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M. smegmatis MC2 155 MSMEG_1495 (-)

annotation: HAD-superfamily protein hydrolase subfamily protein IA, variant 3, putative
coordinates: 1586745 - 1587569
length: 274

MGHSDGVSPVQEKAWRAGRFWWDCTQSADPGAHPLRALILDLDAMSDLDLDGHRVVFNAAFAAHGLELTW
SPARYRQLLALHDERQRVGAELRKRCVGPECDVLVELLADEICATKDMIFDEMILDLGPSPRAGLVDLVM
DAFADGVPVGVVSGGRRRWVEPLVRQLVGDGLVDTIVTGDDVSDTAARGEAYRHALWELGVAPHEALGIA
GSGAALRAANATGLGTVLVGADTDGAGRPAIAVRADYACADGLRLAVCRRLLGQWWAQHSPSAA

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. smegmatis MC2 155 MSMEG_1495 - - 100% (274) HAD-superfamily protein hydrolase subfamily protein IA, variant 3, putative

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3068c serB2 7e-05 32.22% (90) phosphoserine phosphatase
M. gilvum PYR-GCK Mflv_5013 - 8e-66 50.55% (273) hydrolase
M. tuberculosis H37Rv Rv3042c serB2 8e-05 32.22% (90) phosphoserine phosphatase
M. leprae Br4923 MLBr_01727 - 7e-05 31.11% (90) putative phosphoserine phosphatase
M. abscessus ATCC 19977 - - - - -
M. marinum M - - - - -
M. avium 104 - - - - -
M. thermoresistible (build 8) TH_3247 - 7e-53 44.92% (256) PUTATIVE putative Haloacid dehalogenase domain protein
M. ulcerans Agy99 - - - - -
M. vanbaalenii PYR-1 Mvan_1359 - 5e-68 52.17% (276) hydrolase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_5013|M.gilvum_PYR-GCK          -----------------------------------MRSVQSTQQKAWRAG
Mvan_1359|M.vanbaalenii_PYR-1       --------------------------------------MQPTQQKAWRAG
MSMEG_1495|M.smegmatis_MC2_155      --------------------------------MGHSDGVSPVQEKAWRAG
TH_3247|M.thermoresistible__bu      --------------------------------------VPRTRERTART-
Mb3068c|M.bovis_AF2122/97           --MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTL
Rv3042c|M.tuberculosis_H37Rv        --MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTL
MLBr_01727|M.leprae_Br4923          MNTPPKVSVLITVTGVDQPGVTSALFAVLSRHGGELLNVEQVVIRGRLTL
                                                                          :  .  :   : 

Mflv_5013|M.gilvum_PYR-GCK          RFWWDW----SETGEPDGRSLTTLSAVIFDLD------------------
Mvan_1359|M.vanbaalenii_PYR-1       RFWWDWPAQTSESSEAEVRRLTPLSAVIFDLD------------------
MSMEG_1495|M.smegmatis_MC2_155      RFWWDC----TQSADPG---AHPLRALILDLD------------------
TH_3247|M.thermoresistible__bu      -FWWEH-------GRPAGAAEEPLRAVLFNLDG-----------------
Mb3068c|M.bovis_AF2122/97           GVLVSCPLDVADGTALRDDVASAIHGVGLDVAIERSDDLPIIRQPSTHTI
Rv3042c|M.tuberculosis_H37Rv        GVLVSCPLDVADGTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTI
MLBr_01727|M.leprae_Br4923          GVLVLCPPEVAAYTALRDDVQAAIRRVGLDVTIERSDDLPIIREPSTHTI
                                     .                    .:  : :::                   

Mflv_5013|M.gilvum_PYR-GCK          ------------------------------ALADVERTGHRLAFNAAFAE
Mvan_1359|M.vanbaalenii_PYR-1       ------------------------------ALADIDSAGHRLAFNAAFAE
MSMEG_1495|M.smegmatis_MC2_155      ------------------------------AMSDLDLDGHRVVFNAAFAA
TH_3247|M.thermoresistible__bu      ------------------------------AVADLHRDGHRAAFNAAFAA
Mb3068c|M.bovis_AF2122/97           FVLGRPITAGAFSAVAREVAALGVNIDFIRGISDYPVTGLELRVSVPPGC
Rv3042c|M.tuberculosis_H37Rv        FVLGRPITAGAFSAVARGVAALGVNIDFIRGISDYPVTGLELRVSVPPGC
MLBr_01727|M.leprae_Br4923          FVLGRPITARAFGAVAREVAALDVNIDVIRGISDYPVTGLELRVSAPLEA
                                                                  .::*    * .  ....   

