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VTTIDRRAYARMFGPTRGDRIRLADSDLFVEVEHDHTVAGYELLSGAGKSVRDGEGYRPSSKPSDGALDY VIMNAVVIDAVAGIIKCDIGIRDGRIVGIGKAGNPDTMPGVTESMVVGSATTPIPAEGMIVTAGAIETHA HLISPQQTEHALSTGTTTLIGGSLGPSFEVATGGPRNLGMFLKAGDYTPMNYVPFGRGSSDPAAVLEMVA AGAGAVKIHEDFGASPDIIDKTLQAADSADFAVHLHTDSINEFGFSETTMLTIGDRTIHLYHVEGAGGGH APDLIRCVSFDNVIPGTTNPTNPYTLGGLDEGVPMTMAAHLMNWESPEDIAFAEARIRPQTMVAEDLLHD MGAISIFGSDTQGMGRVAENIANCWQLAAVMKQRVGRLPEEKTVAADNERVKRYIAKLTINPAISVGADD HIGSVEVGKVADLVIWKPAFFGVKPQVVLKNGYIAWAALGDAAGSISSSEPIIQRPNWAALGDAAADGGF VFMSSLAIDAGVPERLGLRKHVLPIKSVRSLRKKDMVRNDALPHVEVDPRTFDVRADGVLLTAEPAVSVP FSRKFLLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1094 | ureC | - | 100% (568) | urease subunit alpha |
| M. smegmatis MC2 155 | MSMEG_3625 | ureC | e-151 | 48.79% (578) | urease subunit alpha |
| M. smegmatis MC2 155 | MSMEG_0883 | - | 1e-05 | 29.91% (107) | amidohydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1881 | ureC | 1e-153 | 50.43% (575) | urease subunit alpha |
| M. gilvum PYR-GCK | Mflv_1685 | ureC | 1e-161 | 49.74% (567) | urease subunit alpha |
| M. tuberculosis H37Rv | Rv1850 | ureC | 1e-153 | 50.43% (575) | urease subunit alpha |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2425 | ureC | 1e-154 | 49.65% (578) | urease subunit alpha |
| M. marinum M | MMAR_2724 | ureC | 1e-152 | 48.87% (575) | urease alpha subunit UreC |
| M. avium 104 | MAV_5277 | - | 7e-05 | 28.57% (105) | amidohydrolase family protein, putative |
| M. thermoresistible (build 8) | TH_1059 | ureC | 1e-132 | 50.83% (484) | Urease alpha subunit ureC (Urea amidohydrolase) |
| M. ulcerans Agy99 | MUL_3029 | ureC | 1e-152 | 48.70% (575) | urease subunit alpha |
| M. vanbaalenii PYR-1 | Mvan_3082 | ureC | 1e-149 | 48.26% (576) | urease subunit alpha |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1881|M.bovis_AF2122/97 --MARLSRERYAQLYGPTTG-DRIRLADTNLLVEVTEDRCGGPGLAGDEA
Rv1850|M.tuberculosis_H37Rv --MARLSRERYAQLYGPTTG-DRIRLADTNLLVEVTEDRCGGPGLAGDEA
MMAR_2724|M.marinum_M --MARLSRERYAQLYGPTTG-DRIRLADTDLLVEITEDRCGGPGLAGDEA
MUL_3029|M.ulcerans_Agy99 --MARLSRERYAQLYGPTTG-DRIRLADTDLLVEITEDRCGGPGLAGDEA
Mvan_3082|M.vanbaalenii_PYR-1 --MTQLSRERYAALYGPTTG-DRIRLADTDLLIEITEDRSGGPGLAGDEA
