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VNGAYSLLTTLVDHGVEVCFANPGTSEMHFVAALDAVPRMRGVLTLFEGVATGAADGYARMTGTPAAVLL HLGPGLGNGLANLHNARRAHVPMVVVVGDHATYHKQYDAPLESDIDALARTVSGWTRRTLDCGDIAVDAV DAVTASRAGIVSTLILPADVSWSDGEPAERSLRSDHVPDPFLPEVEPVAADEDAVRDAADVLNSGAPAVL LIGGDATRMPGLSAAARIAEATGARVLCETFPARLQRGAGVPAVERLAYFAEAAEEQLRGAEHLILAGAA APVSFFAYPGRASSLVPPGCEVRTLAQHLGATAALEALADELTSDTRVRVASSARPDMPTGHLTAFSAAG VIGALLPEGAVLVDESNTAGIGVASATAGAPAHDVLTLTGGAIGYGMPAAIGAAIAAPGRPVVSLQADGS AMYTVSALWTQARENLDVTTVIFANGAYDILRLELHRVGAANAEAPGPRALQLLDLGSPTIDFVNIAEGM GVPGRRVTTAEELADALSAAFAEPGPHLIEAVVPSLASSAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1545 | - | - | 100% (531) | hypothetical protein Mflv_1545 |
| M. gilvum PYR-GCK | Mflv_3445 | - | 6e-24 | 26.53% (554) | pyruvate decarboxylase |
| M. gilvum PYR-GCK | Mflv_4239 | - | 4e-16 | 23.81% (567) | acetolactate synthase 1 catalytic subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3539c | ilvX | 0.0 | 70.59% (527) | hypothetical protein Mb3539c |
| M. tuberculosis H37Rv | Rv3509c | ilvX | 0.0 | 70.59% (527) | hypothetical protein Rv3509c |
| M. leprae Br4923 | MLBr_00354 | ilvX | 0.0 | 69.00% (529) | hypothetical protein MLBr_00354 |
| M. abscessus ATCC 19977 | MAB_2165 | - | 2e-23 | 25.36% (548) | acetolactate synthase large subunit |
| M. marinum M | MMAR_4997 | ilvX | 0.0 | 70.83% (528) | acetohydroxyacid synthase IlvX |
| M. avium 104 | MAV_0648 | - | 0.0 | 70.64% (528) | hypothetical protein MAV_0648 |
| M. smegmatis MC2 155 | MSMEG_4348 | - | 1e-151 | 57.25% (531) | hypothetical protein MSMEG_4348 |
| M. thermoresistible (build 8) | TH_2440 | - | 1e-16 | 22.67% (569) | PUTATIVE acetolactate synthase, large subunit |
| M. ulcerans Agy99 | MUL_4072 | ilvX | 0.0 | 70.83% (528) | hypothetical protein MUL_4072 |
| M. vanbaalenii PYR-1 | Mvan_5213 | - | 0.0 | 80.94% (530) | hypothetical protein Mvan_5213 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1545|M.gilvum_PYR-GCK ----------------------------------------------MNGA
Mvan_5213|M.vanbaalenii_PYR-1 ----------------------------------------------MNGA
Mb3539c|M.bovis_AF2122/97 ----------------------------------------------MNGA
Rv3509c|M.tuberculosis_H37Rv ----------------------------------------------MNGA
MMAR_4997|M.marinum_M ----------------------------------------------MNGA
MUL_4072|M.ulcerans_Agy99 ----------------------------------------------MNGA
MAV_0648|M.avium_104 ----------------------------------------------MNGA
MLBr_00354|M.leprae_Br4923 ----------------------------------------------MNGA
MSMEG_4348|M.smegmatis_MC2_155 ----------------------------------------MTDSQESTGA
TH_2440|M.thermoresistible__bu VSAPTTRTAERAAPHANGAAGTAAPEPTNPPAKPASAGQKRIAPHQLTGA
MAB_2165|M.abscessus_ATCC_1997 ------------------------------------------------MV
.