Mflv_5013|M.gilvum_PYR-GCK          LG-LDISWSETRYRQLQELPDERRRVAAELRKRGVSTECDVLAELLVDEI
Mvan_1359|M.vanbaalenii_PYR-1       LG-LDIEWSAARYRQLQALTDERRRVAAELRKRGVCTECDVLAELLVDEI
MSMEG_1495|M.smegmatis_MC2_155      HG-LELTWSPARYRQLLALHDERQRVGAELRKRCVGPECDVLVELLADEI
TH_3247|M.thermoresistible__bu      HG-LPVRWDVEQYRHALRIRDDRRRIAAALRRRGYGRDS----AALAAEV
Mb3068c|M.bovis_AF2122/97           VGPLQIALTKVAAEEHVDVAVEDYGLAWRTKRLIVFDVDSTLVQGEVIEM
Rv3042c|M.tuberculosis_H37Rv        VGPLQIALTKVAAEEHVDVAVEDYGLAWRTKRLIVFDVDSTLVQGEVIEM
MLBr_01727|M.leprae_Br4923          AGSLRTALNRVATEEHVDVAVEGYGLARRIKRLIVFDVDSTLVQGEVIEM
                                     * *         ..   :  :   :.   ::              . *:

Mflv_5013|M.gilvum_PYR-GCK          CATKEMILGETILDADITAR------------------------------
Mvan_1359|M.vanbaalenii_PYR-1       CATKAMILGETILDADITAR------------------------------
MSMEG_1495|M.smegmatis_MC2_155      CATKDMIFDEMILDLGPSPR------------------------------
TH_3247|M.thermoresistible__bu      LRTKDALFERCVLDGDVSPR------------------------------
Mb3068c|M.bovis_AF2122/97           LAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPATVIDDVAEQ
Rv3042c|M.tuberculosis_H37Rv        LAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPATVIDDVAEQ
MLBr_01727|M.leprae_Br4923          LAARAGAQGTVAAITEAAMRGELDFAESLQQRVATLAGLPVTVVDEVANQ
                                      ::             : *                              

Mflv_5013|M.gilvum_PYR-GCK          ----PGMAELIAEAYGAGIAVGLVSCGSHTWVEPLVRQLVGEGMVGAIVT
Mvan_1359|M.vanbaalenii_PYR-1       ----PGMVELVAEAYGAGIGVGLVSTGNHSWVEPLVRQLVGEGMVRTIVT
MSMEG_1495|M.smegmatis_MC2_155      ----AGLVDLVMDAFADGVPVGVVSGGRRRWVEPLVRQLVGDGLVDTIVT
TH_3247|M.thermoresistible__bu      ----PGLIDLVTSLFVAGIDVAVVSTGARSWVEPLVRQLIGDGLAATVVS
Mb3068c|M.bovis_AF2122/97           LELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELE
Rv3042c|M.tuberculosis_H37Rv        LELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELE
MLBr_01727|M.leprae_Br4923          LQLMPGARTTLRTLRRLGFRCGVVSGGFRRIIEPLAHELMLDFVAANELE
                                        .*    :      *.  .:** * :  :***.::*: : :.   : 

Mflv_5013|M.gilvum_PYR-GCK          VDDAP--------------REDLFRAALAELGAPAHGSLAFAGSQGSRRA
Mvan_1359|M.vanbaalenii_PYR-1       ADEVP--------------LGELYRTALAELGAPAYDSLAFAGSQASRRA
MSMEG_1495|M.smegmatis_MC2_155      GDDVSDT----------AARGEAYRHALWELGVAPHEALGIAGSGAALRA
TH_3247|M.thermoresistible__bu      RDDLTVV----------GPDPDVYGHALWELGLPPEHALAVESSAAGLSA
Mb3068c|M.bovis_AF2122/97           IVDGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDM
Rv3042c|M.tuberculosis_H37Rv        IVDGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDM
MLBr_01727|M.leprae_Br4923          IVDGILTGRVVGTIVDRPGKAKALRYFSEQAGVPMEQTVAVGDGANDIDM
                                      :                  .       : * .   ::.. ..      

Mflv_5013|M.gilvum_PYR-GCK          AVAAGLPTVLVDGAETAP------------------LRIADCQRIHDSWY
Mvan_1359|M.vanbaalenii_PYR-1       AVASGVATVYVEG-DGAP------------------LRVADCQRMHDSWH
MSMEG_1495|M.smegmatis_MC2_155      ANATGLGTVLVGADTDGAGRPA--IAVRADYACADGLRLAVCRRLLGQWW
TH_3247|M.thermoresistible__bu      ATAAKLTTLVVTTPYTAGQDFTGAAAVRHRYDEPQPLRASGCVALHRRWL
Mb3068c|M.bovis_AF2122/97           LGAAGLGIAFNAKPALREVADAS---LSHPYLDTVLFLLGVTRGEIEAAD
Rv3042c|M.tuberculosis_H37Rv        LGAAGLGIAFNAKPALREVADAS---LSHPYLDTVLFLLGVTRGEIEAAD
MLBr_01727|M.leprae_Br4923          LTAAGLGIAFNAKPALRAVADAS---LSHPYLDTVLFVLGVTRGEIEAAD
                                      *: :                              :  .          

Mflv_5013|M.gilvum_PYR-GCK          ETHPRPTAA-----
Mvan_1359|M.vanbaalenii_PYR-1       ETHHRPTAA-----
MSMEG_1495|M.smegmatis_MC2_155      AQHS-PSAA-----
TH_3247|M.thermoresistible__bu      VANG----------
Mb3068c|M.bovis_AF2122/97           AGDCGVRRVEIPAD
Rv3042c|M.tuberculosis_H37Rv        AGDCGVRRVEIPAD
MLBr_01727|M.leprae_Br4923          AADGGVRRVEIPPD
                                      .

species	id	gene	e-value	identity (len)	annotation
M. smegmatis MC2 155	MSMEG_1495	-	-	100% (274)	HAD-superfamily protein hydrolase subfamily protein IA, variant 3, putative