MAB_2425|M.abscessus_ATCC_1997 --MTRLTREHYAKLYGPTTG-DRIRLADTDLIIEITEDRCGGPGLAGEEA
TH_1059|M.thermoresistible__bu --MTELSRARYGDLYGPTTG-DRIRLADTDLFIEITEDRSGGPGRAGDEA
Mflv_1685|M.gilvum_PYR-GCK -MGHRISRSHYAELYGPTTG-DRVRLADTELLAKVEHDAT----VYGDES
MSMEG_1094|M.smegmatis_MC2_155 --MTTIDRRAYARMFGPTRG-DRIRLADSDLFVEVEHDHT----VAGYEL
MAV_5277|M.avium_104 MFDLKITGGTVVDGTGAQRYRADVGIRDGKIVDVVRADGSEAGGLATAEA
: *. : : * .:. : * *
Mb1881|M.bovis_AF2122/97 ---VFGGGKVLRESMG-QGRASRADGAPDTVITGAVIID-YWGIIKADIG
Rv1850|M.tuberculosis_H37Rv ---VFGGGKVLRESMG-QGRASRADGAPDTVITGAVIID-YWGIIKADIG
MMAR_2724|M.marinum_M ---VFGGGKVLRESMG-QGRVTRAEGAPDTVITGAVIID-YWGIIKADIG
MUL_3029|M.ulcerans_Agy99 ---VFGGGKVLRESMG-QGRVTRAEGAPDTVITGAVIID-YWGIIKANIG
Mvan_3082|M.vanbaalenii_PYR-1 ---VFGGGKVLRESMG-QSRVTRADGAPDTVITGAVILD-YWGIIKADIG
MAB_2425|M.abscessus_ATCC_1997 ---VFGGGKVLRESMG-QSRLTRAGGAPDTVITGAIIID-HWGIIKADIG
TH_1059|M.thermoresistible__bu ---VFGGGKVLRESMG-QGRATRADGTPDTVITGAVIVD-HWGIIKADIG
Mflv_1685|M.gilvum_PYR-GCK ---VFGGGKTMREGMAVHGDITNADGALDFVITNVLIIDAVLGIRKADIG
MSMEG_1094|M.smegmatis_MC2_155 ---LSGAGKSVRDGEGYRPSSKPSDGALDYVIMNAVVIDAVAGIIKCDIG
MAV_5277|M.avium_104 AETIDATGKIVAPGFVDIHTHYDGQVSWDSLLEPSSGHG-VTTVVTGNCG
: . ** : . . : * :: . : . : *
Mb1881|M.bovis_AF2122/97 IRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHV
Rv1850|M.tuberculosis_H37Rv IRDGRIVGIGKAGNPDIMTGVHRDLVVGPSTEIISGNRRIVTAGTVDCHV
MMAR_2724|M.marinum_M IRDGRIVAIGKAGNPNIMSGIHPDLVVGPSTEIIGGNGRIVTAGAIDCHV
MUL_3029|M.ulcerans_Agy99 IRDGRIVAIGKAGNPNIMSGIHPDLVVGPSTEIIGGNGRIVTAGAIDCHV
Mvan_3082|M.vanbaalenii_PYR-1 IRDGRITAIGKAGNPDIMTGVHPGLVVGPSTEIIAGNGRIVTAGAIDCHV
MAB_2425|M.abscessus_ATCC_1997 IRDGRIVGIGKAGNPDIMDGVDPALIVGPSTEIIAGNNRIVTAGGIDCHV
TH_1059|M.thermoresistible__bu IRDGRIVAIGKAGNPDIMTGVHPDLVVGPSTEIIAGNGRILTAGGVDCHV
Mflv_1685|M.gilvum_PYR-GCK IRDGRIAGIGKSGNPRTMDGVDPDLVIGAGTDIRAGEGMIATAGGIDVHV
MSMEG_1094|M.smegmatis_MC2_155 IRDGRIVGIGKAGNPDTMPGVTESMVVGSATTPIPAEGMIVTAGAIETHA
MAV_5277|M.avium_104 VG----FAPVRPGTEQWLIELMEGVEDIPGTALTEG----ITWGWETYPE
: . :.*. : : : ..* . * *
Mb1881|M.bovis_AF2122/97 HLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPGEWHLARMLESLD
Rv1850|M.tuberculosis_H37Rv HLICPQIIVEALAAGTTTIIGGGTGPAEGTKATTVTPGEWHLARMLESLD
MMAR_2724|M.marinum_M HLICPQVIAEALGSGITTIIGGGTGPAEGSKSTTVTPGGWHLARMLEALD