Mflv_1545|M.gilvum_PYR-GCK YSLLTTLVDHGVEVCFANPGTSEMHFVAALDAVPRMRGVLTLFEGVATGA
Mvan_5213|M.vanbaalenii_PYR-1 RSLLTTLVDQGVDVCFANPGTSEMHFVAALDTVPGMRGVLTLFEGVATGA
Mb3539c|M.bovis_AF2122/97 QALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGA
Rv3509c|M.tuberculosis_H37Rv QALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGA
MMAR_4997|M.marinum_M QALINTLVDGGVDVCFANPGTSEMHFVAALDTVADMRGVLALFEGVATGA
MUL_4072|M.ulcerans_Agy99 QALINTLVDGGVDVCFANPGTSEMHFVAALDTVADMRGVLALFEGVATGA
MAV_0648|M.avium_104 QALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGA
MLBr_00354|M.leprae_Br4923 QAMISTLVDGGVDVCFANPGTSEMHFVAALDTVAGMRGVLTLFEGVATGA
MSMEG_4348|M.smegmatis_MC2_155 QVVMRRLLAEGVDVCFANPGTSEMHFVAALDTAPGMRPVLCLFEGVATGA
TH_2440|M.thermoresistible__bu QAVIRALEELDVDVIFGIPGGAVLPVYDPLFDSKKLRHVLVRHEQGAGHA
MAB_2165|M.abscessus_ATCC_1997 DWLVSELRRHAVDFVFGVDGANIEDLYDAVHYAPGMQAVVAKHEFSAGTM
:: * *:. *. * . .: :: :: .* *
Mflv_1545|M.gilvum_PYR-GCK ADGYARMTGTPAAVLLHLGPGLGNGLANLHNARRAHVPMVVVVGDHATYH
Mvan_5213|M.vanbaalenii_PYR-1 ADGYARMSGKPAAVLLHLGPGLGNGLANLHNARRAHVPMVVVVGDHATYH
Mb3539c|M.bovis_AF2122/97 ADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
Rv3509c|M.tuberculosis_H37Rv ADGYARIAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MMAR_4997|M.marinum_M ADGYARMADKPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MUL_4072|M.ulcerans_Agy99 ADGYARMADKPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MAV_0648|M.avium_104 ADGYARIADRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MLBr_00354|M.leprae_Br4923 ADGYARIAGRPAVVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYH
MSMEG_4348|M.smegmatis_MC2_155 ADGYARIAGRPAATLLHLGPGMANGLANLHNARRAHSPVVNIVGDHATNH
TH_2440|M.thermoresistible__bu ASGYAHATGRVGVCMATSGPGATNLVTPLADAHMDSIPVVAITGQVGRGL
MAB_2165|M.abscessus_ATCC_1997 ADGYARVTSRMSVVATTSGGGAVNLVPALAESYASAVPVLAIVGQPPRSL
*.***: :. .. * * * :. * :: *:: :.*:
Mflv_1545|M.gilvum_PYR-GCK KQYDAPLES-------DIDALARTVSGWTRRTLDCGDIAVDAVDAVTASR
Mvan_5213|M.vanbaalenii_PYR-1 KKYDAPLES-------DIDALAHTVSGWVRRTLDVGDIAVDAVDAVAASR
Mb3539c|M.bovis_AF2122/97 KKYDAPLES-------DIDAVAGTVSGWVRRTEAAADVGADAEAAIAASR
Rv3509c|M.tuberculosis_H37Rv KKYDAPLES-------DIDAVAGTVSGWVRRTEAAADVGADAEAAIAASR
MMAR_4997|M.marinum_M KKYDAPLES-------DIDALAGTVSGWVHRTETAADVGADTAKAIAASR
MUL_4072|M.ulcerans_Agy99 KKYDAPLES-------DIDALAGTVSGWVHRTETAADVGADTAKAIAASR
MAV_0648|M.avium_104 KKYDAPLES-------DIDALAGSVSGWVRRTSDASQVSADAVEGIAASR
MLBr_00354|M.leprae_Br4923 KKYDAPLES-------DIDALAGTVSGWLHRTMDTADVGVDAAEAISASL
MSMEG_4348|M.smegmatis_MC2_155 KALDAPLES-------DIDALGTWLHGAVHRPESAADLDAAVRDAVRDAV
TH_2440|M.thermoresistible__bu IGTDAFQEA-------DISGITMPITKHNFLVRDGDDIPRILAEAFHIAS
MAB_2165|M.abscessus_ATCC_1997 EGNGAFQDGSGRAGSMDLRAVFRPVSGYCARVEHSGEIAEALSGALAAIR
.* :. *: .: : :: ..
