4997|M.marinum_M DLLDISRPTMDFVKIAEGMGVPARRVGSCEEFADALRGAFNEPG-PHLID
MUL_4072|M.ulcerans_Agy99 DLLDISRPTMDFVKIAAGMGVPARRVSSCEEFADALRGAFNEPG-PHLID
MAV_0648|M.avium_104 SLLDLSDPAMDFVKISEGMGVPARRVSTAEEFADALRAALAEPG-PHLID
MLBr_00354|M.leprae_Br4923 SLLDLSSPTMDFVKIAEGMGVSARRVNTTEGLADALRLAFTEPG-PHLID
MSMEG_4348|M.smegmatis_MC2_155 SLLDIGNPNIDFAAIAQGFGVPATRATTAEELAAQFAAAVEEPG-PHLID
MAB_3323c|M.abscessus_ATCC_199 DLATHSRRIPDFVKLAEALGCVGLRCEREEDVAKVIEEARAINDRPVVID
TH_2440|M.thermoresistible__bu DLATHTQRIPDFVKLAEALGCVGLRCEREEDVADVIAQARAINDRPVVID
* **. :: .:* . * * .* : * . * :*:
Mvan_5213|M.vanbaalenii_PYR-1 AVVPSLVNT--------------------------------
Mflv_1545|M.gilvum_PYR-GCK AVVPSLASSAV------------------------------
Mb3539c|M.bovis_AF2122/97 VVVPSLVG---------------------------------
Rv3509c|M.tuberculosis_H37Rv VVVPSLVG---------------------------------
MMAR_4997|M.marinum_M AVVPSLLG---------------------------------
MUL_4072|M.ulcerans_Agy99 AVVPSLLG---------------------------------
MAV_0648|M.avium_104 AVVPSIAG---------------------------------
MLBr_00354|M.leprae_Br4923 TVVPSIVG---------------------------------
MSMEG_4348|M.smegmatis_MC2_155 AVLSRVP----------------------------------
MAB_3323c|M.abscessus_ATCC_199 FIVGADAQVWPMVAAGTSNDEIQAARGIRPLFDDDELVADE
TH_2440|M.thermoresistible__bu FIVGADAQVWPMVAAGTSNDEIMAARDIRPLFDESDEGHA-
::