MUL_3029|M.ulcerans_Agy99 HLICPQVIAEALSSGITTIIGGGTGPAEGSKSTTVTPGGWHLARMLEALD
Mvan_3082|M.vanbaalenii_PYR-1 HLICPQIMAEALGGGITTIVAGGTGPAEGSKATTVTPGAWHLARMLEALD
MAB_2425|M.abscessus_ATCC_1997 HFICPQILPEALSGGITTMIGGGTGPAEGSKATTVTPGAWHLGRMLQALD
TH_1059|M.thermoresistible__bu HLICPQLAAEALGSGITTLIGGGTGPAEGSKATTVSPGAWHLGRMLEALD
Mflv_1685|M.gilvum_PYR-GCK HFDSAGLVEEAISSGITTMIGGGLGPVTVG---ITTSGPNNLARMLRAAE
MSMEG_1094|M.smegmatis_MC2_155 HLISPQQTEHALSTGTTTLIGGSLGP----SFEVATGGPRNLGMFLKAGD
MAV_5277|M.avium_104 YLDAIGKQKFAIDVGSQVAHGAIRAYAMGERGARNEPATPDDIEAMGRLV
:: . *: * . .. . . . :
Mb1881|M.bovis_AF2122/97 GWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCLAV
Rv1850|M.tuberculosis_H37Rv GWPVNFALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSTPAAIDTCLAV
MMAR_2724|M.marinum_M SWPVNIALLGKGNTVNPDALWEQLRGGASGFKLHEDWGSSPAAIDACLTV
MUL_3029|M.ulcerans_Agy99 SWPVNIALLGKGNTVNPDALWEQLRGGASGFKLHEDWGKSPAAIDACLTV
Mvan_3082|M.vanbaalenii_PYR-1 TWPLNIALLGKGNTVSAEAMWEQLRGGAAGFKLHEDWGTTPAAIDACLTV
MAB_2425|M.abscessus_ATCC_1997 GWPMNILMLGKGNTVNPDAMWEQLRGGAAGFKLHEDWGTTPAVIDACLRV
TH_1059|M.thermoresistible__bu CWPLNIALLGKGNTVNPSALWEQLRGGAAGFKLHEDWGSTPAAIDACLTV
Mflv_1685|M.gilvum_PYR-GCK GFPMNFGFIANGSASSTAPLIEQGLAGAIGYKIHEDWGATPAAIRASLDA
MSMEG_1094|M.smegmatis_MC2_155 YTPMNYVPFGRG-SSDPAAVLEMVAAGAGAVKIHEDFGASPDIIDKTLQA
MAV_5277|M.avium_104 REAIEAGALGFSTSRTMGHRAMDGEPVPGTFAAEEELFGLGRAMAAGGQA
.:: :. . : . .*: : .
Mb1881|M.bovis_AF2122/97 ADVAGVQVALHSDTLN---ETGFVEDTIGAIAGRSIHAYHTEGAGGGHAP
Rv1850|M.tuberculosis_H37Rv ADVAGVQVALHSDTLN---ETGFVEDTIGAIAGRSIHAYHTEGAGGGHAP
MMAR_2724|M.marinum_M ADAAGVQVALHSDTLN---EMGFVEDTLAAIAGRSIHTYHTEGAGGGHAP
MUL_3029|M.ulcerans_Agy99 ADAAGVQVALHSDTLN---EMGFVEDTLAAIAGRSIHTYHTEGAGGGHAP
Mvan_3082|M.vanbaalenii_PYR-1 CDAAGVQANIHTDTLN---EAGFVEHTLAAIKGRSIHAYHTEGAGGGHAP
MAB_2425|M.abscessus_ATCC_1997 ADEADVQVALHSDTLN---ETGFVEGTLAAIGGRAIHAYHTEGAGGGHAP
TH_1059|M.thermoresistible__bu ADAAGVQVALHSDTLN---EAGFVESTLAAIAGRSIHAYHTEGAGGGHAP
Mflv_1685|M.gilvum_PYR-GCK GDELDLQVQIHTDTLN---ESGFFEDTMRAIGGRPIHTYHAEGAGGGHAP
MSMEG_1094|M.smegmatis_MC2_155 ADSADFAVHLHTDSIN---EFGFSETTMLTIGDRTIHLYHVEGAGGGHAP
MAV_5277|M.avium_104 VFELAPQGAAGEDIIGPKKELDWMRRLSGEIDRPVSFALIQVDADPNLWR
* :. * .: . * . .*. .