Mflv_1545|M.gilvum_PYR-GCK AG--IVSTLILPADVSWSDGEPAERSLRSDHVPDPFLPEVEPVAADEDAV
Mvan_5213|M.vanbaalenii_PYR-1 AG--VVSTMIVPADVSWNDGEPTEPLPAGHPAPG----------IDDDAV
Mb3539c|M.bovis_AF2122/97 SGS-QIATLILPADVCWSDGAHAAAGVPAQAAAAP-----------VDVG
Rv3509c|M.tuberculosis_H37Rv SGS-QIATLILPADVCWSDGAHAAAGVPAQAAAAP-----------VDVG
MMAR_4997|M.marinum_M QGP-QVCTLILPADASWSDGAEPAVVPPAQPAPVT-----------GDVV
MUL_4072|M.ulcerans_Agy99 EGS-QVSTLILPADASWSDGAEPAMVPPAQPAPVT-----------GDVV
MAV_0648|M.avium_104 WGS-QISTLILPADVSWSDGAQLFSTMDARPAGAD-----------PLLA
MLBr_00354|M.leprae_Br4923 VGS-QISTLILPADVSWSDGAIPAASVSDQPASAG-----------VDVG
MSMEG_4348|M.smegmatis_MC2_155 GPLGKVATVILPADFSWGPAEVPAAEVEPSEQSDS--------SETIDVT
TH_2440|M.thermoresistible__bu SGRPGPVLVDIPKDILQGQCTFSWPPRFELPGYKPN------TKPHSRQI
MAB_2165|M.abscessus_ATCC_1997 DG--LPAVLLIPKDVQQARLAVEPQLREPLPRLGTVP---------VQLA
: :* *
Mflv_1545|M.gilvum_PYR-GCK RDAADVLNSGAPAVLLIGGDATRMPGLSAAARIAEATGARVLCETFPARL
Mvan_5213|M.vanbaalenii_PYR-1 REAADALNSGVPTVLLVGGDATLAPGLSAAVRIAERTGAKVLCETFPARL
Mb3539c|M.bovis_AF2122/97 P-VAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCL
Rv3509c|M.tuberculosis_H37Rv P-VAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCL
MMAR_4997|M.marinum_M S-IAKMLRSAEPALLLIGGDATRGPGLAAAARIAEATGARWLCETFPTRL
MUL_4072|M.ulcerans_Agy99 S-IAKMLRSAEPALLLIGGDATRGPGLAAAARIAEATGARWLCETFPTRL
MAV_0648|M.avium_104 PEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRL
MLBr_00354|M.leprae_Br4923 A-VRTALESGEPTVILIGADATGWSGLAAVARIGAATGARWFCETFPARL
MSMEG_4348|M.smegmatis_MC2_155 AAAELLRAHGDKVVILLGGTATGASGVSAAARIHAATGARTLVETFPARL
TH_2440|M.thermoresistible__bu REAAKLIAAARKPVLYVGGGVIRGAAGEELRELAELTGIPVVTTLMARGA
MAB_2165|M.abscessus_ATCC_1997 DFAGHLIKTPGRILVVAGPEVARQDAREELADLVDRLDALVAVSPDAKDT
:: * . . : . .
Mflv_1545|M.gilvum_PYR-GCK QRGAGVPAVERLAYFAEAAEEQLRGAEHLILAG-------AAAPVSFFAY
Mvan_5213|M.vanbaalenii_PYR-1 QRGAGVPAVERLAYFAEGAEAQLVGAEHLILAG-------AASPVSFFAY
Mb3539c|M.bovis_AF2122/97 ERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAG-------ARSPVSFFAY
Rv3509c|M.tuberculosis_H37Rv ERGAGIPAVERLAYFAEGAAAQLDGVKHLVLAG-------ARSPVSFFAY
MMAR_4997|M.marinum_M ERGAGVPSVERLGYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAY
MUL_4072|M.ulcerans_Agy99 ERGAGVPAVERLGYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAY
MAV_0648|M.avium_104 ERGAGIPAVERLAYFAEAAAAQLDGAKHLVLAG-------AKSPVSFFAY
MLBr_00354|M.leprae_Br4923 ERGAGVPAVERLAYFAEVAAAQLDGAKHLVLAG-------AQSPVSFFAY
MSMEG_4348|M.smegmatis_MC2_155 ARGRGIPPLDRLQYLGEVATQQLAGATHLILAG-------TRKPVWFFAY
TH_2440|M.thermoresistible__bu FPDSHPQNLGMPGMHGTVAAVAAMQKSDLLIALGTRFDDRVTGQLDSFAP
MAB_2165|M.abscessus_ATCC_1997 VKSENPRLLGVIGVMGHPAVEQVMRHGVTCVCVG------TTMPVMTRGA
. : . * :. . : .
Mflv_1545|M.gilvum_PYR-GCK PG--RASSLVPPGCEVRTLAQHLGATAALEALADELTSDTRVRVA-----
Mvan_5213|M.vanbaalenii_PYR-1 PG--RPSDLVPQGCEVHVLAGHSGAAAALEQLADDVAPGTTASVA-----
Mb3539c|M.bovis_AF2122/97 PG--MPSDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVA-----
Rv3509c|M.tuberculosis_H37Rv PG--MPSDLVPAGCEVHVLAEPGGAADALAALADEVAPGTVAPVA-----
MMAR_4997|M.marinum_M PG--MASDLVPAGCTVHELAGHRGAADALIALADEVAPGTSAPLA-----
MUL_4072|M.ulcerans_Agy99 PG--MASDLVPAGCTVHELAGHRGAADALIALADEVAPGTSAPLA-----
MAV_0648|M.avium_104 PG--MPSDLVPAGCEVHVLAGHTGAADALSALADQLAPGTAAPVA-----
MLBr_00354|M.leprae_Br4923 PG--MPSDLVPAGCEVHVLAEHGGAAYALNALADEVASGTAAPVV-----
MSMEG_4348|M.smegmatis_MC2_155 PG--KPSELAPEDAQVHTLAP-----ADLEKLADALGAVAPEPAE-----
TH_2440|M.thermoresistible__bu EAKVIHADIDPAEIGKNRHADVPIVGDVKAVIADLLAVLRRDGVADSIKI
MAB_2165|M.abscessus_ATCC_1997 VDFSKIPVLSIGSAAPHVASRHLQTHDLVSTLAGLAAALPARPETSDSE-
. : . : :*.
Mflv_1545|M.gilvum_PYR-GCK --------------SSARPDMPTGHLTAFSAAGVIGALLPEGAVLVDESN
Mvan_5213|M.vanbaalenii_PYR-1 --------------PLMRPDLPTGELTAFSAAAVIGALLPEGAVVVDESN
Mb3539c|M.bovis_AF2122/97 --------------GASRPQLPTGDLTSVSAADVVGALLPERAIVVDESN
Rv3509c|M.tuberculosis_H37Rv --------------GASRPQLPTGDLTSVSAADVVGALLPERAIVVDESN
MMAR_4997|M.marinum_M --------------ALSRPQLPTGALTSMSAADVIGALMPERAIVVDESN
MUL_4072|M.ulcerans_Agy99 --------------ALSRPQLPTGALTSMSAADVIGALMPERAIVVDESN
MAV_0648|M.avium_104 --------------AASRPALPTGPLTSVSAADVIGALLPERAIVVDESN
MLBr_00354|M.leprae_Br4923 --------------AASRPQLPSGPLTSGAAANVIGALLPERAIVVDESN
MSMEG_4348|M.smegmatis_MC2_155 --------------PDPLP-APTGPLTVQNWPLVIGALLPENAIISDEAN
TH_2440|M.thermoresistible__bu DGWWEYLRGVQQTYPLSYGPQSDGSLSPEYVIETLGKMAGPDAIYVAGVG
MAB_2165|M.abscessus_ATCC_1997 --------TLYAPAHLEPPAHDGDGVRYHDVMHVLDRAIPAGADIFVDAG
. : .:. * .
Mflv_1545|M.gilvum_PYR-GCK TAGIGVASATAGAPAHDVLTLTG-GAIGYGMPAAIGAAIAAPGRPVVSLQ
Mvan_5213|M.vanbaalenii_PYR-1 TAGVGVAAATAGAPGHDVLTLTG-GAIGYGMPAAIGAAMAAPDRPVLSLQ
Mb3539c|M.bovis_AF2122/97 TCGVLLPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLE
Rv3509c|M.tuberculosis_H37Rv TCGVLLPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLE
MMAR_4997|M.marinum_M TSGVLLPQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPERPVLCLQ
MUL_4072|M.ulcerans_Agy99 TSGVLLPQATAGAPAHDWLTLTG-GAIGYGIPAGVGAAVAAPERPVLCLQ
MAV_0648|M.avium_104 TSGVLLAQATAGAPAHDWLTLTG-GAIGYGIPAAVGAAVAAPDRPVLCLE
MLBr_00354|M.leprae_Br4923 TSGVLLAAATAGAPAHDWLTLTG-GAIGHGIPASVGAAVAAPDRPVLCLE
MSMEG_4348|M.smegmatis_MC2_155 TSGVLLPAATASSPPHDVLTLTG-GAIGQGLPVAVGAAVAAPDRPVIALQ
TH_2440|M.thermoresistible__bu QHQMWAAQFISYEKPQTWINSGGLGTMGFAVPAAMGAKMGRPDAEVWAID
MAB_2165|M.abscessus_ATCC_1997 NTGAAAVHYLGARQHGRYVVALGMGGMGYAFGAGIGCAFARPGR-TVVIA