Mb1881|M.bovis_AF2122/97 DIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAF
Rv1850|M.tuberculosis_H37Rv DIITVAAQPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAF
MMAR_2724|M.marinum_M DIITVAAHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPRIPEDLAF
MUL_3029|M.ulcerans_Agy99 DIITVAAHPNVLPSSTNPTRPHTVNALDEHLDMLMVCHHLNPRIPDDLAF
Mvan_3082|M.vanbaalenii_PYR-1 DIITVAGHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLNPSVPEDLAF
MAB_2425|M.abscessus_ATCC_1997 DIITVASHPNVMPSSTNPTRPHTVNTLDEHLDMLMVCHHLNAAVPEDLAF
TH_1059|M.thermoresistible__bu DIITVAAHPNVLPSSTNPTRPHTVNTLDEHLDMLMVCHHLHPGVPEDLAF
Mflv_1685|M.gilvum_PYR-GCK DIMRVVGEPYCLPSSTNPTNPYTLNTFDEHLDMVMVCHHLSPRIPEDVAF
MSMEG_1094|M.smegmatis_MC2_155 DLIRCVSFDNVIPGTTNPTNPYTLGGLDEGVPMTMAAHLMNWESPEDIAF
MAV_5277|M.avium_104 EMLDLSADAHAAGARLYP----QIAARPFGMMIGFQGHHGFSHRPTYRRL
::: . . * : : : : * * :
Mb1881|M.bovis_AF2122/97 AESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMK
Rv1850|M.tuberculosis_H37Rv AESRIRPSTIAAEDVLHDMGAISMIGSDSQAMGRVGEVVLRTWQTAHVMK
MMAR_2724|M.marinum_M AESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRVGEVVMRTWQTAHVMK
MUL_3029|M.ulcerans_Agy99 AESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRVGEVVMRTWQTAHVMK
Mvan_3082|M.vanbaalenii_PYR-1 AESRIRPSTIAAEDLLHDIGAISMIGSDAQAMGRIGEVVMRTWQTAHVMK
MAB_2425|M.abscessus_ATCC_1997 AESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVMRTWQTAHVMK
TH_1059|M.thermoresistible__bu AESRIRPSTIAAEDLLHDIGAISMIGSDSQAMGRIGEVVLRTWQTAHVMK
Mflv_1685|M.gilvum_PYR-GCK AESRIRRETIAAEDVLHDLGAISAMGSDSQGMGRIGETIARTWQLASHMR
MSMEG_1094|M.smegmatis_MC2_155 AEARIRPQTMVAEDLLHDMGAISIFGSDTQGMGRVAENIANCWQLAAVMK
MAV_5277|M.avium_104 AAECSREE--LAQRLADPAVKAAILGEDDLPVDPT-LLFDGMFALVQHSL
* * . *: : . : :*.* :. . : .
Mb1881|M.bovis_AF2122/97 ARRGALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKL
Rv1850|M.tuberculosis_H37Rv ARRGALEGDPSGSQAADNNRVRRYIAKYTICPAIAHGMDHLIGSVEVGKL
MMAR_2724|M.marinum_M QRRGALEGDPSGRYSADNNRARRYVAKYTICPAVAHGLDHEVGSVEVGKL
MUL_3029|M.ulcerans_Agy99 QRRGALEGDPSGRYSADNNRARRYVAKYTICPAVAHGLDHEVGSVEVGKL
Mvan_3082|M.vanbaalenii_PYR-1 RRRGFLPGDT----KADNARAKRYVAKYTICPAVAHGLDGEIGSVEVGKL
MAB_2425|M.abscessus_ATCC_1997 KRRGALPGDPSGPNGNDNNRVRRYVAKYTICPAITHGIDHEIGSVEVGKL
TH_1059|M.thermoresistible__bu RRRGALPGDTGGPHGADNHRVRRYVAKYTICPAIAHGLDREVGSVEVGKL
Mflv_1685|M.gilvum_PYR-GCK ATRGPLPGDEG--TGADNARILRYVAKLTINPARLFGIDHEVGSLEPGKL
MSMEG_1094|M.smegmatis_MC2_155 QRVGRLPEEKT--VAADNERVKRYIAKLTINPAISVGADDHIGSVEVGKV
MAV_5277|M.avium_104 HRLYALGDPPDYEPTPDRTVAAIAEARGEDPLATLYDLMLDADATNMLML
* *. *: * . .: : :
Mb1881|M.bovis_AF2122/97 ADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTP-QPVLPRPMFG