. : * * :* .. ..:*. .. * . :
Mflv_1545|M.gilvum_PYR-GCK ADGSAMYTVSALWTQARENLDVTTVIFANGAYDILRLELHRVGAANAEAP
Mvan_5213|M.vanbaalenii_PYR-1 ADGSAMYTVSALWTQARENLDVTTVIFGNGAYDILRIELQRVGAENAATP
Mb3539c|M.bovis_AF2122/97 SDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG--SDP
Rv3509c|M.tuberculosis_H37Rv SDGSAMYTISGLWSQARENLDVTTVIYNNGAYDILRIELQRVGAG--SDP
MMAR_4997|M.marinum_M SDGSAMYTISGLWTQARENLDVTTVIYNNGAYDILRVELQRVGAG--SAP
MUL_4072|M.ulcerans_Agy99 SDGSAMYTISGLWTQARENLDVTTVIYNNGAYDILRVELQRVGAG--SAP
MAV_0648|M.avium_104 SDGSAMYTISGLWTQARENLNVTTVLYDNSAYDILRIELQRVGAG--SAP
MLBr_00354|M.leprae_Br4923 SDGSAMYTISGLWTQARENLDVTTIIYNNGAYNILRIELQRMGAG--STP
MSMEG_4348|M.smegmatis_MC2_155 ADGSAAYTISALWTMAREQLDVTVVILNNRSYAILQMELQRVGTA---AT
TH_2440|M.thermoresistible__bu GDGCFQMTNQELATCAVEGVPIKVALINNGNLGMVRQWQTLFYEER----
MAB_2165|M.abscessus_ATCC_1997 GDGAFFMHGMEIHTAIEHRLPVTFVIVNNNAHAMCVTREQLYYGG-----
.**. : : . : :. : * :
Mflv_1545|M.gilvum_PYR-GCK GPRALQLLDLGSPTIDFVNIAEGMGVPGRRVTTAEELADALSAAFAEPG-
Mvan_5213|M.vanbaalenii_PYR-1 GPSALRLLDLGSPTLDFVKIAEGMGVPARRVSTAEDLAAALTEAFAAPG-
Mb3539c|M.bovis_AF2122/97 GPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPG-
Rv3509c|M.tuberculosis_H37Rv GPKALDLLDISRPTMDFVKIAEGMGVPARRVTTCEEFADALRAAFAEPG-
MMAR_4997|M.marinum_M GPKALDLLDISRPTMDFVKIAEGMGVPARRVGSCEEFADALRGAFNEPG-
MUL_4072|M.ulcerans_Agy99 GPKALDLLDISRPTMDFVKIAAGMGVPARRVSSCEEFADALRGAFNEPG-
MAV_0648|M.avium_104 GPEALSLLDLSDPAMDFVKISEGMGVPARRVSTAEEFADALRAALAEPG-
MLBr_00354|M.leprae_Br4923 GPKALSLLDLSSPTMDFVKIAEGMGVSARRVNTTEGLADALRLAFTEPG-
MSMEG_4348|M.smegmatis_MC2_155 GERSRSLLDIGNPNIDFAAIAQGFGVPATRATTAEELAAQFAAAVEEPG-
TH_2440|M.thermoresistible__bu -YSQTDLATHTQRIPDFVKLAEALGCVGLRCEREEDVADVIAQARAINDR
MAB_2165|M.abscessus_ATCC_1997 ---SYSFNRFAPSHIASGLGAMFPGLMCHSADTVADLEAAMQQVMTHHG-
: : * . : . .
Mflv_1545|M.gilvum_PYR-GCK PHLIEAVVPSLASS--AV------------------------------
Mvan_5213|M.vanbaalenii_PYR-1 PHLIEAVVPSLVNT----------------------------------
Mb3539c|M.bovis_AF2122/97 PHLIDVVVPSLVG-----------------------------------
Rv3509c|M.tuberculosis_H37Rv PHLIDVVVPSLVG-----------------------------------
MMAR_4997|M.marinum_M PHLIDAVVPSLLG-----------------------------------
MUL_4072|M.ulcerans_Agy99 PHLIDAVVPSLLG-----------------------------------
MAV_0648|M.avium_104 PHLIDAVVPSIAG-----------------------------------
MLBr_00354|M.leprae_Br4923 PHLIDTVVPSIVG-----------------------------------
MSMEG_4348|M.smegmatis_MC2_155 PHLIDAVLSRVP------------------------------------
TH_2440|M.thermoresistible__bu PVVIDFIVGADAQV--WPMVAAGTSNDEIMAARDIRPLFDESDEGHA-
MAB_2165|M.abscessus_ATCC_1997 PSVVEVICSTDEIPPFAPFLSPEIAKERTHDRHDCKNGQSWPQSLARA
* ::: :