Rv1850|M.tuberculosis_H37Rv ADLVLWEPAFFGVRPHVVLKGGAIAWAAMGDANASIPTP-QPVLPRPMFG
MMAR_2724|M.marinum_M ADLVLWEPAFFGVRPHAVVKGGAIAWAAMGDANASIPTP-QPVLPRPMFG
MUL_3029|M.ulcerans_Agy99 ADLVLWEPAFFGVRPHAVVKGGAIAWAAMGDANASIPTP-QPVLPRPMFG
Mvan_3082|M.vanbaalenii_PYR-1 ADLVLWEPAFFGVRPHAVVKGGMIAWAAMGDANASIPTP-QPVLPRPMFG
MAB_2425|M.abscessus_ATCC_1997 ADLVLWEPAFFGVRPHAVIKGGGIVWAAMGDANASIPTP-QPVFPRPMFS
TH_1059|M.thermoresistible__bu ADLVLWEPKFFGVRPHAVLKGGMIAWAAMGDANASIPTP-QPVLPXXXPP
Mflv_1685|M.gilvum_PYR-GCK ADIVLWEPKFFGIRPEVVFKGGFPAWSVMGEANASLMTC-EPLRYRPQWA
MSMEG_1094|M.smegmatis_MC2_155 ADLVIWKPAFFGVKPQVVLKNGYIAWAALGDAAGSISSS-EPIIQRPNWA
MAV_5277|M.avium_104 PLFNYADGNCDAIREMLLHPAGVLGLSDGGAHCGMICDASYPTFLLTHWA
. : . .:: : * : * . : *
Mb1881|M.bovis_AF2122/97 AAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLN
Rv1850|M.tuberculosis_H37Rv AAAATAAATSVHFVAPQSIDARLADRLAVNRGLAPVADVRAVGKTDLPLN
MMAR_2724|M.marinum_M ASPAVAAATSVHFVAAQSIEAGLADQIAVDRRLVPVADVRAVGKADMPLN
MUL_3029|M.ulcerans_Agy99 ASPAVAAATSVHFVAAQSIEAGLADQIAVDRRLVPVADVRAVGKADMPLN
Mvan_3082|M.vanbaalenii_PYR-1 AAPAAAAATSVHFVAPQAIEDGLADRIAVNRKLVAVGNVRGVGKAQMPLN
MAB_2425|M.abscessus_ATCC_1997 AMHAVAAGLAVHFVSPTAIEDDLAARLALRRRLVPTRDVRNRGKADLPLN
TH_1059|M.thermoresistible__bu PPPDPYGPDRPRFVQSSHPLIGSAP-----DRRVPCPQVGG-GPACAPRR
Mflv_1685|M.gilvum_PYR-GCK AFGRAPADVSVNFVAGAAIDAGLGQQLGLDTRLVACRGARALTKADLLHN
MSMEG_1094|M.smegmatis_MC2_155 ALGDAAADGGFVFMSSLAIDAGVPERLGLRKHVLPIKSVRSLRKKDMVRN
MAV_5277|M.avium_104 RDRSRGDKLALEYVIRKQSRDTAHLFGLTDRGTIEPGKKADINVIDMDAL
::
Mb1881|M.bovis_AF2122/97 DALP------------SIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFL
Rv1850|M.tuberculosis_H37Rv DALP------------SIEVDPDTFTVRIDGQVWQPQPAAELPMTQRYFL
MMAR_2724|M.marinum_M DAQP------------RIEVDPDTFTVRIDGEVWEQQPATELPMAQRYFL
MUL_3029|M.ulcerans_Agy99 DAQP------------RIEVDPDTFTVRIDGEVWEQQPATELPMAQRYFL
Mvan_3082|M.vanbaalenii_PYR-1 DATP------------DIEVDPDTFTVRIDGEVWQEQPATELPMAQRYFL
MAB_2425|M.abscessus_ATCC_1997 DAMP------------DIRVDPDTFTVRIDGEVWEEHPAAELPMAQRYFL
TH_1059|M.thermoresistible__bu RVSS------------HPGV------------------------------
Mflv_1685|M.gilvum_PYR-GCK DHLP------------DIRIEPDTYRVTVDGQPCVSTPMTEVPLGRRYTL
MSMEG_1094|M.smegmatis_MC2_155 DALP------------HVEVDPRTFDVRADGVLLTAEPAVSVPFSRKFLL
MAV_5277|M.avium_104 RLHPAAMAFDLPAGGNRILQGASGYAATIVSGTVTRRNDVDTGARPGRLV
.
Mb1881|M.bovis_AF2122/97 F---
Rv1850|M.tuberculosis_H37Rv F---
MMAR_2724|M.marinum_M F---
MUL_3029|M.ulcerans_Agy99 F---
Mvan_3082|M.vanbaalenii_PYR-1 F---
MAB_2425|M.abscessus_ATCC_1997 F---
TH_1059|M.thermoresistible__bu ----
Mflv_1685|M.gilvum_PYR-GCK K---
MSMEG_1094|M.smegmatis_MC2_155 R---
MAV_5277|M.avium_104 RGAR